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target organs, and the fullerene existed in the blood was possibly excreted rapidly into the urine through kidney. But there is possibility fullerene might be metabolized to metabolites by metabolic enzymes. 1195 AIRWAY INFLAMMATION IN MICE EXPOSED TO OVALBUMIN ALLERGEN AND MULTI-WALLED CARBON NANOTUBES (MWCNT) IS REGULATED BY CYCLOOXYGENASE-2 (COX-2). B. C. Sayers 1 , E.E.Glista 1 , A. J. Taylor 1 , R. Langenbach 2 and J. C. Bonner 1 . 1 Environmental and Molecular Toxicology, North Carolina State University, Raleigh, NC and 2 Laboratory of Molecular Carcinogenesis, NIEHS, Research Triangle Park, NC. Growing evidence suggests inhalation exposure to multi-walled carbon nanotubes (MWCNT) pose a significant human health risk by causing lung injury, inflammation, and fibrosis. We previously showed that inhaled MWCNT cause airway fibrosis in mice that were pre-exposed to ovalbumin (OVA) allergen challenge. Cyclooxygenase-2 (COX-2) is an important mediator of pulmonary fibrosis and asthma. This study was designed to test the hypothesis that COX-2 plays a protective role in airway inflammation and fibrosis in mice exposed to OVA and MWCNT. COX-2-deficient (COX-2-/-) mice or wild-type (COX-2+/+) mice were pre-exposed to saline or OVA prior to oropharyngeal aspiration (OPA) of MWCNT (4 mg/kg) or vehicle (0.1% pluronic in saline). Lungs were collected at 1 and 14 days after MWCNT exposure for histopathology, RNA, protein, and collection of bronchoalveolar lavage fluid (BALF). MWCNT delivered by the OPA method were evenly distributed throughout the lung and contained mainly within alveolar macrophages. Differential counts of BALF cells at 1 day showed that OVA alone, but not MWCNT alone, caused a significant increase in inflammatory cells from either COX-2+/+ or COX-2-/- mice. Combined OVA/MWCNT exposure increased total cell counts in COX-2+/+ above that seen with OVA alone. BALF cell counts were elevated even more in COX-2-/- mice exposed to OVA/MWCNT as compared to COX-2+/+ mice. OVA alone increased IL-13 protein in BALF to a similar level in either COX-2+/+ and COX-2-/- mice (~25 pg/ml) whereas IL-13 was not detectable in saline or MWCNT groups. Combined OVA/MWCNT also increased IL-13 to ~25 pg/ml in COX-2+/+ mice, yet OVA/MWCNT caused a significant increase in IL-13 in COX-2-/- mice (~75 pg/ml). These findings suggest that COX-2 plays an important role in reducing MWCNT-induced airway inflammation in individuals with pre-existing asthma. (Funded by NIEHS RC2-ES018772-01 and NIEHS T32-ES007046) 1196 RESPIRATORY EFFECTS OF INHALED SINGLE- WALLED CARBON NANOTUBES: THE ROLE OF IRON AND PARTICLE MORPHOLOGY. A. K. Madl, A. Tsumura, K. Johnson, V. Seshachellam, P. C. Edwards, S. V. Teague, T. Guo, L. S. Van Winkle, J. E. Evans and K. E. Pinkerton. University of California, Davis, Davis, CA. With worldwide production of carbon nanotubes (CNTs) exceeding over 500 metric tons annually and industry growth expecting to double over the next 5 yr, there are concerns our understanding of the hazards of these nanomaterials may not be keeping pace with market demand. The physicochemical properties of CNTs may delineate the key features that determine either toxicity or biocompatibility and assist in evaluating the potential health risks posed in industrial and consumer product settings. We hypothesized that the iron content and morphology of inhaled single-walled carbon nanotubes (SWCNTs) influences the extent of cellular injury and alters homeostasis in the lung. Rats (SD) were exposed (1 mg/m3) to either aerosolized SWCNTs (raw FeSWCNT or purified cSWCNT), carbon black (CB), crocidolite, or fresh air via nose-only inhalation for 6 hr/d for 10 d. Markers of inflammation and cytotoxicity in lung lavage and mucin in different airway generations were used to assess immediate and persistent effects. The oxidant and inflammatory capacity of microdissected airways of exposed animals was used to assess the ability to withstand an additional oxidant insult. Results showed different timing and extent of responses resulting from exposure to SWCNTs containing varied amounts of iron. Depending on the endpoint of interest, responses of SWCNTs sometimes followed that of CB while in other circumstances matched that of crocidolite. Notably, FeSWCNTs exposed animals were unable to respond to an additional oxidant challenge and cSWCNTs exposed animals had a latent and persistent development of mucous cells in the distal airways. In conclusion, while some toxicity endpoints follow patterns comparable to CB or crocidolite, the respiratory effects of inhaled FeSWCNTs and cSWCNTs appear to be unique. Further research is needed to evaluate whether these changes are suggestive of precursor events to pathologic changes that might develop under more severe or prolonged exposure conditions. UC TSRT&P and RC1ES018232 256 SOT 2011 ANNUAL MEETING 1197 IN VIVO TOXICITY STUDY OF QUANTUM DOT NANOPARTICLES FOLLOWING INTRAVENOUS ADMINISTRATION IN MICE. J. Treadway 2 , J. Bartel 2 , J. Schatz 3 and S. Kim 1 . 1 Design-for-Environment, Life Technologies, Foster City, CA, 2 Life Technologies, Eugene, OR and 3 Design-for- Environment, Life Technologies, Madison, WI. Quantum dots provide the revolutionary fluorescence performance inherent in the nanocrystal structure with a highly customizable surface for directing the bioactivity of the nanocrystals or for conjugating them to a wide range of biomolecules of interest, and hence are increasingly used in a wide variety of biomedical research. In this study, we have evaluated various Qdot® nanocrystals (Qdot® 655 Carboxyl and PEGylated amine-functionalized variant) for in vivo toxicity in mice (CD-1/female; 12 or 18 / group; intravenous via tail vein; 0.333 -33.3 nM/Kg, 5 ml/Kg). LD50 values could not be estimated as maximally concentrated dosages were found to be non-lethal in all cases, but limiting values will be described. Additionally, no physiological, behavioral, or histological evidence of toxicological impact was observed within a wide range of practical working dosages, even following repeated dosing. Nevertheless, at very high doses, some toxicity was seen in the liver as determined by elevated liver enzymes (AST and ALT) after exposure to Qdot® 655 Carboxyl nanoparticles. Interestingly, studies on related test materials showed no toxic effect on the liver even at the highest dose strongly suggesting that particle composition is a strong determinant of toxicological behavior at these high dosages. These physiological changes were further evidenced by subtle histological changes found in the liver at the higher doses. Inflammatory changes were seen, predominantly around the portal veins. There was an increase in inflammation with some areas showing necrosis and changes suggesting early granuloma formation. In conclusion, clinical chemistry and histological changes were observed only for the highest doses, which are significantly higher than practical concentration for imaging in vivo in mice and the results of this study suggests that the Qdot® nanocrystals used in this study are not toxic at a useful concentration for in vivo imaging applications (approx. 20 pmol/animal). 1198 EXPOSURE AND DISEASE SUSCEPTIBILITY DIFFERENCES IN U.S. AND SWEDISH POPULATIONS: IMPLICATIONS FOR ASSESSMENT OF RISKS FROM USE OF TOBACCO PRODUCTS. C. Ward, G. Mariano and A. Santamaria. Environ International, Arlington, VA. As the US looks to the Swedish experience with the smokeless tobacco product, snus, as a possible model for reducing harm from smoked tobacco, researchers have asked questions about the applicability of health effects data generated on the Swedish population to US populations. Numerous epidemiology and clinical studies exist on the potential population harms from snus in the Swedish population. We sought to understand whether the findings from these health studies can be expected in the US, even under the same or similar tobacco exposure scenarios, in terms of comparability of populations, on several levels of disease-related factors. First, standardized rates of tobacco-related diseases from the two countries were identified and compared. We also identified and compared rates of demographic, behavioral, and lifestyle factors that may influence susceptibility and disease risk. These include differences in diets, exercise and other lifestyle factors, and differences in potential influences from other environmental exposures, such as metals and persistent chemicals. A specific example is given for cadmium, a known nephrotoxicant. Cadmium exposures for smokers are known to be higher than those of nonsmokers, and the body burdens of cadmium in the Swedish population have decreased measurably over several decades, attributed to reductions in smoking rates. We discuss whether similar reductions in cadmium body burdens can be expected in the US from similar declines in smoking, and the implications for disease risk. In addition, we summarize known population differences between the US and Sweden in specific genetic polymorphisms and the potential influence of these differences on disease risk. 1199 PULMONARY FUNCTION TESTING IN BOAT MANUFACTURER WORKERS. G. T. Johnson, S. C. Harbison, J. D. McCluskey, P. Xu, L. Thomas, S. Goldman and R. D. Harbison. Environmental and Occupational Health, University of South Florida, Tampa, FL. Styrene is widely used in boat manufacturing and uncontrolled exposure may lead to pulmonary function (PF) impairment in workers. This investigation used occupational health monitoring examination data to characterize PF in a population currently employed as boat manufacturer workers. PF tests for workers (n = 105) who required health examinations to ensure fitness for continued respirator use were compared to NHANES III Raw Spirometry subjects (n = 8,873) to determine
if abnormal PF was associated with employment as a boat manufacturer worker. Mean FVC and FEV1 values were determined and linear regression was used to evaluate the impact of boat manufacturer worker status on PF after adjusting for confounders. Workers produced statistically significant higher mean FVC and FEV1 values of 4.94 L (95%CI 4.75 - 5.13) and 3.86 L (95%CI 3.72 - 4.01) respectively compared to mean NHANES III subject values of 4.01 L (95%CI 3.98 - 4.02) and 3.20 L (95%CI 3.18-3.21). Stratification by age, height, and smoking status yielded similar results. Multivariate regression analysis demonstrated that significant predictors of FEV1 included age, height, gender, and pack-years of smoking (all p-values < 0.0001), but not boat manufacturer employment (p = 0.2023). Significant predictors of FVC included age, height, and gender (all p-values < 0.0001). Employment as a boat manufacturer worker was significantly associated with an increase in FVC (p < 0.0001). The moderate increase in PF observed in boat manufacturer workers is likely due to a combination of effective exposure controls in the workplace and the healthy worker effect. 1200 CIRCULATING LEVELS OF PERSISTENT ORGANIC POLLUTANTS ASSOCIATE IN DIVERGENT WAYS TO FAT MASS IN HUMANS. M. Rönn1 , L. Lind1 , B. van Bavel2 , S. Salihovic2 , K. Michaelsson3 and M. P. Lind1 . 1Department of Medical Sciences, Uppsala University, Uppsala, Sweden, 2MTM Research Center, Örebro University, Örebro, Sweden and 3Department of Surgical Sciences, Uppsala University, Uppsala, Sweden. Background: Environmental contaminants have recently been implicated in the pathogenesis of obesity. The present study aims to explore the relationship between Persistent Organic Pollutants (POPs) and fat mass in humans. Material and methods: In the Prospective Study of the Vasculature in Uppsala Seniors (PIVUS) study, fat mass was determined by dual-energy X-ray absorptiometry (DXA) together with twenty-one POPs (including 16 polychlorinated biphenyl (PCB) congeners, 3 organochlorine (OC) pesticides, 1 brominated diphenyl ether (BDE47) and 1 dioxin) measured in plasma (high resolution chromatography coupled with high resolution mass spectrometry) collected at baseline in 890 participants aged 70 years. Results: Lipid-standardized plasma concentrations of Octa-chlorinated dioxin (OCDD), the PCBs 74, 99, 105 and 118 and the pesticides hexachlorobenzene (HCB), transnonachlordane (TNK) and dichlorodiphenyldichloroethylene (DDE), were all positively related to fat mass (p=0.03-0.0001). On the contrary, the PCBs 156, 157, 169, 170, 180, 189, 194, 206 and 209 were negatively related to fat mass (p=0.0001). Following adjustment for smoking, physical activity, education level, height, lean mass and gender these results remained significant (p=0.01-0.0001) except for PCB 74 and 99. For some of the negatively related PCBs the effects were more pronounced in women than in men. Conclusion: Plasma concentrations of some pesticides are positively related to fat mass, while divergent effects are seen for the PCBs. These results implicate a complex role of POPs in obesity. 1201 CIRCULATING LEVELS OF PHTHALATES, BISPHENOL A, AND ABDOMINAL OBESITY. M. P. Lind1 , M. Rönn1 , K. Michaelsson2 , D. A. Birkholz3 , L. Johansson4 , H. Ahlström4 and L. Lind5 . 1Department of Medical Sciences, Occupational and Environmental Medicine, Uppsala University, Uppsala, Sweden, 2Department of Surgical Sciences, Uppsala University, Uppsala, Sweden, 3Environmental Division, ALS, Edmonton, AB, Canada, 4Department of Radiology, University Hospital, Uppsala, Sweden and 5Department of Medical Sciences, Acute and Internal Medicine, Uppsala University, Uppsala, Sweden. BACKGROUND: The plastic manufacture substances phthalates and bisphenol A (BPA) has previously been suggested to be obesogens. Since abdominal obesity is more closely related to cardiovascular disease than peripheral obesity, we investigated the relationship between circulating levels of some phthalate metabolites, BPA and obesity measures obtained by Magnetic resonance imaging (MRI) and Dual energy X-ray absorptiometry (DXA). METHODS: In the population-based Prospective Investigation of the Vasculature in Uppsala Seniors (PIVUS) study (1016 subjects all aged 70), serum levels of BPA and phthalate metabolites were measured by Isotope Dilution-High Performance Liquid Chromatography-Tandem Mass Spectrometry. Waist circumference and trunk fat mass by DXA were measured in 890 subjects, while subcutaneous and visceral abdominal fat were evaluated by MRI in 287 individuals. RE- SULTS: BPA and four phthalate metabolites (Monoisobutyl phthalate (MiBP), Monomethyl phthalate (MMP), Monoethyl phthalate (MEP), Mono-(2-ethylhexyl) phthalate (MEHP)) were detectable in almost all subjects. MiBP was related to waist circumference (p=0.013), trunk fat at DXA (p=0.004) and subcutaneous abdominal fat at MRI (p=0.001) in women, but not in men (p=0.05-0.003) for gender difference in association). BPA and the other 3 detectable phthalates did not relate to obesity measures. CONCLUSION: The phthalate metabolite MiBP is related to central obesity in women, but not in men. 1202 ATHEROSCLEROSIS IS RELATED TO CIRCULATING LEVELS OF PERSISTENT ORGANIC POLLUTANTS (POPS) IN THE ELDERLY. L. Lind 1 , B. van Bavel 2 , S. Salihovic 2 and M. P. Lind 3 . 1 Acute and Internal Medicine, Department of Medical Sciences, Uppsala University Hospital, Uppsala, Sweden, 2 MTM Research Centre, School of Science and Technology, Örebro University, Örebro, Sweden and 3 Occupational and Environmental Medicine, Department of Medical Sciences, Uppsala University, Uppsala, Sweden. BACKGROUND: Increased circulating levels of persistent organic pollutants (POPs) have previously been associated with myocardial infarction. Since myocardial infarction is an atherosclerotic disease, we here investigated if levels of POPs are related to atherosclerosis. METHODS AND RESULTS: In the population-based Prospective Investigation of the Vasculature in Uppsala Seniors (PIVUS) study (1016 subjects all aged 70), the prevalence of carotid artery plaques were recorded by ultrasound. The number of carotid arteries with plaques (0, 1 or 2) was recorded. Also the thickness (IMT) and grey scale (IM-GSM) of the intima-media complex were measured. Twenty-one different POPs including 14 PCBs, 5 pesticides, one dioxin and one brominated compound (BDE47) were analysed by high resolution chromatography coupled to high resolution mass spectrometry (HRGC/ HRMS). Nine out of the PCBs (congeners 99, 153, 138, 156, 180,170, 194, 206 and 209) were related to the number of carotid arteries with plaques even after adjustment for gender, waist circumference, body mass index, fasting blood glucose, systolic and diastolic blood pressure, HDL and LDL-cholesterol, serum triglycerides, smoking, antihypertensive treatment and statin use (p=0.004-0.0001). High levels of the highly chlorinated PCBs (194,206 and 206) were associated with an echolucent IM-GSM (p
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The Toxicologist Supplement to Toxi
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The Toxicologist Supplement to Toxi
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1 BIODEGRADABLE MATERIALS FOR TISSU
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that genetic toxicology data are ge
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well-orchestrated lung inflammation
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scribed in the literature. We have
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years ago). We will illustrate how
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involved in the biodegradation proc
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stem cells but rather a treatment i
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additional compound showed agreemen
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82 COMPARISON OF 3H-THYMIDINE INCOR
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irritants. While in practice these
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alleles are especially vulnerable t
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109 CD4+ T CELL INTRINSIC TNF RECEP
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118 TO STUDY THE SIGNAL TRANSDUCTIO
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PAHs, such as dioxins, are prevalen
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containing substituents and/or hydr
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146 COMPUTATIONAL MODELING FOR QT P
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suggest that the combination of too
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164 TRANSLOCATOR PROTEIN (18 KDA) (
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function as a metal binding protein
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laboratory has demonstrated that NR
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known. The aim of this study was to
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from 5 to 28 days in duration) in e
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positive cells, caspase-3 activatio
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creased level in the 46 kDa preproe
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invasiveness at concentrations repr
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thracene (DMBA,50 μg in acetone, a
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247 CO-CARCINOGENESIS OF N, N- DIET
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sponds to the endosomal dsRNA that
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ODD in both WT (maximum 177% of con
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Lastly, using p53siRNA cells, p53 w
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its receptor Mpl to exert its funct
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294 LOW LEVEL OF LEAD CAN INDUCE PH
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lunar surface presented potential h
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lar about cellular export mechanism
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DNA in the kidney medulla, grandula
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5.00 and 7.50 mg/kg/day by oral gav
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events and carcinogenesis. Here we
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tinization of cells of the hair fol
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358 CHARACTERIZATION OF GENOME-WIDE
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RNAi were also performed to identif
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376 A FUNCTIONAL CROSSTALK BETWEEN
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UGT1A gene induction, while this re
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tivity, specifically peroxisome pro
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and cytotoxic effects; however, its
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histone deacetylase that is necessa
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ment. Paradoxically, buthionine sul
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drug leflunomide and its major (A77
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442 GENE EXPRESSION AND MORPHOLOGIC
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451 INHIBITION OF THE MITOCHONDRIAL
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460 SULFORAPHANE PREVENTS ACETAMINO
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drophilic/lipophilic balance. Other
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pharmacokinetic and toxicological p
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489 USE OF ‘OMICS DATA TO IMPROVE
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498 APPLICATION OF AGE-SPECIFIC ADJ
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507 A DOSE VOLUME TOLERABILITY STUD
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involved the use of an acute inflam
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sorption in the gastrointestinal (G
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(ABC) transporters actively transpo
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545 BEHAVIORAL EFFECTS OF REPIN IN
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a blood pressure phenotype that res
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and inhalation exposure system that
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and lethality associated with these
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position, on vascular reactivity an
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therefore more accurate and reprodu
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commercial chrysotile product that
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elative to their controls. ST-depre
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ats. The majority of the studies fo
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in the China Jintan Child Cohort St
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corneum thickness, cellular epiderm
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645 EVALUATION OF THE IN VITRO EPIS
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654 TCDD ADSORBED ONTO NATURAL AND
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tion revealed no test article-relat
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671 INFLAMMATION AND TISSUE DAMAGE
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model, ethanol was found to inhibit
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689 ENHANCED SUPPRESSIVE FUNCTION O
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NAC + LPS yielded different levels
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707 LIFE-STAGE PBPK MODELS FOR MULT
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downstream of the apical endpoint o
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726 UPDATED ALUMINUM PHARMACOKINETI
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global parameter sensitivity analys
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and renal inflammation induced by 2
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754 PLASMA, URINE, AND TISSUE CONCE
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cently characterized transporter OA
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exposure system was developed from
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lood cell mass and decrease in urin
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practical alternatives to MC in non
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imals dosed with 167 mg/kg THU alon
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and organ weights, clinical signs a
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yet is induced in most bladder and
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830 RISK ASSESSMENT OF THE SPILL: C
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knowledgebase creation. Results are
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852 UNDERSTANDING STRUCTURAL AND PH
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for integrating epidemiology and an
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motor activity, including age of th
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y partial purification of urine (fr
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pacity for self-renewal and may dif
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sue. The depth of our analysis led
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910 IMPLEMENTING CALIFORNIA’S GRE
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concentrations in six tissues and b
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934 THE FDA’S LIVER TOXICITY KNOW
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943 GENOME-WIDE DNA METHYLATION DIF
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membrane localization and subsequen
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Page 239 and 240: events in the liver. AZD9056 was ev
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cisplatin; 1.2-, 1.9- and 2.9-fold
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Day 11 and started to recover on Da
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1448 DEVELOPMENT OF A METHOD FOR QU
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1457 GLOBAL GENE PROFILING REVEALS
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cluding mouse and human macrophage,
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model of lung inflammation and host
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1484 NANOTOXICOLOGY AND NANOHEALTH
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throughput in vitro approach was us
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1502 IMMUNOLOGICAL ASPECTS OF AN AN
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(CIA) and the Streptococcal cell wa
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sitizers were 100% concordant among
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1530 MINIMAL RISK LEVELS FOR STYREN
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ical groups in the field of regulat
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vitro with this potentially insect-
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their performance on toxicological
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need for a better understanding of
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1577 AN IN VITRO MODEL SYSTEM FOR A
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gene expression post-transcriptiona
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1595 GENE EXPRESSION PROFILE OF RAT
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to confirm a hepatotoxic property o
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1613 AN INVESTIGATION OF THE CLEARA
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its nuclear translocation was reduc
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were collected from TK animals at d
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egulated targets were selected for
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U/L after tetracycline. Minocycline
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peri-pubertal FasL-/- mice show a d
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showed similar levels of apoptosis
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1676 TWO BIOMARKERS FOR EVALUATION
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motifs selected. This system was ap
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1693 VOC SERUM LEVELS IN THE GENERA
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1702 DOES THE CLOCK MAKE THE POISON
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those with high nickel content are
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isk assessment. However, unique cha
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model of APAP metabolism and glutat
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logically & morphologically similar
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posure, blood chemistry was analyze
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elated to oxidative stress by measu
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ostasis), but work is needed to tra
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tokine products during carcinogenes
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ways as chemical stressors and, the
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toxicity of nanomaterials relates s
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1815 MEASURING COMPOUND SELECTIVITY
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1825 EFFECTS OF METABOLISM BY INTES
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cyanoacetic acid increased 2-3 fold
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1845 IS THE PROMISCUITY OF THE ARYL
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crorarray analysis. RT-PCR results
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are a family of phase-II biotransfo
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ous labs. As a result of positive s
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down the doses may produce more tox
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spectively. Below 100 mg/l of gemfi
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1900 GENERATION OF PRECISION CUT LI
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iomarkers or observation of lesions
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creased reticulocytes and lymphocyt
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statistically significant interacti
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monize sample preparation and analy
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NPC and sinonasal cancer in neighbo
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showed incidences of lung and nasal
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utylbenzenes, exhibited most simila
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1975 DIFFERENTIAL MODULATION OF CYP
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organic As to MMA(V) and a lower ca
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ole in invasion and metastasis of c
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3T3-L1 cells to low-levels of arsen
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2011 IDENTIFICATION OF A NOVEL VX M
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This work was supported by Cooperat
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2029 EFFICACY OF ENDOTRACHEAL ADMIN
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Diazepam injections and its combina
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2047 ESTERASE ACTIVITIES AND HEMOST
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nanoparticle-induced toxicity progr
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house, were iv infused into rats ov
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een explored. This study investigat
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croscopic analysis revealed that on
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egg yolk collected from turtles inh
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consistency of results in both expe
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2111 CYTOCHROME P450 3A5 GENOTYPE I
Page 459 and 460:
esidues of organophosphates or thei
Page 461 and 462:
manganism. Recent work from our lab
Page 463 and 464:
Aβ1-40 in CSF and hippocampus in P
Page 465 and 466:
2147 CATALASE MANIPULATIONS MODIFY
Page 467 and 468:
ation based on real-world exposure
Page 469 and 470:
NPs. Aggregation of citrate-stabili
Page 471 and 472:
2175 THE ROLE OF SURFACE CHEMISTRY
Page 473 and 474:
seen rapid uptake in biological ima
Page 475 and 476:
effect on uterine weight or vaginal
Page 477 and 478:
dicating widespread exposure. While
Page 479 and 480:
components into the liver parenchym
Page 481 and 482:
2223 ISOLATION AND DETECTION OF RIC
Page 483 and 484:
stored (-20 celsius degree). The co
Page 485 and 486:
2241 DDA, A BIOMARKER FOR ENVIRONME
Page 487 and 488:
2249 INTERACTION BETWEEN DIETARY SE
Page 489 and 490:
2258 PHARMACOKINETICS, EXCRETION BA
Page 491 and 492:
2267 SENSITIVE AND SPECIFIC FLUORES
Page 493 and 494:
2276 METABOLISM AND DISPOSITION OF
Page 495 and 496:
ment of hypertension in companion a
Page 497 and 498:
for the propyl series can be used f
Page 499 and 500:
2304 IN VITRO EXPOSURE AND EVALUATI
Page 501 and 502:
2313 THE SYNERGISTIC EFFECT OF SODI
Page 503 and 504:
genes that play a crucial role in M
Page 505 and 506:
2330 THE ROLE OF TRANSFORMING GROWT
Page 507 and 508:
ined following up to 96 h continuou
Page 509 and 510:
effect doses obtained with the rat
Page 511 and 512:
diated transcriptional response of
Page 513 and 514:
docrine disruptor activities of EDC
Page 515 and 516:
individuals. Week 6 results were qu
Page 517 and 518:
functionality of photosystem II and
Page 519 and 520:
wild mice (Mus musculus) from areas
Page 521 and 522:
2406 TOXICITY AND BIOACCUMULATION O
Page 523 and 524:
Isocitric acid is the acid in the h
Page 525 and 526:
2425 EFFECTS OF FUMONISINS IN ETHAN
Page 527 and 528:
centration(μg/g) were: 5.1-95.3; 2
Page 529 and 530:
2445 AUTOPHAGY IN DEVELOPMENT: A LI
Page 531 and 532:
sures to inhaled Mn in dust. Nevert
Page 533 and 534:
2466 CRITICAL EVALUATION OF ANIMAL
Page 535 and 536:
elationships predict that resting r
Page 537 and 538:
2489 COMPARATIVE TOXICITY OF BIODIE
Page 539 and 540:
2497 TRANSCRIPTIONAL REGULATION OF
Page 541 and 542:
2506 TOXICOLOGICAL CONSIDERATIONS O
Page 543 and 544:
launched with the aim of developing
Page 545 and 546:
forms mRNA expression levels were a
Page 547 and 548:
2534 CUTANEOUS WOUND HEALING IN THE
Page 549 and 550:
wells (0, 1, 5, 10, 25, 50, 100, an
Page 551 and 552:
2553 AN ORGANOTYPIC MICROLIVER PLAT
Page 553 and 554:
serum-free media. At 24 hrs, the gr
Page 555 and 556:
2572 INCREASED ARSENIC BIOACCESSIBI
Page 557 and 558:
nology to develop improved methods.
Page 559 and 560:
tuna, swordfish, or mako shark (3.5
Page 561 and 562:
nificantly reduce circulating thyro
Page 563 and 564:
grouped into 9 observation periods
Page 565 and 566:
histopathological or biochemical ev
Page 567 and 568:
exhibited a hyperactive phenotype,
Page 569 and 570:
the search of effective drugs for e
Page 571 and 572:
2644 COVALENT BINDING OF 14 C 2-MET
Page 573 and 574:
aries targeting all transcription f
Page 575 and 576:
(p 9 weeks) and CSC phenotype acqui
Page 577 and 578:
2673 IMMUNE-MEDIATED VASCULAR INJUR
Page 579 and 580:
for risk identification and charact
Page 581 and 582:
to control toxicant delivery in tob
Page 583 and 584:
Author Index (Continued) The numera
Page 585 and 586:
Page 587 and 588:
Page 589 and 590:
Page 591 and 592:
Page 593 and 594:
Page 595 and 596:
Page 597 and 598:
Page 599 and 600:
Page 601 and 602:
Page 603 and 604:
Page 605 and 606:
Page 607 and 608:
Page 609 and 610:
Page 611 and 612:
Keyword Index (Continued) Arsenite
Page 613 and 614:
Keyword Index (Continued) Covalent
Page 615 and 616:
Keyword Index (Continued) flow cyto
Page 617 and 618:
Keyword Index (Continued) innate im
Page 619 and 620:
Keyword Index (Continued) nanoparti
Page 621 and 622:
Keyword Index (Continued) preservat
Page 623 and 624:
Keyword Index (Continued) Thrombocy
Page 625 and 626:
Toxicological Sciences The Official
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The Toxicologist - Society of Toxicology

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