The Toxicologist - Society of Toxicology

More documents

Recommendations

Info

KEY WORD INDEX Keyword Index (Continued) safety assessment: non-phamaceutical ........................................... 1560 safety biomarker ............................... 124 safety evaluation ............ 467, 491, 1552 Safety Pharmacology .......... 3, 201, 852, 1724, 2468, 2469, 2471 Safety testing ............................ 11, 2684 Salmonella mutagenicity assay ........ 336 Salmonella/microsome mutagenicity assay ......................... 1409 sandwich-cultured hepatocytes ...... 1081 SAR ................................................ 1965 Sarcocysis. fayeri ........................... 1211 sarin ...................................... 1334, 2035 SAS .................................................. 490 SBDP-145 ...................................... 1443 school ............................................. 1546 Science and Decisions .................... 1962 science outreach ............................. 1866 Science Policy ...................... 1484, 2508 Scopolamine ............... 1646, 2016, 2041 Screening ..................... 867, 1523, 1910, 2452, 2675 screening assays ............................. 2367 screening levels ................................ 863 Sculpin ........................................... 2386 SDF-1b ........................................... 1664 Seafood .......................................... 1974 seafood safety ................................. 1963 Secondhand Smoke .............. 1253, 1254 secondhand tobacco smoke .............. 834 segmental duplication .................... 1770 Seizure .................................... 399, 1742 seizures ... 1804, 1806, 1807, 1808, 2020 Selection ......................................... 1675 Selenium ...................... 311, 1398, 2249 Semicarbazide .................................. 627 senescence ...................................... 1764 senna ................................................ 235 sennosides ........................................ 235 sensitive populations ........................ 472 sepiapterin reductase ...................... 1399 Serine hydrolases ........................... 1336 serine protease inhibitor ................. 2364 serotonin ......................... 346, 964, 1881 serotonin transporter gene .............. 1363 SERT .............................................. 1829 Sertoli cell .......................................... 66 serum .................................... 1023, 2562 sex .................................................. 2492 sex differences................................ 2600 sexual development ........................ 1071 sexual differentiation.......................... 20 sexual dimorphism ................... 266, 396 sexual maturity ............................... 1923 SHE cell transformation ................. 1528 SHetA2 ........................................... 1885 Shiga toxins .............................. 37, 2414 Shipping ......................................... 1431 short time exposure ........................ 1001 Short-term health effects .................. 829 Sick Building Syndrome ................ 1573 Sick-building Syndrome ................ 1225 signal transduction ......... 400, 937, 2314 Signaling Pathways ................ 328, 1891 Signature .......................................... 876 SILAC .............................................. 970 silica ..................................... 2083, 2173 silica nanoparticles ............... 2053, 2085 siloxanes ........................................... 700 Silver .................................... 1759, 2181 Silver nanoparticle ............... 1762, 1763 Silver Nanoparticles ............ 1456, 1467, 1758, 1761, 2063, 2064, 2067, 2071, 2075, 2079 Similarity Ensemble Approach ........ 854 single cell toxicity .......................... 1234 single nucleotide polymorphism ... 1365, 1366, 1371 single walled carbon nanotubes ......... 59 618 SOT 2011 ANNUAL MEETING siRNA, ............................................. 553 Sirt 1 ................................................. 414 Sirt1 ................................................ 2499 Size ................................................. 2065 skeletal muscle ............................... 1451 skeletal muscle toxicity .................. 1589 skills ............................................... 2481 skin ............ 83, 508, 543, 544, 632, 637, 641, 642, 1006, 1750, 1751, 1780, 1781, 1782, 1993, 2026, 2030, 2072, 2554 skin absorption ................................. 634 skin carcinogenesis ......... 222, 237, 958, 1783, 1784 skin cells ........................................... 639 Skin corrosion .................................. 646 skin inflammation ................ 1783, 2574 Skin injury ............................ 1756, 2013 Skin irritation ............. 91, 469, 645, 646 skin model ...................................... 1005 skin penetration .......... 1107, 2154, 2155 skin permeability .............................. 633 skin rash ..................... 1364, 1501, 1505 skin sensitization ... 86, 90, 91, 465, 967, 974, 978, 1000, 1002, 1009, 1010, 2513, 2527, 2536, 2551 skin sensitization assay ...................... 88 skin substitute................................... 892 skin toxicity .............................. 965, 966 skin tumorigenesis ........................... 954 small Maf proteins ......................... 2127 small scale inhalation studies ........... 577 Smoke .............................................. 592 smoke inhalation .............................. 567 Smokeless Tobacco ........................ 1558 smoking .......................................... 1287 smoking cessation .......................... 1363 Smooth muscle of trachea .............. 1456 S-nitrosylation .................................. 257 social anxiety disorder ..................... 802 Social Media .................................... 419 society ............................................ 1880 SOD.................................................. 165 sodium .............................................. 203 Sodium channel ...................... 170, 1341 sodium channels ................... 1343, 1353 soft electrophiles .............. 503, 504, 505 Soil ......................................... 526, 1265 Soil Dust........................................... 670 Soil Ingestion ................................. 2572 solute carrier transporter (SLC) ..... 1597 Solutol .............................................. 781 solvent neurotoxicity ...................... 1575 soman ......................... 2020, 2034, 2039 Sp proteins ....................................... 956 Sp Transcription factors ........... 226, 955 SP1 ................................................. 1858 species differences ......................... 2100 Specificity Protein ............................ 384 Specificity protein transcription factors ............................................... 956 Specificity proteins .......................... 220 spectroscopy ................................... 2312 sperm count .................................... 2230 sperm whale ................................... 2405 sperm whales .................................. 2252 Spermatogenesis ................................ 63 sphinganine 1-phosphate ................ 1448 Sphingolipids ................................... 241 Spirulina ......................................... 2436 spleen ............................................... 112 spleen lymphocytes ........................ 1411 splenocytes ..................................... 2364 Splenotoxity ..................................... 390 Splice Variants.................................. 375 Sprague-Dawley Rat ...................... 1028 Sprague-Dawley rats .............. 531, 2075 SPRAYERS .................................... 2116 Spring Valley .................................... 928 ST depression ................................... 570 Stability .......................................... 1431 stable isotope dilution tandem mass spectrometry .......................... 1681 startle response ............................... 2617 STAT1alpha ...................................... 403 STAT3 ...................................... 441, 956 static diffusion cell ........................... 634 statin ................................................. 789 statistical association ...................... 2594 Statistics ................................... 134, 727 status epilepticus ............................ 2039 steatogenic hepatotoxicity .............. 1118 steatohepatitis ................................. 1114 Steatosis ............................... 1958, 2586 Stem cell ...... 74, 894, 1155, 1171, 1992, 1993, 2450 Stem Cell-derived Cardiomyocytes ............................. 1894 Stem cells ........ 14, 68, 72, 79, 890, 891, 895, 982, 1159, 1166, 2451, 2452, 2665, 2677 Stent ............................................... 1320 stereology ....................................... 1348 Steroid hormones ........................... 1436 steroid pathway ................................ 999 Steroidogenesis ......... 1037, 1039, 1041, 1048, 2352, 2368, 2383, 2547, 2549 Steroids .......................................... 2135 stochastic gene expression ............... 123 Store-operated calcium channels ... 1672 S-transalkylation ............................ 1305 StrataTest .......................................... 647 stress ............................. 165, 1205, 2151 Stress Response .................................. 34 stress response mutant .................... 1467 stress test .......................................... 608 striatum ............................................ 506 Strombus gigas (conch) .................. 1068 Structural Alerts ............................... 154 Structure ........................................... 857 Structure activity relationships ........ 468 Structure Activity Relationships (SAR) ..................... 141, 488, 860, 1595 structure bioactivity relationship .... 1800 structure-activity ............................ 1967 structure-activity relationships ... 75, 936 Styrene ............ 1199, 1226, 1359, 1530, 1860, 2643 subcellular localization .................. 2300 subchronic toxicity ......................... 2421 subchronic toxicology .................... 1918 Subcutaneous ................................... 618 subretinal .......................................... 524 substrate-competitive ....................... 401 Substructure Identification ............... 153 suicidality ....................................... 1541 sulfolane ......................................... 1542 sulforaphane ........................... 460, 2638 Sulfotransferase .............................. 1862 Sulfur donors .................................. 2046 Sulfur Mustard ................ 114, 544, 641, 1748, 1749, 1752, 1753, 1754, 1755, 1756, 2013, 2019, 2026, 2027, 2028, 2030, 2036, 2040 Sulfuryl Fluoride ............................ 2100 SULT1A1 ....................................... 1368 Sunitinib ......................................... 1159 Superantigen .................................. 1512 Superfund ............................... 323, 1675 Surface cleanup ................................ 863 surfactant protein-D ......................... 257 surfactants ...................................... 1526 Surgery ............................................. 270 surgical glove ................................. 1557 Surrogate ........................................ 1965 survival ........................................... 1361 susceptibility ........ 271, 819, 1337, 1338 susceptibility biomarkers ............... 2112 susceptible populations .................. 2461 Suspension Cells .............................. 316 sustainable ........................ 908, 909, 910 SW-480 .......................................... 2233 SWCNT .......................................... 1179 Swedish snus .................................. 1198 Swine................................................ 526 synaptic plasticity ........................... 2625 synaptogenesis ............................... 2620 synchrotron .................................... 1633 Synergy .......................................... 2306 Synoviocytes .................................... 362 Synthetic Tandem Repeat Promoter screening ........................ 1703 System biology................................. 481 Systemic Dose ................................ 2107 systemic toxicity .................. 1312, 1549 Systems biology .......... 9, 135, 366, 937, 1721, 1734, 1736, 1737, 1739 Systems Toxicology ............. 1593, 1739 T cell ........................................ 687, 694 T cell independent antibody response ............................................ 649 T cell subsets ...................................... 93 Tacrolimus ...................................... 2284 Tai Chi ............................................ 2204 TAM-DNA adducts ........................ 2656 Tamoxifen .............................. 428, 2656 TARC ............................................. 2209 Target Safety ............................ 125, 522 Taurine ....................... 1271, 2583, 2584 TCCD ............................................. 1704 TCDD ........................ 78, 197, 198, 213, 654, 709, 1091, 1122, 1123, 1128, 1135, 1137, 1584, 1588, 1624, 1647, 1684, 1777 TCP ................................................ 1692 TD50 ................................................ 487 TDAR ....................................... 660, 664 teeth ................................................ 1237 Telemetry ............. 562, 568, 1919, 1920 tellurium tetrachloride ...................... 302 Telomere........................................... 121 Telomeres ....................................... 2251 temperature .................................... 2381 Tempol ............................................. 961 TEQ ...................................... 1959, 1961 teratogen ............................... 1610, 2506 teratogenesis ................................... 1045 teratogenicity ...................................... 75 Teratology ...................................... 1617 terpenes .......................................... 2154 testes ........................... 1022, 1041, 1048 testicular toxicity ................................ 69 testis ..................... 64, 1441, 2084, 2191 Testosterone ............... 1032, 1039, 2088 Testosterone proprionate ................ 2189 tetrabromobisphenol A ......... 1056, 2246 Tetrachloroethylene ........................ 2641 tetrahydrouridine .............................. 799 tetrazolate ....................................... 1544 Tetrodotoxin ................................... 2430 Text Mining ...................................... 728 Tg2576 mice .................................. 1331 TGFbeta ........................................... 222 TGF-beta .......................................... 687 Th17 ............................................... 1506 Th17 cells ....................................... 1501 Thalidomide ..................................... 839 Therapeutic Antibody ..................... 1891 therapy ............................................ 1790 Thermodynamics-Based Partition Index .............................................. 1815 Thermoluminescence ..................... 2385 Thiabendazole ................................ 1821 thiazolidinedione .............................. 422 Thioarsenates ................................. 1162 Thiols-Redox .................................. 2336 thioredoxin ................................. 95, 877 thioredoxin reductase ............. 458, 1663 THP-1 ............................................... 966 THPI ............................................... 2278 Threshold ......................................... 477
Keyword Index (Continued) Thrombocytopenia ........................... 778 Thrombopoietin ................................ 284 thrombosis ........................................ 190 Thryoid Hormone ........................... 2360 thyroid .................................. 2608, 2668 Thyroid disruption ......................... 2350 Thyroid Gland ................................ 1423 thyroid hormone ................... 1618, 2349 Thyroid hormones .......................... 2135 tiered approach ............................... 1001 Time-Course ..................................... 194 time-dependent ............................... 1718 time-dependent inhibition .............. 2280 TIMP-2 ............................................... 66 TiO2 ..................................... 2073, 2078 TiPARP ................................... 356, 1599 Tissue Cross Reactivity .................... 881 Tissue distribution .......................... 2386 Tissue Dosimetry ........................... 1719 Tissue exposure ................................ 856 tissue:air partition coefficient (Pta) .................................................. 722 Tissue-Selective Carcinogens .......... 488 titanium dioxide ..................... 655, 1483 Titanium dioxide nanoparticles ..... 1455, 1461, 1471, 2066, 2077 Titanium dioxide particles ............. 1801 titanium nanoparticle ..................... 2180 titanium nanoparticles .................... 1454 Titanium Nanostructure ................. 2061 titanium particulates ......................... 566 TLR4 ................................................ 697 TNIP1 ............................................... 384 Tobacco ..................... 1372, 2694, 2695, 2698, 2699 tobacco carcinogens ....................... 2697 Tobacco products ........................... 2696 Tobacco smoke .... 969, 990, 1409, 1565, 2295, 2330 tobacco toxicant biomarkers ........... 834, 2697 TOC ................................................ 1523 Toll Like Receptors .......................... 686 toll-like receptor 4 .......................... 1495 Toluene ................................. 1298, 1583 topiramate ........................................ 810 Torcetrapib ............................... 387, 556 Tottering ......................................... 1385 ToxCast .................... 141, 143, 715, 727 toxic effects .................................... 2392 Toxic Load ....................................... 572 toxic tort ......................................... 2152 Toxicant Exposure............................ 749 Toxicant susceptibility ................... 1395 Toxicants ........................................ 2295 Toxicity ............................................. 10, 18, 266, 275, 305, 515, 582, 746, 797, 820, 930, 1250, 1453, 1668, 1740, 1821, 1826, 1882, 1883, 1900, 2004, 2006, 2076, 2206, 2407, 2408, 2426, 2631 Toxicity Biomarkers in Mouse Lung ................................................. 671 toxicity mechanisms ........ 569, 735, 939, 2060, 2590 Toxicity path .................................... 134 toxicity pathway ........... 822, 1813, 2505 Toxicity pathways .................. 962, 1583 Toxicity prediction ..................... 33, 935 toxicity screening ............................. 973 Toxicity study ................................. 1574 Toxicity Testing in the 21st century .................................... 2505 toxicogenomic ................................ 1541 toxicogenomics ................... 19, 41, 124, 138, 139, 436, 823, 824, 906, 917, 1586, 1589, 1593, 1603, 2073, 2152, 2401, 2651, 2652, 2681 Toxicogenomics and mode of action ......................................... 1596 Toxicogenomics, Hepatotoxicity, Liver ..................................... 1592, 1606 Toxicokinetic ................ 517, 2108, 2259 Toxicokinetics ... 807, 1230, 1240, 2105, 2107, 2265, 2271, 2272, 2693 toxicological screening .................. 2519 Toxicology .......... 5, 8, 47, 56, 592, 788, 1576, 2676 Toxicology 21 ................................ 1309 Toxicology education ..................... 1874 toxicology history ............................ 922 Toxicology Jobs ............................. 1879 toxicology screening .......................... 14 Toxicology training ........................ 1876 Toxicophores .................................... 153 toxicoproteomics ............ 128, 513, 2500 toxin ............................................... 2219 ToxInsight ........................................ 398 TPP1 ................................................. 801 trace metals .................................... 2395 Traditional medicine ...................... 2206 training ........................................... 1877 Transcript ‘Omics ............................ 489 transcript profiling ........................... 868 transcription factor ................. 410, 1969 transcriptional alterations ............... 2633 transcriptional regulation ............... 2647 transcriptome ................ 387, 1599, 1627 transcriptomics .................. 60, 79, 1591, 1600, 1718 Transcriptomics /gene expressing ............................ 1595, 2378 transepithelial electrical resistance ........................................ 1021 Transfluthrin ................................... 2646 transformation ........................ 236, 1155 Transforming growth factor beta .. 1293, 2330 transgenic animal model .................. 204 transgenic mice .............................. 2578 transglutaminase ............................ 1515 transition metal oxide nanoparticles .................................. 2177 translational imaging ...................... 1322 translational inhibition ................... 2565 Translational Toxicology................ 1014 translocation ................................... 2163 transplacental carcinogenesis ......... 2665 transplacental exposure ........ 2169, 2506 transport ....................... 761, 1478, 2247 transport kinetics .............................. 311 Transporters ...... 938, 1047, 1077, 1079, 1706, 2269 triaryl phosphate ............................... 169 triazoles .............................................. 71 tributyltin................................ 663, 2388 Tributyltin (TBT) ........................... 1068 Trichloroacetate ............................... 251 Trichloroacetic acid ........................ 2283 Trichloroethene .............................. 1510 trichloroethylene ......... 550, 1685, 1836, 2641, 2687 Trichloroethylene, .......................... 1817 trichothecene .................................. 2424 Triclosan ......................... 254, 379, 2350 trimethyltin ..................................... 1375 Triple Uptake Inhibitors ................. 1430 trivalent chromium ........................... 915 trivalent methylated metabolites .... 1986 Troglitazone ................. 510, 1080, 2633 trophoblast ...................................... 1056 troponin ............................................ 555 troponin I .............................. 1161, 1437 TRP channel ................................... 2335 TRPA1 ............................................ 2334 TSCA................................................ 417 TSPO/PBR ....................................... 164 TTC ........................................ 487, 1767 tubulin .............................................. 335 tularemia ........................................ 2042 Tumor Analysis ................................ 490 tumor necrosis factor ..... 109, 238, 1508, 1658 tumor progression ............................ 777 tumor transcriptome ....................... 1707 tumorigenesis ......................... 234, 2636 Tungstate .......................................... 656 tungsten .............. 291, 1383, 1604, 2310 Tungsten alloy .................................. 290 turkey ............................................... 972 Tutorial ........................................... 1875 two-electron reduction ................... 1305 Two-generation reproductive toxicity ........................................... 1044 Type 2 diabetes.......... 1281, 2468, 2469, 2470, 2473, 2582 Tyrosine hydroxylase ..................... 1400 ubiquitination ................................... 306 ubiquitin-conjugating enzyme ......... 770 UC-II .............................................. 1893 Uganda ........................................... 2206 UGT ................................................. 385 Ultrafine Particles ........ 191, 1491, 2488 ultrafine particulates ......................... 596 ultrasound imaging ......................... 1092 ultraviolet light ............................... 1784 Umbilical cord ....................... 621, 2200 Uncertainty Factor ........................... 866 uncertainty factors ............................ 713 uncoupling proteins .......................... 958 Undergraduate Education .... 1871, 1873, 1874 Undergraduate research.................. 1872 Unexploded Ordnance ..................... 927 Unfolded Protein Response ............ 1083 uptake ................................... 2165, 2562 Uptake kinetics ....................... 313, 2390 uranium .................................. 282, 1696 urban particulate matter ................... 571 Urethane ........................................... 286 Urinary ........................................... 1679 urinary biomarkers ................. 742, 1694 Urinary bladder ...................... 232, 2646 Urinary Cadmium .................... 767, 768 urinary fibrinogen ............................ 744 urinary protein biomarker ................ 743 Urine biomarkers ............................. 463 urothelial carcinomas ....................... 250 UROtsa ........................................... 1162 Usnic acid ....................................... 2418 UV .................................................... 113 uv inactivation ................................ 2413 UVA .................................................. 638 UVB ............................................... 2033 vaccine potency .............................. 2581 vaccine safety ................................. 2581 vaccine safety assessment .............. 1027 vaginal irritation testing ....... 1049, 1314 vaginal tissue model ............. 1049, 2373 validation ..................... 529, 1016, 1017, 2152, 2545 Valproic acid .................................... 992 Vanadium ......... 284, 285, 286, 287, 288 vanadium pentoxide ......................... 289 Vanin-1 ............................................. 444 vapor intrusion ............................... 1236 vapor uptake modeling ................... 2289 variability ....................................... 2691 vascular .......................................... 1493 vascular development ....... 836, 837, 840 vascular injury ........................ 838, 2671 Vascular permeability ....................... 959 Vascular reactivity ............................ 193 vascular toxicity ............................. 2670 Vasculitis ...................... 797, 2669, 2673 VCD ............................................... 1054 vector control ................................. 1476 vegan bone treat ............................. 2410 vegetable ........................................ 2119 VEGFR1 ........................................ 2587 vehicle-effect .................................... 963 vehicles ............................................ 963 Ventilator-associated pneumonia ... 2337 vesicant .......................................... 1751 Vesicant injury ............. 894, 2031, 2033 vesicants ............................... 1752, 2032 Vibrio vulnificus .............................. 688 Vimentin ......................................... 2637 Vinculin .......................................... 1386 viral infection ................................... 256 Viral load monitoring ..................... 1149 virtual liver ....................................... 733 Virtual Tissues ................................ 1619 Vitamin A ....................................... 2411 Vitamin D ....................................... 2412 Vitamin K ....................................... 1613 Vitamin-status .................................. 310 vitellogenin ................................ 17, 976 VMAT2 .................................... 181, 182 VOC ..................................... 1424, 1693 VOCs.................................... 1573, 1952 volatile organic compounds .... 502, 596, 977, 1245, 2399 VX .............................. 1543, 2011, 2022 warfare organophosphates.............. 2047 water column .................................... 827 watercress ....................................... 2232 weapons ............................................ 930 weathering ........................................ 827 Weight of Evidence ...... 727, 1944, 1948 welding ............................................. 563 welding fume ....................... 2317, 2322 Werner syndrome protein ................. 121 WGA .............................................. 1369 whale cells ............................ 2342, 2392 Wistar Rats ................. 1552, 1574, 1951 WKY rats ....................................... 1062 Wnt ................................................. 1624 Wnt signaling ................................. 1626 Wnt/b-Catenin ................................ 1741 Wnt/beta catenin pathway ................ 249 Wood combustion .................... 671, 672 wood furnace .................................. 1213 wood smoke ................................... 1127 Workers .......................................... 1218 Wound .................................. 2021, 2022 wound healing ...... 893, 895, 2534, 2556 wound repair .................................. 2575 Writing ........................................... 1768 WTC ..................................... 1235, 1259 xCT Transporter ............................. 1513 xenobiotic metabolism ........... 647, 1707 xenobiotics ....................................... 376 Xenoestrogens .................................. 110 Xenopus ......................................... 2379 Xenopus laevis ................................. 347 Xpa(-/-)p53(+/-) mice .................... 2658 XPC ...................................... 1360, 1991 X-radiation ......................................... 65 x-ray fluorescence (xrf) .................. 1686 yeast ....................................... 340, 2558 yeast deletion library ...................... 2253 Y-family DNA Polymerases ............. 120 Yil006w ............................................ 308 Yucatan Minipig ............................... 635 Zebrafish ......................... 197, 198, 871, 873, 896, 897, 898, 942, 976, 1071, 1461, 1479, 1483, 1588, 1629, 1633, 1642, 1740, 1741, 1742, 1743, 1744, 1745, 1746, 1747, 1779, 1840, 1859, 2090, 2093, 2142, 2143, 2144, 2168, 2310, 2339, 2363, 2388, 2389, 2514, 2539, 2548, 2628 Zebrafish embryo toxicity ... 1607, 1610, 1627, 2380 zebrafish larvae ...................... 872, 1895 Zidovudine ..................................... 1304 Zinc .................................................. 314 zinc deficiency ................................. 756 zinc finger nuclease .......................... 535 SOT 2011 ANNUAL MEETING 619 KEY WORD INDEX
Page 1 and 2:
The Toxicologist Supplement to Toxi
Page 3 and 4:
The Toxicologist Supplement to Toxi
Page 5 and 6:
1 BIODEGRADABLE MATERIALS FOR TISSU
Page 7 and 8:
that genetic toxicology data are ge
Page 9 and 10:
well-orchestrated lung inflammation
Page 11 and 12:
scribed in the literature. We have
Page 13 and 14:
years ago). We will illustrate how
Page 15 and 16:
involved in the biodegradation proc
Page 17 and 18:
stem cells but rather a treatment i
Page 19 and 20:
additional compound showed agreemen
Page 21 and 22:
82 COMPARISON OF 3H-THYMIDINE INCOR
Page 23 and 24:
irritants. While in practice these
Page 25 and 26:
alleles are especially vulnerable t
Page 27 and 28:
109 CD4+ T CELL INTRINSIC TNF RECEP
Page 29 and 30:
118 TO STUDY THE SIGNAL TRANSDUCTIO
Page 31 and 32:
PAHs, such as dioxins, are prevalen
Page 33 and 34:
containing substituents and/or hydr
Page 35 and 36:
146 COMPUTATIONAL MODELING FOR QT P
Page 37 and 38:
suggest that the combination of too
Page 39 and 40:
164 TRANSLOCATOR PROTEIN (18 KDA) (
Page 41 and 42:
function as a metal binding protein
Page 43 and 44:
laboratory has demonstrated that NR
Page 45 and 46:
known. The aim of this study was to
Page 47 and 48:
from 5 to 28 days in duration) in e
Page 49 and 50:
positive cells, caspase-3 activatio
Page 51 and 52:
creased level in the 46 kDa preproe
Page 53 and 54:
invasiveness at concentrations repr
Page 55 and 56:
thracene (DMBA,50 μg in acetone, a
Page 57 and 58:
247 CO-CARCINOGENESIS OF N, N- DIET
Page 59 and 60:
sponds to the endosomal dsRNA that
Page 61 and 62:
ODD in both WT (maximum 177% of con
Page 63 and 64:
Lastly, using p53siRNA cells, p53 w
Page 65 and 66:
its receptor Mpl to exert its funct
Page 67 and 68:
294 LOW LEVEL OF LEAD CAN INDUCE PH
Page 69 and 70:
lunar surface presented potential h
Page 71 and 72:
lar about cellular export mechanism
Page 73 and 74:
DNA in the kidney medulla, grandula
Page 75 and 76:
5.00 and 7.50 mg/kg/day by oral gav
Page 77 and 78:
events and carcinogenesis. Here we
Page 79 and 80:
tinization of cells of the hair fol
Page 81 and 82:
358 CHARACTERIZATION OF GENOME-WIDE
Page 83 and 84:
RNAi were also performed to identif
Page 85 and 86:
376 A FUNCTIONAL CROSSTALK BETWEEN
Page 87 and 88:
UGT1A gene induction, while this re
Page 89 and 90:
tivity, specifically peroxisome pro
Page 91 and 92:
and cytotoxic effects; however, its
Page 93 and 94:
histone deacetylase that is necessa
Page 95 and 96:
ment. Paradoxically, buthionine sul
Page 97 and 98:
drug leflunomide and its major (A77
Page 99 and 100:
442 GENE EXPRESSION AND MORPHOLOGIC
Page 101 and 102:
451 INHIBITION OF THE MITOCHONDRIAL
Page 103 and 104:
460 SULFORAPHANE PREVENTS ACETAMINO
Page 105 and 106:
drophilic/lipophilic balance. Other
Page 107 and 108:
pharmacokinetic and toxicological p
Page 109 and 110:
489 USE OF ‘OMICS DATA TO IMPROVE
Page 111 and 112:
498 APPLICATION OF AGE-SPECIFIC ADJ
Page 113 and 114:
507 A DOSE VOLUME TOLERABILITY STUD
Page 115 and 116:
involved the use of an acute inflam
Page 117 and 118:
sorption in the gastrointestinal (G
Page 119 and 120:
(ABC) transporters actively transpo
Page 121 and 122:
545 BEHAVIORAL EFFECTS OF REPIN IN
Page 123 and 124:
a blood pressure phenotype that res
Page 125 and 126:
and inhalation exposure system that
Page 127 and 128:
and lethality associated with these
Page 129 and 130:
position, on vascular reactivity an
Page 131 and 132:
therefore more accurate and reprodu
Page 133 and 134:
commercial chrysotile product that
Page 135 and 136:
elative to their controls. ST-depre
Page 137 and 138:
ats. The majority of the studies fo
Page 139 and 140:
in the China Jintan Child Cohort St
Page 141 and 142:
corneum thickness, cellular epiderm
Page 143 and 144:
645 EVALUATION OF THE IN VITRO EPIS
Page 145 and 146:
654 TCDD ADSORBED ONTO NATURAL AND
Page 147 and 148:
tion revealed no test article-relat
Page 149 and 150:
671 INFLAMMATION AND TISSUE DAMAGE
Page 151 and 152:
model, ethanol was found to inhibit
Page 153 and 154:
689 ENHANCED SUPPRESSIVE FUNCTION O
Page 155 and 156:
NAC + LPS yielded different levels
Page 157 and 158:
707 LIFE-STAGE PBPK MODELS FOR MULT
Page 159 and 160:
downstream of the apical endpoint o
Page 161 and 162:
726 UPDATED ALUMINUM PHARMACOKINETI
Page 163 and 164:
global parameter sensitivity analys
Page 165 and 166:
and renal inflammation induced by 2
Page 167 and 168:
754 PLASMA, URINE, AND TISSUE CONCE
Page 169 and 170:
cently characterized transporter OA
Page 171 and 172:
exposure system was developed from
Page 173 and 174:
lood cell mass and decrease in urin
Page 175 and 176:
practical alternatives to MC in non
Page 177 and 178:
imals dosed with 167 mg/kg THU alon
Page 179 and 180:
and organ weights, clinical signs a
Page 181 and 182:
yet is induced in most bladder and
Page 183 and 184:
830 RISK ASSESSMENT OF THE SPILL: C
Page 185 and 186:
knowledgebase creation. Results are
Page 187 and 188:
852 UNDERSTANDING STRUCTURAL AND PH
Page 189 and 190:
for integrating epidemiology and an
Page 191 and 192:
motor activity, including age of th
Page 193 and 194:
y partial purification of urine (fr
Page 195 and 196:
pacity for self-renewal and may dif
Page 197 and 198:
sue. The depth of our analysis led
Page 199 and 200:
910 IMPLEMENTING CALIFORNIA’S GRE
Page 201 and 202:
concentrations in six tissues and b
Page 203 and 204:
934 THE FDA’S LIVER TOXICITY KNOW
Page 205 and 206:
943 GENOME-WIDE DNA METHYLATION DIF
Page 207 and 208:
membrane localization and subsequen
Page 209 and 210:
trols, respectively. Subtoxic and t
Page 211 and 212:
survival using both smoking regimes
Page 213 and 214:
as non-, weak, moderate, or strong
Page 215 and 216:
988 NNK-INDUCED CYTOKINE ALTERATION
Page 217 and 218:
group (one-way ANOVA, p90 % viabili
Page 219 and 220:
ered as an organ involved in xenobi
Page 221 and 222:
Transport of CPZ across the Caco-2
Page 223 and 224:
estrous cycle and sexual behavior d
Page 225 and 226:
mRNA expression levels. Collectivel
Page 227 and 228:
1043 THE EFFECTS OF ENDOCRINE DISRU
Page 229 and 230:
1052 MONO-2-ETHYLHEXYL PHTHALATE IN
Page 231 and 232:
Results: MC was variable within and
Page 233 and 234:
UtSMCs. Phosphorylation of FoxO1 wa
Page 235 and 236:
nonpregnant and pregnant diabetic m
Page 237 and 238:
1089 PFOA-INDUCED LIVER EFFECTS IN
Page 239 and 240:
events in the liver. AZD9056 was ev
Page 241 and 242:
The peppermint oil caused a concent
Page 243 and 244:
OA did not affect food consumption.
Page 245 and 246:
1126 PERSISTENT DEVELOPMENTAL ARYLH
Page 247 and 248:
1135 BACH2 BINDING TO Prdm1 AS A ME
Page 249 and 250:
The purpose of this project was to
Page 251 and 252:
one marrow. Since Chk1 is an attrac
Page 253 and 254:
1163 THE MRNA AND MIRNA PROFILE OF
Page 255 and 256:
have now compared the IC50 values b
Page 257 and 258:
1181 ELUCIDATION OF FACTORS DETERMI
Page 259 and 260:
enced by pre-exposure to cigarette
Page 261 and 262:
if abnormal PF was associated with
Page 263 and 264:
weight (P=0.016) and small for gest
Page 265 and 266:
portant cause of death, compared to
Page 267 and 268:
posure groups. However, the differe
Page 269 and 270:
Naphthalene is routinely analyzed i
Page 271 and 272:
1245 SEASONAL CHARACTERIZATION OF H
Page 273 and 274:
1255 URINARY T, T MUCONIC ACID LEVE
Page 275 and 276:
modating a reliable data evaluation
Page 277 and 278:
enzoquinone generate ROS and arylat
Page 279 and 280:
teins (e.g. C3, 4, and 5, APOB, VDB
Page 281 and 282:
1293 TRANSFORMING GROWTH FACTOR BET
Page 283 and 284:
mation was decreased to the same le
Page 285 and 286:
1312 EVALUATION OF THE SENSITIVITY
Page 287 and 288:
luted OFR and CRL. Culture media ex
Page 289 and 290:
urinary TCPy levels, blood and brai
Page 291 and 292:
activity. The dose-response curves
Page 293 and 294:
mice, each with 4 dose groups. One
Page 295 and 296:
exposure to both ATR and DACT has a
Page 297 and 298:
third tetratricopeptide repeats (TP
Page 299 and 300:
7d. 28d after TMT injury there was
Page 301 and 302:
subunits. Each cell type was treate
Page 303 and 304:
1394 COMPARATIVE EFFECTS OF METHYLM
Page 305 and 306:
1403 GENOTOXICITY AND PRE-NEOPLASTI
Page 307 and 308:
vated only in high-dose-treated ani
Page 309 and 310:
1421 DOSE-RESPONSE OF NAPHTHALENE-I
Page 311 and 312:
cisplatin; 1.2-, 1.9- and 2.9-fold
Page 313 and 314:
Day 11 and started to recover on Da
Page 315 and 316:
1448 DEVELOPMENT OF A METHOD FOR QU
Page 317 and 318:
1457 GLOBAL GENE PROFILING REVEALS
Page 319 and 320:
cluding mouse and human macrophage,
Page 321 and 322:
model of lung inflammation and host
Page 323 and 324:
1484 NANOTOXICOLOGY AND NANOHEALTH
Page 325 and 326:
throughput in vitro approach was us
Page 327 and 328:
1502 IMMUNOLOGICAL ASPECTS OF AN AN
Page 329 and 330:
(CIA) and the Streptococcal cell wa
Page 331 and 332:
sitizers were 100% concordant among
Page 333 and 334:
1530 MINIMAL RISK LEVELS FOR STYREN
Page 335 and 336:
ical groups in the field of regulat
Page 337 and 338:
vitro with this potentially insect-
Page 339 and 340:
their performance on toxicological
Page 341 and 342:
need for a better understanding of
Page 343 and 344:
1577 AN IN VITRO MODEL SYSTEM FOR A
Page 345 and 346:
gene expression post-transcriptiona
Page 347 and 348:
1595 GENE EXPRESSION PROFILE OF RAT
Page 349 and 350:
to confirm a hepatotoxic property o
Page 351 and 352:
1613 AN INVESTIGATION OF THE CLEARA
Page 353 and 354:
its nuclear translocation was reduc
Page 355 and 356:
were collected from TK animals at d
Page 357 and 358:
egulated targets were selected for
Page 359 and 360:
U/L after tetracycline. Minocycline
Page 361 and 362:
peri-pubertal FasL-/- mice show a d
Page 363 and 364:
showed similar levels of apoptosis
Page 365 and 366:
1676 TWO BIOMARKERS FOR EVALUATION
Page 367 and 368:
motifs selected. This system was ap
Page 369 and 370:
1693 VOC SERUM LEVELS IN THE GENERA
Page 371 and 372:
1702 DOES THE CLOCK MAKE THE POISON
Page 373 and 374:
those with high nickel content are
Page 375 and 376:
isk assessment. However, unique cha
Page 377 and 378:
model of APAP metabolism and glutat
Page 379 and 380:
logically & morphologically similar
Page 381 and 382:
posure, blood chemistry was analyze
Page 383 and 384:
elated to oxidative stress by measu
Page 385 and 386:
ostasis), but work is needed to tra
Page 387 and 388:
tokine products during carcinogenes
Page 389 and 390:
ways as chemical stressors and, the
Page 391 and 392:
toxicity of nanomaterials relates s
Page 393 and 394:
1815 MEASURING COMPOUND SELECTIVITY
Page 395 and 396:
1825 EFFECTS OF METABOLISM BY INTES
Page 397 and 398:
cyanoacetic acid increased 2-3 fold
Page 399 and 400:
1845 IS THE PROMISCUITY OF THE ARYL
Page 401 and 402:
crorarray analysis. RT-PCR results
Page 403 and 404:
are a family of phase-II biotransfo
Page 405 and 406:
ous labs. As a result of positive s
Page 407 and 408:
down the doses may produce more tox
Page 409 and 410:
spectively. Below 100 mg/l of gemfi
Page 411 and 412:
1900 GENERATION OF PRECISION CUT LI
Page 413 and 414:
iomarkers or observation of lesions
Page 415 and 416:
creased reticulocytes and lymphocyt
Page 417 and 418:
statistically significant interacti
Page 419 and 420:
monize sample preparation and analy
Page 421 and 422:
NPC and sinonasal cancer in neighbo
Page 423 and 424:
showed incidences of lung and nasal
Page 425 and 426:
utylbenzenes, exhibited most simila
Page 427 and 428:
1975 DIFFERENTIAL MODULATION OF CYP
Page 429 and 430:
organic As to MMA(V) and a lower ca
Page 431 and 432:
ole in invasion and metastasis of c
Page 433 and 434:
3T3-L1 cells to low-levels of arsen
Page 435 and 436:
2011 IDENTIFICATION OF A NOVEL VX M
Page 437 and 438:
This work was supported by Cooperat
Page 439 and 440:
2029 EFFICACY OF ENDOTRACHEAL ADMIN
Page 441 and 442:
Diazepam injections and its combina
Page 443 and 444:
2047 ESTERASE ACTIVITIES AND HEMOST
Page 445 and 446:
nanoparticle-induced toxicity progr
Page 447 and 448:
house, were iv infused into rats ov
Page 449 and 450:
een explored. This study investigat
Page 451 and 452:
croscopic analysis revealed that on
Page 453 and 454:
egg yolk collected from turtles inh
Page 455 and 456:
consistency of results in both expe
Page 457 and 458:
2111 CYTOCHROME P450 3A5 GENOTYPE I
Page 459 and 460:
esidues of organophosphates or thei
Page 461 and 462:
manganism. Recent work from our lab
Page 463 and 464:
Aβ1-40 in CSF and hippocampus in P
Page 465 and 466:
2147 CATALASE MANIPULATIONS MODIFY
Page 467 and 468:
ation based on real-world exposure
Page 469 and 470:
NPs. Aggregation of citrate-stabili
Page 471 and 472:
2175 THE ROLE OF SURFACE CHEMISTRY
Page 473 and 474:
seen rapid uptake in biological ima
Page 475 and 476:
effect on uterine weight or vaginal
Page 477 and 478:
dicating widespread exposure. While
Page 479 and 480:
components into the liver parenchym
Page 481 and 482:
2223 ISOLATION AND DETECTION OF RIC
Page 483 and 484:
stored (-20 celsius degree). The co
Page 485 and 486:
2241 DDA, A BIOMARKER FOR ENVIRONME
Page 487 and 488:
2249 INTERACTION BETWEEN DIETARY SE
Page 489 and 490:
2258 PHARMACOKINETICS, EXCRETION BA
Page 491 and 492:
2267 SENSITIVE AND SPECIFIC FLUORES
Page 493 and 494:
2276 METABOLISM AND DISPOSITION OF
Page 495 and 496:
ment of hypertension in companion a
Page 497 and 498:
for the propyl series can be used f
Page 499 and 500:
2304 IN VITRO EXPOSURE AND EVALUATI
Page 501 and 502:
2313 THE SYNERGISTIC EFFECT OF SODI
Page 503 and 504:
genes that play a crucial role in M
Page 505 and 506:
2330 THE ROLE OF TRANSFORMING GROWT
Page 507 and 508:
ined following up to 96 h continuou
Page 509 and 510:
effect doses obtained with the rat
Page 511 and 512:
diated transcriptional response of
Page 513 and 514:
docrine disruptor activities of EDC
Page 515 and 516:
individuals. Week 6 results were qu
Page 517 and 518:
functionality of photosystem II and
Page 519 and 520:
wild mice (Mus musculus) from areas
Page 521 and 522:
2406 TOXICITY AND BIOACCUMULATION O
Page 523 and 524:
Isocitric acid is the acid in the h
Page 525 and 526:
2425 EFFECTS OF FUMONISINS IN ETHAN
Page 527 and 528:
centration(μg/g) were: 5.1-95.3; 2
Page 529 and 530:
2445 AUTOPHAGY IN DEVELOPMENT: A LI
Page 531 and 532:
sures to inhaled Mn in dust. Nevert
Page 533 and 534:
2466 CRITICAL EVALUATION OF ANIMAL
Page 535 and 536:
elationships predict that resting r
Page 537 and 538:
2489 COMPARATIVE TOXICITY OF BIODIE
Page 539 and 540:
2497 TRANSCRIPTIONAL REGULATION OF
Page 541 and 542:
2506 TOXICOLOGICAL CONSIDERATIONS O
Page 543 and 544:
launched with the aim of developing
Page 545 and 546:
forms mRNA expression levels were a
Page 547 and 548:
2534 CUTANEOUS WOUND HEALING IN THE
Page 549 and 550:
wells (0, 1, 5, 10, 25, 50, 100, an
Page 551 and 552:
2553 AN ORGANOTYPIC MICROLIVER PLAT
Page 553 and 554:
serum-free media. At 24 hrs, the gr
Page 555 and 556:
2572 INCREASED ARSENIC BIOACCESSIBI
Page 557 and 558:
nology to develop improved methods.
Page 559 and 560:
tuna, swordfish, or mako shark (3.5
Page 561 and 562:
nificantly reduce circulating thyro
Page 563 and 564:
grouped into 9 observation periods
Page 565 and 566:
histopathological or biochemical ev
Page 567 and 568:
exhibited a hyperactive phenotype,
Page 569 and 570:
the search of effective drugs for e
Page 571 and 572: 2644 COVALENT BINDING OF 14 C 2-MET
Page 573 and 574: aries targeting all transcription f
Page 575 and 576: (p 9 weeks) and CSC phenotype acqui
Page 577 and 578: 2673 IMMUNE-MEDIATED VASCULAR INJUR
Page 579 and 580: for risk identification and charact
Page 581 and 582: to control toxicant delivery in tob
Page 583 and 584: Author Index (Continued) The numera
Page 611 and 612: Keyword Index (Continued) Arsenite
Page 613 and 614: Keyword Index (Continued) Covalent
Page 615 and 616: Keyword Index (Continued) flow cyto
Page 617 and 618: Keyword Index (Continued) innate im
Page 619 and 620: Keyword Index (Continued) nanoparti
Page 621: Keyword Index (Continued) preservat
Page 625 and 626: Toxicological Sciences The Official
show all

The Toxicologist - Society of Toxicology

You also want an ePaper? Increase the reach of your titles

Delete template?

Save as template?