The Toxicologist - Society of Toxicology

More documents

Recommendations

Info

were correlated with proximity to agricultural uses of Maneb. Here we tested the hypothesis that Maneb use increases agricultural soil Mn levels, and thereby may serve as a source of increased house dust Mn loadings in agricultural communities. Procedures: Agricultural soil was aliquoted in 6x6x8 cm containers and treated with 1) Control (DI water vehicle), 2) Annual Equivalent Maneb application (Maneb 80 WP), or 3) 5x Annual Equivalent Maneb (n=5/trt). Maneb was applied every other day over 6 days (3 applications total) to achieve soil surface application levels equivalent to annual or 5x annual use. Plots were maintained in full sunlight and watered daily. Soil was then sieved to
posure groups. However, the different exposure scenarios involving average styrene exposure or peak exposures did not significantly alter the performance to any test. Several factors could have influenced our results: definition of peaks, statistical power or short exposure time. 1227 UTILITY OF C6-GLIOMA CELLS FOR EXPLORATORY RISK ASSESSMENT OF MIXTURES OF INSECTICIDES. D. M. Romero 1 , M. L. Kotler 1 and M. J. Wolansky 1, 2 . 1 Biological Chemistry (Toxicology), ARG NRC / University of Buenos Aires School of Science, Buenos Aires, Argentina and 2 ARG National Agency for Scientific and Technological Promotion, Buenos Aires, Argentina. Low levels of organophosphate (OP) and pyrethroid (PYR) insecticides may cooccur in real environments and food products. Considering each compound independently, these residue loadings may be considered safe for humans. However, there is a consensus on the need of considering joint neurotoxicity data to improve the accuracy of health risk estimates for these chemicals. We use a C6-glioma cell culture as an exploratory in vitro system derived from rat nervous system aimed to identify toxicologically relevant OP-PYR mixtures that may require cumulative risk analysis efforts in in vivo models. First, 4 OPs (chlorpyrifos; acephate; methidathion; diazinon) and 4 PYRs (type I: bifenthrin, tefluthrin; type II: α-cypermethrin, deltamethrin) were examined in single-compound assays carried out in C6cells after 4-48 hr exposure to each compound (0.1-250 μM). Threshold doses for cell viability status were determined using optical microscopy and MTT assays. We generated time- and dose-effect data, and ED15 values were computed from assays conducted at t=24 hr. In general, micromolar exposures produced dose-related alterations in cell viability at 24-48 hr. ED15s were 5-100 μM for PYRs and 5-30 μM for OPs. Second, we evaluated the effects of each insecticide on nucleus morphology using Hoechst 33258 staining. We found dose-related increases in anomalous nuclei shapes from the low μM range up. Last, we examined a mixture of equitoxic levels of the 4 PYRs (1X mixture = Σ ED15) using the MTT assay. This type-I/II mixture produced a dose-related, dual joint action at 24 hr: while addition of individual effects was observed after exposure to the 1X mixture, dose-addition was apparent at a 0.1X dose, i.e., well below the single-compound thresholds for mitochondrial impact. We plan to evaluate other mixtures of insecticides in order to select toxicologically relevant combinations for in vivo testing of cumulative neurotoxicity. 1228 BARIUM INTAKE IN THE CANARY ISLANDS: A TOTAL DIET STUDY. C. Rubio, D. González-Weller, J. Gutiérrez and A. Hardisson. Toxicology, University of La Laguna, La Laguna, Spain. Sponsor: A. Anadon. Barium (Ba) is a divalent metal widely distributed in nature. Commercial uses make it a potential food contaminant. The main sources of exposure for humans are food consumption, water consumption, and inhalation. Ba appears in many common foods at concentrations ranging from 0.21 to 11.0 mg/kg. Chronic exposure to this element is often associated with toxic effects on the cardiovascular system of mammals. Objectives: To quantify the concentration of Ba in 22 food groups as categorized by the Canary Islands Nutrition Survey (ENCA, 2000) and to estimate the total Ba intake in various segments of the population and the general population. Material and Methods: A total of 440 samples were analyzed to determine the Ba levels in various food groups. Ba was determined by Optical Emission Spectrometry with Inductively Coupled Plasma (ICP-OES). Results: The average concentration of Ba in the analyzed food groups was 0.65 mg/kg, implying an intake of 0.69 mg/day of Ba in the adult population of the Canary Islands. All groups had detectable Ba levels. Concentration levels ranged from 0.04 ± 0,04 mg/L in water to 5.21 ± 2,12 mg/kg in nuts. The food consumption patterns of various genders and age groups were considered along with the Ba levels in the 22 food groups. The highest estimated dietary intake levels were observed in the 45-54 age group, for both men and women. Conclusions: This study demonstrates the need to assess, understand and monitor both the levels of metals in various food groups and the dietary intake of the population, in order to determine a safe intake level. 1229 HOUSE DUST-MEDIATED PAH EXPOSURES RELATED TO SEALED PARKING LOTS MAY EXCEED DIETARY INTAKES IN CHILDREN. E. S. Williams 1 , B. J. Mahler 2 and P. C. Van Metre 2 . 1 Center for Reservoir and Aquatic Systems Research, Baylor University, Waco, TX and 2 U.S. Geologic Survey, Austin, TX. Most assessments have indicated that dietary ingestion is the primary route of exposure to carcinogenic polycyclic aromatic hydrocarbons (B2 PAHs; the seven PAH compounds classified as probable human carcinogens by the EPA) for adults and children. Studies have estimated that dietary B2 PAH intakes in children are 24.8 ng/kg/day or less, generally larger those associated with inhalation or non-dietary ingestion of soil and house dust. Recent research has indicated that the use of coal tar-based (CT) sealants on parking lots may be associated with increased concentrations of B2 PAHs in settled house dust (SHD) in nearby living spaces (compared with unsealed asphalt lots). We hypothesized that, for young children living in residences adjacent to CT-sealed parking lots, exposures to B2 PAHs through ingestion of SHD might surmount dietary intake as the primary route of exposure. Using default exposure assumptions of 17.4 kg body weight and 10 and 50 mg/day for dust ingestion rates, doses of 25.01 and 125.03 ng/kg/day B2 PAH were calculated for a 4 year old child living in a residence next to a CT-sealed parking lot, compared to 1.73 and 8.65 ng/kg/day for children living near unsealed asphalt parking lots. According to this screening-level exposure model, children in living spaces adjacent to parking lots sealed with CT-based products may be exposed to B2 PAHs primarily through ingestion of SHD. 1230 DIRECT COMPARISON OF DRIED BLOOD SPOT (DBS) ANALYSIS TO PLASMA AND WHOLE BLOOD ANALYSIS IN TOXICOKINETIC STUDIES OF RATS. L. Patrone 1 , G. Liu 2 , H. M. Snapp 2 , A. Batog 1 , J. Valentine 1 , R. S. Mangipudy 1 , A. Tymiak 2 , Q. C. Ji 2 and M. E. Arnold 2 . 1 Drug Safety Evaluation, Bristol-Myers Squibb, New Brunswick, NJ and 2 Bioanalytical Sciences, Bristol-Myers Squibb, Lawrenceville, NJ. Dried blood spot (DBS) analysis is a method gaining recognition for obtaining drug exposure data. To evaluate the fidelity of DBS analysis compared to the accepted practice of plasma analysis, comparison of the data obtained by these methods is necessary. The primary objective of this presentation is to demonstrate how BMS is exploring DBS toxicokinetic applications in rats by directly comparing plasma to DBS from the same animal. In this study, 2 compounds were evaluated; BMS-X and Omeprazole (a marketed proton pump inhibitor). Twelve rats were evaluated for each compound, and 4 rats were used as controls to determine contamination potential. 300 ul blood was drawn from each rat. Blood was spotted directly from the collection tube onto the DBS cards in four 15 ul aliquots. The remaining blood was centrifuged to obtain plasma. The ratio of blood to plasma concentration was calculated and the “predicted” blood concentrations were obtained by applying the ratio to the plasma concentrations. Toxicokinetic curves were constructed by averaging the concentrations at each time point. Results obtained from DBS, blood, and plasma were consistent while liquid whole blood analysis was slightly more variable. Advantages of DBS include no need to centrifuge samples, easy sample storage and shipment, small sample volume, and easier sample preparation for analysis. Challenges include difficulties in assay development for hydrophilic compounds. Carry-over and cross contamination during sample analysis was not an issue. However, additional precaution is needed to prevent this when an assay has a low lower limit of quantitation (LLOQ). 1231 DRIED BLOOD SPOT (DBS): A POTENTIAL APPROACH TO MONITORING DRUG EXPOSURE IN RAT FOETUSES. S. Cinelli 1 , F. Pastori 2 , R. Cicalese 3 , S. Villa 4 and G. Oberto 1 . 1 Scientific Direction, Research Toxicology Centre RTC, Pomezia - Rome, Italy, 2 Analytical Chemistry, Research Toxicology Centre, Pomezia - Rome, Italy, 3 Toxicology, Research Toxicology Centre, Pomezia - Rome, Italy and 4 Operative Direction, Research Toxicology Centre, Pomezia- Rome, Italy. Sponsor: J. Brightwell. Dried Blood Spot (DBS) is a promising technique to reduce blood sample volume during non-clinical and clinical studies. For this reason the technique has been extensively applied in the human paediatric population and could be used to monitor foetal drug exposure during non-clinical reprotoxicity studies. For this experiment oxacarbazepine was orally administered to pregnant rats and, following validation, the DBS technique was used to evaluate placental barrier crossing, testing blood from both dams and foetuses. Oxacarbazepine is an antiepileptic drug which is known to cross the placental barrier. Analytical methods were validated using Ultra Performance Liquid Chromatography and Tandem Mass Spectrometry (UPLC- MS/MS) on plasma samples, applying the traditional extraction procedure, and on whole blood spotted on DBS cards. Oxacarbazepine was administered to pregnant Sprague Dawley female rats by oral gavage during the gestation period. Blood samples were collected at necropsy from dams and foetuses. Blood taken from dams was used to generate both plasma and DBS samples to compare performance of the two procedures. Blood samples taken from foetuses were sufficient only to apply the DBS technique. The results of the described experiment, demonstrating placental transfer of oxacarbazepine, confirmed the applicability of DBS technique to evaluate drug levels in dams and litters during reprotoxicity studies. SOT 2011 ANNUAL MEETING 263
Page 1 and 2:
The Toxicologist Supplement to Toxi
Page 3 and 4:
The Toxicologist Supplement to Toxi
Page 5 and 6:
1 BIODEGRADABLE MATERIALS FOR TISSU
Page 7 and 8:
that genetic toxicology data are ge
Page 9 and 10:
well-orchestrated lung inflammation
Page 11 and 12:
scribed in the literature. We have
Page 13 and 14:
years ago). We will illustrate how
Page 15 and 16:
involved in the biodegradation proc
Page 17 and 18:
stem cells but rather a treatment i
Page 19 and 20:
additional compound showed agreemen
Page 21 and 22:
82 COMPARISON OF 3H-THYMIDINE INCOR
Page 23 and 24:
irritants. While in practice these
Page 25 and 26:
alleles are especially vulnerable t
Page 27 and 28:
109 CD4+ T CELL INTRINSIC TNF RECEP
Page 29 and 30:
118 TO STUDY THE SIGNAL TRANSDUCTIO
Page 31 and 32:
PAHs, such as dioxins, are prevalen
Page 33 and 34:
containing substituents and/or hydr
Page 35 and 36:
146 COMPUTATIONAL MODELING FOR QT P
Page 37 and 38:
suggest that the combination of too
Page 39 and 40:
164 TRANSLOCATOR PROTEIN (18 KDA) (
Page 41 and 42:
function as a metal binding protein
Page 43 and 44:
laboratory has demonstrated that NR
Page 45 and 46:
known. The aim of this study was to
Page 47 and 48:
from 5 to 28 days in duration) in e
Page 49 and 50:
positive cells, caspase-3 activatio
Page 51 and 52:
creased level in the 46 kDa preproe
Page 53 and 54:
invasiveness at concentrations repr
Page 55 and 56:
thracene (DMBA,50 μg in acetone, a
Page 57 and 58:
247 CO-CARCINOGENESIS OF N, N- DIET
Page 59 and 60:
sponds to the endosomal dsRNA that
Page 61 and 62:
ODD in both WT (maximum 177% of con
Page 63 and 64:
Lastly, using p53siRNA cells, p53 w
Page 65 and 66:
its receptor Mpl to exert its funct
Page 67 and 68:
294 LOW LEVEL OF LEAD CAN INDUCE PH
Page 69 and 70:
lunar surface presented potential h
Page 71 and 72:
lar about cellular export mechanism
Page 73 and 74:
DNA in the kidney medulla, grandula
Page 75 and 76:
5.00 and 7.50 mg/kg/day by oral gav
Page 77 and 78:
events and carcinogenesis. Here we
Page 79 and 80:
tinization of cells of the hair fol
Page 81 and 82:
358 CHARACTERIZATION OF GENOME-WIDE
Page 83 and 84:
RNAi were also performed to identif
Page 85 and 86:
376 A FUNCTIONAL CROSSTALK BETWEEN
Page 87 and 88:
UGT1A gene induction, while this re
Page 89 and 90:
tivity, specifically peroxisome pro
Page 91 and 92:
and cytotoxic effects; however, its
Page 93 and 94:
histone deacetylase that is necessa
Page 95 and 96:
ment. Paradoxically, buthionine sul
Page 97 and 98:
drug leflunomide and its major (A77
Page 99 and 100:
442 GENE EXPRESSION AND MORPHOLOGIC
Page 101 and 102:
451 INHIBITION OF THE MITOCHONDRIAL
Page 103 and 104:
460 SULFORAPHANE PREVENTS ACETAMINO
Page 105 and 106:
drophilic/lipophilic balance. Other
Page 107 and 108:
pharmacokinetic and toxicological p
Page 109 and 110:
489 USE OF ‘OMICS DATA TO IMPROVE
Page 111 and 112:
498 APPLICATION OF AGE-SPECIFIC ADJ
Page 113 and 114:
507 A DOSE VOLUME TOLERABILITY STUD
Page 115 and 116:
involved the use of an acute inflam
Page 117 and 118:
sorption in the gastrointestinal (G
Page 119 and 120:
(ABC) transporters actively transpo
Page 121 and 122:
545 BEHAVIORAL EFFECTS OF REPIN IN
Page 123 and 124:
a blood pressure phenotype that res
Page 125 and 126:
and inhalation exposure system that
Page 127 and 128:
and lethality associated with these
Page 129 and 130:
position, on vascular reactivity an
Page 131 and 132:
therefore more accurate and reprodu
Page 133 and 134:
commercial chrysotile product that
Page 135 and 136:
elative to their controls. ST-depre
Page 137 and 138:
ats. The majority of the studies fo
Page 139 and 140:
in the China Jintan Child Cohort St
Page 141 and 142:
corneum thickness, cellular epiderm
Page 143 and 144:
645 EVALUATION OF THE IN VITRO EPIS
Page 145 and 146:
654 TCDD ADSORBED ONTO NATURAL AND
Page 147 and 148:
tion revealed no test article-relat
Page 149 and 150:
671 INFLAMMATION AND TISSUE DAMAGE
Page 151 and 152:
model, ethanol was found to inhibit
Page 153 and 154:
689 ENHANCED SUPPRESSIVE FUNCTION O
Page 155 and 156:
NAC + LPS yielded different levels
Page 157 and 158:
707 LIFE-STAGE PBPK MODELS FOR MULT
Page 159 and 160:
downstream of the apical endpoint o
Page 161 and 162:
726 UPDATED ALUMINUM PHARMACOKINETI
Page 163 and 164:
global parameter sensitivity analys
Page 165 and 166:
and renal inflammation induced by 2
Page 167 and 168:
754 PLASMA, URINE, AND TISSUE CONCE
Page 169 and 170:
cently characterized transporter OA
Page 171 and 172:
exposure system was developed from
Page 173 and 174:
lood cell mass and decrease in urin
Page 175 and 176:
practical alternatives to MC in non
Page 177 and 178:
imals dosed with 167 mg/kg THU alon
Page 179 and 180:
and organ weights, clinical signs a
Page 181 and 182:
yet is induced in most bladder and
Page 183 and 184:
830 RISK ASSESSMENT OF THE SPILL: C
Page 185 and 186:
knowledgebase creation. Results are
Page 187 and 188:
852 UNDERSTANDING STRUCTURAL AND PH
Page 189 and 190:
for integrating epidemiology and an
Page 191 and 192:
motor activity, including age of th
Page 193 and 194:
y partial purification of urine (fr
Page 195 and 196:
pacity for self-renewal and may dif
Page 197 and 198:
sue. The depth of our analysis led
Page 199 and 200:
910 IMPLEMENTING CALIFORNIA’S GRE
Page 201 and 202:
concentrations in six tissues and b
Page 203 and 204:
934 THE FDA’S LIVER TOXICITY KNOW
Page 205 and 206:
943 GENOME-WIDE DNA METHYLATION DIF
Page 207 and 208:
membrane localization and subsequen
Page 209 and 210:
trols, respectively. Subtoxic and t
Page 211 and 212:
survival using both smoking regimes
Page 213 and 214:
as non-, weak, moderate, or strong
Page 215 and 216: 988 NNK-INDUCED CYTOKINE ALTERATION
Page 217 and 218: group (one-way ANOVA, p90 % viabili
Page 219 and 220: ered as an organ involved in xenobi
Page 221 and 222: Transport of CPZ across the Caco-2
Page 223 and 224: estrous cycle and sexual behavior d
Page 225 and 226: mRNA expression levels. Collectivel
Page 227 and 228: 1043 THE EFFECTS OF ENDOCRINE DISRU
Page 229 and 230: 1052 MONO-2-ETHYLHEXYL PHTHALATE IN
Page 231 and 232: Results: MC was variable within and
Page 233 and 234: UtSMCs. Phosphorylation of FoxO1 wa
Page 235 and 236: nonpregnant and pregnant diabetic m
Page 237 and 238: 1089 PFOA-INDUCED LIVER EFFECTS IN
Page 239 and 240: events in the liver. AZD9056 was ev
Page 241 and 242: The peppermint oil caused a concent
Page 243 and 244: OA did not affect food consumption.
Page 245 and 246: 1126 PERSISTENT DEVELOPMENTAL ARYLH
Page 247 and 248: 1135 BACH2 BINDING TO Prdm1 AS A ME
Page 249 and 250: The purpose of this project was to
Page 251 and 252: one marrow. Since Chk1 is an attrac
Page 253 and 254: 1163 THE MRNA AND MIRNA PROFILE OF
Page 255 and 256: have now compared the IC50 values b
Page 257 and 258: 1181 ELUCIDATION OF FACTORS DETERMI
Page 259 and 260: enced by pre-exposure to cigarette
Page 261 and 262: if abnormal PF was associated with
Page 263 and 264: weight (P=0.016) and small for gest
Page 265: portant cause of death, compared to
Page 269 and 270: Naphthalene is routinely analyzed i
Page 271 and 272: 1245 SEASONAL CHARACTERIZATION OF H
Page 273 and 274: 1255 URINARY T, T MUCONIC ACID LEVE
Page 275 and 276: modating a reliable data evaluation
Page 277 and 278: enzoquinone generate ROS and arylat
Page 279 and 280: teins (e.g. C3, 4, and 5, APOB, VDB
Page 281 and 282: 1293 TRANSFORMING GROWTH FACTOR BET
Page 283 and 284: mation was decreased to the same le
Page 285 and 286: 1312 EVALUATION OF THE SENSITIVITY
Page 287 and 288: luted OFR and CRL. Culture media ex
Page 289 and 290: urinary TCPy levels, blood and brai
Page 291 and 292: activity. The dose-response curves
Page 293 and 294: mice, each with 4 dose groups. One
Page 295 and 296: exposure to both ATR and DACT has a
Page 297 and 298: third tetratricopeptide repeats (TP
Page 299 and 300: 7d. 28d after TMT injury there was
Page 301 and 302: subunits. Each cell type was treate
Page 303 and 304: 1394 COMPARATIVE EFFECTS OF METHYLM
Page 305 and 306: 1403 GENOTOXICITY AND PRE-NEOPLASTI
Page 307 and 308: vated only in high-dose-treated ani
Page 309 and 310: 1421 DOSE-RESPONSE OF NAPHTHALENE-I
Page 311 and 312: cisplatin; 1.2-, 1.9- and 2.9-fold
Page 313 and 314: Day 11 and started to recover on Da
Page 315 and 316: 1448 DEVELOPMENT OF A METHOD FOR QU
Page 317 and 318:
1457 GLOBAL GENE PROFILING REVEALS
Page 319 and 320:
cluding mouse and human macrophage,
Page 321 and 322:
model of lung inflammation and host
Page 323 and 324:
1484 NANOTOXICOLOGY AND NANOHEALTH
Page 325 and 326:
throughput in vitro approach was us
Page 327 and 328:
1502 IMMUNOLOGICAL ASPECTS OF AN AN
Page 329 and 330:
(CIA) and the Streptococcal cell wa
Page 331 and 332:
sitizers were 100% concordant among
Page 333 and 334:
1530 MINIMAL RISK LEVELS FOR STYREN
Page 335 and 336:
ical groups in the field of regulat
Page 337 and 338:
vitro with this potentially insect-
Page 339 and 340:
their performance on toxicological
Page 341 and 342:
need for a better understanding of
Page 343 and 344:
1577 AN IN VITRO MODEL SYSTEM FOR A
Page 345 and 346:
gene expression post-transcriptiona
Page 347 and 348:
1595 GENE EXPRESSION PROFILE OF RAT
Page 349 and 350:
to confirm a hepatotoxic property o
Page 351 and 352:
1613 AN INVESTIGATION OF THE CLEARA
Page 353 and 354:
its nuclear translocation was reduc
Page 355 and 356:
were collected from TK animals at d
Page 357 and 358:
egulated targets were selected for
Page 359 and 360:
U/L after tetracycline. Minocycline
Page 361 and 362:
peri-pubertal FasL-/- mice show a d
Page 363 and 364:
showed similar levels of apoptosis
Page 365 and 366:
1676 TWO BIOMARKERS FOR EVALUATION
Page 367 and 368:
motifs selected. This system was ap
Page 369 and 370:
1693 VOC SERUM LEVELS IN THE GENERA
Page 371 and 372:
1702 DOES THE CLOCK MAKE THE POISON
Page 373 and 374:
those with high nickel content are
Page 375 and 376:
isk assessment. However, unique cha
Page 377 and 378:
model of APAP metabolism and glutat
Page 379 and 380:
logically & morphologically similar
Page 381 and 382:
posure, blood chemistry was analyze
Page 383 and 384:
elated to oxidative stress by measu
Page 385 and 386:
ostasis), but work is needed to tra
Page 387 and 388:
tokine products during carcinogenes
Page 389 and 390:
ways as chemical stressors and, the
Page 391 and 392:
toxicity of nanomaterials relates s
Page 393 and 394:
1815 MEASURING COMPOUND SELECTIVITY
Page 395 and 396:
1825 EFFECTS OF METABOLISM BY INTES
Page 397 and 398:
cyanoacetic acid increased 2-3 fold
Page 399 and 400:
1845 IS THE PROMISCUITY OF THE ARYL
Page 401 and 402:
crorarray analysis. RT-PCR results
Page 403 and 404:
are a family of phase-II biotransfo
Page 405 and 406:
ous labs. As a result of positive s
Page 407 and 408:
down the doses may produce more tox
Page 409 and 410:
spectively. Below 100 mg/l of gemfi
Page 411 and 412:
1900 GENERATION OF PRECISION CUT LI
Page 413 and 414:
iomarkers or observation of lesions
Page 415 and 416:
creased reticulocytes and lymphocyt
Page 417 and 418:
statistically significant interacti
Page 419 and 420:
monize sample preparation and analy
Page 421 and 422:
NPC and sinonasal cancer in neighbo
Page 423 and 424:
showed incidences of lung and nasal
Page 425 and 426:
utylbenzenes, exhibited most simila
Page 427 and 428:
1975 DIFFERENTIAL MODULATION OF CYP
Page 429 and 430:
organic As to MMA(V) and a lower ca
Page 431 and 432:
ole in invasion and metastasis of c
Page 433 and 434:
3T3-L1 cells to low-levels of arsen
Page 435 and 436:
2011 IDENTIFICATION OF A NOVEL VX M
Page 437 and 438:
This work was supported by Cooperat
Page 439 and 440:
2029 EFFICACY OF ENDOTRACHEAL ADMIN
Page 441 and 442:
Diazepam injections and its combina
Page 443 and 444:
2047 ESTERASE ACTIVITIES AND HEMOST
Page 445 and 446:
nanoparticle-induced toxicity progr
Page 447 and 448:
house, were iv infused into rats ov
Page 449 and 450:
een explored. This study investigat
Page 451 and 452:
croscopic analysis revealed that on
Page 453 and 454:
egg yolk collected from turtles inh
Page 455 and 456:
consistency of results in both expe
Page 457 and 458:
2111 CYTOCHROME P450 3A5 GENOTYPE I
Page 459 and 460:
esidues of organophosphates or thei
Page 461 and 462:
manganism. Recent work from our lab
Page 463 and 464:
Aβ1-40 in CSF and hippocampus in P
Page 465 and 466:
2147 CATALASE MANIPULATIONS MODIFY
Page 467 and 468:
ation based on real-world exposure
Page 469 and 470:
NPs. Aggregation of citrate-stabili
Page 471 and 472:
2175 THE ROLE OF SURFACE CHEMISTRY
Page 473 and 474:
seen rapid uptake in biological ima
Page 475 and 476:
effect on uterine weight or vaginal
Page 477 and 478:
dicating widespread exposure. While
Page 479 and 480:
components into the liver parenchym
Page 481 and 482:
2223 ISOLATION AND DETECTION OF RIC
Page 483 and 484:
stored (-20 celsius degree). The co
Page 485 and 486:
2241 DDA, A BIOMARKER FOR ENVIRONME
Page 487 and 488:
2249 INTERACTION BETWEEN DIETARY SE
Page 489 and 490:
2258 PHARMACOKINETICS, EXCRETION BA
Page 491 and 492:
2267 SENSITIVE AND SPECIFIC FLUORES
Page 493 and 494:
2276 METABOLISM AND DISPOSITION OF
Page 495 and 496:
ment of hypertension in companion a
Page 497 and 498:
for the propyl series can be used f
Page 499 and 500:
2304 IN VITRO EXPOSURE AND EVALUATI
Page 501 and 502:
2313 THE SYNERGISTIC EFFECT OF SODI
Page 503 and 504:
genes that play a crucial role in M
Page 505 and 506:
2330 THE ROLE OF TRANSFORMING GROWT
Page 507 and 508:
ined following up to 96 h continuou
Page 509 and 510:
effect doses obtained with the rat
Page 511 and 512:
diated transcriptional response of
Page 513 and 514:
docrine disruptor activities of EDC
Page 515 and 516:
individuals. Week 6 results were qu
Page 517 and 518:
functionality of photosystem II and
Page 519 and 520:
wild mice (Mus musculus) from areas
Page 521 and 522:
2406 TOXICITY AND BIOACCUMULATION O
Page 523 and 524:
Isocitric acid is the acid in the h
Page 525 and 526:
2425 EFFECTS OF FUMONISINS IN ETHAN
Page 527 and 528:
centration(μg/g) were: 5.1-95.3; 2
Page 529 and 530:
2445 AUTOPHAGY IN DEVELOPMENT: A LI
Page 531 and 532:
sures to inhaled Mn in dust. Nevert
Page 533 and 534:
2466 CRITICAL EVALUATION OF ANIMAL
Page 535 and 536:
elationships predict that resting r
Page 537 and 538:
2489 COMPARATIVE TOXICITY OF BIODIE
Page 539 and 540:
2497 TRANSCRIPTIONAL REGULATION OF
Page 541 and 542:
2506 TOXICOLOGICAL CONSIDERATIONS O
Page 543 and 544:
launched with the aim of developing
Page 545 and 546:
forms mRNA expression levels were a
Page 547 and 548:
2534 CUTANEOUS WOUND HEALING IN THE
Page 549 and 550:
wells (0, 1, 5, 10, 25, 50, 100, an
Page 551 and 552:
2553 AN ORGANOTYPIC MICROLIVER PLAT
Page 553 and 554:
serum-free media. At 24 hrs, the gr
Page 555 and 556:
2572 INCREASED ARSENIC BIOACCESSIBI
Page 557 and 558:
nology to develop improved methods.
Page 559 and 560:
tuna, swordfish, or mako shark (3.5
Page 561 and 562:
nificantly reduce circulating thyro
Page 563 and 564:
grouped into 9 observation periods
Page 565 and 566:
histopathological or biochemical ev
Page 567 and 568:
exhibited a hyperactive phenotype,
Page 569 and 570:
the search of effective drugs for e
Page 571 and 572:
2644 COVALENT BINDING OF 14 C 2-MET
Page 573 and 574:
aries targeting all transcription f
Page 575 and 576:
(p 9 weeks) and CSC phenotype acqui
Page 577 and 578:
2673 IMMUNE-MEDIATED VASCULAR INJUR
Page 579 and 580:
for risk identification and charact
Page 581 and 582:
to control toxicant delivery in tob
Page 583 and 584:
Author Index (Continued) The numera
Page 585 and 586:
Page 587 and 588:
Page 589 and 590:
Page 591 and 592:
Page 593 and 594:
Page 595 and 596:
Page 597 and 598:
Page 599 and 600:
Page 601 and 602:
Page 603 and 604:
Page 605 and 606:
Page 607 and 608:
Page 609 and 610:
Page 611 and 612:
Keyword Index (Continued) Arsenite
Page 613 and 614:
Keyword Index (Continued) Covalent
Page 615 and 616:
Keyword Index (Continued) flow cyto
Page 617 and 618:
Keyword Index (Continued) innate im
Page 619 and 620:
Keyword Index (Continued) nanoparti
Page 621 and 622:
Keyword Index (Continued) preservat
Page 623 and 624:
Keyword Index (Continued) Thrombocy
Page 625 and 626:
Toxicological Sciences The Official
show all

The Toxicologist - Society of Toxicology

You also want an ePaper? Increase the reach of your titles

Delete template?

Save as template?