The Toxicologist - Society of Toxicology

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obtain “additional lines on a resume” that distinguishes you from most other applicants. Among these are obtaining certificates in job-related fields, participation in committees, mentoring/teaching, applying and receiving awards, as well as interests outside the lab all of which demonstrate your future employer that you have enthusiasm, leadership skills, are a team-player, and are able and willing to compete. This presentation will discuss potential opportunities available at most Universities, over the internet, and surrounding communities as well as provide examples on how applicants can acquire experiences that make you stand out amongst your peers. 2484 COMMUNICATION SKILLS: AN ESSENTIAL ELEMENT TO YOUR PORTFOLIO. D. L. Costa. Office of Research & Development, U.S. EPA, Research Triangle Park, NC. As scientists we are trained to think logically using innovative tools to ferret out answers to our research questions or test our hypotheses. We are trained in focused science and we have accepted the responsibility of knowing all there is know about that science question or given topic. But it is how we communicate that science by which we as scientists are often judged. Even when we talk with our peers or seek career opportunities, our science is often judged on how well we deliver the science message – which in the end, is a direct reflection of who we are as scientists, colleagues or coworkers. While some of us may be gifted communicators, most of us are introverts and spend our leisure time reading science to get the next great idea and less on literature to hone our use of language. Nor do we spend a lot of time speaking to varied groups who may not be “subject matter experts” but who need to understand, i.e., selling ourselves. Appreciating these facts is the first step in developing communication skills as an essential element of our portfolios. Those skills include organized and focused writing, framing the essence of the message and delivering that message at whatever level of detail is appropriate to the intended audience, and ensuring that it is as succinct and clear as possible. In our oral communications, clarity and focus are critical to selling ourelves to the audience. Cluttering the important data or message with ancillary (though not necessarily unimportant) information, or worse overly dense visual aids can kill a presentation and the desired personal image we want to communicate as a blossoming scientist. This tutorial will focus on the elements (and do’s and don’ts) of good communication - written, visual and oral – that the young scientist should incorporate into his/her skill-mix moving ahead in the professional world. These skills are invaluable in getting the position you want, being effective in that position and moving up the professional ladder, and, not to be forgotten, when interfacing with the public who is our ultimate stakeholder. 2485 WHAT IS THE EMPLOYER LOOKING FOR? INSIGHT FROM A JOB PLACEMENT PROFESSIONAL. T. Leyden. The Leyden Group, Greenwood Village, CO. Sponsor: A. Farraj. While it is important to seek appropriate scientific training and strive to round out one’s experience in a variety of ways, perhaps two of the most critical elements of one’s success in obtaining a job offer are well-written resumes/CVs and effective interviewing. Terry will share his experience in portraying what employers in the chemical, pharmaceutical, consumer product and contract research industries seek from job applicants. Terry will offer useful tips in resume/CV preparation, how to get your resume/CV in the hands of the employer, and the job interview. 2486 AN INSIDER PERSPECTIVE: HIRING PROCESSES WITHIN THE BIOTECH/PHARMACEUTICAL INDUSTRY. R. Ragsdale. HR, Genentech & Roche, South San Francisco, CA. Sponsor: A. Farraj. This presentation will give prospective job seekers an insider look into key hiring & recruiting methods within HR departments. Learn how to best position yourself to be selected in the job application and interview process by informing yourself on key HR practices and what hiring managers look for. Key topics to be discussed include types of positions (e.g., full time, contract, post doctoral fellowship, internship, co-op), qualifications (to include education, certification, and work experience), the application process (focus on who the key players are, where they look for talent, time lines, how to set yourself apart in the informational interviews, on 532 SOT 2011 ANNUAL MEETING phone screens and during on-site interviews, selection & decision making process, and offers). Lastly, we’ll spend a few minutes discussing transitioning from academia to industry; and from CRO to pharmaceutical/biotechnology companies. 2487 TISSUE CONCENTRATIONS AND IMMUNOLOGICAL EFFECTS IN C3H/HEJ MICE, FOLLOWING AN INHALATION EXPOSURE TO TWO PARTICLES SIZE OF BE AND BEAL. A. Adam-Poupart 1 , C. Muller 1 , F. Salehi 2 , B. Mazer 2 , G. Chevalier 3 , Y. Cloutier 3 , G. Truchon 4 , J. Lambert 5 and J. Zayed 1 . 1 Department of Environmental and Occupational Health, Faculty of Medicine, University of Montreal, Montreal, QC, Canada, 2 Meakins-Christie Laboratories, McGill University, Montreal, QC, Canada, 3 Department of Biological Sciences, University of Quebec in Montreal, Montreal, QC, Canada, 4 Institut de Recherche Robert-Sauvé en Santé et en Sécurité du Travail, Montreal, QC, Canada and 5 Department of Social and Preventive medicine, Faculty of Medicine, University of Montreal, Montreal, QC, Canada. Beryllium (Be) is a naturally occurring element essential for the energy, medical and electronics industries. Used in solid form, this element doesn’t show health hazard for the public. However, workers exposed through inhalation may develop acute sensitization (BeS), chronic beryllium disease (CBD) and lung cancer. Be toxicity is influenced by many factors, such as concentration, chemical form, solubility and particle size. This study investigated the impact of particle sizes (Mass median aerodynamic diameter ranging between 1.5 and 6.5 μm) of two Be chemical forms (Be metal and Be aluminum) on Be-induced toxicity. Two hundred male mice C3H/HeJ equally divided into 5 groups were exposed by inhalation (nose-only) during 3 consecutive weeks, 5 days/week, 6 hr/day. The first group,exposed to HEPA-filtered air, was used as a control,while the four other groups were exposed to approximately 250 μg/m3 of Be: 1.5 and 4.1 μm and BeAl 4.4 and 6.5 μm. The concentrations of Be were measured in lung, liver, kidneys, spleen and blood while the levels of cells expression and cytokines in spleen (CD4+, CD8+, CD19 and IFN-γ flow) and in bronchoalveolar lavage (IL-2, IL-4, IL-12, TNF-α and IFN-γ) were quantified. Histological scores of lung were also classified by the severity of inflammation. Overall, tissues concentrations and cytokine levels were higher and pulmonary inflammation was greater in the group exposed to smaller particles compared to the group exposed to larger particles for Be and BeAl. These results suggested that particle size might be a critical parameter in the Be-induced toxicity. 2488 CIGARETTE SMOKE EXTRACT ENHANCED AMBIENT ULTRAFINE PARTICLE-INDUCED OXIDATIVE STRESS IN ENDOTHELIAL CELLS. Y. Mo 1 , R. Wan 1 , S. Chien 2 , D. J. Tollerud 1 and Q. Zhang 1 . 1 Environmental and Occupational Health Sciences, University of Louisville, Louisville, KY and 2 Surgery, University of Louisville, Louisville, KY. A number of epidemiological studies have shown that cigarette smoke induces cardiovascular diseases. However, we have identified no studies that address the potential combined effects of UFPs and cigarette smoke on vascular endothelial cells. We hypothesize that co-exposure to UFPs with cigarette smoke extract (CSE) may cause combined effects on activation of endothelial cells and dysfunction of endothelium by oxidative stress through activation of NADPH oxidase. We determined the combined effects of UFPs with or without CSE on mouse pulmonary microvascular endothelial cells (MPMVEC) obtained from wild-type mice and gp91phox knock-out mice, respectively (Gp91phox is one of the key components of NADPH oxidase, which is located in the cell membrane). Our results showed that exposure of MPMVEC from wide-type mice to UFPs, CSE or UFPs with CSE, at a non-toxic dose, induced reactive oxygen species (ROS) generation, increased phosphorylation of p38 and Erk1/2, and up-regulation of early growth response -1 (Egr-1) and IL-6 expression. Furthermore, exposure to UFPs with CSE caused significantly more ROS generation in MPMVEC from wide-type mice than those of exposure to UFPs or CSE alone. Our results also showed that there were combined effects, including increased phosphorylation of p38 and Erk1/2, and upregulation of Egr-1 and IL-6 expression when MPMVEC from wide-type mice were exposed to UFPs with CSE. However, exposure of MPMVEC from gp91phox knock-out mice did not induce the above effects. Our results suggest that UFPs, CSE, and UFPs with CSE caused the activation of NADPH oxidase. This causes ROS generation that leads to activation of MAPKs through induced phosphorylation of p38 and ERK1/2 MAPKs, and upregulation of Egr-1 that may further result in endothelial dysfunction through production of cytokines such as IL-6. Our results suggest that co-exposure to UFPs and cigarette smoke causes synergistic injury to endothelial cells. Grant Supports: KSEF-1686-RED-11, T32-ES011564.
2489 COMPARATIVE TOXICITY OF BIODIESEL EXHAUST AND PETROLEUM DIESEL EXHAUST PARTICULATE MATTER USING WKY RAT ALVEOLAR MACHROPHAGES. L. Bhavaraju 2 , J. Shannahan 2 , A. Williams 3 , R. McCormick 3 , J. McGee 1 , U. Kodavanti 1 and M. Madden 1 . 1 ORD, NHEERL, EPHD, U.S. EPA, Chapel Hill, NC, 2 Curriculum in Toxicology, University of North Carolina, Chapel Hill, NC and 3 Fuels Performance Group, National Renewable Energy Lab., Golden, CO. Exposure to fine ambient particulate matter
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The Toxicologist Supplement to Toxi
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The Toxicologist Supplement to Toxi
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1 BIODEGRADABLE MATERIALS FOR TISSU
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that genetic toxicology data are ge
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well-orchestrated lung inflammation
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scribed in the literature. We have
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years ago). We will illustrate how
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involved in the biodegradation proc
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stem cells but rather a treatment i
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additional compound showed agreemen
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82 COMPARISON OF 3H-THYMIDINE INCOR
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irritants. While in practice these
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alleles are especially vulnerable t
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109 CD4+ T CELL INTRINSIC TNF RECEP
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118 TO STUDY THE SIGNAL TRANSDUCTIO
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PAHs, such as dioxins, are prevalen
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containing substituents and/or hydr
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146 COMPUTATIONAL MODELING FOR QT P
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suggest that the combination of too
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164 TRANSLOCATOR PROTEIN (18 KDA) (
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function as a metal binding protein
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laboratory has demonstrated that NR
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known. The aim of this study was to
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from 5 to 28 days in duration) in e
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positive cells, caspase-3 activatio
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creased level in the 46 kDa preproe
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invasiveness at concentrations repr
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thracene (DMBA,50 μg in acetone, a
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247 CO-CARCINOGENESIS OF N, N- DIET
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sponds to the endosomal dsRNA that
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ODD in both WT (maximum 177% of con
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Lastly, using p53siRNA cells, p53 w
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its receptor Mpl to exert its funct
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294 LOW LEVEL OF LEAD CAN INDUCE PH
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lunar surface presented potential h
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lar about cellular export mechanism
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DNA in the kidney medulla, grandula
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5.00 and 7.50 mg/kg/day by oral gav
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events and carcinogenesis. Here we
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tinization of cells of the hair fol
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358 CHARACTERIZATION OF GENOME-WIDE
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RNAi were also performed to identif
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376 A FUNCTIONAL CROSSTALK BETWEEN
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UGT1A gene induction, while this re
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tivity, specifically peroxisome pro
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and cytotoxic effects; however, its
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histone deacetylase that is necessa
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ment. Paradoxically, buthionine sul
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drug leflunomide and its major (A77
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442 GENE EXPRESSION AND MORPHOLOGIC
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451 INHIBITION OF THE MITOCHONDRIAL
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460 SULFORAPHANE PREVENTS ACETAMINO
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drophilic/lipophilic balance. Other
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pharmacokinetic and toxicological p
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489 USE OF ‘OMICS DATA TO IMPROVE
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498 APPLICATION OF AGE-SPECIFIC ADJ
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507 A DOSE VOLUME TOLERABILITY STUD
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involved the use of an acute inflam
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sorption in the gastrointestinal (G
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(ABC) transporters actively transpo
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545 BEHAVIORAL EFFECTS OF REPIN IN
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a blood pressure phenotype that res
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and inhalation exposure system that
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and lethality associated with these
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position, on vascular reactivity an
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therefore more accurate and reprodu
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commercial chrysotile product that
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elative to their controls. ST-depre
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ats. The majority of the studies fo
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in the China Jintan Child Cohort St
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corneum thickness, cellular epiderm
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645 EVALUATION OF THE IN VITRO EPIS
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654 TCDD ADSORBED ONTO NATURAL AND
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tion revealed no test article-relat
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671 INFLAMMATION AND TISSUE DAMAGE
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model, ethanol was found to inhibit
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689 ENHANCED SUPPRESSIVE FUNCTION O
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NAC + LPS yielded different levels
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707 LIFE-STAGE PBPK MODELS FOR MULT
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downstream of the apical endpoint o
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726 UPDATED ALUMINUM PHARMACOKINETI
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global parameter sensitivity analys
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and renal inflammation induced by 2
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754 PLASMA, URINE, AND TISSUE CONCE
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cently characterized transporter OA
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exposure system was developed from
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lood cell mass and decrease in urin
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practical alternatives to MC in non
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imals dosed with 167 mg/kg THU alon
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and organ weights, clinical signs a
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yet is induced in most bladder and
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830 RISK ASSESSMENT OF THE SPILL: C
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knowledgebase creation. Results are
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852 UNDERSTANDING STRUCTURAL AND PH
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for integrating epidemiology and an
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motor activity, including age of th
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y partial purification of urine (fr
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pacity for self-renewal and may dif
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sue. The depth of our analysis led
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910 IMPLEMENTING CALIFORNIA’S GRE
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concentrations in six tissues and b
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934 THE FDA’S LIVER TOXICITY KNOW
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943 GENOME-WIDE DNA METHYLATION DIF
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membrane localization and subsequen
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trols, respectively. Subtoxic and t
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survival using both smoking regimes
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as non-, weak, moderate, or strong
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988 NNK-INDUCED CYTOKINE ALTERATION
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group (one-way ANOVA, p90 % viabili
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ered as an organ involved in xenobi
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Transport of CPZ across the Caco-2
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estrous cycle and sexual behavior d
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mRNA expression levels. Collectivel
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1043 THE EFFECTS OF ENDOCRINE DISRU
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1052 MONO-2-ETHYLHEXYL PHTHALATE IN
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Results: MC was variable within and
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UtSMCs. Phosphorylation of FoxO1 wa
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nonpregnant and pregnant diabetic m
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1089 PFOA-INDUCED LIVER EFFECTS IN
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events in the liver. AZD9056 was ev
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The peppermint oil caused a concent
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OA did not affect food consumption.
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1126 PERSISTENT DEVELOPMENTAL ARYLH
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1135 BACH2 BINDING TO Prdm1 AS A ME
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The purpose of this project was to
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one marrow. Since Chk1 is an attrac
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1163 THE MRNA AND MIRNA PROFILE OF
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have now compared the IC50 values b
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1181 ELUCIDATION OF FACTORS DETERMI
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enced by pre-exposure to cigarette
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if abnormal PF was associated with
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weight (P=0.016) and small for gest
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portant cause of death, compared to
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posure groups. However, the differe
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Naphthalene is routinely analyzed i
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1245 SEASONAL CHARACTERIZATION OF H
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1255 URINARY T, T MUCONIC ACID LEVE
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modating a reliable data evaluation
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enzoquinone generate ROS and arylat
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teins (e.g. C3, 4, and 5, APOB, VDB
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1293 TRANSFORMING GROWTH FACTOR BET
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mation was decreased to the same le
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1312 EVALUATION OF THE SENSITIVITY
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luted OFR and CRL. Culture media ex
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urinary TCPy levels, blood and brai
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activity. The dose-response curves
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mice, each with 4 dose groups. One
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exposure to both ATR and DACT has a
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third tetratricopeptide repeats (TP
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7d. 28d after TMT injury there was
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subunits. Each cell type was treate
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1394 COMPARATIVE EFFECTS OF METHYLM
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1403 GENOTOXICITY AND PRE-NEOPLASTI
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vated only in high-dose-treated ani
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1421 DOSE-RESPONSE OF NAPHTHALENE-I
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cisplatin; 1.2-, 1.9- and 2.9-fold
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Day 11 and started to recover on Da
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1448 DEVELOPMENT OF A METHOD FOR QU
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1457 GLOBAL GENE PROFILING REVEALS
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cluding mouse and human macrophage,
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model of lung inflammation and host
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1484 NANOTOXICOLOGY AND NANOHEALTH
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throughput in vitro approach was us
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1502 IMMUNOLOGICAL ASPECTS OF AN AN
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(CIA) and the Streptococcal cell wa
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sitizers were 100% concordant among
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1530 MINIMAL RISK LEVELS FOR STYREN
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ical groups in the field of regulat
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vitro with this potentially insect-
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their performance on toxicological
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need for a better understanding of
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1577 AN IN VITRO MODEL SYSTEM FOR A
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gene expression post-transcriptiona
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1595 GENE EXPRESSION PROFILE OF RAT
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to confirm a hepatotoxic property o
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1613 AN INVESTIGATION OF THE CLEARA
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its nuclear translocation was reduc
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were collected from TK animals at d
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egulated targets were selected for
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U/L after tetracycline. Minocycline
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peri-pubertal FasL-/- mice show a d
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showed similar levels of apoptosis
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1676 TWO BIOMARKERS FOR EVALUATION
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motifs selected. This system was ap
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1693 VOC SERUM LEVELS IN THE GENERA
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1702 DOES THE CLOCK MAKE THE POISON
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those with high nickel content are
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isk assessment. However, unique cha
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model of APAP metabolism and glutat
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logically & morphologically similar
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posure, blood chemistry was analyze
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elated to oxidative stress by measu
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ostasis), but work is needed to tra
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tokine products during carcinogenes
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ways as chemical stressors and, the
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toxicity of nanomaterials relates s
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1815 MEASURING COMPOUND SELECTIVITY
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1825 EFFECTS OF METABOLISM BY INTES
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cyanoacetic acid increased 2-3 fold
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1845 IS THE PROMISCUITY OF THE ARYL
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crorarray analysis. RT-PCR results
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are a family of phase-II biotransfo
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ous labs. As a result of positive s
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down the doses may produce more tox
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spectively. Below 100 mg/l of gemfi
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1900 GENERATION OF PRECISION CUT LI
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iomarkers or observation of lesions
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creased reticulocytes and lymphocyt
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statistically significant interacti
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monize sample preparation and analy
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NPC and sinonasal cancer in neighbo
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showed incidences of lung and nasal
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utylbenzenes, exhibited most simila
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1975 DIFFERENTIAL MODULATION OF CYP
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organic As to MMA(V) and a lower ca
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ole in invasion and metastasis of c
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3T3-L1 cells to low-levels of arsen
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2011 IDENTIFICATION OF A NOVEL VX M
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This work was supported by Cooperat
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2029 EFFICACY OF ENDOTRACHEAL ADMIN
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Diazepam injections and its combina
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2047 ESTERASE ACTIVITIES AND HEMOST
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nanoparticle-induced toxicity progr
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house, were iv infused into rats ov
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een explored. This study investigat
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croscopic analysis revealed that on
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egg yolk collected from turtles inh
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consistency of results in both expe
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2111 CYTOCHROME P450 3A5 GENOTYPE I
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esidues of organophosphates or thei
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manganism. Recent work from our lab
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Aβ1-40 in CSF and hippocampus in P
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2147 CATALASE MANIPULATIONS MODIFY
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ation based on real-world exposure
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NPs. Aggregation of citrate-stabili
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2175 THE ROLE OF SURFACE CHEMISTRY
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seen rapid uptake in biological ima
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effect on uterine weight or vaginal
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dicating widespread exposure. While
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components into the liver parenchym
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2223 ISOLATION AND DETECTION OF RIC
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stored (-20 celsius degree). The co
Page 485 and 486: 2241 DDA, A BIOMARKER FOR ENVIRONME
Page 487 and 488: 2249 INTERACTION BETWEEN DIETARY SE
Page 489 and 490: 2258 PHARMACOKINETICS, EXCRETION BA
Page 491 and 492: 2267 SENSITIVE AND SPECIFIC FLUORES
Page 493 and 494: 2276 METABOLISM AND DISPOSITION OF
Page 495 and 496: ment of hypertension in companion a
Page 497 and 498: for the propyl series can be used f
Page 499 and 500: 2304 IN VITRO EXPOSURE AND EVALUATI
Page 501 and 502: 2313 THE SYNERGISTIC EFFECT OF SODI
Page 503 and 504: genes that play a crucial role in M
Page 505 and 506: 2330 THE ROLE OF TRANSFORMING GROWT
Page 507 and 508: ined following up to 96 h continuou
Page 509 and 510: effect doses obtained with the rat
Page 511 and 512: diated transcriptional response of
Page 513 and 514: docrine disruptor activities of EDC
Page 515 and 516: individuals. Week 6 results were qu
Page 517 and 518: functionality of photosystem II and
Page 519 and 520: wild mice (Mus musculus) from areas
Page 521 and 522: 2406 TOXICITY AND BIOACCUMULATION O
Page 523 and 524: Isocitric acid is the acid in the h
Page 525 and 526: 2425 EFFECTS OF FUMONISINS IN ETHAN
Page 527 and 528: centration(μg/g) were: 5.1-95.3; 2
Page 529 and 530: 2445 AUTOPHAGY IN DEVELOPMENT: A LI
Page 531 and 532: sures to inhaled Mn in dust. Nevert
Page 533 and 534: 2466 CRITICAL EVALUATION OF ANIMAL
Page 535: elationships predict that resting r
Page 539 and 540: 2497 TRANSCRIPTIONAL REGULATION OF
Page 541 and 542: 2506 TOXICOLOGICAL CONSIDERATIONS O
Page 543 and 544: launched with the aim of developing
Page 545 and 546: forms mRNA expression levels were a
Page 547 and 548: 2534 CUTANEOUS WOUND HEALING IN THE
Page 549 and 550: wells (0, 1, 5, 10, 25, 50, 100, an
Page 551 and 552: 2553 AN ORGANOTYPIC MICROLIVER PLAT
Page 553 and 554: serum-free media. At 24 hrs, the gr
Page 555 and 556: 2572 INCREASED ARSENIC BIOACCESSIBI
Page 557 and 558: nology to develop improved methods.
Page 559 and 560: tuna, swordfish, or mako shark (3.5
Page 561 and 562: nificantly reduce circulating thyro
Page 563 and 564: grouped into 9 observation periods
Page 565 and 566: histopathological or biochemical ev
Page 567 and 568: exhibited a hyperactive phenotype,
Page 569 and 570: the search of effective drugs for e
Page 571 and 572: 2644 COVALENT BINDING OF 14 C 2-MET
Page 573 and 574: aries targeting all transcription f
Page 575 and 576: (p 9 weeks) and CSC phenotype acqui
Page 577 and 578: 2673 IMMUNE-MEDIATED VASCULAR INJUR
Page 579 and 580: for risk identification and charact
Page 581 and 582: to control toxicant delivery in tob
Page 583 and 584: Author Index (Continued) The numera
Page 585 and 586: Author Index (Continued) The numera
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Author Index (Continued) The numera
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Keyword Index (Continued) Arsenite
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Keyword Index (Continued) Covalent
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Keyword Index (Continued) flow cyto
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Keyword Index (Continued) innate im
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Keyword Index (Continued) nanoparti
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Keyword Index (Continued) preservat
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Keyword Index (Continued) Thrombocy
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Toxicological Sciences The Official
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