The Development of Novel Antibiotics Using ... - Jacobs University

Intens.
[%]
100
80
60
40
20
0
O
H N
N N H
O H
H
O
O
H H
N O
O N
H N
H
8
H
N
H
N H
N
O N
H
O
H
N N
H
O
Figure 23. ESI-MS 2 for macrocycle 8 in the positive ion mode.
O
H O
H
O
600 700 800 900 1000 1100 1200 m/z
959.5
Intens.
[%]
100
80
60
40
20
465.5
491.4
517.4
OCN
709.4
741.4 761.4
689.5
H
N H
N
O N
H
H 2 N
C 22 H 24 N 6 NaO 6
491
O
NH
H
O H
O
O
960.5
0
500 550 600 650 700 750 800 850 900 m/z
Figure 24. Tandem ESI-MS for macrocycle 8 in the positive ion mode.
Intens.
[%]
100
1043.5
80
60
40
20
0
500 1000 1500 2000 2500
m/z
Figure 25. ESI-MS 2 for macrocycle 9 in the positive ion mode.
Intens.
[%]
100
533.4
80
60
40
20
0
1044.5
559.4
507.5
759.4 791.5 843.4
307.4
817.5
300 400 500 600 700 800 900 1000 m/z
Figure 26. Tandem ESI-MS for macrocycle 9 in the positive ion mode.
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