The Development of Novel Antibiotics Using ... - Jacobs University

Introduction
Figure 2.6 Energy-minimized structure for host/guest complex 4/20 at the MM+ level.
Trianglamine-Cu(OAc) 2 complex, obtained by stirring of trianglamine 27 (All-S) and Cu(OAc) 2
in dichloromethane (DCM) at room temperature, has been used as an efficient catalyst for the
Henry reaction of aldehydes (i.e., 24) and nitromethane 25. 23 The β-hydroxynitroalkanes (i.e.,
26) obtained by this approach form with high enantioselectivity (82-93% ee) under mild solvent
free condition. The products from the reactions were obtained in the (R)-form (Figure 2.7).
Figure 2.7 Enantioselective Henry reaction catalyzed by Trianglamine-Cu(OAc) 2 .
23 | P a g e