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amniotic fluid<br />

placenta<br />

LEARNING TIP<br />

Use questions to check your<br />

understanding of amniocentesis. Ask<br />

yourself, “What is involved in this<br />

procedure? What are the advantages<br />

and disadvantages of this procedure?<br />

What else is it used for?”<br />

fetal cells<br />

wall of<br />

uterus<br />

Figure 2 Amniocentesis removes<br />

amniotic fluid, which contains fetal cells.<br />

These cells are karyotyped.<br />

Other information, such as whether the fetus has a spinal cord defect, can<br />

also be obtained from amniotic fluid. As well, in the third trimester, the<br />

amniotic fluid can be analyzed to determine how well the fetus’s lungs have<br />

developed. The levels of certain chemicals in the fluid indicate whether the<br />

lungs of the fetus are mature enough to function well outside the womb. GO<br />

If you would like to learn more<br />

about amniocentesis, go to<br />

www.science.nelson.com GO<br />

Chorionic Villus Sampling<br />

Chorionic villus sampling involves inserting a catheter<br />

through the vagina into the uterus to sample cells of<br />

the placenta. The chorionic villi are extensions of the<br />

chorion, the layer of the placenta that connects to the<br />

uterus (Figure 3). The chorionic villi contain many<br />

more fetal cells than the amniotic fluid. The sample<br />

is taken between 8 and 12 weeks of pregnancy. The<br />

karyotype of the fetus can be determined much<br />

earlier in the pregnancy than with amniocentesis.<br />

However, the test does not provide information<br />

about possible spinal cord defects or lung maturity.<br />

Egg Collection<br />

Women who choose in vitro fertilization have some<br />

eggs collected and tested for genetic disorders. An<br />

optical device called laparoscope is inserted into the<br />

abdominal cavity to view the ovary. A suction device<br />

is inserted to collect some eggs, which are then tested<br />

in a laboratory. If they are healthy, the eggs will<br />

undergo in vitro fertilization. Examining eggs will<br />

only detect disorders from the mother’s genes.<br />

NEL<br />

uterus<br />

chorionic<br />

villus<br />

maternal portion<br />

of the placenta<br />

fetal portion<br />

of the placenta<br />

umbilical cord<br />

sampling tube<br />

Figure 3 Chorionic villus sampling provides fetal cells, from which a<br />

karyotype is made.<br />

4.6 Prenatal Procedures 131

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