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Unit A Reproduction

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could clone frogs, they were unable to develop techniques to clone mammals.<br />

Then, in 1997, Scottish scientist Ian Wilmut cloned a sheep, which he named<br />

Dolly. Even though Dolly died in 2003, she is probably the most famous clone<br />

to date. Dolly was a normal female sheep, grown from a single cell of another<br />

sheep. She even gave birth to several lambs conceived in the normal way. Since<br />

then, other mammals have been cloned.<br />

The Cloning Process<br />

Dolly was created through a process that involved several steps (Figure 2).<br />

First, Wilmut and his team removed a body cell from the udder of one adult<br />

female sheep and an egg cell from another adult female sheep. They removed<br />

the nucleus from the egg cell and replaced it with the nucleus of the udder<br />

cell. They then used an electric shock to stimulate cell division in the new<br />

cell. Once the new cell had divided several times, they inserted the new embryo<br />

(developing organism) into the uterus of a third sheep. (The uterus is the<br />

organ in which the embryo develops.) The embryo continued to develop,<br />

and the sheep gave birth to Dolly.<br />

Figure 2 The cloning process involves<br />

combining the nucleus of a body cell<br />

with the cytoplasm of an egg cell.<br />

Finn Dorset<br />

Scottish Blackface<br />

1. Udder cells<br />

are frozen.<br />

2. Egg is taken<br />

from sheep.<br />

LEARNING TIP<br />

A concept map (Figure 2) is a<br />

collection of words or pictures, or<br />

both, connected with lines or arrows.<br />

For more information on concept<br />

maps, refer to the Skills Handbook.<br />

3. The nucleus is<br />

removed from the<br />

egg cell.<br />

4. Two cells are fused.<br />

5. Egg undergoes cell divisions.<br />

6. Cell mass (embryo) is transferred<br />

into the uterus of a<br />

Scottish Blackface sheep.<br />

Scottish<br />

Blackface<br />

Finn<br />

Dorset<br />

7. Blackface sheep<br />

carries the clone.<br />

8. Dolly is born.<br />

62 <strong>Unit</strong> A <strong>Reproduction</strong><br />

NEL

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