Global Tuberculosis Report -- 2012.pdf

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BRAZILPopulation 2011 197 millionHIGH TB BURDEN | HIGH HIV BURDENEstimates of TB burden a 2011NUMBER (thousands) RATE (per 100 000 population)Mortality (excludes HIV+TB) 5.6 (4.6–6.8) 2.9 (2.3–3.4)Prevalence (includes HIV+TB) 91 (36–170) 46 (18–87)Incidence (includes HIV+TB) 83 (69–97) 42 (35–50)Incidence (HIV+TB) 16 (13–19) 8.2 (6.8–9.7)Case detection, all forms (%) 91 (77–110)TB case notifications 2011NEW CASES (%) RETREATMENT CASES (%)Smear-positive 40 294 (56) Relapse 3 555 (35)Smear-negative 12 683 (18) Treatment after failure 199 (2)Smear-unknown/not done 8 278 (12) Treatment after default 3 344 (33)Extrapulmonary 10 067 (14) Other 2 947 (29)Other 15 (
CAMBODIAPopulation 2011 14 millionHIGH TB BURDEN | HIGH HIV BURDENEstimates of TB burden a 2011NUMBER (thousands) RATE (per 100 000 population)Mortality (excludes HIV+TB) 9.1 (4.2–16) 63 (29–111)Prevalence (includes HIV+TB) 120 (99–140) 817 (690–954)Incidence (includes HIV+TB) 61 (52–70) 424 (364–489)Incidence (HIV+TB) 3.1 (2.6–3.6) 22 (18–25)Case detection, all forms (%) 64 (55–74)TB case notifications 2011NEW CASES (%) RETREATMENT CASES (%)Smear-positive 15 812 (41) Relapse 367 (25)Smear-negative 7 686 (20) Treatment after failure 49 (3)Smear-unknown/not done 0 (0) Treatment after default 30 (2)Extrapulmonary 14 690 (38) Other 1 036 (70)Other 0 (0)Total new 38 188 Total retreatment 1 482Mortality (excludes HIV+TB) (rateper 100 000 population per year)Prevalence(rate per 100 000 population)3002502001501005020001500100001990 1995 2000 2005 201050001990 1995 2000 2005 2010Other (history unknown) 0Total new and relapse 38 555 Total cases notifi ed 39 670New casesSMEAR-NEGATIVE/SMEAR-POSITIVE UNKNOWN/NOT DONE EXTRAPULMONARYM:F ratio 1.2Age < 15 73Laboratories 2011Smear (per 100 000 population) 1.5Culture (per 5 million population) 1.0Drug susceptibility testing (per 5 million population) 0.3Is second-line drug susceptibility testing available?Yes, outside countryIs there a national reference laboratory?YesTreatment success rate 2010 (%)New smear-positiveIs rifampicin used throughout(and/or culture-positive) 94 treatment for new patients? YesNew smear-negative/extrapulmonary 85Retreatment 75TB/HIV 2011 NUMBER (%)TB patients with known HIV status 32 544 (82)HIV-positive TB patients 1 650 (5)HIV-positive TB patients on co-trimoxazole preventive therapy (CPT) 1 456 (88)HIV-positive TB patients on antiretroviral therapy (ART) 1 306 (79)HIV-positive people screened for TB 4 747HIV-positive people provided with IPT 1 305Estimates of MDR-TB burden 2011 a NEW RETREATMENT% of TB cases with MDR-TB 1.4 (0.71–2.5) 11 (4.0–22)MDR-TB cases among notifi edpulmonary TB cases 330 (170–590) 160 (60–320)<strong>Report</strong>ed cases of MDR-TB 2011 NEW RETREATMENT TOTALCases tested for MDR-TB 18 (
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GLOBALTUBERCULOSISREPORT2012
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ContentsAbbreviationsivAcknowledgem
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AcknowledgementsThis report on glob
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WHO Western Pacific RegionShalala A
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Executive SummaryThe World Health O
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CHAPTER 1IntroductionBOX 1.1Basic f
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TABLE 1.1 Targets for the scale-up
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TABLE 1.2 Reporting of data in the
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BOX 2.1Uncertainty in estimates of
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TABLE 2.2 Estimated burden of disea
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FIGURE 2.5 Estimated TB incidence r
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FIGURE B2.2.1Reporting of notificat
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FIGURE 2.8Estimated TB incidence ra
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FIGURE 2.11 Countries (in blue) for
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FIGURE 2.12 Trends in estimated TB
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● producing and widely disseminat
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FIGURE 2.16 Progress in global cove
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BOX 2.6Efforts by the Task Force to
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CHAPTER 3TB case notificationsand t
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BOX 3.1 1Definitions of TB casesDef
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TABLE 3.3 Contribution of public-pr
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BOX 3.4Integrating community-based
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TABLE 3.4 Estimates of the case det
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TABLE 3.5 Treatment success for new
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CHAPTER 4Drug-resistant TBKEY FACTS
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FIGURE 4.2 Percentage of new TB cas
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BOX 4.1Frequencies of resistance to
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FIGURE 4.6 Number of MDR-TB cases e
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FIGURE 4.7Notified cases of MDR-TB
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egimens globally, providing more su
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5.1 Funding for TB care and control
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TABLE 5.2 NTP budgets, available fu
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FIGURE 5.5Trends in domestic and do
Page 68 and 69: FIGURE 5.6Domestic funding as a per
Page 70 and 71: FIGURE 5.8Cost per TB patient succe
Page 72 and 73: FIGURE 5.10 Total cost and unit cos
Page 74 and 75: ● The 14 countries not included i
Page 76 and 77: on public health by an external Exp
Page 78 and 79: evised as a result of the introduct
Page 80 and 81: TABLE 6.2 Incorporation of WHO poli
Page 82 and 83: FIGURE 6.3The Supranational Referen
Page 84 and 85: of TB disease by 65%, irrespective
Page 86 and 87: FIGURE 7.3Percentage of TB patients
Page 88 and 89: BOX 7.1Accelerating progress in pro
Page 90 and 91: TABLE 7.2 Assumptions used to estim
Page 92 and 93: FIGURE 8.1 The development pipeline
Page 94 and 95: sputum specimens and TB isolates fr
Page 96 and 97: cal trial sites and building labora
Page 98: new TB vaccine candidate. A Phase I
Page 102 and 103: This annex explains the methods tha
Page 104 and 105: 2011. On average, 15 data points we
Page 106 and 107: may suffer from biases. These biase
Page 108 and 109: TABLE A1.3Parameter estimates used
Page 110 and 111: 5. Estimates of TB prevalence, 1990
Page 112: the Republic of Moldova, Romania, t
Page 116 and 117: AFGHANISTANPopulation 2011 32 milli
Page 120 and 121: CHINAPopulation 2011 1 348 millionH
Page 122 and 123: ETHIOPIAPopulation 2011 85 millionH
Page 124 and 125: INDONESIAPopulation 2011 242 millio
Page 126 and 127: MOZAMBIQUEPopulation 2011 24 millio
Page 128 and 129: NIGERIAPopulation 2011 162 millionH
Page 130 and 131: PHILIPPINESPopulation 2011 95 milli
Page 132 and 133: SOUTH AFRICAPopulation 2011 50 mill
Page 134 and 135: UGANDAPopulation 2011 35 millionHIG
Page 136 and 137: VIET NAMPopulation 2011 89 millionH
Page 138: ANNEX 3Regional profiles
Page 141 and 142: WHO REGION OF THE AMERICASPopulatio
Page 143 and 144: WHO EUROPEAN REGIONPopulation 2011
Page 145 and 146: WHO WESTERN PACIFIC REGIONPopulatio
Page 148 and 149: SUMMARY BY WHO REGIONTable A4.1 Est
Page 150 and 151: MORTALITY (EXCLUDING HIV) PREVALENC
Page 152 and 153: NEW AND RELAPSENOTIFICATION RATE aY
Page 154 and 155: -% OF TB PATIENTS WITHKNOWN HIV STA
Page 156 and 157: AFRICAN REGIONTable A4.1 Estimates
Page 162 and 163: INCIDENCE (INCLUDING HIV) INCIDENCE
Page 164 and 165: NEW AND RELAPSENOTIFICATION RATE aY
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TREATMENT SUCCESS (%) a1995-2010YEA
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-% OF TB PATIENTS WITHKNOWN HIV STA
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YEARTOTALCONFIRMEDCASES OFMDR-TB aE
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MALEYEAR 0-14 15-24 25-34 35-44 45-
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REGION OF THE AMERICASTable A4.1 Es
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MORTALITY (EXCLUDING HIV) PREVALENC
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INCIDENCE (INCLUDING HIV) INCIDENCE
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NEW AND RELAPSENOTIFICATION RATE a1
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% OF COHORTTREATMENT SUCCESS (%) a1
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MALEFEMALEYEAR 0-14 15-24 25-34 35-
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EASTERN MEDITERRANEAN REGIONTable A
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EUROPEAN REGIONTable A4.1 Estimates
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SOUTH-EAST ASIA REGIONTable A4.1 Es
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SMEAR LABS % OF SMEARPER 100K LABS
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Estimates of mortality, prevalence
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YEARPOPULATION(MILLIONS)MORTALITY (
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YEARPOPULATION(MILLIONS)INCIDENCE (
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YEARPOPULATION(MILLIONS)INCIDENCE (
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SMEAR LABS % OF SMEARPER 100K LABS
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