Global Tuberculosis Report -- 2012.pdf

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MORTALITY (EXCLUDING HIV) PREVALENCE (INCLUDING HIV) INCIDENCE (INCLUDING HIV)YEARPOPULATION(MILLIONS)NUMBER(THOUSANDS)RATE aNUMBER(THOUSANDS)RATE aNUMBER(THOUSANDS)<strong>Global</strong> 1990 5 283 1 300 (1 100–1 500) 24 (20–28) 14 000 (13 000–16 000) 268 (243–294) 7 800 (7 100–8 400) 147 (135–159)1995 5 702 1 300 (1 100–1 600) 24 (20–28) 15 000 (14 000–17 000) 269 (246–293) 8 400 (7 900–8 900) 148 (139–157)2000 6 097 1 400 (1 100–1 600) 22 (19–26) 16 000 (14 000–17 000) 257 (234–282) 9 100 (8 500–9 600) 148 (140–157)2005 6 481 1 200 (1 100–1 400) 19 (16–22) 14 000 (13 000–16 000) 221 (199–244) 9 200 (8 700–9 700) 142 (135–150)2009 6 792 1 100 (900–1 200) 16 (13–18) 12 000 (11 000–14 000) 184 (163–206) 8 800 (8 500–9 200) 130 (125–135)2010 6 870 1 000 (870–1 200) 15 (13–17) 12 000 (11 000–14 000) 177 (156–200) 8 800 (8 400–9 100) 128 (123–133)2011 6 948 990 (840–1 100) 14 (12–17) 12 000 (10 000–13 000) 170 (150–192) 8 700 (8 300–9 000) 125 (120–130)Africa 1990 507 200 (130–290) 40 (25–57) 1 900 (1 200–2 800) 372 (231–545) 1 200 (950–1 600) 245 (188–310)1995 580 230 (150–310) 39 (26–54) 2 200 (1 500–2 900) 372 (262–500) 1 600 (1 300–1 900) 276 (227–330)2000 656 240 (160–340) 37 (25–51) 2 500 (1 700–3 300) 374 (266–500) 2 000 (1 700–2 400) 311 (256–371)2005 742 240 (170–330) 32 (22–44) 2 600 (1 900–3 400) 352 (256–462) 2 300 (1 900–2 700) 310 (263–361)2009 817 220 (180–270) 27 (22–33) 2 500 (2 100–2 900) 304 (255–358) 2 300 (2 100–2 400) 276 (256–296)2010 837 220 (180–280) 27 (21–33) 2 500 (2 100–3 000) 303 (250–361) 2 300 (2 100–2 500) 271 (249–293)2011 857 220 (180–270) 26 (21–31) 2 500 (2 100–3 000) 293 (243–347) 2 300 (2 100–2 400) 262 (242–283)The Americas 1990 723 41 (34–49) 5.7 (4.7–6.8) 680 (480–910) 94 (67–126) 430 (360–490) 59 (50–68)1995 777 37 (33–42) 4.8 (4.2–5.5) 540 (420–670) 69 (54–87) 380 (350–410) 49 (46–53)2000 834 30 (26–34) 3.6 (3.2–4.0) 460 (360–580) 55 (43–70) 340 (320–370) 41 (38–44)2005 885 25 (22–28) 2.8 (2.4–3.1) 410 (320–520) 46 (36–59) 310 (290–330) 34 (32–37)2009 924 22 (19–25) 2.3 (2.0–2.7) 350 (260–440) 38 (29–48) 270 (260–290) 30 (28–32)2010 933 21 (18–24) 2.3 (1.9–2.6) 340 (260–430) 36 (27–46) 270 (250–280) 29 (27–30)2011 943 21 (18–24) 2.2 (1.9–2.5) 330 (250–420) 35 (26–44) 260 (240–280) 28 (26–29)Eastern 1990 381 120 (58–200) 32 (15–54) 1 000 (570–1 600) 269 (149–425) 470 (360–590) 123 (95–154)Mediterranean 1995 433 130 (68–210) 30 (16–49) 1 100 (680–1 700) 260 (158–388) 530 (480–590) 123 (110–137)2000 484 140 (71–230) 29 (15–47) 1 200 (700–1 800) 245 (145–371) 570 (510–640) 118 (104–132)2005 538 120 (67–190) 23 (12–36) 1 100 (700–1 600) 207 (130–302) 610 (540–680) 113 (100–126)2009 585 100 (61–150) 17 (10–26) 1 000 (660–1 500) 177 (113–255) 640 (570–720) 109 (97–123)2010 597 99 (61–150) 17 (10–25) 1 000 (660–1 500) 173 (110–249) 650 (580–730) 109 (97–122)2011 609 99 (61–150) 16 (10–24) 1 000 (660–1 500) 170 (108–246) 660 (590–740) 109 (97–122)Europe 1990 846 37 (34–41) 4.4 (4.0–4.8) 580 (480–690) 68 (56–82) 360 (350–380) 43 (41–45)1995 862 58 (56–60) 6.7 (6.5–7.0) 970 (780–1 200) 112 (90–137) 560 (530–590) 65 (62–69)2000 868 69 (67–71) 8 (7.7–8.2) 1 100 (840–1 300) 123 (96–153) 640 (600–680) 74 (69–78)2005 880 65 (63–66) 7.3 (7.2–7.5) 860 (660–1 100) 98 (75–124) 560 (520–600) 64 (60–68)2009 893 52 (51–54) 5.9 (5.7–6.0) 610 (460–790) 69 (52–88) 440 (410–470) 49 (46–53)2010 897 49 (47–50) 5.4 (5.3–5.6) 560 (410–730) 63 (46–81) 410 (380–440) 46 (43–49)2011 899 45 (44–46) 5 (4.9–5.1) 500 (370–650) 56 (41–73) 380 (350–400) 42 (39–45)South-East 1990 1 317 570 (410–750) 43 (31–57) 6 100 (5 300–7 100) 465 (400–536) 2 900 (2 500–3 200) 217 (191–245)Asia 1995 1 446 630 (460–840) 44 (32–58) 6 800 (5 800–7 800) 468 (404–538) 3 100 (2 800–3 400) 217 (197–238)2000 1 572 680 (500–890) 43 (31–57) 7 000 (6 000–8 100) 445 (383–513) 3 400 (3 200–3 700) 218 (202–235)2005 1 694 620 (480–780) 37 (28–46) 6 300 (5 200–7 400) 370 (309–436) 3 600 (3 300–3 900) 212 (196–228)2009 1 785 530 (390–690) 30 (22–39) 5 400 (4 200–6 700) 301 (235–376) 3 500 (3 300–3 800) 197 (182–211)2010 1 808 500 (370–660) 28 (20–37) 5 200 (3 900–6 600) 285 (217–363) 3 500 (3 200–3 700) 193 (179–207)2011 1 830 480 (350–630) 26 (19–34) 5 000 (3 800–6 300) 271 (206–344) 3 500 (3 200–3 700) 189 (176–203)Western 1990 1 510 310 (270–350) 21 (18–23) 3 900 (3 600–4 200) 255 (236–276) 2 400 (2 000–2 800) 159 (133–187)Pacific 1995 1 605 260 (220–300) 16 (14–19) 3 800 (3 400–4 100) 236 (214–258) 2 200 (1 900–2 500) 137 (119–157)2000 1 683 200 (160–240) 12 (9.5–14) 3 500 (3 100–3 900) 209 (186–233) 2 000 (1 800–2 300) 120 (107–134)2005 1 743 160 (130–180) 9 (7.7–10) 3 100 (2 700–3 400) 176 (157–195) 1 800 (1 700–2 000) 106 (96–116)2009 1 788 130 (110–160) 7.5 (6.2–8.9) 2 600 (2 300–2 900) 147 (131–163) 1 700 (1 600–1 900) 96 (88–105)2010 1 798 130 (110–150) 7.2 (5.9–8.6) 2 600 (2 300–2 900) 143 (127–159) 1 700 (1 500–1 800) 94 (86–102)2011 1 809 130 (100–150) 6.9 (5.7–8.3) 2 500 (2 200–2 800) 138 (123–154) 1 700 (1 500–1 800) 92 (84–100)RATE aSUMMARY BY WHO REGIONaRates are per 100 000 population.GLOBAL TUBERCULOSIS REPORT 2012 Data can be downloaded from www.who.int/tb/data 141
YEARPOPULATION(MILLIONS)INCIDENCE (INCLUDING HIV) INCIDENCE HIV-POSITIVE NOTIFIED NEW AND RELAPSE CASE DETECTIONNUMBER(THOUSANDS)RATE aNUMBER(THOUSANDS)RATE a NUMBER RATE a PERCENT<strong>Global</strong> 1990 5 283 7 800 (7 100–8 400) 147 (135–159) 350 (310–410) 6.7 (5.8–7.7) 3 740 193 71 48 (45–52)1995 5 702 8 400 (7 900–8 900) 148 (139–157) 710 (640–790) 12 (11–14) 3 400 234 60 40 (38–43)2000 6 097 9 100 (8 500–9 600) 148 (140–157) 1 100 (990–1 200) 18 (16–20) 3 746 673 61 41 (39–44)2005 6 481 9 200 (8 700–9 700) 142 (135–150) 1 200 (1 100–1 300) 19 (17–21) 5 130 170 79 56 (53–59)2009 6 792 8 800 (8 500–9 200) 130 (125–135) 1 100 (1 100–1 200) 17 (16–18) 5 803 251 85 66 (63–68)2010 6 870 8 800 (8 400–9 100) 128 (123–133) 1 100 (1 000–1 200) 16 (15–17) 5 763 310 84 66 (63–68)2011 6 948 8 700 (8 300–9 000) 125 (120–130) 1 100 (1 000–1 200) 16 (15–17) 5 772 224 83 67 (64–69)Africa 1990 507 1 200 (950–1 600) 245 (188–310) 290 (240–340) 57 (48–67) 418 520 83 34 (27–44)1995 580 1 600 (1 300–1 900) 276 (227–330) 560 (490–630) 96 (84–109) 504 377 87 31 (26–38)2000 656 2 000 (1 700–2 400) 311 (256–371) 850 (740–960) 129 (113–147) 792 911 121 39 (33–47)2005 742 2 300 (1 900–2 700) 310 (263–361) 960 (850–1 100) 130 (115–145) 1 186 801 160 52 (44–61)2009 817 2 300 (2 100–2 400) 276 (256–296) 900 (830–980) 110 (101–119) 1 380 577 169 61 (57–66)2010 837 2 300 (2 100–2 500) 271 (249–293) 880 (810–960) 105 (97–114) 1 380 294 165 61 (56–66)2011 857 2 300 (2 100–2 400) 262 (242–283) 870 (800–950) 102 (93–111) 1 367 193 159 61 (56–66)The Americas 1990 723 430 (360–490) 59 (50–68) 30 (24–37) 4.2 (3.3–5.2) 231 186 32 54 (47–64)1995 777 380 (350–410) 49 (46–53) 44 (37–51) 5.6 (4.8–6.5) 258 188 33 68 (63–73)2000 834 340 (320–370) 41 (38–44) 45 (38–52) 5.3 (4.6–6.2) 238 580 29 70 (65–75)2005 885 310 (290–330) 34 (32–37) 33 (30–36) 3.8 (3.4–4.1) 228 018 26 75 (70–80)2009 924 270 (260–290) 30 (28–32) 34 (30–37) 3.7 (3.3–4.0) 201 608 22 73 (69–78)2010 933 270 (250–280) 29 (27–30) 31 (28–34) 3.3 (3.0–3.6) 214 045 23 80 (75–86)2011 943 260 (240–280) 28 (26–29) 37 (34–40) 3.9 (3.6–4.2) 218 328 23 84 (79–90)Eastern 1990 381 470 (360–590) 123 (95–154) 3 (2.5–3.5) 0.8 (0.65–0.93) 234 620 62 50 (40–65)Mediterranean 1995 433 530 (480–590) 123 (110–137) 4.9 (4.2–5.8) 1.1 (0.96–1.3) 121 745 28 23 (21–26)2000 484 570 (510–640) 118 (104–132) 6.9 (5.9–7.9) 1.4 (1.2–1.6) 141 748 29 25 (22–28)2005 538 610 (540–680) 113 (100–126) 8 (6.9–9.2) 1.5 (1.3–1.7) 287 158 53 47 (42–54)2009 585 640 (570–720) 109 (97–123) 8.6 (7.4–9.9) 1.5 (1.3–1.7) 411 172 70 64 (57–73)2010 597 650 (580–730) 109 (97–122) 9.1 (7.9–10) 1.5 (1.3–1.7) 409 834 69 63 (56–71)2011 609 660 (590–740) 109 (97–122) 8.7 (7.6–9.9) 1.4 (1.3–1.6) 411 587 68 62 (55–70)Europe 1990 846 360 (350–380) 43 (41–45) 2.7 (2.6–2.8) 0.3 (0.31–0.34) 242 429 29 67 (64–70)1995 862 560 (530–590) 65 (62–69) 4.6 (4.2–5.1) 0.5 (0.49–0.59) 289 874 34 52 (49–54)2000 868 640 (600–680) 74 (69–78) 12 (10–13) 1.3 (1.2–1.5) 372 921 43 58 (55–62)2005 880 560 (520–600) 64 (60–68) 21 (19–24) 2.4 (2.1–2.7) 364 961 41 65 (61–70)2009 893 440 (410–470) 49 (46–53) 24 (21–26) 2.6 (2.3–3.0) 328 862 37 75 (70–80)2010 897 410 (380–440) 46 (43–49) 19 (17–21) 2.1 (1.9–2.3) 309 727 35 76 (71–81)2011 899 380 (350–400) 42 (39–45) 23 (20–25) 2.5 (2.2–2.8) 285 789 32 76 (71–81)South-East 1990 1 317 2 900 (2 500–3 200) 217 (191–245) 25 (22–28) 1.9 (1.7–2.1) 1 719 365 131 60 (53–68)Asia 1995 1 446 3 100 (2 800–3 400) 217 (197–238) 90 (72–110) 6.2 (5.0–7.5) 1 401 096 97 45 (41–49)2000 1 572 3 400 (3 200–3 700) 218 (202–235) 160 (130–190) 10 (8.5–12) 1 414 228 90 41 (38–44)2005 1 694 3 600 (3 300–3 900) 212 (196–228) 170 (140–200) 10 (8.4–12) 1 789 186 106 50 (46–54)2009 1 785 3 500 (3 300–3 800) 197 (182–211) 150 (120–180) 8.4 (7.0–10) 2 124 371 119 61 (56–65)2010 1 808 3 500 (3 200–3 700) 193 (179–207) 140 (120–170) 8 (6.7–9.5) 2 123 119 117 61 (57–66)2011 1 830 3 500 (3 200–3 700) 189 (176–203) 140 (120–170) 7.7 (6.4–9.1) 2 138 688 117 62 (58–66)Western 1990 1 510 2 400 (2 000–2 800) 159 (133–187) 3.3 (2.7–3.9) 0.2 (0.18–0.26) 894 073 59 37 (32–45)Pacific 1995 1 605 2 200 (1 900–2 500) 137 (119–157) 14 (11–17) 0.9 (0.69–1.0) 824 954 51 37 (33–43)2000 1 683 2 000 (1 800–2 300) 120 (107–134) 23 (19–27) 1.4 (1.1–1.6) 786 285 47 39 (35–43)2005 1 743 1 800 (1 700–2 000) 106 (96–116) 32 (26–37) 1.8 (1.5–2.1) 1 274 046 73 69 (63–76)2009 1 788 1 700 (1 600–1 900) 96 (88–105) 33 (28–39) 1.9 (1.5–2.2) 1 356 661 76 79 (72–87)2010 1 798 1 700 (1 500–1 800) 94 (86–102) 33 (28–39) 1.8 (1.5–2.2) 1 326 291 74 79 (72–86)2011 1 809 1 700 (1 500–1 800) 92 (84–100) 36 (31–42) 2 (1.7–2.3) 1 350 639 75 81 (75–89)aRates are per 100 000 population.142 Data can be downloaded from www.who.int/tb/data GLOBAL TUBERCULOSIS REPORT 2012
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GLOBALTUBERCULOSISREPORT2012
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ContentsAbbreviationsivAcknowledgem
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AcknowledgementsThis report on glob
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WHO Western Pacific RegionShalala A
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Executive SummaryThe World Health O
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CHAPTER 1IntroductionBOX 1.1Basic f
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TABLE 1.1 Targets for the scale-up
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TABLE 1.2 Reporting of data in the
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BOX 2.1Uncertainty in estimates of
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TABLE 2.2 Estimated burden of disea
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FIGURE 2.5 Estimated TB incidence r
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FIGURE B2.2.1Reporting of notificat
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FIGURE 2.8Estimated TB incidence ra
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FIGURE 2.11 Countries (in blue) for
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FIGURE 2.12 Trends in estimated TB
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● producing and widely disseminat
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FIGURE 2.16 Progress in global cove
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BOX 2.6Efforts by the Task Force to
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CHAPTER 3TB case notificationsand t
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BOX 3.1 1Definitions of TB casesDef
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TABLE 3.3 Contribution of public-pr
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BOX 3.4Integrating community-based
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TABLE 3.4 Estimates of the case det
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TABLE 3.5 Treatment success for new
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CHAPTER 4Drug-resistant TBKEY FACTS
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FIGURE 4.2 Percentage of new TB cas
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BOX 4.1Frequencies of resistance to
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FIGURE 4.6 Number of MDR-TB cases e
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FIGURE 4.7Notified cases of MDR-TB
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egimens globally, providing more su
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5.1 Funding for TB care and control
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TABLE 5.2 NTP budgets, available fu
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FIGURE 5.5Trends in domestic and do
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FIGURE 5.6Domestic funding as a per
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FIGURE 5.8Cost per TB patient succe
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FIGURE 5.10 Total cost and unit cos
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● The 14 countries not included i
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on public health by an external Exp
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evised as a result of the introduct
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TABLE 6.2 Incorporation of WHO poli
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FIGURE 6.3The Supranational Referen
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of TB disease by 65%, irrespective
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FIGURE 7.3Percentage of TB patients
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BOX 7.1Accelerating progress in pro
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TABLE 7.2 Assumptions used to estim
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FIGURE 8.1 The development pipeline
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sputum specimens and TB isolates fr
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cal trial sites and building labora
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new TB vaccine candidate. A Phase I
Page 102 and 103: This annex explains the methods tha
Page 104 and 105: 2011. On average, 15 data points we
Page 106 and 107: may suffer from biases. These biase
Page 108 and 109: TABLE A1.3Parameter estimates used
Page 110 and 111: 5. Estimates of TB prevalence, 1990
Page 112: the Republic of Moldova, Romania, t
Page 116 and 117: AFGHANISTANPopulation 2011 32 milli
Page 118 and 119: BRAZILPopulation 2011 197 millionHI
Page 120 and 121: CHINAPopulation 2011 1 348 millionH
Page 122 and 123: ETHIOPIAPopulation 2011 85 millionH
Page 124 and 125: INDONESIAPopulation 2011 242 millio
Page 126 and 127: MOZAMBIQUEPopulation 2011 24 millio
Page 128 and 129: NIGERIAPopulation 2011 162 millionH
Page 130 and 131: PHILIPPINESPopulation 2011 95 milli
Page 132 and 133: SOUTH AFRICAPopulation 2011 50 mill
Page 134 and 135: UGANDAPopulation 2011 35 millionHIG
Page 136 and 137: VIET NAMPopulation 2011 89 millionH
Page 138: ANNEX 3Regional profiles
Page 141 and 142: WHO REGION OF THE AMERICASPopulatio
Page 143 and 144: WHO EUROPEAN REGIONPopulation 2011
Page 145 and 146: WHO WESTERN PACIFIC REGIONPopulatio
Page 148 and 149: SUMMARY BY WHO REGIONTable A4.1 Est
Page 152 and 153: NEW AND RELAPSENOTIFICATION RATE aY
Page 154 and 155: -% OF TB PATIENTS WITHKNOWN HIV STA
Page 156 and 157: AFRICAN REGIONTable A4.1 Estimates
Page 158 and 159: MORTALITY (EXCLUDING HIV) PREVALENC
Page 162 and 163: INCIDENCE (INCLUDING HIV) INCIDENCE
Page 164 and 165: NEW AND RELAPSENOTIFICATION RATE aY
Page 166 and 167: NEW AND RELAPSENOTIFICATION RATE a1
Page 168 and 169: TREATMENT SUCCESS (%) a1995-2010YEA
Page 176 and 177: YEARTOTALCONFIRMEDCASES OFMDR-TB aE
Page 178 and 179: MALEYEAR 0-14 15-24 25-34 35-44 45-
Page 180 and 181: REGION OF THE AMERICASTable A4.1 Es
Page 186 and 187: INCIDENCE (INCLUDING HIV) INCIDENCE
Page 192 and 193: % OF COHORTTREATMENT SUCCESS (%) a1
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YEARTOTALCONFIRMEDCASES OFMDR-TB aE
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MALEFEMALEYEAR 0-14 15-24 25-34 35-
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EASTERN MEDITERRANEAN REGIONTable A
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MORTALITY (EXCLUDING HIV) PREVALENC
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INCIDENCE (INCLUDING HIV) INCIDENCE
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NEW AND RELAPSENOTIFICATION RATE a1
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% OF COHORTTREATMENT SUCCESS (%) a1
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-% OF TB PATIENTS WITHKNOWN HIV STA
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EUROPEAN REGIONTable A4.1 Estimates
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SOUTH-EAST ASIA REGIONTable A4.1 Es
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SMEAR LABS % OF SMEARPER 100K LABS
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Estimates of mortality, prevalence
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YEARPOPULATION(MILLIONS)MORTALITY (
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YEARPOPULATION(MILLIONS)INCIDENCE (
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YEARPOPULATION(MILLIONS)INCIDENCE (
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TREATMENT SUCCESS (%) a1995-2010YEA
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TREATMENT SUCCESS (%) a1995-2010YEA
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SMEAR LABS % OF SMEARPER 100K LABS
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