NSERC grants at Laurentian University Subventions du CRSNG `a l ...

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134the cell has multiple mechanisms to control ERK activity. A great deal ofresearch on drugs that can block the ERK pathway has been carried out,and a number of compounds that block the pathway upstream of ERK havebeen identified and are in common use. The MEK inhibitors in particularare often used to demonstrate the involvement of ERK in cellular regulation.However, there are no drugs that can directly inhibit ERK. Given that ERKcan be activated by mechanisms that bypass the classical pathway, inhibitionof MEK is not always sufficient to identify ERK regulated processes. Wehave recently identified a drug, SU1498, which directly inhibits ERK kinaseactivity. The studies proposed here are designed to understand how SUl498works as an ERK inhibitor and to examine the effects of SUl498 in severaldifferent cell systems. SUl498 will provide the basis for the development ofa new class of ERK inhibitor compounds with greater potency and selectivity.These drugs will permit the study of ERK regulated processes in bothnormal and dysfunctional cells.
135David MacLeanMechanisms regulating blood flow during hypoxia: The roleof the interstitial spaceA grant of $28,420 per year.Une subvention de 28 420 $ par année.Discovery Grant – Subvention à la découverteHypoxia (a reduction in oxygen content in the blood) is commonly seen ina variety of disease states including heart failure, shock, pulmonary embolism,and lung disease. When this occurs a number of mechanisms are activatedto try and compensate for the deceased in oxygen delivery to tissues. Theseinclude an increase in ventilation, heart rate, and cardiac output as well as anincrease in (muscle) blood flow. A number of compounds have been identifiedthat contribute to an increase in muscle blood flow (vasodilatation). Theseinclude adenosine, nitric oxide and potassium (to name only a few). Manyof these compounds are produced by endothelial cells, that line the insideof the blood vessels. However, some may be produced by muscle or even inthe interstitial space (the space between the vasculature and muscle). Thisspace is extremely important as it may function to integrate all the chemicalsignals at the tissue (cell) level. Therefore, it is vitally importan to simultaneouslymeasure putative regulators of vascular tone in this space. Currentlythe microdialysis technique allows for the measurement and quantification ofcompounds in the interstitial space and represents a powerful research tool.Thus, the studies in this research proposal will determine the relative contributionof these compounds to vasodilatation by decreasing the amount ofoxygen in the blood of rodents. A number of other unique methodologies (inaddition to the microdialysis technique) will be employed including the use ofthe isolated perfused rat hindlimb preparation to induce ischemia (a decreasein blood flow), an alternative method for inducing hypoxia. Understandingthe role that the interstitial space plays in regulating mechanisms associatedwith vascular function is an important question to basic scientists as well asclinicians as it contributes to our understanding of how chemical signalingsystems are integrated.
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For any questions, please contactPo
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2Kabwe Nkongolo with/avec Peter Bec
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8kind of work, which is not the cas
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ForewordPréfaceDr. Liette VasseurA
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IntroductionNSERC (pronounced n’s
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point de vue d’un chercheur qui a
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18are limited in time and the direc
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Research, Development and Creativit
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Department of BiologyDépartement d
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25Madhur AnandDisturbance dynamics
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27Mery Martinez GarciaPhysiological
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29John Gunn with/avec William Kelle
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31Jacqueline LitzgusGeographic vari
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33Kabwe NkongoloGenome organization
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35Kabwe Nkongolo with/avec Peter Be
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37Charles RamcharanNew directions i
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39Peter RyserEcological significanc
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41Albrecht Schulte-Hostedde with/av
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Department of Chemistry andBiochemi
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45Nelson Belzile 1Biogeochemistry o
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47François CaronMethod development
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Altogether, this research program w
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51Éric GauthierWater-jacketed CO 2
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53Helen JolyMetal-atom mediated che
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55Hoyun LeeDetermining the hamster
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57Louis MercierFunctional nanoporou
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59Sabine MontautCancer chemoprevent
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61Sabine Montaut with/avec Nelson B
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63Stefan SiemannRole of Metal Ions
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65Stefan Siemann with/avec Éric Ga
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The funding will enable the recruit
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2. extend our ability to use second
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72sea level high stand and low stan
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74and prosperity are linked to succ
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76Bruno LafranceStructural controls
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78C. Michael LesherIn partnership w
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80Darrel LongPrecambrian and Early
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82The ultimate goal is to address h
Page 86 and 87: 84Phillips ThurstonGreenstone belt
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Page 91 and 92: 89Peter KaiserIn partnership with/E
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Page 97 and 98: 95Julia JohnsonReverse rough set me
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Page 115 and 116: 113Gregory BaidenTelemining researc
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Page 119 and 120: 117Vassilios KazakidisFlexibility a
Page 121 and 122: 119Helen (Huilan) ShangIdentificati
Page 123 and 124: 121Nick VayenasReliability assessme
Page 125 and 126: 123Turgut YalcinDissolved gas appli
Page 127 and 128: 125Zhibin YeDeveloping advanced pol
Page 129 and 130: School of Human KineticsÉcole des
Page 131 and 132: 129Robin MichelNerve trophic contro
Page 133 and 134: 131Robin Michel with/avec Éric Gau
Page 135: Northern Ontario School of Medicine
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Page 141 and 142: 139Fiona Hunter with/avec M. J. Bid
Page 143 and 144: 141heavy water. The SNO experiment
Page 145 and 146: David Sinclair with/avec A. Belleri
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NSERC grants at Laurentian University Subventions du CRSNG `a l ...

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