Book 4 - Self Instructional Manual for Cancer Registrars - SEER ...

CORPUSUTERII I _ 'PRIMARY] ENDOMETRIUM (mucosa) ] MYOMETRIUM ] SEROSASITE , , (3 muscle layers) [ (Perimetrium)Columnar B StromaEpithelium AS(Lamina Propria)ECorpus Uteri Yes Yes Yes Yes(C54.__)M EMI I I IThe wall of the uterine corpus is composed of the following microscopic layers:• The EPITHELIAL LAYER contains no blood vessels or lymphatics.The BASEMENT MEMBRANE is a sheet of extracellular material that functionsas a filtration barrier and boundary which helps to generate and maintain tissuestructure.The LAMINA PROPRIA, composed of areolar connective tissue, contains bloodvessels, nerves, and, in some regions, glands. Once tumor has broken through thebasement membrane into the lamina propria, it can spread by way of the lymphaticsand blood vessels to other parts of the body.• There is NO MUSCULARIS MUCOSAE OR SUBMUCOSA in the endometrium.• The MYOMETRIUM, the thick middle layer, is composed of three layers ofsmooth muscle fibers: longitudinal, transverse, and oblique, that extend in alldirections and give great strength to the uterus. It contains an abundance of bloodvessels, lymphatics, and nerves.The uterine cervix is composed of:• A MUCOSA of columnar glandular epithelium in the upper portion of the cervicalcanal (endocervix) which is continuous with that of the corpus. It becomesstratified squamous epithelium at the lower end of the canal extending onto the lipof the cervix (ectocervix or exocervix).• A LAMINA PROPRIA (stroma) of dense connective tissue which contains a fewsmooth muscle fibers and the cervical glands.274