Book 4 - Self Instructional Manual for Cancer Registrars - SEER ...

Hodgkin's disease. The histologic classification of Hodgkin's disease has changed over the years.The original classification of Hodgkin's disease by Jackson and Parker in 1947 consisted ofparagranuloma, granuioma, and Hodgkin's sarcoma. These all have specific code numbers in ICD-O,first edition, and ICD-O-2. However, such terms are rarely used any more. The Lukes-Butlerclassification came into existence in the early 1960's and was modified at the Rye, NY Conferencein 1966 and was then called the Rye classification or modification. It represents a spectrum basedon the relative proportion of malignant cells seen, as follows:• Lymphocytic predominance type (LP)• Nodular sclerosis type (NS)• Mixed cellularity type (MC)• Lymphocytic depletion type (LD)• Unclassified type (NOS)Further additions or splits can be seen in ICD-O-2, such as splitting lymphocytic predominance bywhether it is diffuse or nodular.One of the requirements for a diagnosis of Hodgkin's disease is the identification by the pathologistof Reed-Sternberg cells1 (malignant cells) in an appropriate cellular environment.There is indirect evidence that Hodgkin's disease involves the T-cell component of the immunesystem.1Reed-Sternberg cell--Characteristic giant cell with large, inclusion-like nucleoli and double ormultiple nuclei.90