Book 4 - Self Instructional Manual for Cancer Registrars - SEER ...

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Hodgkin's disease. The histologic classification of Hodgkin's disease has changed over the years.The original classification of Hodgkin's disease by Jackson and Parker in 1947 consisted ofparagranuloma, granuioma, and Hodgkin's sarcoma. These all have specific code numbers in ICD-O,first edition, and ICD-O-2. However, such terms are rarely used any more. The Lukes-Butlerclassification came into existence in the early 1960's and was modified at the Rye, NY Conferencein 1966 and was then called the Rye classification or modification. It represents a spectrum basedon the relative proportion of malignant cells seen, as follows:• Lymphocytic predominance type (LP)• Nodular sclerosis type (NS)• Mixed cellularity type (MC)• Lymphocytic depletion type (LD)• Unclassified type (NOS)Further additions or splits can be seen in ICD-O-2, such as splitting lymphocytic predominance bywhether it is diffuse or nodular.One of the requirements <strong>for</strong> a diagnosis of Hodgkin's disease is the identification by the pathologistof Reed-Sternberg cells1 (malignant cells) in an appropriate cellular environment.There is indirect evidence that Hodgkin's disease involves the T-cell component of the immunesystem.1Reed-Sternberg cell--Characteristic giant cell with large, inclusion-like nucleoli and double ormultiple nuclei.90
Q23Benign tumors of lymphoid tissue are frequent/rare.(Circle one.)Q24Malignant tumors of the lymphoid tissue may be divided into two general categories:1.2.Q25Name the four major types of Hodgkin's disease according tO the histologic classification:1.2.3.4.Q26One requirement <strong>for</strong> a diagnosis of Hodgkin's disease is identification by the pathologist ofthe presence of cells.91
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SEER ProgramSelf Instructional Manu
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CONTENTSBOOK 4: HUMAN ANATOMY AS RE
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ILLUSTRATIONS(Figures 1-82, cont'd)
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ACKNOWLEDGEMENTSPortions of Book 4
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SECTIONAOBJECTIVES AND CONTENT OF B
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BSECTIONBTERMS USED TO INDICATE BOD
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Directional Planes of the BodySagit
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Relative Positional and Directional
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Figure 3. ANATOMIC DIVISIONSOF THE
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Answers to Practical ExerciseNote t
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SECTIONCTHE INTEGUMENTARYSYSTEM19
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EpidermisThe epidermis (Figure 4A)
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Q1a. What are the two primary layer
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Epidermis is epithelial tissue deri
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Answer:Q2The three glands of the sk
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Q3Q4Accessory skin organs are found
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Benign TumorsThere is a large group
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Q5 Match the malignant tumors of th
Page 47 and 48: MalignantMelanomaMalignant melanoma
Page 49: The description of the level 1 of i
Page 52 and 53: Q9"Clark's Classification" of malig
Page 54 and 55: Lymphatic Drainage of the SkinThe l
Page 57 and 58: Q10Match the regions of the skin on
Page 59: SECTIONTHE LYMPHATICDSYSTEM51
Page 62 and 63: T-Cells Versus B-CeilsThe two princ
Page 64 and 65: Answer:Q1The lymphatic system colle
Page 66 and 67: Figures 8A-8B. LYMPHATIC DRAINAGE O
Page 68 and 69: Answer:Q3The lymphatic system colle
Page 70 and 71: Lymph nodes accomplish two separate
Page 73 and 74: Q6The lymph nodes have two main fun
Page 75 and 76: SpleenThe spleen, the largest lymph
Page 77 and 78: Q9Match each lymphatic organ or tis
Page 79 and 80: LymphaticDrainageLymph nodes, most
Page 81 and 82: Answer:QllLymphatics tend to parall
Page 83 and 84: Q14A general term for lymph nodes l
Page 85: Lymph Nodes of the ThoraxThe lymph
Page 88 and 89: Answer:Q18Lymph nodes of the thorax
Page 91 and 92: Q20Lymph nodes of the abdomen may a
Page 93: Lymph Nodes of Upper and Lower Extr
Page 96 and 97: Answer:Q22c 1. Popliteal Heela 2. A
Page 100 and 101: Answer:Q23Benign tumors of lymphoid
Page 102 and 103: Extralymphatic/ExtranodalSitesLymph
Page 104 and 105: Answer:Q27Non-Hodgkin's lymphomas m
Page 106 and 107: TilE CARDIOVASCULAR SYSTEMIonatod
Page 108 and 109: CIRCULATORY SYSTEMFigure 14D. BLOOD
Page 110 and 111: Answer:Q1The cardiovascular system
Page 112 and 113: The heart lies in a loose-fitting s
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Page 116 and 117: Answer:Q5The heart has four chamber
Page 118 and 119: Answer:QIODeoxygenated blood from t
Page 120 and 121: Portal System (portal circulation)V
Page 122 and 123: Answer:QllThe three kinds of blood
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Page 126 and 127: Answer:QlgThe three main types of b
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Page 130 and 131: Answer:Q18White blood cells which a
Page 132 and 133: DEVELOPMENTOF WHITE BLOOD CELLSStem
Page 134 and 135: Answer:Q20Malignant diseases of the
Page 136 and 137: Answer:Q25b 1. Leukemia An uncontro
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Page 142 and 143: Answer:Q1The parts of the respirato
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Page 146 and 147: Answer:Q41. Serves as a passageway
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140
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Answer:Q7The pharynx can be divided
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The larynx can be divided into thre
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146
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Answer:Q10The three single cartilag
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150
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Answer:Q14The windpipe or trachea s
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The lungs provide a place where lar
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Answer:Q16The main bronchus, pulmon
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Clinical ManifestationsClinical man
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Answer:Q19The interpleural space ma
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Answer:Q24_g_ 1. Exchange of oxygen
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DIGESTIVE SYSTEM: Esophagus-RectumP
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The organs of the digestive system
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Answer:Q1The main organs of the dig
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• Lips. The lips form the upper a
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Answer:Q5The lip consists of an exp
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Malignant TumorsMalignant lesions a
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Answer:Q8The tongue is composed of
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• Gums (gingiva). The gums are fo
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Answer:Qllb__ 1. GumMucosal coverin
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182
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Answer:Q12The palate is the roof of
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186
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Answer:Q18The major salivary glands
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190
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Answer:Q21c 1. Gum Retropharyngeala
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Oropharynx. The air and food passag
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196
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Answer:Q23Another name for the hypo
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Answer:Q25a__ 1. HypopharynxServes
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Answer:Q28a. Tonsillar pillar - Oro
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Figure 31. MEASUREMENTS OF THE ESOP
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206
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Answer:Q30The esophagus extends fro
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The medial border of the stomach is
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Q33The stomach lies just below thei
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Answer:Q33The stomach lies just bel
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216
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Answer:Q38The small intestine is ab
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The large intestine receives the fl
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Malignantand Benign TumorsThe usual
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224
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Answer:Q41The large intestine is ab
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Answer:Q433. The ileocolic lymph no
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Metastatic tumors involving the liv
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Answer:Q45The most common primary t
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234
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Answer: 046The function of the gall
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238
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Answer:Q48.The pancreas plays an im
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Figure 39. PRINCIPAL PARTS OF THE U
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The microscopic structure of the re
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Answer:Q1The urinary system consist
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Figure 41. A NEPHRON_ Otomes_JLus_;
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250
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Answer:Q4The blood is circulated th
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254
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Answer:Q8The regional lymph node dr
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258
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Answer:Q12The tube which carries ur
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URINARY BLADDER, RENAL PELVIS AND U
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Malignant TumorsBladder cancer is t
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Answer:Q14The urinary bladder is a
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Q18Theis a membranous tube which co
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Answer:Q18The urethra is a membrano
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Figure 44.FEMALE PELVIS (frontal vi
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CORPUSUTERII I _ 'PRIMARY] ENDOMETR
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Answer:Q1The female reproductiveorg
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• Choriocarcinoma, a highly malig
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Answer:Q6For corpus uteri you might
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FallopiantubesThe fallopian tubes,
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Answer:Q7b 1. Uterus Pear-shaped mu
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Q8Name the three openings of the ut
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Answer: 08In naming the three openi
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Regional Lymph NodesThe regional ly
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6. Vaginal orifice f. Glands that s
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Answer:Q14The vagina is situated be
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296
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298
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Answer:Q19The breasts overlie the p
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A tumor specified as "subareolar" i
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Answer:Q22One of the first and most
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306
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ANSWERS TO REVIEW TESTd 1. Gonads i
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310
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Answer:Q25The male gonads consist o
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314
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Answer:Q27c 1. Epididymis Tube loca
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Figure 51. PROSTATE GLAND (frontal
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Answer:Q29b 1. Prostate Gland which
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RegionalLymph NodesThe regional lym
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324
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Answer:Q30Male hormones are produce
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Figure 53. ENDOCRINEGLANDS328
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• Prolactin (luteotrophic hormone
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Parathyroid GlandThere are four par
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Thymus GlandThe thymus gland is loc
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Q2Match the hormone on the left wit
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Answer:Q1d 1. Hormones Organic secr
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340
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Figure 58.AXIAL SKELETONSkuLl.342
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344
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Answer:Q1The skeletal system is com
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348
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Answer:Q4One characteristic which d
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352
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Answer:Q8The purpose of the sesamoi
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Structure of BoneEach long bone of
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Answer:QllThe numbered parts of the
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Facial bones. The facial bones are
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Figure 65. BONES OF THE THORAX Figu
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Q17Match the bones on the left with
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Figure 67. APPENDICULARSKELETON366
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Malignant TumorsBone is derived fro
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Q20Sites from which metastases to b
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Q22Match the description on the lef
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Answer:Q21c 1. Angiosarcoma A malig
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Figure 68.MUSCLE TYPES376
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Figure 69. HISTOLOGICAL COMPARISONS
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Answer:Q1The three types of muscle
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382
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Answer:Q61. True Malignant tumors o
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• Supinators turn the palm upward
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Answer:Q8The three general function
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Answer:Q11Match the muscle groups o
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392
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Figure 70.NERVE CELL (neuron)394
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Answer:Q1The central nervous system
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Figure 71.CEREBRUMCEREBRUMC_ere_etr
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400
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Figure 74 CRANIAL NERVES402
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MalignantTumorsGliomas are tumors o
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406
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Answer:Q6Match each term on the lef
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410
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412
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Answer:Q1The five major sensesof th
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416
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Answer:Q3The three layers which com
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420
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Answer:Q5The eyeball/s not a solid
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424
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Answer:Q8Name the lymph nodes which
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Figure 80. TONGUE: Areas of tasteUv
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Answer:QllReceptors for the sense o
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Malignant TumorsTumors of the nasal
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Answer:Q13The nasal fossa is divide
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Regional Lymph NodesThe lymphatics
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Answer:Q16b 1. External ear Made up
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440
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HISTOLOGIC TYPE PRIMARY SITELeukemi
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444
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DETERMINATION OF SUBSEQUENT PRIMARI
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470
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OTHER ICD-O-2 CODES TO BE CONSIDERE
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474
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SELECTED BIBLIOGRAPHY (cont'd)Paul,
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478
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Adenocarcinoma (continued)Primary s
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Arteries (see also Vessels) (contin
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Blood (see also Cardiovascular syst
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Bone tissue (osseous, vascular tiss
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Breast (mammary gland) (continued)H
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Cartilage (nonvascular tissue) (con
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Cerebrum (forebrain, telencephalon)
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Cortisol, 329, 333, 336, 338Cortiso
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Ducts (see also Endocrine system an
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Estradiol, 281Estrogen-producing ca
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Follicular adenocarcinoma, 331, 337
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Glycogen, 229Gonadotrophic hormone
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Histologic type of cancer, 439-441H
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Integumentary system (skin) (contin
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Kidney (see also Urinary system) (c
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Leukocyte (WBC),Agranular, 119B-Cel
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Luteal cell, 281Luteinizing hormone
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Lymph nodes (continued)Perivesical,
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Lymphoma (continued)Nasopharynx (ph
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Metastases (continued)Lymph node, 6
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Muscle (see also Muscular system) (
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Nervous system, Cranial (continued)
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Ovary (female gonad), 273, 281,285,
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Peripheral nervous system, 393, 396
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Prostate (continued)Urethra (prosta
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Salivary gland (see also Parotid, S
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Skull (diploe), 351, 354, 356, 359,
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Sulcus,Buccal, 178Nasolabial, 39Sup
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Tibia (shin bone), 351, 369Tumors o
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Tumor (see also specific histologic
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Urethra (female, male) (continued)L
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Vertebral cavity, 10Vertebral colum
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