TECHNICAL PROGRAM - American Chemical Society Publications

BIOL TECHNICAL PROGRAM
111. His115 is a major determinant of the
specificity of paraoxonase-1. D. G. Mata,
T. C. Otto, C. K. Harsch, N. Bharwani,
D. M. Cerasoli, D. E. Lenz, T. J. Magliery
112. Directed evolution of bacteriorhodopsin
for biomimetics. N. L. Wagner,
E. E. Duffy, M. R. Gillespie, R. R. Birge
113. Kinetic and structural insights into the
mechanism of ampylation by VopS FIC
domain. D. R. Tomchick,P.Luong,
L. N. Kinch, C. A. Brautigam,
N. V. Grishin, K. Orth
114. Molecular mechanisms of action of Vernonia
Amygdalina as anti-cancer in the
management of breast cancer.
C. G. Yedjou, P. B. Tchounwou,
E. B. Izevbigie
115. Quorum sensing-regulated antibiotic
production from Burkholderia thailandensis.
M. R. Seyedsayamdost,
E. Greenberg, J. Clardy
116. Proteomics of human lymph and
plasma reveals a unique self peptidome
associated with the lymph.
C. C. Clement, L. Santambrogio
117. Toward understanding an unusual His-
Tyr ligated c-heme: X-ray crystal structures
of MauG point mutants.
L. M. Jensen, N. Abu Tarboush,
V. L. Davidson, C. M. Wilmot
118. Depletion of the negatively charged
membrane lipid phosphatidyl glycerol
leads to daptomycin resistance in Bacillus
subtilis. A. G. Hachmann,
J. D. Helmann
119. Quorum quenching effects of PON 1 on
pathogenic bacterial inhabitants of the
human colon. L. M. Simons,
K. Jankowski, Y. Harris
120. Cholesterol transport in model-membrane
systems studied by time resolve
small angle neutron scattering. S. Garg,
L. Porcar, U. Perez-Salas, P. Butler
121. Chitosan treatment affects TGF-�2 expression
in two ovarian cancer cell lines.
E. C. Regisford, T. Taylor, J. Stone,
R. Petrofes-Chapa, C. Johnson,
M. Stewart, P. Traisawatwong,
C. Kelly-Brown, L. E. Carson
122. Understanding and modeling of therapeutic
monoclonal antibody aggregation.
V. Kayser, N. Chennamsetty, V. Voynov,
B. Helk, K. Forrer, B. L. Trout
123. Kindlin 2, its N-terminal structure and
function. D. Perera, J. Yang, J. Qin
124. Photon induced activation of archeal
thioredoxin. M. Dey, S. J. Elliott,
C. L. Drennan
125. Investigating the noncooperative mechanism
of a hyperthermophillic archaeal
enzyme for drug development studies.
L. Eligene, S. Mohamed, V. Curry,
K. A. Stieglitz
126. Refinement and analysis of the structure
of a cobalamin-bound class II ribonucleotide
reductase. M. A. Funk,
M. D. Sintchak, N. Ando, J. Stubbe,
C. Drennan
127. Crystallographic study of a human DNA
repair protein: Alkyladenine DNA glycosylase
(AAG). J. W. Setser, G. M. Lingaraju,
C. Davis, L. D. Samson, C. L. Drennan
128. Probing the role of H-NOX proteins as
sensors for small signaling molecules.
Z. Dai,E.M.Boon
129. Biosynthesis of polyhydroxybutyrate
(PHB) in the Gram-negative aquatic bacterium
Caulobacter crescentus.
R. M. Buckley, J. Stubbe, K. N. Allen
MONDAY MORNING
Section A
Boston Convention & Exhibition Center
Room 253C
Repligen Award Symposium
Four Corners of Biological Chemistry
14–TECH
R. T. Raines, Organizer, Presiding
‡ Cooperative Cosponsorship
8:30 130. Structure, function, and inhibition
of human O-GlcNAc transferase.
S. Walker
9:10 131. Chemical approaches to sorting
out protein acetylation. P. A. Cole
9:50 132. Dicer and beyond: Mechanisms of
regulatory RNA processing and targeting.
J. Doudna
10:30 133. Ribonuclease: From model system
to the clinic. R. T. Raines
Section A
Boston Convention & Exhibition Center
Room 253C
Goodman Award Symposium
Biogenesis of Enzyme Cofactors
J. Bollinger, Organizer
J. Stubbe, Organizer, Presiding
11:20 134. In vivo and in vitro characterization
of Fe-S cluster assembly by the
stress-responsive Suf pathway.
F. W. Outten
11:55 135. In crystallo biosynthesis of the
tryptophan tryptophylquinone cofactor of
methylamine dehydrogenase by the enzyme
MauG. C. M. Wilmot, L. M. Jensen,
R. Sanishvili, V. L. Davidson
12:30 136. Biosynthesis of the H-cluster of
the [FeFe]-hydrogenase. J. B. Broderick,
E. M. Shepard, B. R. Duffus,
S. E. McGlynn, A. L. Bueling,
C. S. Grady-Smith, S. J. George,
S. P. Cramer, J. W. Peters
1:05 137. Assembly of the diferric and dimanganese-tyrosyl
radical cofactors in
class Ia and Ib ribonucleotide reductases.
J. Stubbe, J. A. Cotruvo, C. Shih,
A. K. Boal, A. C. Rosenzweig
1:40 138. Structural basis for activation of
class Ib ribonucleotide reductase.
A. K. Boal, J. A. Cotruvo, Jr., J. Stubbe,
A. C. Rosenzweig
Chemistry and Policy: Solving Problems at
the Interface
The Interface, Health, Environment, and
Security Sponsored by CHED, Cosponsored
by AGRO, ANYL, BIOL, CCPA, CHAS, COLL,
HIST, I&EC, INOR, NUCL, ORGN, POLY,
PRES, SCHB, and WCC
The Community Structure-Activity
Resource (CSAR) Scoring Challenge
Sponsored by COMP, Cosponsored by BIOL,
CINF, and MEDI
MONDAY AFTERNOON
Section A
Boston Convention & Exhibition Center
Room 253C
The Chemistry of Epigenetic Regulation
Cosponsored by MEDI
P. Cole, Organizer, Presiding
2:45 139. Studies on the chemistry of oxygen
dependent regulation of expression.
C. J. Schofield
3:25 140. Modulating the modulator: Epigenetic
control beyond the histone code.
M. Zhou
4:05 141. Structural perspective of methylation
mark-mediated epigenetic regulation.
D. Patel
4:45 142. Exploring the roles of epigenetic
and chromatin regulatory proteins in
mental retardation. Y. Shi
The Community Structure-Activity
Resource (CSAR) Scoring Challenge
Sponsored by COMP, Cosponsored by BIOL,
CINF, and MEDI
Undergraduate Research Posters
Biochemistry Sponsored by CHED,
Cosponsored by BIOL and SOCED
Women at the Forefront of Preventing and
Combating Disease Sponsored by WCC,
Cosponsored by BIOL, MEDI, and PROF
MONDAY EVENING
Sci-Mix
J. Bollinger, Organizer
8:00–10:00
26, 42, 54, 73, 81, 87, 116. See previous listings.
171, 174, 177, 180, 182, 194, 195, 199, 202,
205, 229, 242, 246. See subsequent listings.
TUESDAY MORNING
Section A
Boston Convention & Exhibition Center
Room 253C
Pfizer Award Symposium
V. Bandarian, Organizer, Presiding
8:30 143. Radical-dependent mechanisms
of post-translational modification.
S. J. Booker
9:10 144. Substrate and product analogs as
suicide inactivators of ethanolamine ammonia-lyase.
G. H. Reed, A. L. Menefee
9:50 145. Genetic and molecular basis for
sunscreen biosynthesis in cyanobacteria.
C. T. Walsh, E. Balskus
10:30 146. Uncovering the paradigm for biosynthesis
of 7-deazapurine containing
natural products. V. Bandarian
Section A
Boston Convention & Exhibition Center
Room 253C
Design, Discovery, and Directed Evolution
of Enzyme Activities Cosponsored by COMP
and POLY
T. Magliery, Organizer, Presiding
11:30 147. Elucidating specificity determinants
in Bcl-2 family protein-peptide interactions.
A. E. Keating, S. Dutta,
S. Gulla, T. Chen, E. Fire, R. A. Grant
12:10 148. Privileged scaffolds, “underlying”
promiscuity, and convergence in the evolution
of new enzyme functions.
P. C. Babbitt
12:50 149. Rational design of functional
metalloenzymes. Y. Lu, N. Yeung,
N. M. Marshall, K. D. Miner, S. New,
A. Mukherjee
1:30 150. Engineering proteins for stability
and function with statistical and highthroughput
approaches. T. J. Magliery
Oligonucleotide Therapeutics Sponsored by
CARB, Cosponsored by ANYL, BIOL, MEDI,
and ORGN
The Community Structure-Activity
Resource (CSAR) Scoring Challenge
Sponsored by COMP, Cosponsored by BIOL,
CINF, and MEDI
TUESDAY AFTERNOON
Section A
Boston Convention & Exhibition Center
Room 253C
Natural Products Biosynthesis Cosponsored
by MEDI and ORGN
Y. Tang, Organizer, Presiding
2:30 151. Biosynthesis of natural products
in ascidians and their symbionts.
E. W. Schmidt
3:10 152. Expression of complete fungal
biosynthetic gene clusters by promoter
replacement in Aspergillus oryzae.
R. J. Cox, L. M. Halo, M. N. Heneghan
3:50 153. Posttranslational modifications in
natural product biosynthesis.
W. van der Donk
4:30 154. Novel drug leads from natural
products and their derivation from microbial
and biosynthetic diversity.
D. Sherman
Oligonucleotide Therapeutics Sponsored by
CARB, Cosponsored by ANYL, BIOL, MEDI,
and ORGN
TUESDAY EVENING
Section A
Boston Convention & Exhibition Center
Hall C
Advances in Biological Chemistry
New Methods
J. Bollinger, Organizer
5:30–7:30
155. Codon scanning mutagenesis by asymmetric
transposons. J. Liu,T.Cropp
156. Genetically encoded photocaged N � -
methyl-L-lysine. Y. Wang, B. Wu, W. Liu
157. Increased functional expression of the
biosynthetic enzymes responsible for the
synthesis of Ramoplanin A2 using Streptomyces
chaperones. A. J. Hoertz,
J. B. Hamburger, D. M. Gooden,
D. G. McCafferty
158. Split-tetracysteine-FlAsH: A novel strategy
for assessing transmembrane helix
association. C. J. Pace, Q. Huang, J. Gao
159. Shaken deepwell microplate screening
to identify high yielding cell clones.
F. B. Cataniag, J. Mendoza, J. Liu,
P. Gilbert
160. Engineering paraoxonase-1 for druglike
properties, bacterial expression, and
solubility. V. S. Shete, B. J. Competty,
T. J. Magliery
161. Improving lipid production from bagasse
hydrolysate with Trichosporon fermentans
using response surface methodology.
R. Li, H. Wu, C. Huang, M. Zong
162. New generation of antibody: Chicken
antibody IgY. J. L. Chan
163. NMR screening of competitive inhibitors
for NHERF 1 and 2.
J. M. Fitzpatrick, D. Mierke,
M. Pellegrini, G. Gaidos
164. Quantitative characterization of polymer
– polymer and polymer – protein interaction
via tracer sedimentation equilibrium.
A. A. Fodeke,A.P.Minton
165. Biodiesel production catalyzed by Rhizomucor
miehei lipase-displaying Pichia
pastoris whole-cell in an isooctane system.
H. Shuangyan, H. Dengfeng,
H. Zhenlin, L. Ying
166. New method for determining the antibody
affinities. M. A. Demchenko,
S. A. Bobrovnik
167. Liquid crystal state derived from �-casein
amyloid fibrils. J. Chun,Y.Choi,
S. Lee, S. Paik
168. Photoelectric hybrid biomaterial prepared
with amyloid fibrils of �-synuclein
in the presence of iron and pthalocyanine
tetrasulfonate. Y. Choi, H. Koo, D. Lee,
S. Paik
169. Energetic contributions of fluorinated
aromatic amino acids to protein stability.
H. Zheng,J.Gao
170. Harnessing biosynthetic enzymes from
Pseudomonas aeruginosa for the study of
asparagine-linked glycosylation.
A. Larkin, B. Imperiali
171. Multiplexed and reiterative fluorescence
labeling via DNA-circuitry. D. Y. Duose,
R. M. Schweller, M. R. Diehl,
W. N. Hittelman
172. Photochemical and thermal stability of
green and blue proteorhodopsins: Implications
for protein-based bioelectronic
devices. M. J. Ranaghan, S. Shima,
L. Ramos, D. S. Poulin, G. Whited,
S. Rajasekaran, J. A. Stuart, A. D. Albert,
R. R. Birge
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