TECHNICAL PROGRAM - American Chemical Society Publications

ORGN TECHNICAL PROGRAM
734. Efficient synthesis of protected aminoxyacyl
sterols and terpenes.
B. Draghici, B. El-Dien M. El-Gendy
735. Encapsulation and release of Histagged
proteins from collagen microflorettes.
D. Ernenwein, M. M. Pires,
J. Chmielewski
736. Chemical tools for investigating cell migration:
Semisynthesis of photoactivated
myosin regulatory light chain. B. Goguen,
B. Imperiali
737. Total synthesis of tubulysins. T. Shibue,
M. Yamazaki, H. Ebisu, T. Hirai,
I. Okamoto, N. Morita, O. Tamura
738. Design and synthesis of novel peptidomimetic-AApeptide.
Y. Hu, J. Cai
739. Chirality control in peptide-metal complexes.
M. Vázquez,G.Rama,
J. M. Blanco, H. Ishida,
M. Vázquez-López
740. New fullerene array based on peptide
nanotubes. C. Reiriz, R. J. Brea,
J. R. Granja
741. Controlled protein trans-splicing by using
photo-labile protecting group.
Y. Kwon
742. Stitching �-helical peptides by tandem
ring-closing metathesis. Y. Kim,
P. S. Kutchukian, C. M. Crenshaw,
S. S. Stanton, A. Chang, G. L. Verdine
743. Tag-assisted solution-phase peptide
synthesis featuring multistep process.
M. Sugai, T. Gegen, S. Kim, K. Chiba
744. Origin of conformational organization of
�-peptide nucleic acids (PNAs).
M. J. Crawford, R. Gil, D. H. Ly
745. Synthesis and structure-activity relationship
(SAR) of tetrapeptides with Phe
analogs reversible inhibitors of thrombin.
C. C. Clement, M. Philipp
746. Thioester-based strategy for synthesis
of linear and cyclic peptide libraries.
S. Santra, M. E. Bucks, S. N. Savinov
747. Bioactive synthetic nanostructured extracellular
matrices for biomedical applications.
W. Suh, G. D. Stucky, M. Tirrell
748. Withdrawn
749. Evidence for the utilization of formate as
a substrate by carbamoyl phosphate synthetase.
L. Lund, H. J. Williams,
F. M. Raushel
750. Chemical ligations of S-acyl isopeptides.
S. R. Tala, N. E. Abo-Dya,
A. R. Katritzky
751. Modifying proteins with kosmotropes
for enhanced activities and targeted drug
delivery. D. Prashar,D.Cui,Y.Shi,
D. Bandyopadhyay, J. Dabrowiak,
Y. Y. Luk
752. Polyvinylimidazoles/pyridoxamines with
hydrophobic chains as enzymes/co-enzymes
mimics for the catalysis of the
transamination reaction in water.
R. Skouta, S. Wei, R. Breslow
753. On the design and synthesis of activatable
dsDNA-binding peptides.
A. Jiménez, B. Martínez, O. Vázquez,
M. E. Vázquez, J. L. Mascareñas
754. Proteins for imaging applications.
P. D. Garimella, M. B. Francis
755. i,i�3 Stapling: Highly stereospecific
ring-closing metathesis on �-helices.
Y. Kim, S. Shim, M. J. Kolar,
P. S. Kutchukian, G. L. Verdine
756. Targeting proteins with iron-based oxidants.
J. Prakash, J. J. Kodanko
757. Strand invasion of extended, mixed-sequence
B-DNA by �PNAs (�-peptide nucleic
acids). G. He, S. Rapireddy,
R. Bahal, B. Sahu, D. H. Ly
758. Design and synthesis of highly functionalized
and complex Bis-Peptide macromolecules.
M. F. Parker,
C. E. Schafmeister
759. Catalytic asymmetric intramolecular hydrosilylation
of 2-alkyl allyl silyl ethers.
S. Singh, S. M. Sieburth
760. Unprecedented cross coupling reaction
of allyltrifluroborate and benzoyl halides.
K. Liu, M. Al-Masum
94–TECH
‡ Cooperative Cosponsorship
761. Palladium-catalyzed microwave irradiated
direct coupling of potassium arylvinyltrifluoroborates
and benzoyl chlorides.
E. Ng, M. Wai, M. Al-Masum
762. Chiral synthesis of novel anticancer
�-lactams. S. Mukherje, I. Banik,
S. Samajdar, F. F. Becker, B. K. Banik
763. Diasteroselectivity of �-lactam formation
with polyaromatic imines: Synthesis
of novel anticancer agents.
D. Bandyopadhyay, L. C. Turrubiartes,
F. F. Becker, B. K. Banik
764. Synthetic aspects and photochemical
studies of deoxy-adenosine analogs.
B. Saha, M. S. Platz
765. Synthesis and NMR studies of imidazole-2-carboxamides
as DNA bases
reader. F. Liang, S. Lindsay, P. Zhang
766. Synthesis and characterization of functionalized
graphite nanofibers.
T. Pellenbarg, J. A. Hull, A. Tuladhar,
H. Yoo, E. Assenmacher, R. Giuliano
767. Hydroarylation of 2-azabicyclo[2.2.1]
hept-5-en-3-one followed by ring opening
as a facile and stereodefined synthesis
of trisubstituted cyclopentanes.
J. Polivkova, D. W. Piotrowski
768. New methodology for the stereoselective
synthesis of unnatural a-amino acids.
L. J. Drummond, A. Sutherland
769. Solution synthesis of peptides using
solid phase reagents and microwave
heating. R. Lundin, P. Ioannidis
770. Total synthesis of erythronolides.
K. Liu, L. J. Williams, H. Kim
771. Cyclodextrin/dextran based drug carriers
for a controlled release of hydrophobic
drugs in zebrafish embryos. K. Peng,
I. Tomatsu, A. Kros
WEDNESDAY MORNING
Section A
Boston Convention & Exhibition Center
Ballroom East
Technical Achievements in Organic
Chemistry Award Symposium
J. Cohen, C. Welch, Organizers
P. Mahaney, Presiding
8:00 Introductory Remarks
8:05 772. Identification and optimization of
1,5-diarylpyrazoles as CCK-1 receptor
antagonists. K. McClure,
J. G. Breitenbucher, L. Gomez, C. Sehon,
M. Morton, T. D. Barrett, J. M. Friedman,
C. E. Prendergast, V. Moreno, J. Pyati,
K. Figueroa, L. Li, N. P. Shankley
8:30 773. Overcoming synthetic challenges
to prepare novel gamma-secretase inhibitors.
C. M. Semko
8:55 774. Discovery of PF-610355: An inhaled
once-daily Beta-2 adrenoceptor
agonist for asthma and COPD.
P. A. Glossop
9:20 775. Development of processes supporting
the manufacture of 5-amino-3bromo-4-pyridinyl
substituted isothiazoles.
P. C. Heath, D. S. Coffey,
M. K. Hawk, J. F. Mick
9:45 776. Use of organic rheology control
agents in water-borne and solvent-borne
paint systems and ring opening polymerization
(ROP) of macrocyclics.
M. W. Cobb
10:10 777. Discovery of 5-(6-[(3R)-1-
Azabicyclo[2.2.2]oct-3-yloxy]pyridazin-3yl)-1H-indole
as a novel a7 neuronal nicotinic
receptor (NNR) agonist. T. Li
10:35 778. Chemical development of an
NHE3 inhibitor for the treatment of sleep
apnea. A. Hillegass, J. J. Shay, N. Choy,
T. A. Ayers, H. Gill
11:00 779. Identification of novel HCV NS3
protease inhibitors. J. A. O’Meara
Section C
Boston Convention & Exhibition Center
Room 206A
New Reactions and Methodology
S. Sieburth, Organizer
C. Goldsmith, Presiding
8:00 780. Mechanisms of palladium-catalyzed
processes for the formation of fluorine-containing
aromatic compounds.
T. Kinzel,S.L.Buchwald
8:20 781. Stereochemical and skeletal diversity
by coupling Petasis reaction to intramolecular
1,3-dipolar cycloaddition reactions.
G. Muncipinto, T. Kaya,
P. A. Clemons, N. Kumagai,
S. L. Schreiber
8:40 782. Photoredox catalysis: Enabling
chemical synthesis with visible light.
C. R. Stephenson
9:00 783. Bidirectional synthesis of ketones
from monomeric formaldehyde by catalytic
C-H insertion with diazoalkanes.
A. J. Wommack,J.S.Kingsbury
9:20 784. Fluoride-promoted cross-coupling
of chloro(mono-, di-, or triphenyl)germanes
with aryl halides in “moist” toluene.
J. Pitteloud, Z. Zhang, L. Cabrera,
Y. Liang, M. Toribio, S. F. Wnuk
9:40 785. Gold (I) catalysed reactions wth
cyclopropenes. M. S. Hadfield
10:00 786. New reactivity of esters: An intramolecular
oxy–acylation reaction of
alkenes initiated by rhodium catalyzed
acyl C–O bond activation. G. T. Hoang,
C. J. Douglas
10:20 787. Preparation of peptide isosteres
through a one-pot tandem homologationcyclopropanation-lactonization
of betaketo
imides. I. S. Taschner, C. K. Zercher
10:40 788. Selective dioxygenation of
alkenes using Pd catalysis.
S. R. Neufeldt,M.S.Sanford
11:00 789. Synthesis of the tetracyclic core
of mulberrofuran G via a chromene
dimerization approach. Y. Luan,
S. E. Schaus
11:20 790. Macrocyclic ring closing metathesis
of vinylsiloxanes and its application.
Y. Wang, A. S. Hansen, E. Raiber,
D. W. Young, S. L. Schreiber
11:40 791. Kinetic resolution of secondary
alcohols through enantioselective silylation.
S. L. Wiskur
12:00 792. Direct carbon–carbon bond formation
via soft enolization of thioesters.
D. M. Coltart
Section D
Boston Convention & Exhibition Center
Room 203
Heterocycles and Aromatics
S. Sieburth, Organizer
M. G. Kociolek, Presiding
8:00 793. New reactivities from bistriazole
metal catalysts. X. Shi, W. Yan
8:20 794. 1, 2, 3 Triazole-Au complex catalyzed
alkynes activation. X. Shi, X. YE,
D. Wang
8:40 795. Development of new transition
metal catalyst from bis-1,2,3-triazole ligands.
Q. Wang
9:00 796. Enantioselective [4 � 2] cycloadditions
of iminoacetonitriles: Application
to the total synthesis of quinolizidine
207I. S. D. Fontaine,M.K.Virdi,
R. L. Danheiser
9:20 797. Anti-Markovnikov additions to vinylpyrimidines,
quinoxalines, quinazolines,
and other heterocycles.
D. A. Klumpp, M. A. Sheets, Y. Zhang
9:40 798. Radical-mediated indole functionalization
and application in natural product
synthesis. L. Furst, B. S. Matsuura,
C. R. Stephenson
10:00 799. Synthesis, characterization,
mechanism of decomposition, and antiproliferative
activity of a new class of
PEGylated benzopolysulfanes with enhanced
water solubility. A. Mahendran,
A. Vuong, D. Aebisher, Y. Gong,
R. Bittman, G. Arthur, A. Kawamura,
A. Greer
10:20 800. Microwave accelerated fluorination
and fluoroalkylation methods.
M. S. Placzek, P. LaBeaume,
G. B. Jones
10:40 801. Reaction of nitrile-oxide precursors
with heterocyclic enamines.
C. Altug, Y. Durust, M. C. Elliott,
B. M. Kariuki
11:00 802. New approach to �-carbolines
via inverse electron demand Diels-Alder
reaction. Z. Ma, F. Ni, G. Woo, S. Lo,
P. Roveto, S. Schaus, J. K. Snyder
11:20 803. Calcium catalyzed intramolecular
hydroamination of olefins.
K. Kunchithapatham, J. P. Stambuli
11:40 804. Preparation of enantiopure 5,6dihydro-1,10-phenanthroline
derivatives
with B-ring functionalization.
E. Schoffers, L. Kohler,S.Tran,
R. J. Pradko, E. Driscoll, M. Zeller,
M. W. Perkovic, C. Schmiesing, E. Sinn
12:00 805. Preparation of a psico-oxetanocin
and investigation of the role of neighboring
group participation. Y. Liang,
N. Hnatiuk, J. M. Rowley, B. Whiting,
G. W. Coates, P. R. Rablen, A. R. Howell
Section E
Boston Convention & Exhibition Center
Room 204A
Molecular Recognition and Self-Assembly
S. Sieburth, Organizer
M. Case, Presiding
8:00 806. Developing a universal reader for
DNA sequencing by transbase tunneling.
P. Zhang, F. Liang, S. Chang, S. Huang,
J. He, X. Chen, S. Li, O. Sankey,
S. Lindsay
8:20 807. Boronic acid functionalized peptidyl
synthetic lectins: Combinatorial library
design and selective recognition of glycoproteins.
K. L. Bicker, J. Sun, M. Harrell,
J. J. Lavigne, P. R. Thompson
8:40 808. Structure activity relationships between
anionic amphiphilic dendrimer assemblies
and antimicrobial properties.
E. Welsch
9:00 809. Phase behavior of repulsive polymer-tethered
colloids. B. Bozorgui,
M. Sen, W. L. Miller, J. P. Pamies,
A. Cacciuto
9:20 810. Colorimetric ion sensing by molecular
tweezers. S. Saha
9:40 811. Metal helicates supported by
chiral tetradentate ligands: Solution dynamics
and structural interconversion.
J. Jung, J. Jo, M. Laskar, M. Pink, D. Lee
10:00 812. Detection of molecular interactions
with modified ferrocene self-assembled
monolayers. M. Ho, P. Li, P. Estrela,
S. Goodchild, P. Migliorato
10:20 813. Arranging virus capsids in 1D
nanoscale arrays using DNA origami.
N. Stephanopoulos, M. Liu, G. J. Tong,
Z. Li, Y. Ke, H. Yan, M. B. Francis
10:40 814. Squaraine catenanes: A new
family of luminescent interlocked molecules.
J. Lee,B.D.Smith
11:00 815. Biomolecular assembly of viral
arrays. J. M. Rego,H.Yi
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