TECHNICAL PROGRAM - American Chemical Society Publications

TOXI TECHNICAL PROGRAM
1:00 Founders’ Award Presentation
1:10 12. Mechanisms in chemical toxicology:
Letting the molecules point the way.
R. N. Loeppky
1:25 13. Recent studies on chemical mechanisms
of carcinogenicity: N-Nitrosamines,
aldehydes, and polycyclic aromatic
hydrocarbons. S. S. Hecht,
M. Wang, G. Cheng, Y. Zhong, S. Zhang,
S. G. Carmella
2:05 14. Alkylanilines: Complexities in
chemistry, toxicity, mutagenicity, and
carcinogenesis. S. R. Tannenbaum,
P. L. Skipper, G. N. Wogan, C. Liang,
L. Trudel, W. Ye
2:45 Intermission
3:05 15. Chemistry and biochemistry of biselectrophiles,
thiols, and peptides related
to DNA blockage and miscoding.
F. P. Guengerich
3:45 16. Reactive metabolites in the biotransformation
of furan-containing molecules.
L. A. Peterson
4:25 17. Chemistry and biology of DNA
damage by structurally interesting heterocyclic
compounds. K. S. Gates
MONDAY MORNING
Section A
Boston Convention & Exhibition Center
Room 252B
Young Investigators
I. Stepanov, Organizer, Presiding
8:15 18. Synthesis and quantitation of carboxymethylated
DNA Lesions induced by
diazoacetate. J. Wang,Y.Wang
8:30 19. Differential expression of proteins
in response to arsenic stress in Chlamydomonas
reinhardtii.
C. Walliwalagedara, H. van Keulen,
B. Willard, R. Wei
8:45 20. Nucleosome effect on deamination
rate of 5-methyl cytosine in cyclobutane
pyrimidine dimer DNA photoproduct.
Q. Song, J. S. Taylor
9:00 21. Small-molecule screening for suppressors
of beta-cell apoptosis induced
by inflammatory cytokines. D. Chou,
P. W. Faloon, H. A. Carrinski,
N. E. Bodycombe, P. A. Clemons,
S. L. Schreiber, B. K. Wagner
9:15 22. Exocyclic deoxyadenosine adducts
of 1,2,3,4-diepoxybutane: Synthesis and
effects on DNA structure.
U. I. Seneviratne, N. Y. Tretyakova
9:30 23. Analysis of r-7,t-8,9,c-10-tetrahydroxy-7,8,9,10-tetrahydrobenzo[a]pyrene
in human urine: A biomarker for directly
assessing carcinogenic polycyclic aromatic
hydrocarbon metabolic activation.
Y. Zhong, S. G. Carmella,
J. B. Hochalter, S. S. Hecht
9:45 24. Repair of the hydantoin lesions
guanidinohydantoin (Gh) and spiroiminodihydantoin
(Sp) by bacterial nucleotide
excision repair. P. L. McKibbin,
B. Van Houten, S. S. David
10:00 Intermission
10:20 25. Structural characterization of
formaldehyde-induced DNA-protein
cross-links. K. Lu, W. Ye, L. Zhou,
L. B. Collins, X. Chen, A. Gold, L. M. Ball,
J. A. Swenberg
10:35 26. Reactive carbonyl species derived
from omega-3 and omega-6 fatty acids.
Y. Wang, J. S. Wishnok,
S. R. Tannenbaum
10:50 27. Beas2B cells as a model of polycyclic
aromatic hydrocarbon metabolism
in noncancerous human lung: Metabolic
consequences of [ 3 H]-B[a]P and [ 3 H]-
B[a]P-7,8-dihydrodiol treatment.
M. E. Kushman, S. L. Gelhaus,
T. M. Penning
11:05 28. Effect of O 2 -arylated diazeniumdiolates
on cellular glutathione status.
R. J. Holland, J. E. Saavedra,
L. K. Keefer, A. E. Maciag, H. Chakrapani
30–TECH
‡ Cooperative Cosponsorship
11:20 29. Stereoselective formation of N 2 -
dG:N 2 -dG carbinolamine interstrand
cross-link arising from trans-4-Hydroxynonenal
derived exocyclic
(6S,8R,11S)1,N 2 -dG adduct. H. Huang,
I. D. Kozekov, A. Kozekova, S. Banerjee,
C. J. Rizzo, M. P. Stone
11:35 30. Sequence-dependent oxidation of
8-oxoguanine in DNA. K. Lim,L.Cui,
K. Taghizadeh, J. S. Wishnok,
S. R. Tannenbaum, P. C. Dedon
MONDAY AFTERNOON
Section A
Boston Convention & Exhibition Center
Room 252B
Protein Adducts and Stress Response
Pathways
D. Liebler, Organizer, Presiding
1:15 31. Redox-dependent anti-inflammatory
lipid mediator generation and actions.
B. Freeman
2:00 32. Identifying and quantifying cysteome
modifications in response to NO
donor and quinone donor drugs.
G. R. Thatcher, R. E. Chandrasena,
V. Sinha, G. T. Wijewickrama, T. Dunlap,
S. C. Piyankarage, H. Xu, J. Bolton,
I. T. Schiefer, P. D. Edirisinghe, Y. Wang
2:45 Intermission
3:05 33. Systems analysis of electrophileinduced
gene expression: Role of HSF1affected
genes in cellular viability.
A. T. Jacobs
3:50 34. Apoptosis signal-regulating kinase
1 (ASK1), a sensor-trigger for proapoptotic
signaling in electrophile stress.
D. C. Liebler
MONDAY EVENING
Section A
Boston Convention & Exhibition Center
Room 252B
Perspectives Lecture
L. Peterson, Organizer, Presiding
5:00 Introductory Remarks
TUESDAY MORNING
Section A
Boston Convention & Exhibition Center
Room 252B
Mechanisms of Food-Drug Interactions
K. Myung, J. Manthey, S. Sturla,
Organizers, Presiding
8:30 35. Role of lipoproteins on the biological
activity and pharmacokinetics of hydrophobic
drugs. K. M. Wasan
9:05 36. Interactions of dietary supplement
mixtures and pure compounds on phase I
drug metabolism. D. J. Kroll
9:40 37. Impact of food on the function of
oral drug delivery systems. R. L. Carrier
10:15 Intermission
10:35 38. Transporter-mediated drug-herb
and drug-food interactions. M. E. Morris
11:10 39. Mechanisms of cytochrome P450mediated
food-drug interactions: Mechanism-based
inactivators and the grapefruit
juice effect. P. Hollenberg
TUESDAY AFTERNOON
Section A
Boston Convention & Exhibition Center
Room 252B
Improving Drug Candidates by Design: A
Focus on Physical Properties to Improve
Disposition and Safety Cosponsored by
MEDI
N. Meanwell, F. Guengerich, Organizers,
Presiding
1:30 Introductory Remarks
1:35 40. Physicochemical and pharmacological
properties as predictors of drug
safety and success. J. Empfield
2:25 41. Aromatic ring count and compound
developability. S. J. Macdonald,
T. J. Ritchie, R. Young, A. Hill
3:15 Intermission
3:30 42. Molecular matched pairs derived
QSAR for the optimization of ADMET
properties. S. Johnson, M. Davis,
S. Posy, B. Claus
4:20 43. Moving beyond rules: The development
of a central nervous system multiparameter
optimization (CNS MPO) approach
to enable alignment of drug-like
properties. T. T. Wager,X.Hou,
P. R. Verhoest, A. Villalobos
TUESDAY EVENING
Section A
Boston Convention & Exhibition Center
Room 210A/B
General Posters
K. Mitra, Organizer
6:30–8:30
44. Affinity purification of kidney enzymes
that bind mercapturic acids. E. Veldman,
P. Josephy
45. Translesion synthesis past the �-radiation-induced
guanine- thymine intrastrand
crosslink G[8,5-Me]T.
P. Raychaudhury,A.K.Basu
46. Structural studies of a repair-resistant
dibenzo[a,l]pyrene-derived DNA adduct
in a nucleosome. Y. Cai, N. E. Geacintov,
S. Broyde
47. Base flipping free energy profiles for
damaged DNA. H. Zheng,Y.Cai,
Y. Zhou, S. Wang, N. E. Geacintov,
S. Broyde, Y. Zhang
48. Experimental approach to enhance parent
ion fragmentation for metabolite identification
studies: Application of stepped
CID and HCD in an Orbitrap-XL.
J. L. Bushee, U. A. Argikar
49. Effects of pharmaceutical excipients on
4-methyl umbelliferone glucuronidation:
An application for compounds with low
solubility. U. A. Argikar, G. Liang,
J. L. Bushee, V. Hosagrahara, W. Lee,
L. Shah, S. Garad
50. Translesion synthesis past the 2,6-diamino-4-hydroxy-N
5 -(methyl)-formamidopyrimidine
(MeFAPy-dG) adduct in oligonucleotides
by DNA polymerases and
selective incision of the �-anomer of Me-
FAPy-dG by Escherichia coli Endo IV.
P. P. Christov, C. J. Rizzo
51. Quinone-enhanced reduction of nitric oxide
by xanthine/xanthine oxidase.
A. E. Alegria, P. Sanchez-Cruz
52. Quantification of four oxidized guanine
lesions from reaction of DNA with 3-morpholinosydnonimine.
L. Cui,
E. G. Prestwich, L. J. Trudel,
J. S. Wishnok, P. C. Dedon,
S. R. Tannenbaum
53. Quantitative mapping of cysteome for
the protein S-nitrosylation.
R. P. Chandrasena, G. T. Wijewickrama,
V. Sinha, H. Xu, G. R. Thatcher
54. Proteomic analysis of protein covalent
modification by quinone methide-releasing
drugs. S. C. Piyankarage, T. Dunlap,
R. P. Chandrasena, G. R. Thatcher
55. Genotoxicity screening validation using
electro-optical and magnetic bioreactor
arrays. L. Zhao,S.Pan,
J. B. Schenkman, J. F. Rusling
56. Characterization of a deoxyguanosine-lysine
crosslink induced by methylgyoxal.
K. V. Petrova, A. D. Millsap, C. J. Rizzo
57. Metabolic profiling of mitochondrial dysfunction.
Q. Xu, H. Vu, W. H. Schaefer,
L. Liu, J. Monroe, C. Chiu
58. Evaluation of 9,12-dioxo-10(E)-dodecenoic
acid and 4-oxo-2(E)-nonenal derived
lysine adducts as potential biomarkers of
inflammation. F. Li, E. Iffrig, C. Knutson,
J. S. Wishnok, S. R. Tannenbaum
59. Utility of hepatocyte bioreactor proteomics
for identification of drug-induced liver
toxicity. V. Brahmbhatt,A.Dash,
S. W. Inman, L. Griffith,
S. R. Tannenbaum
60. Assembly and characterization of a system
for delivering biologically relevant
levels of nitric oxide and oxygen for studies
of inflammation. V. Dendroulakis,
B. S. Russell, C. E. Elmquist, L. J. Trudel,
G. N. Wogan, P. C. Dedon, W. M. Deen
61. Quantitative profiling of serum bile acids
by LC/MRM during liver tumor promotion
associated with chronic Helicobacter infection
and nuclear receptor deficiency.
Y. Zeng, A. Garcia, J. S. Wishnok,
J. G. Fox, S. R. Tannenbaum
62. Cytotoxicity study of nanomaterials
based on bioimpedance analysis and
confirmed by cellular uptake.
K. Kandasamy, M. Marimuthu, S. Kim
63. DNA-protein cross-links mediated by hydrogen
peroxide. E. K. Hawkins,
C. J. Rizzo
64. Metabolism of benzo[a]pyrene-7,8-dione
in human lung cells. M. Huang, X. Liu,
I. A. Blair, T. M. Penning
65. Effects of cytosine methylation on O 6 -alkylguanine
DNA alkyltransferase repair of
O 6 -(pyridyloxobutyl)guanine adducts in
CG dinucleotides. D. Kotandeniya,
A. E. Pegg, N. Y. Tretyakova
66. Detoxification of structurally diverse PAH
o-quinones by human recombinant
COMT via o-methylation of PAH catechins.
L. Zhang, S. Bhat, I. A. Blair,
T. M. Penning
67. Changes in the spectrum of tRNA secondary
modifications as biomarker signatures
of exposure to toxic stimuli.
C. Chan, M. Dyavaiah, K. Taghizadeh,
T. J. Begley, P. C. Dedon
68. Inhibition of 4-aminobiphenyl-induced
DNA damage by Sulforaphane and 5,6-
Dihydrocyclopenta[c]-dithiole-3(4H)thione
in bladder cells and tissues.
K. L. Randall, Y. Ding, J. D. Paonessa,
D. Argoti, R. Munday, Y. Zhang,
P. Vouros
69. Oxidative stress-induced protein modification:
Application of clickable linoleic
acid analogs. P. Slade, R. Aggeler,
T. Nyberg, C. Pikens, U. Singh, B. Agnew
70. Paradoxical down-regulation of benzo-
[a]pyrene-mediated DNA-adduct formation
and concurrent up-regulation of glutathione-adduct
formation by 2,3,7,8tetrachlorodibenzo-p-dioxin
in human
lung cells. S. L. Gelhaus, T. M. Penning,
I. A. Blair
71. Stable isotope dilution HPLC-ESI - -
MS/MS analysis of urinary butadiene metabolites
as biomarkers of exposure to
1,3-butadiene. S. Kotapati, B. A. Matter,
D. Sangaraju, N. Y. Tretyakova
72. Sensitive liquid chromatography/mass
spectrometry method for the quantification
of low levels of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol
(NNAL) in
urine of non-smokers. S. H. Bhat,
S. L. Gelhaus, C. A. Mesaros, I. A. Blair
73. Persistent ROS generation in H358 cells
treated with PAH-o-quinones. S. S. Basu,
S. L. Gelhaus, M. Huang, T. Penning,
I. Blair
74. Identification of tyrosine chlorination
sites in human serum albumin for potential
inflammatory disease biomarker discovery.
P. Kang, Y. Zeng, J. S. Wishnok,
S. R. Tannenbaum
75. Total synthesis of Aristolochic acidsI&II
and their derivatives. S. Attaluri,
R. R. Bonala, F. Johnson
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