TECHNICAL PROGRAM - American Chemical Society Publications

ORGN TECHNICAL PROGRAM
4:00 95. Catalytic enantioselective dearomatization:
A strategy for the rapid generation
of non-racemic complex molecular
architecture. A. E. Williamson,
M. J. Gaunt
4:20 96. Copper-catalyzed meta-selective
direct arylation of �-arylacetamides.
R. E. Gilligan, H. A. Duong, M. J. Gaunt
4:40 97. Two-carbon homologation of ketones
to 3-methyl unsaturated aldehydes.
R. J. Petroski, K. Vermillion
5:00 98. Intermolecular aryne insertion into
the C-O bonds of carboxylic acids.
A. V. Dubrovskiy, R. C. Larock
Section D
Boston Convention & Exhibition Center
Room 203
Peptides, Proteins and Amino Acids
S. Sieburth, Organizer
T. Tolbert, Presiding
1:00 99. Staudinger reactions with unsymmetrical
phosphites: Applications to the
synthesis of phosphoramidate-linked glycopeptides
and the functionalization of
proteins. C. P. Hackenberger
1:20 100. Rational design of functional macromolecular
bis-peptides.
C. E. Schafmeister, Z. Brown, M. Parker,
K. Akula, M. Jackson
1:40 101. Synthesis and application of porphyrin-peptide-conjugates
in photodynamic
inactivation of bacteria. E. Feese,
R. A. Ghiladi
2:00 102. Targeted photodynamic therapy
of leukemia T cells using dual-surface
modified virus capsids.
N. Stephanopoulos,G.J.Tong,
S. C. Hsiao, M. B. Francis
2:20 103. Genome-free viral capsids as multivalent
carriers for taxol delivery. W. Wu,
S. C. Hsiao, K. Wai, M. B. Francis
2:40 104. Protein modification for enhanced
activities and targeted drug delivery.
D. Prashar, D. Cui, Y. Shi,
D. Bandyopadhyay, J. Dabrowiak,
Y. Y. Luk
3:00 105. Water-driven reactions for protein
modification without side products.
Y. Y. Luk, D. Cui, D. Prashar
3:20 106. Exon-encoded polypeptides as
primordial enzymes. Y. Ivanova,
D. Pamuk, K. Kumar
3:40 107. Self-assembly of cyclic peptides
and potential application as molecular
transporters. D. Mandal, K. Parang
4:00 108. Energetic contribution of fluorinated
aromatics to protein stability.
J. Gao, H. Zheng, C. Pace
4:20 109. Protein core packing by dynamic
combinatorial chemistry. M. A. Case,
L. Roy
4:40 110. Structure and compositional analysis
of polymeric active ingredients for
drug delivery applications using advanced
detection size-exclusion chromatography.
J. Sanchez
5:00 111. Comparison study of cyclic and
linear peptoid libraries for high throughput
screening. Y. Gao, T. Kodadek
Section E
Boston Convention & Exhibition Center
Room 204A
Total Synthesis of Complex Molecules
86–TECH
S. Sieburth, Organizer
S. Rasapalli, Presiding
1:00 112. Intramolecular alpha–glucosaminidation:
Synthesis of mycothiol.
S. Knapp, K. Ajayi, V. V. Thakur,
R. C. Lapo
‡ Cooperative Cosponsorship
1:20 113. Structural assignment and total
synthesis of Gephyronic acid. L. Nicolas,
T. Anderl, L. Sabine, R. E. Taylor
1:40 114. Defining the stereochemical configuration
of chamuvarinin via synthesis.
G. J. Florence
2:00 115. Progress toward the total synthesis
of Sch 47554. B. W. Slafer,
A. G. Barrett, M. Espensen, O. Niemeier
2:20 116. Efforts toward the total synthesis
of leiodelide A. M. F. Chellat, N. Proust,
M. G. Lauer, J. P. Stambuli
2:40 117. Bromonium-initiated epoxideopening
cascades and its application for
the total synthesis of ent-dioxepandehydrothyrsiferol.
J. Tanuwidjaja,S.Ng,
T. F. Jamison
3:00 118. Towards the total synthesis of
Agariblazeispirol C. L. C. Paterson,
W. J. Kerr, A. Sutherland
3:20 119. Highlights on the way to the first
total synthesis of Pl-3. C. R. Lentsch,
R. Fürst, U. Rinner
3:40 120. Toward the first total synthesis of
Pl-4 – a jatrophane dipterpene with remarkable
multidrug resistant reversal
(MDR) effect. R. Fürst, U. Rinner
4:00 121. Synthesis of (�)-eusynstyelamide
A. O. V. Barykina,B.B.Snider
Section F
Boston Convention & Exhibition Center
Room 204B
Asymmetric Reactions and Syntheses
S. Sieburth, Organizer
S. Singh, Presiding
1:00 122. Synthesis of stereochemically diverse
2-pyrrolines through a novel Ag
catalyzed [3�2] cycloaddition.
J. A. Bishop, S. E. Schaus
1:20 123. Copper-catalyzed regio- and enantioselective
formal conjugate addition
of Grignard reagents to �,�-unsaturated
aldehydes. M. Fañanás Mastral,
B. L. Feringa
1:40 124. Investigation of the scope and
mechanism of the palladium-catalyzed
synthesis of enantioenriched allylic esters
from prochiral (Z)-allylic alcohols.
J. S. Cannon, S. F. Kirsch,
L. E. Overman, H. F. Sneddon
2:00 125. Catalytic enantioselective Saucey
Marbet Claisen rearrangement of heterocyclic
substrates. T. Cao,
M. C. Kozlowski
2:20 126. Asymmetric organocatalytic allylation
of acetals. R. M. Gleixner,L.R.Cox
2:40 127. Discovery and development of the
Sc(III)-catalyzed homologation of cycloalkanones
with substituted diazomethanes.
D. C. Moebius, V. L. Rendina,
J. S. Kingsbury
3:00 128. Asymmetric Diels-Alder reaction
with a new bifunctional cinchona alkaloid
catalyst. K. J. Bartelson, R. P. Singh,
L. Deng
3:20 129. (E)-2-Boryl-1,3-butadiene derivatives
of the 10-TMS-9-BBDs: Highly selective
reagents for the asymmetric synthesis
of anti-1,2-disubstituted 3,4pentadien-1-amines.
J. R. Gonzalez,
J. A. Soderquist
3:40 130. Asymmetric allylic alkylations with
preformed ketone and lactone enolates
and doubly deprotonated carboxylic acids.
M. Braun, P. Meletis
4:00 131. Chiral boronate derivatives via
catalytic enantioselective conjugate addition
of Grignard reagents on 3-boronyl
unsaturated esters and thioesters.
J. C. Lee,D.G.Hall
4:20 132. Override of substrate reactivity in
highly enantioselective regiodivergent
ring opening reactions of [2.2.1] oxabicyclic
alkenes: Applications to practical API
synthesis. R. Webster, N. Nguyen,
A. Boyer, C. Boeing, M. Lautens
Section G
Boston Convention & Exhibition Center
Room 207
Physical Organic Chemistry: Calculations,
Mechanisms, Photochemistry and High-
Energy Species
S. Sieburth, Organizer
W. Dichtel, Presiding
1:00 133. Molecular force probes for studying
reaction kinetics under force.
R. Boulatov, T. J. Kucharski
1:20 134. Mechanistic large scale industrial
catalysis: Regioselectivity control in arene
substitution. C. Kring, F. Windlin,
P. Hofmann
1:40 135. Mechanistic investigations into
the role of water in regioselective epoxy
alcohol cyclizations in aqueous media.
J. A. Byers, T. F. Jamison
2:00 136. Quantum chemical studies on the
photochemistry of nitro-aromatic explosives.
J. Quenneville, D. S. Moore
2:20 137. Mechanistic studies of lithium
enolates: Enolate generation and reactivity.
K. J. Kolonko, H. J. Reich
2:40 138. Reaction mechanism of imidazole
formation from glyoxal and amines: A
computational study. J. Kua, H. Krizner
3:00 139. Intermolecular influences on radical
reactions. A. K. Croft,C.J.Cadman,
A. Garcia Cabellero, H. M. Howard-Jones,
S. M. Nalli, C. C. Wood
3:20 140. Brownian dynamic simulations of
the excited-state reversible proton transfer
in the zwitterion-proton pair.
A. V. Popov, K. M. Solntsev, E. Bartolo,
L. M. Tolbert, R. Hernandez
3:40 141. Insights into the catalytic mechanism
of GH97 enzyme from the MD and
QM/MM-MFEP simulations. G. Cui,
W. Yang
4:00 142. Novel off-on fluorescent probes
for visualizing reactive oxygen species in
lipid membranes. K. Krumova,G.Cosa
4:20 143. Mechanism of the �,�-diphenylprolinol
trimethylsilyl ether-catalyzed aza-
Michael reaction. C. Wong
Section A
Boston Convention & Exhibition Center
Ballroom East
JOC: Defining the Frontiers of Organic
Chemistry for 75 Years
C. Burrows, Organizer
R. Boeckman, Organizer, Presiding
1:30 Introductory Remarks by C. D. Poulter
1:40 144. Evolution of anion relay chemistry
(ARC): Construction of architecturally
complex natural and unnatural products.
A. B. Smith, III
2:20 145. Catalytic organometallic carbonheteroatom
bond formation.
J. F. Hartwig
3:00 146. Strategies for the rational chemical
synthesis of fullerenes and carbon
nanotubes. L. T. Scott
3:40 147. Bioactive compounds: A driving
force for the discovery of methods.
J. Cossy
4:20 148. Chemical synthesis in the context
of pharma discovery. S. J. Danishefsky
SUNDAY EVENING
Section A
Boston Convention & Exhibition Center
Hall C
Heterocycles and Aromatics, Metal-
Mediated Reactions & Syntheses,
Molecular Recognition & Self-Assembly
and Physical Organic Chemistry:
Calculations, Mechanisms, Photochemistry
& High-Energy Species
A. Abdel-Magid, Organizer
8:00–10:00
149. Novel syntheses of some 1, 2, 4-triazoles
as potent bacteriocidal agents.
J. R. Patel
150. Radioiodination of functionalized indoles.
A. B. Williams,R.N.Hanson
151. Reverse NO 2 reactivity in the oxidation
of syringyl lignin model compounds in
acetonitrile. S. S. Mustakim, M. R. Karim
152. Novel and efficient synthesis of bendamustine
hydrochloride, the active ingredient
in Treanda®. J. Chen,
K. Przyuski Mowrey, R. Roemmele
153. Sulfonamidophenyl porphyrinic macrocycles
as thiol-activatable photosensitizers
for biological applications.
J. Bhaumik, K. M. Bardon,
R. Weissleder, J. R. McCarthy
154. Modulation of regioselectivity in the
condensation 3-amino-5-methylpyrazole
with unsymmetrical ketones: Applications
to the synthesis of pyrazolo[1,5-�]pyrimidines.
J. R. Rizzo, T. Y. Zhang, M. Jia,
H. Ping
155. p-Iodination and p-bromination of activated
arenes in hydrocarbon media.
D. W. Slocum, P. E. Whitley,B.Fouzia
156. Synthesis of nitrogen- and sulfur-containing
heterocycles from cyclopropanol
fragmentation. G. T. Stoyanov,
K. L. George, K. P. Minbiole
157. Synthesis of a coumarin/phenanthridine-fused
heterocycle: A potential organocatalytic
oxidizing agent. D. Yang,
J. Chen
158. One-step, multicomponent reaction for
the synthesis of fully substituted 5-amino-1,3-thiazole-4-carboxamides.
K. K. Childers, A. M. Haidle,
M. R. Machacek, J. P. Rogers, E. Romeo
159. Carbon-Carbon bond formation under
mild conditions using cyclic ketene
acetals: Reactions of substituted oxazoles
and thiazoles with acid chlorides and isocyanates.
S. Chatterjee, G. Ye, Y. Song,
B. L. Barker, C. U. Pittman, Jr.
160. Asymmetric synthesis of Pyrrolodinopyridine
based CXCR4. R. Zhou, C. Bi,
M. He, R. Hoffman, M. Jalaie, J. Kath,
S. Kupchinsky, T. Ling, J. Lu, M. Marx,
P. Richardson, N. Sach, K. Tran,
N. Barbour, S. Cho-Schultz
161. Tandem Henry-Michael route to the
1,3-disubstituted-1,3-dihydrobenzo[c]furan
system. F. A. Luzzio,J.Chen
162. Fluorous benzaldehyde-based synthesis
of heterocyclic systems. A. Kadam,
S. Ding, R. Fitzgerald, M. Le-Nguyen,
W. Zhang
163. Enhancing the solubility of polycyclic
aromatic hydrocarbons: Advancements
in the total synthesis of a [6,6] carbon
nanotube end cap. A. K. Greene,
F. Liquido, L. T. Scott
164. N-2 aryltriazole as a new fluorophore
with tunible photo reactivity. X. Shi,
W. Yan
165. Development of triazole based proline
as new catalyst in chemistry synthesis.
X. Shi, X. YE
166. Iron catalyzed 1,2,3-triazole propargylation:
A practical route for the preparation
of bis-1,2,3-triazole. Q. Wang,X.Shi
167. Direct copper C-arylation for synthesis
of thiazolyl–pyrazolopyrimidines.
S. K. Boini, J. R. Rizzo, R. K. Vaid,
B. Dominguez, M. Groarke
168. Synthesis of thieno[2,3-b]furans and
furo[2,3-b]furans using a modification of
the Jacobi bis-heteroannulation method.
S. F. McCann, Y. Hu, M. Hendrixson,
R. A. Coats
169. New approaches to the synthesis of indolequinones
as bioreductive anticancer
agents. M. Inman, C. J. Moody
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