TECHNICAL PROGRAM - American Chemical Society Publications

12:00 26. Semisynthesis of chemically modified
antibody fragments and glycoproteins
with multiple N-linked glycosylation
sites. T. J. Tolbert
Section F
Boston Convention & Exhibition Center
Room 204B
Asymmetric Reactions and Syntheses
S. Sieburth, Organizer
M. Bergdahl, Presiding
8:00 27. Isothiourea-mediated stereoselective
C-acylation of silyl ketene acetals.
P. A. Woods, R. A. Bragg, A. D. Smith
8:20 28. Tertiary amine-Lewis acid cooperative
asymmetric catalysis. D. J. Dixon,
F. Sladojevich, T. Yang, A. Ferrali
8:40 29. Asymmetric synthesis of substituted
homotropinone alkaloids from acyclic
N-sulfinyl �-amino ketone ketals.
F. A. Davis, R. Edupuganti
9:00 30. Determination of the relative importance
of Lewis-acid and Lewis-base catalysis
in asymmetric catalysis using bifunctional
catalysts. M. North,
M. Omedes-Pujol, C. Williamson
9:20 31. Asymmetric �-methoxyallylboration
of ketones with the B-[(Z)-g-methoxyallyl]-10-phenyl-9-borabicyclo[3.3.2]
decanes. L. A. Seda, J. A. Soderquist
9:40 32. Reagent control in asymmetric allenylboration
of nonracemic �-amino aldehydes
with the 10-TMS-9-borabicyclo
[3.3.2]decanes. J. M. Guzman,
J. A. Soderquist
10:00 33. Scaffolding ligands: A method for
controlling regio- and stereochemistry in
hydroformylation. K. Tan
10:20 34. Synthesis of enantiomerically pure
1,3-aminoalcohols through organo-, organometallic,
and enzymatic catalysis.
A. M. Träff, R. Millet, M. L. Petrus,
J. Bäckvall
10:40 35. Development of an asymmetric
Michael-Benzoin cascade for the synthesis
of functionalized cyclopentanones.
K. E. Ozboya, T. Rovis
11:00 36. Highly enantioselective phase
transfer reactions with new cinchonium
salts. B. A. Provencher,L.Deng
11:20 37. Efficient preparation of chiral
N-aryl �-amino acids. P. Hermsen,
G. Busscher, L. Lefort, A. de Vries,
H. de Vries
11:40 38. Catalytic methods for enantioselective
C–F bond formation with fluoride
sources. A. Doyle
Section E
Boston Convention & Exhibition Center
Room 204A
Total Synthesis of Complex Molecules
S. Sieburth, Organizer
G. Florence, Presiding
8:20 39. Development of a unified synthetic
strategy to the polyprenylated acylphloroglucinols.
Q. Zhang, J. A. Porco
8:40 40. Total synthesis of the Lycopodium
alkaloid (�)-sieboldine A. S. M. Canham,
D. J. France, L. E. Overman
9:00 41. Piperazic acids in natural products:
Synthetic studies towards chloptosin and
lydiamycin. A. J. Oelke, D. J. France,
G. Wuitschik, T. Hofmann, S. V. Ley
9:20 42. Toward the total synthesis of the
brasilinolides. C. J. Cordier,
M. P. Housden, P. M. Burton,
F. A. Mühlthau, O. Loiseleur, I. Paterson
9:40 43. Total synthesis of (-)-virginiamycin
M 2 using atom-economical and chemoselective
approaches. J. Wu
10:00 44. Studies toward the total synthesis
of dideoxy lomaiviticinone.
A. Baranczak, G. A. Sulikowski
10:20 45. Asymmetric catalytic formal synthesis
of the anti-angiogenic polyketide
(–)-Borrelidin. A. V. Madduri,
A. J. Minnaard
10:40 46. Progress toward the synthesis of
the parnafungins. Q. Zhou,B.B.Snider
11:00 47. Total synthesis of (�)-SCH
351448. K. Zhu
11:20 48. Synthesis, characterisation, and in
vitro cytotoxic activitiy of some Ru(II)
complexes. S. Thota, s. s. karki,
E. d. clercq, j. balzarini
Section G
Boston Convention & Exhibition Center
Room 207
Physical Organic Chemistry: Calculations,
Mechanisms, Photochemistry and High-
Energy Species
S. Sieburth, Organizer
R. McCulla, Presiding
8:20 49. 2-Anthryltriazolyl-containing multidentate
ligands: Zinc-coordination mediated
photophysical processes and thier
potential application in live-cell imaging.
H. A. Michaels,L.Zhu
8:40 50. How solvent modulates hydroxyl
radical reactivity in hydrogen atom abstractions.
S. Mitroka, S. Zimmeck,
D. Troya, J. M. Tanko
9:00 51. Challenges posed to bornyl diphosphate
synthase: Diverging reaction mechanisms
in monoterpenes. D. T. Major,
M. Weitman
9:20 52. Insights into the formation and
isomerization of the benzene metabolite
muconaldehyde and related molecules:
Comparison of computational and experimental
studies of simple, benzo-annelated,
and bridged 2,3-epoxyoxepins.
J. P. Morgan, A. Greenberg
9:40 53. Inverse isotope effect in the Co catalyzed
synthesis of hydrocarbons from
CO and H 2. B. Shi,C.Jin
10:00 54. Computational approach to predicting
gas diffusion in organic cages.
D. Holden, A. Trewin, A. Cooper
10:20 55. Isomerization of cis-1,2-dimethylcyclohexane
in shock tube experiments.
C. M. Rosado-Reyes, W. Tsang
10:40 56. Fluorinated acid amplifiers improve
high resolution imaging.
S. A. Kruger, C. Higgins, B. Cardineau,
R. L. Brainard
11:00 57. Modeling the localization of excitations
in poly-phenylacetylene based
dendrimers. Y. Shin,X.Lin
11:20 58. Marcus theory for hydride transfer
reactions between heteroaromatic compounds.
I. H. Lee
11:40 59. Development and synthesis of
corannulene-based organic light emitters.
D. R. Jones,J.Mack
Section B
Boston Convention & Exhibition Center
Room 205A/B
Young Investigators
D. Huryn, Organizer, Presiding
8:30 Introductory Remarks
8:35 60. Efficient and practical synthesis of
GSK812397, an HIV drug candidate.
V. I. Elitzin
8:55 61. Synthesis and evaluation of NO donor
containing carbonic anhydrase inhibitors.
Q. Huang,M.Cobbs,D.M.Dinh,
H. Gukasyan, J. A. Lafontaine, S. Mehta,
B. D. Patterson, P. F. Richardson,
E. Y. Rui
9:15 62. DNA-programmed chemistry approaches
to macrocyclic lead compounds.
A. W. Fraley
9:35 63. Synthesis of pyridyl amine ligands
for catalyzed ethylene oligomerization.
C. A. Faler
9:55 64. Design and synthesis of novel
�-secretase (BACE) inhibitors.
R. D. Mazzola Jr., S. Babu, J. Caldwell,
X. Chen, J. Cumming, M. Czarniecki,
J. Duo, J. Durkin, W. J. Greenlee, H. Gu,
T. Guo, R. Hunter, U. Iserloh,
M. E. Kennedy, J. Kong, R. Kuvelkar,
L. Hyde, P. Leach, V. Madison,
B. A. Mckittrick, T. Le, T. Meng,
J. Misiaszek, J. Pan, E. Parker, G. Qian,
K. Saionz, A. Stamford, C. Strickland,
D. Tadesse, J. Voigt, L. Wang, J. Wong,
Y. Wu, J. Zhao, Z. Zhu, G. Li, Y. Huang,
Y. Ye, K. Cox, L. Favreau, D. Wyss,
Y. Wang, Z. Sun
10:15 Intermission
10:25 65. Development of an efficient palladium-catalyzed
intramolecular carbometalation
reaction for the synthesis of a
dibenzoxapine-containing tetrasubstituted
exocyclic alkene. H. Yu,
R. N. Richey
10:45 66. Peptide mimetics disrupting protein-protein
interactions discovered by
post-solid phase modifications. F. Liu,
A. G. Stephen, A. A. Waheed, J. Park,
R. J. Fisher, K. S. Lee, E. O. Freed,
T. R. Burke
11:05 67. Asymmetric hydrogenation of unprotected
N-H ketoimines. F. Gosselin
11:25 68. Synthetic ligands (synbodies):
Synthetic alternatives to antibodies.
N. Gupta, P. E. Belcher, M. Shah,
P. Stafford, C. W. Diehnelt,
J. J. Rajasekaran, S. A. Johnston
11:45 69. Practial arene metallation chemistry.
M. M. Bio
12:05 Concluding Remarks
Section A
Boston Convention & Exhibition Center
Ballroom East
Symposium in Memory of Keith Fagnou
T. Rovis, Organizer
G. Hughes, Organizer, Presiding
8:50 Introductory Remarks
8:55 70. Mechanistic aspects of cross-coupling
reactions that form C-C bonds.
J. F. Hartwig, B. P. Carrow, Z. Huang,
Y. Tan
9:40 71. High oxidation state palladium in
catalysis. M. Sanford
10:25 72. Pd(II)/Pd(0) catalysis: A promising
platform for versatileC-Hfunctionalizations.
J. Yu
11:10 73. Mechanism of the hydrolytic kinetic
resolution reaction. E. N. Jacobsen
SUNDAY AFTERNOON
Section B
Boston Convention & Exhibition Center
Room 205A/B
Chemistry for Preventing and Combating
Disease
S. Sieburth, Organizer
X. Qian, Presiding
1:00 74. Insights and applications of using
various aryl-azido compounds for the inactivation
of human immunodeficiency virus
(HIV-1): Towards the generation of a
novel inactivated vaccine strategy.
J. M. Belanger, Y. Raviv, M. Viard,
J. W. Bess, R. Blumenthal
1:20 75. Enhanced radical scavenging activities
of catechin derivatives incorporating
basic amino acids. K. Fukuhara,
I. Nakanishi, K. Imai, A. Ohno, K. Ohkubo,
S. Fukuzumi, A. Nakamura, K. Anzai,
N. Miyata, H. Okuda
1:40 76. Nitric oxide releasing nanoparticles:
A topical therapeutic strategy for the
treatment of superficial and deep soft tissue
infections. A. Friedman,G.Han,
L. Martinez, M. Mihu, J. Nosanchuk,
J. Friedman
2:00 77. Therapeutic strategies based on
siderophores: Iron out Pseudomonas
aeruginosa infections with synthetic
pyochelin? S. Noël, F. Rivault, L. Guillon,
F. Hoegy, V. Gasser, D. Rognan,
I. J. Schalk, G. L. Mislin
2:20 78. Multifuntional porphyrinoids for simultanious
breast cancer detection, imaging,
and therapy. C. M. Drain
2:40 79. Anti-parasitic activity of a bisphosphonamidate
clodronate prodrug.
C. L. Freel Meyers, M. Webster, S. Tang,
T. Shapiro
3:00 80. Chiral surfaces that resist biofouling.
D. Bandyopadhyay, P. Sejwal,
D. Prashar, Y. Y. Luk
3:20 81. Fiber optic device for targeted singlet
oxygen delivery for potential application
in human diseases such as brain tumors.
M. Zamadar, G. Ghosh,
D. Aebisher, M. Alqaim, A. Greer
3:40 82. NMR studies on the mutagenic
nucleosides that can cause viral decay
acceleration of HIV. D. Li,
J. M. Essigmann
4:00 83. New routes to functional adenosine
A 2A receptor antagonists. R. Thomas,
M. Sitkovsky, G. B. Jones
4:20 84. Enantioselective synthesis of a
drug for a low price using open science.
M. Wölfle,M.H.Todd
4:40 85. Converting C-H to C-C bonds: Synthesis
of veratramine. D. F. Taber,
J. F. Berry, P. W. DeMatteo
Section C
Boston Convention & Exhibition Center
Room 206A
New Reactions and Methodology
S. Sieburth, Organizer
N. Bowden, Presiding
1:00 86. Vinylogous aldol products from
chiral crotylsilanes obtained by carbenoid
Si-H insertion. J. Wu
1:20 87. (E)-Enolate equivalents from
alkynes using tandem catalysis: Development
of an anti-selective aldol reaction.
L. K. Chan,M.J.Gaunt
1:40 88. Aqueous Wittig reactions: Highly
stereoselective, chemoselective, organic
solvent and protecting group-free synthesis
of functionalized alkenes. P. Das,
J. McNulty
2:00 89. Di-fluorous tagging strategy for the
automated solution-phase synthesis of
plant oligosaccharides.
S. K. Nagappayya, H. Edwards,
N. L. Pohl
2:20 90. Gold catalyzed cyclization of
propargylic esters with enones to give
Rauhut-Currier type products.
J. W. Cran, M. E. Krafft
2:40 91. Strecker and Mannich reactions of
�-amido p-tolylsulfones. S. T. Kadam,
S. Kim
3:00 92. Pyrazolidin-3-ones as a new scaffold
for iminium ion organocatalysis.
E. R. Gould, A. D. Smith, M. Reid
3:20 93. Iterative metal-catalyzed C-H bond
functionalization for complex natural
product synthesis. L. McMurray,
E. M. Beck, M. J. Gaunt
3:40 94. Nickel-catalyzed stereoselective
formation of 1,2-cis-2-amino-2-deoxy
glucosides and galactosides.
E. A. Mensah, H. M. Nguyen
The official technical program
for the 240th National Meeting
is available at:
www.acs.org/boston2010
ORGN
TECH–85