a) Cell injury: Causes and Mechanism: Ischemic, Toxic.b) Reversible cell injury: Types, morphology: Swelling, vacuolation, hyaline, fatty change.c) Irreversible cell injury : Types of Necrosis3. Amyloidosis and Calcificationa) Calcification : Dystrophic and Metastaticb) Amyloidosis : classification, Pathogenesis, Morphology4. Inflammation and Repaira) Acute inflammation : Features, causes, vascular and cellular events.b) Morphologic variants of acute inflammationc) Inflammatory cells and Mediatorsd) Chronic inflammation: Causes, types, nonspecific and Granulomatous with examplese) Wound healing by primary and secondary union, factors promoting and delaying theprocessf) Healing at specific sites including bone healing5. Circulatory Disturbancesa) Edema : Pathogenesis and typesb) Chronic venous congestion : Pathogenesis and changes in Lung, Liver, Spleenc) Thrombosis and Embolism : Formation, Fate and Effectsd) Infarction : Types, common sites, Gangrenee) Shock : Pathogenesis, Types, Morphologic changesf) Derangements of Fluid and electrolyte imbalance6. Growth Disturbances and Neoplasiaa) Atrophy, Hypertrophy, Hyperplasia, Hypoplasia, Metaplasia, Malformation, Agenesis,Dysplasiab) Neoplasia: Classification, Histogenesis, Biologic Behaviour: Benign and Malignant;Carcinoma and Sarcomac) Malignant Neoplasia: Grades and Stages, Local and distant spreadd) Carcinogenesis: Environmental carcinogens, chemical, viral, occupational, Heredity andcellular oncogenese) Tumour and Host Interactions : Systemic effects including paraneoplastic syndromes,Tumor immunologyf) Laboratory diagnosis : Cytology, Biopsy, Tumor markers7. Immunopathologya) Immune system : organisation, cells, antibodies and regulation of immune responses.b) Hypersensitivity : types and examples, Antibody and cell mediated tissue injury withexamples.c) Primary immunodeficiencyd) Secondary Immunodeficiency including HIV Infection Pathologye) Auto-immune disorders like systemic lupus erythematosis; organ specific and non-organspecific such as polyarteritis nodosa, Hashimoto’s disease.f) Tumor Immunityg) Organ transplantation : Immunologic basis of Rejection and Graft versus host reaction8. Infectious Diseasesa) Mycobacterial Diseases : Tuberculosis and Leprosy
) Bacterial diseases : Pyogenic, Typhoid, Diphtheria, Gram negative infection, Bacillarydysentery, Syphilisc) Viral : Polio, Herpes, Rabies, Measles; Rickettsial, Chlamydial infectiond) Fungal diseases and opportunistic infectionse) Parasitic Diseases: Malaria, Filaria, Amebiasis, Kala-azar, Cysticercosis, Hydatidf) AIDS: Aetiology, modes of transmission, diagnostic procedures and handling of infectedmaterial and health education.9. Miscellaneous Disordersa) Autosomal and sex-linked disorders with examplesb) Metabolic disordersc) Protein energy malnutrition and vitamin deficiency disordersd) Radiation Injurye) Disorders of Pigment and Mineral metabolism such as bilirubin, melanin, hemosiderin(B) SYSTEMIC PATHOLOGY1. Cardiovascular Pathologya) Rheumatic fever and Rheumatic Heart Disease : Pathogenesis, Morphology and effectsb) Infective Endocarditis : Causes, Pathogenesis and Morphologyc) Atherosclerosis and Ischemic Heart Disease; Myocardial Infarctiond) Diseases of blood vessels other than atherosclerosise) Hypertension and Hypertensive Heart Diseasef) Congenital Heart Disease : ASD, VSD, Fallot’s Bicuspid aortic valve, PDAg) Pericarditis and other pericardial diseasesh) Cardiomyopathy2. Respiratory Pathologya) Structure of Bronchial tree and alveolar walls, normal and altered lung function; conceptof obstructive and restrictive lung disordersb) Inflammatory diseases of bronchi: chronic bronchitis, bronchial asthma, bronchiectasis,chronic obstructive lung diseasec) Pneumonias : Lobar, Broncho, Interstitiald) Pulmonary suppuration including lung abscess : Etiopathogenesis and morphologye) Pulmonary Tuberculosis : Primary and Secondary, Morphologic types including pleuritisf) Emphysema : Types, pathogenesisg) Atelectasis and Hyaline Membrane Diseaseh) Tumors : Benign; Carcinoid, Malignant; Squamous cell, Oat cell, Adeno,etiopathogenesis.i) Occupational lung disorders : anthracosis, silicosis, asbestosis, mesothelioma3. Urinary Tract Pathologya) Renal structure, basis of impaired function, urine analysisb) Glomerulonephritis: Classification, Primary Proliferative and Non Proliferativec) Secondary Glomerulonephritis: SLE, Purpura, Polyarteritis, Amyloidosis, Diabetesd) Nephrotic Syndromee) Acute Renal Failure : Acute tubular and cortical necrosisf) Progressive renal failure and end stage renal diseaseg) Pyelonephritis, Reflux Nephropathy, Interstitial Nephritish) Renal tumors : Renal cell carcinoma, Nephroblastoma
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