067. Pandol SJ, Periskic S, Gukovsky I, Zaninovic V, Jung Y, Z<strong>on</strong>g Y, Solom<strong>on</strong> TE, Gukovskaya AS,Tsukamoto H. Ethanol diet increases the sensitivity <str<strong>on</strong>g>of</str<strong>on</strong>g> rats to pancreatitis induced by cholecystokininoctapeptide. Gastroenterology 1999; 117: 706-6.068. Hanck C, Whitcomb DC. Alcoholic pancreatitis. Gastroenterol Clin North Am 2004; 33: 751-65.069. Camer<strong>on</strong> JL, Capuzzi DM, Zuidema GD, Margolis S. Acute pancreatitis with hyperlipemia: theincidence <str<strong>on</strong>g>of</str<strong>on</strong>g> lipid abnormalities in acute pancreatitis. Ann Surg 1973; 177: 483-9.070. Wohlgemuth J. Ueber eine neue Methode zur Bestimmung des diastatischen Fermentes [On anew method for the determinati<strong>on</strong> <str<strong>on</strong>g>of</str<strong>on</strong>g> the diastatic enzyme]. Biochem Zschr 1908; 9: 1.071. Elman R, AN, Graham EA. Value <str<strong>on</strong>g>of</str<strong>on</strong>g> blood amylase estimati<strong>on</strong>s in the diagnosis <str<strong>on</strong>g>of</str<strong>on</strong>g> pancreaticdisease: a <strong>clinical</strong> study. Arch Surg 1929; 19: 943-67.072. O'D<strong>on</strong>nell MD, FitzGerald O, McGeeney KF. Differential serum amylase determinati<strong>on</strong> by use <str<strong>on</strong>g>of</str<strong>on</strong>g>an inhibitor, and design <str<strong>on</strong>g>of</str<strong>on</strong>g> a routine procedure. Clin Chem 1977; 23: 560-6.073. Berk JE, Kizu H, Wilding P, Searcy RL. Macroamylasemia: a newly recognized cause forelevated serum amylase activity. N Engl J Med 1967; 277: 941-6.074. Cherry LS, Crandall JA. Specificity <str<strong>on</strong>g>of</str<strong>on</strong>g> pancreatic lipase: its appearance in blood after pancreaticinjury. Am J Physiol 1932; 100: 266.075. Comfort MW. Serum lipase: its diagnostic value. Proc Staff Meeting Mayo Clin 1935; 10: 810.076. Lankisch PG, Hasel<str<strong>on</strong>g>of</str<strong>on</strong>g>f M, Becher R. No parallel between the biochemical course <str<strong>on</strong>g>of</str<strong>on</strong>g> acutepancreatitis and morphologic findings. Pancreas 1994; 9: 240-3.077. Temler RS, Felber JP. Radioimmunoassay <str<strong>on</strong>g>of</str<strong>on</strong>g> human plasma trypsin. Biochim Biophys Acta 1976;445: 720-8.078. Temler RS, Felber JP. Radioimmunoassay <str<strong>on</strong>g>of</str<strong>on</strong>g> human plasma trypsin. Biochim Biophys Acta 1976;445: 720-8.079. Rinderknecht H, Geokas MC, Silverman P, Lillard Y, Haverback BJ. New methods for thedeterminati<strong>on</strong> <str<strong>on</strong>g>of</str<strong>on</strong>g> elastase. Clin Chim Acta 1968; 19: 327-39.080. Geokas MC, Wollesen F, Rinderknecht H. Radioimmunoassay for pancreatic carboxypeptidase Bin human serum. J Lab Clin Med 1974; 84: 574-83.081. Frey CF. Classificati<strong>on</strong> <str<strong>on</strong>g>of</str<strong>on</strong>g> pancreatitis: state-<str<strong>on</strong>g>of</str<strong>on</strong>g>-the-art, 1986. Pancreas 1986; 1: 62-8.082. Rans<strong>on</strong> JH, Rifkind KM, Roses DF, Fink SD, Eng K, Spencer FC. Prognostic signs and the role<str<strong>on</strong>g>of</str<strong>on</strong>g> operative management in acute pancreatitis. Surg Gynecol Obstet 1974; 139: 69-81.083. Rans<strong>on</strong> JH, Rifkind KM, Roses DF, Fink SD, Eng K, Localio SA. Objective early identificati<strong>on</strong> <str<strong>on</strong>g>of</str<strong>on</strong>g>severe acute pancreatitis. Am J Gastroenterol 1974; 61: 443-51.084. Rans<strong>on</strong> JH. Diagnostic standards for acute pancreatitis. World J Surg 1997; 21: 136-42.085. Sarles H. Proposal adpopted unanimously by the participants <str<strong>on</strong>g>of</str<strong>on</strong>g> the symposium <strong>on</strong> pancreatitis atMarseille, 1963. Bibl Gastroenterol 1965; 7: VII-VIII.086. Sarles H. Definiti<strong>on</strong>s and classificati<strong>on</strong>s <str<strong>on</strong>g>of</str<strong>on</strong>g> pancreatitis. Pancreas 1991; 6: 470-4.087. Bradley EL. A <strong>clinical</strong>ly based classificati<strong>on</strong> system for acute pancreatitis. Summary <str<strong>on</strong>g>of</str<strong>on</strong>g> theInternati<strong>on</strong>al Symposium <strong>on</strong> Acute Pancreatitis, Atlanta, GA, September 11 through 13, 1992. ArchSurg 1993; 128: 586-90.088. Balthazar EJ, Rans<strong>on</strong> JH, Naidich DP, Megibow AJ, Caccavale R, Cooper MM. Acutepancreatitis: prognostic value <str<strong>on</strong>g>of</str<strong>on</strong>g> CT. Radiology 1985; 156: 767-72.
089. McClusky DA, Skandalakis LJ, Colborn GL, Skandalakis JE. Harbinger or hermit? Pancreaticanatomy and surgery through the ages – part 3. World J Surg 2002; 26: 1512-24.090. Paxt<strong>on</strong> JR, Payne JH. Acute pancreatitis. Surg Gynecol Obstet 1948; 86: 69-75.091. Dudrick SJ, Wilmore DW, Vars HM, Rhoads JE. L<strong>on</strong>g-term total parenteral nutriti<strong>on</strong> with growth,development, and positive nitrogen balance. Surgery 1968; 64: 134-42.092. Marik PE, Zaloga GP. Meta-analysis <str<strong>on</strong>g>of</str<strong>on</strong>g> parenteral nutriti<strong>on</strong> versus enteral nutriti<strong>on</strong> in patients withacute pancreatitis. BMJ 2004; 328: 1407.093. Imrie CW, Benjamin IS, Fergus<strong>on</strong> JC, McKay AJ, Mackenzie I, O'Neill J, Blumgart LH. A singlecentredouble-blind trial <str<strong>on</strong>g>of</str<strong>on</strong>g> Trasylol therapy in primary acute pancreatitis. Br J Surg 1978; 65: 337-41.094. K<strong>on</strong>ttinen YP. Epsil<strong>on</strong>-aminocaproic acid in treatment <str<strong>on</strong>g>of</str<strong>on</strong>g> acute pancreatitis. Scand JGastroenterol 1971; 6: 715-8.095. Uhl W, Büchler MW, Malfertheiner P, Beger HG, Adler G, Gaus W. A randomised, double blind,multicentre trial <str<strong>on</strong>g>of</str<strong>on</strong>g> octreotide in moderate to severe acute pancreatitis. Gut 1999; 45: 97-104.096. Andriulli A, Leandro G, Clemente R, Festa V, Caruso N, Annese V, Lezzi G, Lichino E, Bruno F,Perri F. Meta-analysis <str<strong>on</strong>g>of</str<strong>on</strong>g> somatostatin, octreotide and gabexate mesilate in the therapy <str<strong>on</strong>g>of</str<strong>on</strong>g> acutepancreatitis. Aliment Pharmacol <strong>The</strong>r 1998; 12: 237-45.097. Classen M, Ossenberg FW, Wurbs D. Pancreatitis-an indicati<strong>on</strong> for endoscopic papillotomy.Endoscopy 1978; 10: 223 (abstract).098. Safrany L, Cott<strong>on</strong> PB. A preliminary report: urgent duodenoscopic sphincterotomy for acutegallst<strong>on</strong>e pancreatitis. Surgery 1981; 89: 424-8.099. Neoptolemos JP, Carr-Locke DL, L<strong>on</strong>d<strong>on</strong> NJ, Bailey IA, James D, Fossard DP. C<strong>on</strong>trolled trial <str<strong>on</strong>g>of</str<strong>on</strong>g>urgent endoscopic retrograde cholangiopancreatography and endoscopic sphincterotomy versusc<strong>on</strong>servative treatment for acute pancreatitis due to gallst<strong>on</strong>es. Lancet. 1988;2(8618):979-983.100. Moss RW. <strong>The</strong> life and times <str<strong>on</strong>g>of</str<strong>on</strong>g> John Beard, DSc (1858-1924). Integr Cancer <strong>The</strong>r 2008; 7: 229-51.101. Moss RW. Enzymes, trophoblasts, and cancer: the afterlife <str<strong>on</strong>g>of</str<strong>on</strong>g> an idea (1924-2008). Integr Cancer<strong>The</strong>r 2008; 7: 262-75.102. Fernández-Zapico ME. Focus is key to becoming an expert in any field <str<strong>on</strong>g>of</str<strong>on</strong>g> research. An interviewwith Pr<str<strong>on</strong>g>of</str<strong>on</strong>g>. Howard A. Reber, Chief <str<strong>on</strong>g>of</str<strong>on</strong>g> Gastrointestinal Surgery, and Director <str<strong>on</strong>g>of</str<strong>on</strong>g> the R<strong>on</strong>ald S. HirshbergPancreatic Cancer Research Laboratory, University <str<strong>on</strong>g>of</str<strong>on</strong>g> California Los Angeles (UCLA), Los Angeles,Calif., USA. Pancreatology 2009; 9: 197-9.103. Fernández-Zapico ME. Keep at It! Accept the Challenges <str<strong>on</strong>g>of</str<strong>on</strong>g> Your Critics. An Interview with JohnM. Howard, MD, Pr<str<strong>on</strong>g>of</str<strong>on</strong>g>essor Emeritus, Divisi<strong>on</strong> <str<strong>on</strong>g>of</str<strong>on</strong>g> General Surgery, University <str<strong>on</strong>g>of</str<strong>on</strong>g> Toledo, Toledo, Ohio,USA. Pancreatology 2009; 9: 551-3.104. Tanaka M, Shiratori K, Matsuno S, Go VLW. Memorial tribute to Katsusuke Satake, MD.Pancreatology 2009; 9: 977-8.105. Docherty K. Pancreatic stellate cells can form new beta-like cells. Biochem J 2009; 412: e1-4.106. Sanchez D, Mueller CM, Zenilman ME. Pancreatic regenerating gene I and acinar celldifferentiati<strong>on</strong>: influence <strong>on</strong> cellular lineage. Pancreas 2009; 38: 572-7.107. Wandzioch E, Zaret KS. Dynamic signaling network for the specificati<strong>on</strong> <str<strong>on</strong>g>of</str<strong>on</strong>g> embry<strong>on</strong>ic pancreasand liver progenitors. Science 2009; 324: 1707-10.
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REVIEW OF LITERATURE ONCLINICAL PAN
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ABBREVIATIONAAPacute alcoholicABPac
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FMF AIPfocal mass-forming autoimmun
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ODPopen distal pancreatectomyOForga
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USUTDTVESDVTEZESWHOXIAPUnited State
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Ectopic pancreasCircumportal annula
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SymptomsEndocopic ultrasography (EU
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HSP27HuRIGF-1 receptorIntegrinesInt
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HemodialysisSerous cystadenomasSero
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CRPC-reactive proteinCRTchemoradiot
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ITNPintrathecal narcotics pumpJCGAI
- Page 23 and 24:
QSRquantitative systematic
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PANCREATIC HISTORYEarly conceptsPan
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derived from broadly Harveian anato
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acute appendicitis, intestinal obst
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dogma and its implied presence <str
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In the late 19th century, explorato
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performed. In 1880, Carl Thiersch <
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cancer was reported by Nestor Dimit
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Modern pancreatic historyHoward Reb
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PANCREATIC DEVELOPMENT, EMBRYOLOGY
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preparations. They were also employ
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pancreas can be diagnosed without t
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PANCREATIC PHYSIOLOGYSphincter <str
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acid profile and d
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hormones. The roles of</str
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ACUTE PANCREATITISAcute pancreatiti
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necrosis or a severe course, and lo
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of 245 cases <stro
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plasty of the mino
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no significant difference. The stro
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Urinary trypsinogen-2There is not a
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groups. None of th
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evaluated the presence or absence <
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adical, etc, further studies are st
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Precut at sphincterotomyPrecut is p
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indications [204].Hypercalcemia-ind
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endoscopic retrograde cholangiopanc
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(before ERCP), serum TAP was detect
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concentration and clinical symptoms
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However, the recipients of<
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less safe for predominantly cephali
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increased mortality. Mortality in p
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Epidemiology and demographyChinaCHR
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for the first time the significance
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endoscopic ultrasound accurately de
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possible to at least reduce relapse
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etiologies have been proposed and a
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patients, can be performed with mod
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negative binomial model. One hundre
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Halofuginone did n
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years, the risk of
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patients with a proven exocrine pan
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high-risk patients [296].Cystic fib
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TNF-alpha promoter were performed.
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were validated in another series <s
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vascular invasion (14/15). Abnormal
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and other lymph nodes, salivary gla
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HEREDITARY PANCREATITISPatients wit
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Classification of
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historically, but recent life-style
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carcinogen exposure with cancer ris
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the risk of pancre
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conducted a cohort analysis <strong
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emain to be solved in screening for
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considered for women with Lynch syn
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Annexin A5Protein misfolding is a c
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CTNNB1To use fluorescence in situ h
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expression was not associated with
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(ECM) are not fully understood. In
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lines. However, the role of
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andomized to high-dose vitamin A, t
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Synuclein-gammaPerineural invasion
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interventions. Cancer nests were ma
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the optimal combination of<
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which is essential in tumor and nod
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provide conclusive evidence for the
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MD-CT is suitable for evaluating tu
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approved study and imaged during sh
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Quantum dotsIt was reported the suc
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clearly have a very high incidence
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patients for operation and when cou
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demonstrated using the confocal mic
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cancer [468].To evaluate pancreatic
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pancreaticoduodenectomy (PD). The s
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safe option as an interposition gra
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a curative surgery, while double-by
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%), pseudocyst (3 %), and trauma (3
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procedure is failing to progress la
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Glucos metabolism after pancreatect
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Quality of lifeOne
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was observed in the NACRT group. Th
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interval 0.80 to 0.96]. On subgroup
- Page 187 and 188: ate in patients with pancreatic can
- Page 189 and 190: median survival time was 7 versus 7
- Page 191 and 192: and the endoscopic ultrasound-guide
- Page 193 and 194: local recurrence of</strong
- Page 195 and 196: CurcuminCurcumin has been shown to
- Page 197 and 198: size >1.5 cm (odds ratio 2.4), and
- Page 199 and 200: adenocarcinoma must be addressed at
- Page 201 and 202: Molecular biologyCD44v6The purpose
- Page 203 and 204: IPMN were studied. Two-dimensional
- Page 205 and 206: the NT-IPMN-Br group. Eleven patien
- Page 207 and 208: metastatic neoplasms showing cystic
- Page 209 and 210: Solid pseudopapillary neoplasms <st
- Page 211 and 212: The tumor cells were negative for p
- Page 213 and 214: Duodenal tumorsColorectal polyposis
- Page 215 and 216: Colorectal carcinomaPancreatic meta
- Page 217 and 218: It was described a case of<
- Page 219 and 220: evaluation. The purpose of<
- Page 221 and 222: perforation of a p
- Page 223 and 224: the 28 had pancreatic duct injury <
- Page 225 and 226: ENDOCRINE PANCREATIC TUMORSHistoryA
- Page 227 and 228: 25-111 pg/mL). Mean Hemoglobin A1C
- Page 229 and 230: clinical features, misdiagnosis occ
- Page 231 and 232: achieved in selected cases by tissu
- Page 233 and 234: Overall survivalPancreatic neuroend
- Page 235 and 236: REFERENCES001. Metter CC. History <
- Page 237: 044. Fitz RH. The symptomatology an
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