145. Jha RK, Ma Q, Sha H, Palikhe M. Acute pancreatitis: a <str<strong>on</strong>g>literature</str<strong>on</strong>g> <str<strong>on</strong>g>review</str<strong>on</strong>g>. Med Sci M<strong>on</strong>it 2009; 15:RA 147-56.146. Chan YC, Leung PS. Acute pancreatitis: animal models and recent advances in basic research.Pancreas 2007; 34: 1-14.147. Bumbasirevic V, Radenkovic D, Jankovic Z, Karamarkovic A, Jovanovic B, Milic N, Palibrk I,Ivancevic N. Severe acute pancreatitis: overall and early versus late mortality in intensive care units.Pancreas 2009; 38: 122-5.148. Mifkovic A, Skultety J, Pindak D, Pechan J. Specific aspects <str<strong>on</strong>g>of</str<strong>on</strong>g> acute pancreatitis. Bratisl LekListy 2009; 110: 544-52.149. Danaei G, Ding EL, Mozaffarian D, Taylor B, Rehm J, Murray CJ, Ezzati M. <strong>The</strong> preventablecauses <str<strong>on</strong>g>of</str<strong>on</strong>g> death in the United States: comparative risk assessment <str<strong>on</strong>g>of</str<strong>on</strong>g> dietary, lifestyle, and metabolicrisk factors. PLoS Med 2009; 122: 333-4.150. Lankisch PG, Karimi M, Bruns A, Mais<strong>on</strong>neuve P, Lowenfels AB. Temporal trends in incidenceand severity <str<strong>on</strong>g>of</str<strong>on</strong>g> acute pancreatitis in Lüneburg County, Germany: a populati<strong>on</strong>-based study.Pancreatology 2009; 9: 420-6.151. Barreto SG, Rodrigues J. Acute pancreatitis in Goa – a hospital-based study. J Indian Med Assoc2008; 106: 575-6.152. Sasajima K, Futami R, Matsutani T, Nomura T, Makino H, Maruyama H, Miyashita M. Increasesin soluble tumor necrosis factor receptors coincide with increases in interleukin-6 and proteinases aftermajor surgery. Hepatogastroenterology 2009; 56: 1377-81.153. Botoi G, Andercou A. Interleukin 17 – prognostic marker <str<strong>on</strong>g>of</str<strong>on</strong>g> severe acute pancreatitis. Chirurgia2009; 104: 431-8 (in Romanian).154. Milnerowicz H, Jabl<strong>on</strong>owska M, Biz<strong>on</strong> A. Change <str<strong>on</strong>g>of</str<strong>on</strong>g> zinc, copper, and metallothi<strong>on</strong>einc<strong>on</strong>centrati<strong>on</strong>s and the copper-zinc superoxide dismutase activity in patients with pancreatitis.Pancreas 2009: 38: 681-8.155. Crawford MW, Pehora C, Lopez AV. Drug-induced acute pancreatitis in children receivingchemotherapy for acute leukemia: does prop<str<strong>on</strong>g>of</str<strong>on</strong>g>ol increase the risk? Anesth Analg 2009; 109: 379-81.156. Tukiainen E, Kylanpaa ML, Repo H, Orpana A, Methuen T, Salaspuro M, Kemppainen E,Puolakkainen P. Hemostatic gene polymorphisms in severe acute pancreatitis. Pancreas 2009; 38:e43-6.157. Thareja S, Bhardwaj P, Sateesh J, Saraya A. Variati<strong>on</strong>s in the levels <str<strong>on</strong>g>of</str<strong>on</strong>g> oxidative stress andantioxidants during early acute pancreatitis. Trop Gastroenterol 2009; 30: 26-31.158. Wu BU, Johannes RS, C<strong>on</strong>well DL, Banks PA. Early hemoc<strong>on</strong>centrati<strong>on</strong> predicts increasedmortality <strong>on</strong>ly am<strong>on</strong>g transferred patients with acute pancreatitis. Pancreatology 2009; 9: 639-43.159. Hjalmarss<strong>on</strong> C, Stenflo J, Borgström A. Activated protein C-protein C inhibitor complex, activati<strong>on</strong>peptide <str<strong>on</strong>g>of</str<strong>on</strong>g> Carboxypeptidase B and C-reactive protein as predictors <str<strong>on</strong>g>of</str<strong>on</strong>g> severe acute pancreatitis.Pancreatology 2009; 9: 700-7.160. Figueiredo FAF, Giovannini M, M<strong>on</strong>ges G, Charfi S, Bories E, Pesenti C, Caillol F, Delpero JR.Pancreatic endocrine tumors: a large single-center experience. Pancreatology 2009; 9: 947-53.161. Anders<strong>on</strong> F, Thoms<strong>on</strong> SR, Clarke DL, Buccimazza I. Dyslipidaemic pancreatitis <strong>clinical</strong>assessment and analysis <str<strong>on</strong>g>of</str<strong>on</strong>g> disease severity and outcomes. Pancreatology 2009; 9: 252-7.
162. Deshpande AV, Thomas G, Shun A, Roy G, Storm<strong>on</strong> M, Gaskin K. Dominant dorsal ductsyndrome: a rare cause <str<strong>on</strong>g>of</str<strong>on</strong>g> acute recurrent pancreatitis in children revisited. Pancreatology 2009; 9:97-100.163. Ryu JK. Evaluati<strong>on</strong> <str<strong>on</strong>g>of</str<strong>on</strong>g> severity in acute pancreatitis. Korean J Gastroenterol 2009; 54: 205-11 (inKorean).164. Gravante G, Garcea G, Ong SL, Metcalfe MS, Berry DP, Lloyd DM, Dennis<strong>on</strong> AR. Predicti<strong>on</strong> <str<strong>on</strong>g>of</str<strong>on</strong>g>mortality in acute pancreatitis: a systematic <str<strong>on</strong>g>review</str<strong>on</strong>g> <str<strong>on</strong>g>of</str<strong>on</strong>g> the published evidence. Pancreatology 2009; 9:601-14.165. Glisić T, Sijacki A, Vuković V, Subotić A. Bernard Organ Failure Score in estimati<strong>on</strong> <str<strong>on</strong>g>of</str<strong>on</strong>g> mostsevere forms <str<strong>on</strong>g>of</str<strong>on</strong>g> acute pancreatitis. Srp Arh Celok Lek 2009; 137: 166-70 (in Serbian).166. Imamura Y, Hirota M, Ida S, Hayashi N, Watanabe M, Takamori H, Awai K, Baba H. Significance<str<strong>on</strong>g>of</str<strong>on</strong>g> renal rim grade <strong>on</strong> computed tomography in severity evaluati<strong>on</strong> <str<strong>on</strong>g>of</str<strong>on</strong>g> acute pancreatitis. Pancreatology2009; 9: 41-6.167. Vege SS, Gardner TB, Chari ST, Munukuti P, Pears<strong>on</strong> RK, Clain JE, Petersen BT, Bar<strong>on</strong> TH,Farnell MB, Sarr MG. Low mortality and high morbidity in severe acute pancreatitis without organfailure: a case for revising the Atlanta classificati<strong>on</strong> to include "moderately severe acute pancreatitis".Am J Gastroenterol 2009; 104: 710-5.168. Wang X, Cui Z, Zhang J, Li HC, Zhang DP, Miao B, Cui YF, Zhao EP, Li ZG, Cui NQ. Earlypredictive factors <str<strong>on</strong>g>of</str<strong>on</strong>g> inhospital mortality in patients with severe acute pancreatitis. Pancreatology 2009;9: 111-4 (letter).169. Sharma A, Muddana V, Lamb J, Greer J, Papachristou GI, Whitcomb DC. Low serum adip<strong>on</strong>ectinlevels are associated with systemic organ failure in acute pancreatitis. Pancreas 2009; 38: 907-12.170. Lindstrom O, Tukiainen E, Kylanpaa L, Mentula P, Rouhiainen A, Puolakkainen P, Rauvala H,Repo H. Circulating levels <str<strong>on</strong>g>of</str<strong>on</strong>g> a soluble form <str<strong>on</strong>g>of</str<strong>on</strong>g> receptor for advanced glycati<strong>on</strong> end products and highmobilitygroup box chromosomal protein 1 in patients with acute pancreatitis. Pancreatology 2009; 9:e215-20.171. Wu BU. <strong>The</strong> impact <str<strong>on</strong>g>of</str<strong>on</strong>g> hospital volume <strong>on</strong> outcomes in acute pancreatitis: a case for centers <str<strong>on</strong>g>of</str<strong>on</strong>g>excellence? Gastroenterology 2009; 137: 1886-8 (editorial).172. Nguyen GC, Boudreau H, Jagannath SB. Hospital volume as a predictor for undergoingcholecystectomy after admissi<strong>on</strong> for acute biliary pancreatitis. Pancreatology 2009; 9: e42-7.173. Bosmann M, Schreiner O, Galle PR. Coexistence <str<strong>on</strong>g>of</str<strong>on</strong>g> Cullen's and Grey Turner's signs in acutepancreatitis. Am J Med 2009; 122: 333-4.174. Aysan E, Sevinc M, Basak E, Tardu A, Erturk T. Effectivity <str<strong>on</strong>g>of</str<strong>on</strong>g> qualitative urinary trypsinogen-2measurement in the diagnosis <str<strong>on</strong>g>of</str<strong>on</strong>g> acute pancreatitis: a randomized, <strong>clinical</strong> study. Acta Chir Belg 2008;108: 696-8.175. Andersen AM, Novovic S, Ersboll AK, Jörgensen LN, Hansen MB. Urinary trypsinogen-2 dipstickin acute pancreatitis. Pancreatology 2009; 9: 26-30.176. Yamamoto N, Matsumoto S, Komatsu H. A case <str<strong>on</strong>g>of</str<strong>on</strong>g> suspected acute pancreatitis after generalanesthesia. Masui 2009; 58: 187-8 (in Japanese).177. Coté GA, Gottstein JH, Daud A, Blei AT. <strong>The</strong> role <str<strong>on</strong>g>of</str<strong>on</strong>g> etiology in the hyperamylasemia <str<strong>on</strong>g>of</str<strong>on</strong>g> acuteliver failure. Am J Gastroenterol 2009; 104: 592-7.178. Gullo L, Lucrezio L, Calculli L, Salizz<strong>on</strong>i E, Coe M, Migliori M, Casadei R, Costa PL, Nestico V.Magnetic res<strong>on</strong>ance cholangiopancreatography in asymptomatic pancreatic hyperenzymemia.Pancreas 2009; 38: 396-400.
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REVIEW OF LITERATURE ONCLINICAL PAN
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ABBREVIATIONAAPacute alcoholicABPac
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FMF AIPfocal mass-forming autoimmun
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ODPopen distal pancreatectomyOForga
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USUTDTVESDVTEZESWHOXIAPUnited State
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Ectopic pancreasCircumportal annula
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SymptomsEndocopic ultrasography (EU
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HSP27HuRIGF-1 receptorIntegrinesInt
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HemodialysisSerous cystadenomasSero
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CRPC-reactive proteinCRTchemoradiot
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ITNPintrathecal narcotics pumpJCGAI
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QSRquantitative systematic
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PANCREATIC HISTORYEarly conceptsPan
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derived from broadly Harveian anato
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acute appendicitis, intestinal obst
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dogma and its implied presence <str
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In the late 19th century, explorato
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performed. In 1880, Carl Thiersch <
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cancer was reported by Nestor Dimit
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Modern pancreatic historyHoward Reb
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PANCREATIC DEVELOPMENT, EMBRYOLOGY
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preparations. They were also employ
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pancreas can be diagnosed without t
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PANCREATIC PHYSIOLOGYSphincter <str
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acid profile and d
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hormones. The roles of</str
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ACUTE PANCREATITISAcute pancreatiti
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necrosis or a severe course, and lo
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of 245 cases <stro
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plasty of the mino
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no significant difference. The stro
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Urinary trypsinogen-2There is not a
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groups. None of th
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evaluated the presence or absence <
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adical, etc, further studies are st
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Precut at sphincterotomyPrecut is p
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indications [204].Hypercalcemia-ind
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endoscopic retrograde cholangiopanc
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(before ERCP), serum TAP was detect
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concentration and clinical symptoms
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However, the recipients of<
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less safe for predominantly cephali
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increased mortality. Mortality in p
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Epidemiology and demographyChinaCHR
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for the first time the significance
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endoscopic ultrasound accurately de
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possible to at least reduce relapse
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etiologies have been proposed and a
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patients, can be performed with mod
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negative binomial model. One hundre
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Halofuginone did n
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years, the risk of
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patients with a proven exocrine pan
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high-risk patients [296].Cystic fib
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TNF-alpha promoter were performed.
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were validated in another series <s
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vascular invasion (14/15). Abnormal
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and other lymph nodes, salivary gla
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HEREDITARY PANCREATITISPatients wit
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Classification of
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historically, but recent life-style
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carcinogen exposure with cancer ris
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the risk of pancre
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conducted a cohort analysis <strong
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emain to be solved in screening for
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considered for women with Lynch syn
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Annexin A5Protein misfolding is a c
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CTNNB1To use fluorescence in situ h
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expression was not associated with
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(ECM) are not fully understood. In
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lines. However, the role of
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andomized to high-dose vitamin A, t
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Synuclein-gammaPerineural invasion
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interventions. Cancer nests were ma
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the optimal combination of<
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which is essential in tumor and nod
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provide conclusive evidence for the
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MD-CT is suitable for evaluating tu
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approved study and imaged during sh
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Quantum dotsIt was reported the suc
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clearly have a very high incidence
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patients for operation and when cou
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demonstrated using the confocal mic
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cancer [468].To evaluate pancreatic
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pancreaticoduodenectomy (PD). The s
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safe option as an interposition gra
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a curative surgery, while double-by
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%), pseudocyst (3 %), and trauma (3
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procedure is failing to progress la
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Glucos metabolism after pancreatect
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Quality of lifeOne
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was observed in the NACRT group. Th
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interval 0.80 to 0.96]. On subgroup
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ate in patients with pancreatic can
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median survival time was 7 versus 7
- Page 191 and 192: and the endoscopic ultrasound-guide
- Page 193 and 194: local recurrence of</strong
- Page 195 and 196: CurcuminCurcumin has been shown to
- Page 197 and 198: size >1.5 cm (odds ratio 2.4), and
- Page 199 and 200: adenocarcinoma must be addressed at
- Page 201 and 202: Molecular biologyCD44v6The purpose
- Page 203 and 204: IPMN were studied. Two-dimensional
- Page 205 and 206: the NT-IPMN-Br group. Eleven patien
- Page 207 and 208: metastatic neoplasms showing cystic
- Page 209 and 210: Solid pseudopapillary neoplasms <st
- Page 211 and 212: The tumor cells were negative for p
- Page 213 and 214: Duodenal tumorsColorectal polyposis
- Page 215 and 216: Colorectal carcinomaPancreatic meta
- Page 217 and 218: It was described a case of<
- Page 219 and 220: evaluation. The purpose of<
- Page 221 and 222: perforation of a p
- Page 223 and 224: the 28 had pancreatic duct injury <
- Page 225 and 226: ENDOCRINE PANCREATIC TUMORSHistoryA
- Page 227 and 228: 25-111 pg/mL). Mean Hemoglobin A1C
- Page 229 and 230: clinical features, misdiagnosis occ
- Page 231 and 232: achieved in selected cases by tissu
- Page 233 and 234: Overall survivalPancreatic neuroend
- Page 235 and 236: REFERENCES001. Metter CC. History <
- Page 237 and 238: 044. Fitz RH. The symptomatology an
- Page 239 and 240: 089. McClusky DA, Skandalakis LJ, C
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