560. Maemura K, Shinchi H, Noma H, Mataki Y, Kurahara H, Maeda S, Natsugoe S, Takao S.Chemoradiotherapy for locally recurrence after primary resecti<strong>on</strong> <str<strong>on</strong>g>of</str<strong>on</strong>g> biliary-pancreatic cancer. Gan ToKagaku Ryoho 2009; 36: 265-8 (in Japanese).561. Tawada K, Yamaguchi T, Kobayashi A, Ishihara T, Sudo K, Nakamura K, Hara T, Denda T,Matsuyama M, Yokosuka O. Changes in tumor vascularity depicted by c<strong>on</strong>trast-enhancedultras<strong>on</strong>ography as a predictor <str<strong>on</strong>g>of</str<strong>on</strong>g> chemotherapeutic effect in patients with unresectable pancreaticcancer. Pancreas 2009; 38: 30-5.562. Kumagai M, Hara R, Mori S, Yanagi T, Asakura H, Kishimoto R, Kato H, Yamada S, Kandatsu S,Kamada T. Impact <str<strong>on</strong>g>of</str<strong>on</strong>g> intrafracti<strong>on</strong>al bowel gas movement <strong>on</strong> carb<strong>on</strong> i<strong>on</strong> beam dose distributi<strong>on</strong> inpancreatic radiotherapy. Int J Radiat Oncol Biol Phys 2009; 73: 1276-81.563. Spry N, Bydder S, Harvey J, Borg M, Ngan S, Millar J, Graham P, Zissiadis Y, Kneeb<strong>on</strong>e A, EbertM. Accrediting radiati<strong>on</strong> technique in a multicentre trial <str<strong>on</strong>g>of</str<strong>on</strong>g> chemoradiati<strong>on</strong> for pancreatic cancer. J MedImaging Radiat Oncol 2008; 52: 598-604.564. Mackenzie RP, McCollum AD. Novel agents for the treatment <str<strong>on</strong>g>of</str<strong>on</strong>g> adenocarcinoma <str<strong>on</strong>g>of</str<strong>on</strong>g> thepancreas. Expert Rev Anticancer <strong>The</strong>r 2009; 9: 1473-85.565. Abe Y, Ito T, Baba E, Nagafuji K, Kawabe K, Choi I, Arita Y, Miyamoto T, Teshima T, Nakano S,Harada M. N<strong>on</strong>myeloablative allogeneic hematopoietic stem cell transplantati<strong>on</strong> as immunotherapy forpancreatic cancer. Pancreas 2009; 38: 815-9.566. Drag M, Surowiak P, Drag-Zalesinska M, Dietel M, Lage H, Oleksyszyn J. Comparisi<strong>on</strong> <str<strong>on</strong>g>of</str<strong>on</strong>g> thecytotoxic effects <str<strong>on</strong>g>of</str<strong>on</strong>g> birch bark extract, betulin and betulinic acid towards human gastric carcinoma andpancreatic carcinoma drug-sensitive and drug-resistant cell lines. Molecules 2009; 14: 1639-51.567. Sahu RP, Batra S, Srivastava SK. Activati<strong>on</strong> <str<strong>on</strong>g>of</str<strong>on</strong>g> ATM/Chk1 by curcumin causes cell cycle arrestand apoptosis in human pancreatic cancer cells. Br J Cancer 2009; 100: 1425-33.568. Liss<strong>on</strong>i P, Rovelli F, Brivio F, Zago R, Colciago M, Messina G, Mora A, Porro G. A randomizedstudy <str<strong>on</strong>g>of</str<strong>on</strong>g> chemotherapy versus biochemotherapy with chemotherapy plus Aloe arborescens in patientswith metastatic cancer. In vivo 2009; 23: 171-5.569. Joo KR, Shin HP, Cha JM, Nam S, Huh Y. Effect <str<strong>on</strong>g>of</str<strong>on</strong>g> Korean red ginseng <strong>on</strong> superoxide dismutaseinhibitor-induced pancreatitis in rats: a histopathologic and immunohistochemical study. Pancreas2009; 38: 661-6.570. Khashab MA, Emers<strong>on</strong> RE, DeWitt JM. Endoscopic ultrasound-guided fine-needle aspirati<strong>on</strong> forthe diagnosis <str<strong>on</strong>g>of</str<strong>on</strong>g> anaplastic pancreatic carcinoma: a single-center experience. Pancreatology 2009; 9:88-91.571. Bauer A, Kleeff J, Bier M, Wirtz M, Kayed H, Esposito I, Korc M, Hafner M, Hoheisel JH, Friess H.Identificati<strong>on</strong> <str<strong>on</strong>g>of</str<strong>on</strong>g> malignancy factors by analyzing cystic tumors <str<strong>on</strong>g>of</str<strong>on</strong>g> the pancreas Pancreatology 2009; 9:34-44.572. Buscaglia JM, Giday SA, Kantsevoy SV, Jagannath SB, Magno P, Wolfgang CL, Daniels JA,Canto MI, Okolo PI. Patient- and cyst-related factors for improved predicti<strong>on</strong> <str<strong>on</strong>g>of</str<strong>on</strong>g> malignancy withincystic lesi<strong>on</strong>s <str<strong>on</strong>g>of</str<strong>on</strong>g> the pancreas. Pancreatology 2009; 9: 631-8.573. Leffler J, Krejcí T. Cystic neoplasms <str<strong>on</strong>g>of</str<strong>on</strong>g> the pancreas. Rozhl Chir 2008; 87: 456-8 (in Czech).574. Basturk O, Coban I, Adsay NV. Pancreatic cysts: pathologic classificati<strong>on</strong>, differential diagnosis,and <strong>clinical</strong> implicati<strong>on</strong>s. Arch Pathol Lab Med 2009; 133: 423-38.575. Khalid A, Funch-Jensen P, Bendix J, Dutoit Hamilt<strong>on</strong> S, Kruse A, Viborg Mortensen F. Intraductalpapillary mucinous tumor <str<strong>on</strong>g>of</str<strong>on</strong>g> the pancreas (IPMT): follow-up <str<strong>on</strong>g>of</str<strong>on</strong>g> twelve cases. Scand J Surg 2009; 98:25-9.
576. Tanno S, Sasajima J, Koizumi K, Yanagawa N, Nakano Y, Osanai M, Mizukami Y, Fujii T, ObaraT, Okumura T, Kohgo Y. Tumor doubling time in two cases <str<strong>on</strong>g>of</str<strong>on</strong>g> main duct intraductal papillary-mucinousneoplasms <str<strong>on</strong>g>of</str<strong>on</strong>g> the pancreas. Hepatogastroenterology 2009; 56: 1545-8.577. Ferr<strong>on</strong>e CR, Correa-Gallego C, Warshaw AL, Brugge WR, Forci<strong>on</strong>e DG, Thayer SP, FernándezdelCastillo C. Current trends in pancreatic cystic neoplasms. Arch Surg 2009; 144: 448-54.578. Sahani DV, Lin DJ, Venkatesan AM, Sainani N, Mino-Kenuds<strong>on</strong> M, Brugge WR, Fernandez-Del-Castillo C. Multidisciplinary approach to diagnosis and management <str<strong>on</strong>g>of</str<strong>on</strong>g> intraductal papillary mucinousneoplasms <str<strong>on</strong>g>of</str<strong>on</strong>g> the pancreas. Clin Gastroenterol Hepatol 2009; 7: 259-69.579. Tanno S, Nakano Y, Koizumi K, Sugiyama Y, Nakamura K, Sasajima J, Nishikawa T, MizukamiY, Yanagawa N, Fujii T, Okumura T, Obara T, Kohgo Y. Pancreatic ductal adenocarcinomas in l<strong>on</strong>gtermfollow-up patients with branch duct intraductal papillary mucinous neoplasms. Pancreatology2009; 9: 36-40.580. Fritz S, Fernandez-del Castillo C, Mino-Kenuds<strong>on</strong> M, Crippa S, Deshpande V, Lauwers GY,Warshaw AL, Thayer SP, Iafrate AJ. Global genomic analysis <str<strong>on</strong>g>of</str<strong>on</strong>g> intraductal papillary mucinousneoplasms <str<strong>on</strong>g>of</str<strong>on</strong>g> the pancreas reveals significant molecular differences compared to ductaladenocarcinoma. Ann Surg 2009; 249: 440-7.581. Koizumi K, Fujii T, Matsumoto A, Sugiyama R, Suzuki S, Sukegawa R, Ozawa K, Orii F, TaruishiM, Saitoh Y, Sotokawa M, Takada A. Synchr<strong>on</strong>ous double invasive ductal carcinomas <str<strong>on</strong>g>of</str<strong>on</strong>g> the pancreaswith multifocal branch duct intraductal papillary mucinous neoplasms <str<strong>on</strong>g>of</str<strong>on</strong>g> the pancreas. Nipp<strong>on</strong>Shokakibyo Gakkai Zasshi 2009; 106: 98-105 (in Japanese).582. Woo SM, Ryu JK, Lee SH, Yo<strong>on</strong> WJ, Kim YT, Yo<strong>on</strong> YB. Branch duct intraductal papillarymucinous neoplasms in a retrospective series <str<strong>on</strong>g>of</str<strong>on</strong>g> 190 patients. Br J Surg 2009; 96: 405-11.583. Satoi S, Takeyama Y, Nakai T, Haji S, Yasuda C, Ishikawa H, Yasuda T, Shinzaki W, Kamei K,Ohyanagi H. Diameter <str<strong>on</strong>g>of</str<strong>on</strong>g> main pancreatic duct is important for predicti<strong>on</strong> <str<strong>on</strong>g>of</str<strong>on</strong>g> malignancy <str<strong>on</strong>g>of</str<strong>on</strong>g> IPMN.Pancreas 2009; 38: Sep 2 [Epub ahead <str<strong>on</strong>g>of</str<strong>on</strong>g> print].584. Nara S, Onaya H, Hiraoka N, Shimada K, Sano T, Sakamoto Y, Esaki M, Kosuge T. Preoperativeevaluati<strong>on</strong> <str<strong>on</strong>g>of</str<strong>on</strong>g> invasive and n<strong>on</strong>invasive intraductal papillary-mucinous neoplasms <str<strong>on</strong>g>of</str<strong>on</strong>g> the pancreas:<strong>clinical</strong>, radiological, and pathological analysis <str<strong>on</strong>g>of</str<strong>on</strong>g> 123 cases. Pancreas 2009; 38: 8-16.585. Miyasaka Y, Nagai E, Ohuchida K, Nakata K, Hayashi A, Mizumoto K, Tsuneyoshi M, Tanaka M.CD44v6 expressi<strong>on</strong> in intraductal papillary mucinous neoplasms <str<strong>on</strong>g>of</str<strong>on</strong>g> the pancreas. Pancreatology 2009;9: 31-5.586. Shimizu K, Itoh T, Shimizu M, Ku Y, Hori Y. CD133 expressi<strong>on</strong> pattern distinguishes intraductalpapillary mucinous neoplasms from ductal adenocarcinomas <str<strong>on</strong>g>of</str<strong>on</strong>g> the pancreas. Pancreatology 2009; 9:e207-14.587. Toll AD, Witkiewicz AK, Bibbo M. Expressi<strong>on</strong> <str<strong>on</strong>g>of</str<strong>on</strong>g> K homology domain c<strong>on</strong>taining protein (KOC) inpancreatic cytology with corresp<strong>on</strong>ding histology. Acta Cytol 2009; 53: 123-9.588. Nakayama S, Semba S, Maeda N, Matsushita M, Kuroda Y, Yokozaki H. Hypermethylati<strong>on</strong>mediatedreducti<strong>on</strong> <str<strong>on</strong>g>of</str<strong>on</strong>g> WWOX expressi<strong>on</strong> in intraductal papillary mucinous neoplasms <str<strong>on</strong>g>of</str<strong>on</strong>g> thepancreas. Br J Cancer 2009; 100: 1438-43.589. Nakagawa A, Yamaguchi T, Ohtsuka M, Ishihara T, Sudo K, Nakamura K, Hara T, Denda T,Miyazaki M. Usefulness <str<strong>on</strong>g>of</str<strong>on</strong>g> multidetector computed tomography for detecting protruding lesi<strong>on</strong>s inintraductal papillary mucinous neoplasm <str<strong>on</strong>g>of</str<strong>on</strong>g> the pancreas in comparis<strong>on</strong> with single-detector computedtomography and endoscopic ultras<strong>on</strong>ography. Pancreas 2009; 38: 131-36.590. Hirano S, K<strong>on</strong>do S, Tanaka E, Shichinohe T, Suzuki O, Shimizu M, Itoh T. 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REVIEW OF LITERATURE ONCLINICAL PAN
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ABBREVIATIONAAPacute alcoholicABPac
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FMF AIPfocal mass-forming autoimmun
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ODPopen distal pancreatectomyOForga
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USUTDTVESDVTEZESWHOXIAPUnited State
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Ectopic pancreasCircumportal annula
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SymptomsEndocopic ultrasography (EU
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HSP27HuRIGF-1 receptorIntegrinesInt
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HemodialysisSerous cystadenomasSero
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CRPC-reactive proteinCRTchemoradiot
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ITNPintrathecal narcotics pumpJCGAI
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QSRquantitative systematic
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PANCREATIC HISTORYEarly conceptsPan
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derived from broadly Harveian anato
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acute appendicitis, intestinal obst
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dogma and its implied presence <str
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In the late 19th century, explorato
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performed. In 1880, Carl Thiersch <
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cancer was reported by Nestor Dimit
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Modern pancreatic historyHoward Reb
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PANCREATIC DEVELOPMENT, EMBRYOLOGY
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preparations. They were also employ
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pancreas can be diagnosed without t
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PANCREATIC PHYSIOLOGYSphincter <str
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acid profile and d
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hormones. The roles of</str
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ACUTE PANCREATITISAcute pancreatiti
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necrosis or a severe course, and lo
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of 245 cases <stro
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plasty of the mino
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no significant difference. The stro
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Urinary trypsinogen-2There is not a
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groups. None of th
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evaluated the presence or absence <
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adical, etc, further studies are st
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Precut at sphincterotomyPrecut is p
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indications [204].Hypercalcemia-ind
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endoscopic retrograde cholangiopanc
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(before ERCP), serum TAP was detect
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concentration and clinical symptoms
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However, the recipients of<
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less safe for predominantly cephali
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increased mortality. Mortality in p
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Epidemiology and demographyChinaCHR
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for the first time the significance
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endoscopic ultrasound accurately de
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possible to at least reduce relapse
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etiologies have been proposed and a
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patients, can be performed with mod
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negative binomial model. One hundre
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Halofuginone did n
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years, the risk of
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patients with a proven exocrine pan
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high-risk patients [296].Cystic fib
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TNF-alpha promoter were performed.
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were validated in another series <s
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vascular invasion (14/15). Abnormal
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and other lymph nodes, salivary gla
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HEREDITARY PANCREATITISPatients wit
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Classification of
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historically, but recent life-style
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carcinogen exposure with cancer ris
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the risk of pancre
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conducted a cohort analysis <strong
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emain to be solved in screening for
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considered for women with Lynch syn
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Annexin A5Protein misfolding is a c
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CTNNB1To use fluorescence in situ h
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expression was not associated with
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(ECM) are not fully understood. In
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lines. However, the role of
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andomized to high-dose vitamin A, t
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Synuclein-gammaPerineural invasion
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interventions. Cancer nests were ma
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the optimal combination of<
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which is essential in tumor and nod
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provide conclusive evidence for the
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MD-CT is suitable for evaluating tu
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approved study and imaged during sh
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Quantum dotsIt was reported the suc
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clearly have a very high incidence
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patients for operation and when cou
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demonstrated using the confocal mic
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cancer [468].To evaluate pancreatic
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pancreaticoduodenectomy (PD). The s
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safe option as an interposition gra
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a curative surgery, while double-by
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%), pseudocyst (3 %), and trauma (3
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procedure is failing to progress la
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Glucos metabolism after pancreatect
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Quality of lifeOne
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was observed in the NACRT group. Th
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interval 0.80 to 0.96]. On subgroup
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ate in patients with pancreatic can
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median survival time was 7 versus 7
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and the endoscopic ultrasound-guide
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local recurrence of</strong
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CurcuminCurcumin has been shown to
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size >1.5 cm (odds ratio 2.4), and
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adenocarcinoma must be addressed at
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Molecular biologyCD44v6The purpose
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IPMN were studied. Two-dimensional
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the NT-IPMN-Br group. Eleven patien
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metastatic neoplasms showing cystic
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Solid pseudopapillary neoplasms <st
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The tumor cells were negative for p
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Duodenal tumorsColorectal polyposis
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Colorectal carcinomaPancreatic meta
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- Page 219 and 220: evaluation. The purpose of<
- Page 221 and 222: perforation of a p
- Page 223 and 224: the 28 had pancreatic duct injury <
- Page 225 and 226: ENDOCRINE PANCREATIC TUMORSHistoryA
- Page 227 and 228: 25-111 pg/mL). Mean Hemoglobin A1C
- Page 229 and 230: clinical features, misdiagnosis occ
- Page 231 and 232: achieved in selected cases by tissu
- Page 233 and 234: Overall survivalPancreatic neuroend
- Page 235 and 236: REFERENCES001. Metter CC. History <
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