308. Naitoh I, Nakazawa T, Ohara H, Ando T, Hayashi K, Tanaka H, Okumura F, Miyabe K, YoshidaM, Sano H, Takada H, Joh T. Clinical significance <str<strong>on</strong>g>of</str<strong>on</strong>g> extrapancreatic lesi<strong>on</strong>s in autoimmunepancreatitis. Pancreatology 2009; 9: e1-5.309. Kubota K, Wada T, Kato S, Mozaki Y, Y<strong>on</strong>eda M, Fujita K, Takahashi H, Inamori M, Abe Y,Kobayashi N, Kirikoshi H, Saito S, Inayama Y, Nakajima A. Highly active state <str<strong>on</strong>g>of</str<strong>on</strong>g> autoimmunepancreatitis with Mikulicz disease. Pancreatology 2009; 9: e6-10.310. Itoh S, Nagasaka T, Suzuki K, Satake H, Ota T, Naganawa S. Lymphoplasmacytic sclerosingcholangitis: assessment <str<strong>on</strong>g>of</str<strong>on</strong>g> <strong>clinical</strong>, CT, and pathological findings. Clin Radiol 2009; 64: 1104-14.311. Onishi T, Igarashi T, Ichikawa T. Case <str<strong>on</strong>g>of</str<strong>on</strong>g> retroperit<strong>on</strong>eal fibrosis after surgical treatment <str<strong>on</strong>g>of</str<strong>on</strong>g>autoimmune pancreatitis. Hinyokika Kiyo 2009; 55: 551-4 (in Japanese).312. Moerkercke WV, Verhamme M, Meeus G, Oyen R, Steenbergen WV. A case <str<strong>on</strong>g>of</str<strong>on</strong>g> IgG4-relatedsclerosing disease with retroperit<strong>on</strong>eal fibrosis, autoimmune pancreatitis and bilateral focal nephritis.Pancreatology 2009; 9: 825-32.313. Chang WI, Kim BJ, Lee JK, Kang P, Lee KH, Lee KT, Rhee JC, Jang KT, Choi SH, Choi CW,Choi DI, Lim JH. <strong>The</strong> <strong>clinical</strong> and radiological characteristics <str<strong>on</strong>g>of</str<strong>on</strong>g> focal mass-forming autoimmunepancreatitis: comparis<strong>on</strong> with chr<strong>on</strong>ic pancreatitis and pancreatic cancer. Pancreas 2009; 38: 401-8.314. Takahashi N, Fletcher JG, Hough DM, Fidler JL, Kawashima A, Mandrekar JN, Chari ST.Autoimmune pancreatitis: differentiati<strong>on</strong> from pancreatic carcinoma and normal pancreas <strong>on</strong> the basis<str<strong>on</strong>g>of</str<strong>on</strong>g> enhancement characteristics at dual-phase CT. Am J Roentgenol 2009; 193: 479-84.315. Lee TY, Kim MH, Park do H, Seo DW, Lee SK, Kim JS, Lee KT. Utility <str<strong>on</strong>g>of</str<strong>on</strong>g> 18F-FDG PET/CT fordifferentiati<strong>on</strong> <str<strong>on</strong>g>of</str<strong>on</strong>g> autoimmune pancreatitis with atypical pancreatic imaging findings from pancreaticcancer. Am J Roentgenol 2009; 193: 343-8.316. Matsubayashi H, Furukawa H, Maeda A, Matsunaga K, Kanemoto H, Uesaka K, Fukutomi A, OnoH. Usefulness <str<strong>on</strong>g>of</str<strong>on</strong>g> positr<strong>on</strong> emissi<strong>on</strong> tomography in the evaluati<strong>on</strong> <str<strong>on</strong>g>of</str<strong>on</strong>g> distributi<strong>on</strong> and activity <str<strong>on</strong>g>of</str<strong>on</strong>g> systemiclesi<strong>on</strong>s associated with autoimmune pancreatitis. Pancreatology 2009; 9: 694-9.317. Gardner TB, Levy MJ, Takahashi N, Smyrk TC, Chari ST. Misdiagnosis <str<strong>on</strong>g>of</str<strong>on</strong>g> autoimmunepancreatitis: a cauti<strong>on</strong> to clinicians. Am J Gastroenterol 2009; 104: 1620-3.318. Motosugi U, Ichikawa T, Yamaguchi H, Nakazawa T, Katoh R, Itakura J, Fujii H, Sato T, Araki T,Shimizu M. Small invasive ductal adenocarcinoma <str<strong>on</strong>g>of</str<strong>on</strong>g> the pancreas associated with lymphoplasmacyticsclerosing pancreatitis. Pathol Int 2009; 59: 744-7.319. Chan SK, Cheuk W, Chan KT, Chan JK. IgG4-related sclerosing pachymeningitis: a previouslyunrecognized form <str<strong>on</strong>g>of</str<strong>on</strong>g> central nervous system involvement in IgG4-related sclerosing disease. Am JSurg Pathol 2009 ; 33: 1249-52.320. Schorr F, Riemann JF. Pancreas duct stenosis <str<strong>on</strong>g>of</str<strong>on</strong>g> unknown orig<strong>on</strong>. Dtsch Med Wochenschr 2009;134: 477-80 (in German).321. Romero M, Pérez-Grueso MJ, Repiso A, de la Cruz G, García Vela A, Martín Escobedo R,G<strong>on</strong>zález de Frutos C, Carrobles JM. Autoimmune pancreatitis associated with retroperit<strong>on</strong>eal fibrosis:outcome after 24 m<strong>on</strong>ths <str<strong>on</strong>g>of</str<strong>on</strong>g> follow-up. Rev Esp Enferm Dig 2008; 100: 648-51 (in Spanish).322. Rebours V, Boutr<strong>on</strong>-Ruault MC, Jooste V, Bouvier AM, Hammel P, Ruszniewski P, Lévy P.Mortality rate and risk factors in patients with hereditary pancreatitis: uni- and multidimensi<strong>on</strong>alanalyses. Am J Gastroenterol 2009; 104:2312-7.323. Diac<strong>on</strong>u BL, Ciobanu L, Mocan T, Pfützer RH, Scafaru MP, Acalovschi M, Singer MV, SchneiderA. Investigati<strong>on</strong> <str<strong>on</strong>g>of</str<strong>on</strong>g> the SPINK1 N34S mutati<strong>on</strong> in Romanian patients with alcoholic chr<strong>on</strong>icpancreatitis. A <strong>clinical</strong> analysis based <strong>on</strong> the criteria <str<strong>on</strong>g>of</str<strong>on</strong>g> the M-ANNHEIM classificati<strong>on</strong>. J GastrointestinLiver Dis 2009; 18: 143-50.
324. Oh HC, Kim MH, Choi KS, Mo<strong>on</strong> SH, Park DH, Lee SS, Seo DW, Lee SK, Yoo HW, Kim GH.Analysis <str<strong>on</strong>g>of</str<strong>on</strong>g> PRSS1 and SPINK1 mutati<strong>on</strong>s in Korean patients with idiopathic and familial pancreatitis.Pancreas 2009; 38: 180-3.325. Suga K, Kawakami Y, Hiyama A, Hori K, Takeuchi M. F-18 FDG PET-CT findings in Mikuliczdisease and systemic involvement <str<strong>on</strong>g>of</str<strong>on</strong>g> IgG4-related lesi<strong>on</strong>s. Clin Nucl Med 2009; 34: 164-7.326. Hruban RH, Adsay NV. Molecular classificati<strong>on</strong> <str<strong>on</strong>g>of</str<strong>on</strong>g> neoplasms <str<strong>on</strong>g>of</str<strong>on</strong>g> the pancreas. Hum Pathol 2009;40: 612-23.327. Bradley E. L<strong>on</strong>g-term survival after pancreatoduodenectomy for ductal adenocarcinoma: theemperor has no clothes? Pancreas 2008; 37: 349-51.328. Fitzgerald TL, Bradley CJ, Dahman B, Zervos EE. Gastrointestinal malignancies: when does racematter? J Am Coll Surg 2009; 209: 645-52.329. Hiripi E, Lorenzo Bermejo J, Li X, Sundquist J, Hemminki K. Familial associati<strong>on</strong> <str<strong>on</strong>g>of</str<strong>on</strong>g> pancreaticcancer with other malignancies in Swedish families. Br J Cancer 2009; 101: 1792-7.330. Teiblum S, Thygesen LC, Johansen C. Sixty-<strong>on</strong>e years <str<strong>on</strong>g>of</str<strong>on</strong>g> pancreatic cancer in Denmark from1943 to 2003: a nati<strong>on</strong>wide study. Pancreas 2009; 38: 374-8.331. Guérin S, Doy<strong>on</strong> F, Hill C. <strong>The</strong> frequency <str<strong>on</strong>g>of</str<strong>on</strong>g> cancer in France in 2006, mortality trends since1950, incidence trends since 1980 and analysis <str<strong>on</strong>g>of</str<strong>on</strong>g> the discrepancies between these trends. BullCancer 2009; 96: 51-7 (in French).332. Bae JM. Explaining cancer incidence in the Jejudo populati<strong>on</strong>. J Prev Med Public Health 2009;42: 67-72 (in Korean).333. Louchini R, Beaupré M. Cancer incidence and mortality am<strong>on</strong>g Aboriginal people living <strong>on</strong>reserves and northern villages in Quebec, 1988-2004. Int J Circumpolar Health 2008; 67: 445-51.334. Vaktskjold A, Ungurjanu TN, Klestsjinov NM. Cancer incidence in the Nenetskij Avt<strong>on</strong>omnyjOkrug, Arctic Russia. Int J Circumpolar Health 2008; 67: 433-44.335. Hens<strong>on</strong> DE, Schwartz AM, Nsouli H, Albores-Saavedra J. Carcinomas <str<strong>on</strong>g>of</str<strong>on</strong>g> the pancreas,gallbladder, extrahepatic bile ducts, and ampulla <str<strong>on</strong>g>of</str<strong>on</strong>g> Vater share a field for carcinogenesis: apopulati<strong>on</strong>-based study. Arch Pathol Lab Med 2009; 133: 67-71.336. Toyoda Y, Nakayama T, Tsukuma H. Trends in home deaths am<strong>on</strong>g cancer death in Osaka,Japan-1995-2006. Gan To Kagaku Ryoho 2009; 36: 1131-4 (in Japanese).337. Zhang J, Dhakal IB, Gross MD, Lang NP, Kadlubar FF, Harnack LJ, Anders<strong>on</strong> KE. Physicalactivity, diet, and pancreatic cancer: a populati<strong>on</strong>-based, case-c<strong>on</strong>trol study in Minnesota. Nutr Cancer2009; 61: 457-65.338. Zheng W, Lee SA. Well-d<strong>on</strong>e meat intake, heterocyclic amine exposure, and cancer risk. NutrCancer 2009; 61: 437-46.339. Blackford A, Parmigiani G, Kensler TW, Wolfgang C, J<strong>on</strong>es S, Zhang X, Pars<strong>on</strong>s DW, Lin JC,Leary RJ, Eshleman JR, Goggins M, Jaffee EM, Iacobuzio-D<strong>on</strong>ahue CA, Maitra A, Klein A, Camer<strong>on</strong>JL, Olino K, Schulick R, Winter J, Vogelstein B, Velculescu VE, Kinzler KW, Hruban RH. Geneticmutati<strong>on</strong>s associated with cigarette smoking in pancreatic cancer. Cancer Res 2009; 69: 3681-8.340. La Torre G, de Waure C, Specchia ML, Nicolotti N, Capizzi S, Bilotta A, Clemente G, Ricciardi W.Does quality <str<strong>on</strong>g>of</str<strong>on</strong>g> observati<strong>on</strong>al studies affect the results <str<strong>on</strong>g>of</str<strong>on</strong>g> a meta-analysis?: <strong>The</strong> case <str<strong>on</strong>g>of</str<strong>on</strong>g> cigarettesmoking and pancreatic cancer. Pancreas 2009; 38: 241-7.
- Page 1 and 2:
REVIEW OF LITERATURE ONCLINICAL PAN
- Page 3 and 4:
ABBREVIATIONAAPacute alcoholicABPac
- Page 5 and 6:
FMF AIPfocal mass-forming autoimmun
- Page 7 and 8:
ODPopen distal pancreatectomyOForga
- Page 9 and 10:
USUTDTVESDVTEZESWHOXIAPUnited State
- Page 11 and 12:
Ectopic pancreasCircumportal annula
- Page 13 and 14:
SymptomsEndocopic ultrasography (EU
- Page 15 and 16:
HSP27HuRIGF-1 receptorIntegrinesInt
- Page 17 and 18:
HemodialysisSerous cystadenomasSero
- Page 19 and 20:
CRPC-reactive proteinCRTchemoradiot
- Page 21 and 22:
ITNPintrathecal narcotics pumpJCGAI
- Page 23 and 24:
QSRquantitative systematic
- Page 25 and 26:
PANCREATIC HISTORYEarly conceptsPan
- Page 27 and 28:
derived from broadly Harveian anato
- Page 29 and 30:
acute appendicitis, intestinal obst
- Page 31 and 32:
dogma and its implied presence <str
- Page 33 and 34:
In the late 19th century, explorato
- Page 35 and 36:
performed. In 1880, Carl Thiersch <
- Page 37 and 38:
cancer was reported by Nestor Dimit
- Page 39 and 40:
Modern pancreatic historyHoward Reb
- Page 41 and 42:
PANCREATIC DEVELOPMENT, EMBRYOLOGY
- Page 43 and 44:
preparations. They were also employ
- Page 45 and 46:
pancreas can be diagnosed without t
- Page 47 and 48:
PANCREATIC PHYSIOLOGYSphincter <str
- Page 49 and 50:
acid profile and d
- Page 51 and 52:
hormones. The roles of</str
- Page 53 and 54:
ACUTE PANCREATITISAcute pancreatiti
- Page 55 and 56:
necrosis or a severe course, and lo
- Page 57 and 58:
of 245 cases <stro
- Page 59 and 60:
plasty of the mino
- Page 61 and 62:
no significant difference. The stro
- Page 63 and 64:
Urinary trypsinogen-2There is not a
- Page 65 and 66:
groups. None of th
- Page 67 and 68:
evaluated the presence or absence <
- Page 69 and 70:
adical, etc, further studies are st
- Page 71 and 72:
Precut at sphincterotomyPrecut is p
- Page 73 and 74:
indications [204].Hypercalcemia-ind
- Page 75 and 76:
endoscopic retrograde cholangiopanc
- Page 77 and 78:
(before ERCP), serum TAP was detect
- Page 79 and 80:
concentration and clinical symptoms
- Page 81 and 82:
However, the recipients of<
- Page 83 and 84:
less safe for predominantly cephali
- Page 85 and 86:
increased mortality. Mortality in p
- Page 87 and 88:
Epidemiology and demographyChinaCHR
- Page 89 and 90:
for the first time the significance
- Page 91 and 92:
endoscopic ultrasound accurately de
- Page 93 and 94:
possible to at least reduce relapse
- Page 95 and 96:
etiologies have been proposed and a
- Page 97 and 98:
patients, can be performed with mod
- Page 99 and 100:
negative binomial model. One hundre
- Page 101 and 102:
Halofuginone did n
- Page 103 and 104:
years, the risk of
- Page 105 and 106:
patients with a proven exocrine pan
- Page 107 and 108:
high-risk patients [296].Cystic fib
- Page 109 and 110:
TNF-alpha promoter were performed.
- Page 111 and 112:
were validated in another series <s
- Page 113 and 114:
vascular invasion (14/15). Abnormal
- Page 115 and 116:
and other lymph nodes, salivary gla
- Page 117 and 118:
HEREDITARY PANCREATITISPatients wit
- Page 119 and 120:
Classification of
- Page 121 and 122:
historically, but recent life-style
- Page 123 and 124:
carcinogen exposure with cancer ris
- Page 125 and 126:
the risk of pancre
- Page 127 and 128:
conducted a cohort analysis <strong
- Page 129 and 130:
emain to be solved in screening for
- Page 131 and 132:
considered for women with Lynch syn
- Page 133 and 134:
Annexin A5Protein misfolding is a c
- Page 135 and 136:
CTNNB1To use fluorescence in situ h
- Page 137 and 138:
expression was not associated with
- Page 139 and 140:
(ECM) are not fully understood. In
- Page 141 and 142:
lines. However, the role of
- Page 143 and 144:
andomized to high-dose vitamin A, t
- Page 145 and 146:
Synuclein-gammaPerineural invasion
- Page 147 and 148:
interventions. Cancer nests were ma
- Page 149 and 150:
the optimal combination of<
- Page 151 and 152:
which is essential in tumor and nod
- Page 153 and 154:
provide conclusive evidence for the
- Page 155 and 156:
MD-CT is suitable for evaluating tu
- Page 157 and 158:
approved study and imaged during sh
- Page 159 and 160:
Quantum dotsIt was reported the suc
- Page 161 and 162:
clearly have a very high incidence
- Page 163 and 164:
patients for operation and when cou
- Page 165 and 166:
demonstrated using the confocal mic
- Page 167 and 168:
cancer [468].To evaluate pancreatic
- Page 169 and 170:
pancreaticoduodenectomy (PD). The s
- Page 171 and 172:
safe option as an interposition gra
- Page 173 and 174:
a curative surgery, while double-by
- Page 175 and 176:
%), pseudocyst (3 %), and trauma (3
- Page 177 and 178:
procedure is failing to progress la
- Page 179 and 180:
Glucos metabolism after pancreatect
- Page 181 and 182:
Quality of lifeOne
- Page 183 and 184:
was observed in the NACRT group. Th
- Page 185 and 186:
interval 0.80 to 0.96]. On subgroup
- Page 187 and 188:
ate in patients with pancreatic can
- Page 189 and 190:
median survival time was 7 versus 7
- Page 191 and 192:
and the endoscopic ultrasound-guide
- Page 193 and 194:
local recurrence of</strong
- Page 195 and 196:
CurcuminCurcumin has been shown to
- Page 197 and 198:
size >1.5 cm (odds ratio 2.4), and
- Page 199 and 200:
adenocarcinoma must be addressed at
- Page 201 and 202: Molecular biologyCD44v6The purpose
- Page 203 and 204: IPMN were studied. Two-dimensional
- Page 205 and 206: the NT-IPMN-Br group. Eleven patien
- Page 207 and 208: metastatic neoplasms showing cystic
- Page 209 and 210: Solid pseudopapillary neoplasms <st
- Page 211 and 212: The tumor cells were negative for p
- Page 213 and 214: Duodenal tumorsColorectal polyposis
- Page 215 and 216: Colorectal carcinomaPancreatic meta
- Page 217 and 218: It was described a case of<
- Page 219 and 220: evaluation. The purpose of<
- Page 221 and 222: perforation of a p
- Page 223 and 224: the 28 had pancreatic duct injury <
- Page 225 and 226: ENDOCRINE PANCREATIC TUMORSHistoryA
- Page 227 and 228: 25-111 pg/mL). Mean Hemoglobin A1C
- Page 229 and 230: clinical features, misdiagnosis occ
- Page 231 and 232: achieved in selected cases by tissu
- Page 233 and 234: Overall survivalPancreatic neuroend
- Page 235 and 236: REFERENCES001. Metter CC. History <
- Page 237 and 238: 044. Fitz RH. The symptomatology an
- Page 239 and 240: 089. McClusky DA, Skandalakis LJ, C
- Page 241 and 242: 126. Toouli J. Sphincter of
- Page 243 and 244: 162. Deshpande AV, Thomas G, Shun A
- Page 245 and 246: 196. Park JH, Lee TH, Cheon SL, Sun
- Page 247 and 248: 226. Botoi G, Andercou A. Early and
- Page 249 and 250: 260. Nakamura H, Morifuji M, Muraka
- Page 251: 292. Borak GD, Romagnuolo J, Alsola
- Page 255 and 256: 358. Koornstra JJ, Mourits MJ, Sijm
- Page 257 and 258: 391. Chen JY, Amos CI, Merriman KW,
- Page 259 and 260: 421. Horwhat JD, Gerke H, Acosta RD
- Page 261 and 262: 451. Zamboni G, Capelli P, Scarpa A
- Page 263 and 264: 483. Rosa F, Pacelli F, Papa V, Tor
- Page 265 and 266: 517. Isayama H, Nakai Y, Togawa O,
- Page 267 and 268: 545. Pino MS, Milella M, Gelibter A
- Page 269 and 270: 576. Tanno S, Sasajima J, Koizumi K
- Page 271 and 272: 605. Ayadi L, Ellouze S, Khabir A,
- Page 273 and 274: 637. Nagar AM, Raut AA, Morani AC,
- Page 275 and 276: 670. Lejonklou M, Edfeldt K, Johans