531. Turrini O, Viret F, Moureau-Zabotto L, Guiramand J, Moutardier V, Lel<strong>on</strong>g B, de Chaisemartin C,Giovannini M, Delpero JR. Neoadjuvant 5-fluorouracil-cisplatin chemoradiati<strong>on</strong> effect <strong>on</strong> survival inpatients with resectable pancreatic head adenocarcinoma: a ten-year single instituti<strong>on</strong> experience.Oncology 2009; 76: 413-9.532. Moody JS, Sawrie SM, Kozak KR, Plastaras JP, Howard G, B<strong>on</strong>ner JA. Adjuvant radiotherapy forpancreatic cancer is associated with a survival benefit primarily in stage IIB patients. J Gastroenterol2009; 44: 84-91.533. Davila JA, Chiao EY, Hasche JC, Petersen NJ, McGlynn KA, Shaib YH. Utilizati<strong>on</strong> anddeterminants <str<strong>on</strong>g>of</str<strong>on</strong>g> adjuvant therapy am<strong>on</strong>g older patients who receive curative surgery for pancreaticcancer. Pancreas 2009; 38: e18-25.534. Tawada K, Yamaguchi T, Kobayashi A, Ishihara T, Sudo K, Nakamura K, Hara T, Denda T,Matsuyama M, Yokosuka O. Changes in tumor vascularity depicted by c<strong>on</strong>trast-enhancedultras<strong>on</strong>ography as a predictor <str<strong>on</strong>g>of</str<strong>on</strong>g> chemotherapeutic effect in patients with unresectable pancreaticcancer. Pancreas 2009; 38: 30-5.535. Tsumura T, Matsuo H, Maruo T, Kawakami H, Hatano K, Saito S, Nishijima N, Nakatsuji M, IkedaA, Nishikawa H, Kita R, Okabe Y, Kimura T, Amitani R, Osaki Y. Seven cases <str<strong>on</strong>g>of</str<strong>on</strong>g> gemcitabine-inducedlung injury during treatment for pancreatic or biliary tract cancers. Gan To Kagaku Ryoho 2009; 36:785-8 (in Japanese).536. Ishibashi Y, Ito Y. A case <str<strong>on</strong>g>of</str<strong>on</strong>g> drug induced interstitial pneum<strong>on</strong>itis after gemcitabine treatment forpancreatic carcinoma. Gan To Kagaku Ryoho 2009; 36: 651-3 (in Japanese).537. Recchia F, Sica G, Candeloro G, Bisegna R, Bratta M, B<strong>on</strong>fili P, Necozi<strong>on</strong>e S, Tombolini V, ReaS. Chemoradioimmunotherapy in locally advanced pancreatic and biliary tree adenocarcinoma: amulticenter phase II study. Pancreas 2009; 38: e163-8.538. Fukada I, Ikeda H, Yamaguchi K, Okabe M, Tsuruta A, Morimoto Y, Kawamoto K, Sano K, PakuT, Imai S, Yoshida Y, Ito T, Ogasahara K. A case <str<strong>on</strong>g>of</str<strong>on</strong>g> recurrent pancreatic cancer with lung metastasisresp<strong>on</strong>ding to S-1 combined gemcitabine chemotherapy. Gan To Kagaku Ryoho 2009; 36: 1733-6 (inJapanese).539. Sasajima J, Tanno S, Koizumi K, Nakano Y, Habiro A, Chiba A, Fujii T, Sugiyama Y, NakamuraK, Nishikawa T, Mizukami Y, Okumura T, Kohgo Y. Gemcitabine in combinati<strong>on</strong> with S-1 or UFT inpatients with advanced pancreatic cancer Gan To Kagaku Ryoho 2009; 36: 1657-61 (in Japanese).540. Neri B, Cipriani G, Grif<strong>on</strong>i R, Molinara E, Pantaleo P, Rangan S, Vannini A, T<strong>on</strong>elli P, Valeri A,Pantal<strong>on</strong>e D, Taddei A, Bechi P. Gemcitabine plus irinotecan as first-line weekly therapy in locallyadvanced and/or metastatic pancreatic cancer. Oncol Res 2009; 17: 559-64.541. Galloway NR, Aspe JR, Sellers C, Wall NR. Enhanced antitumor effect <str<strong>on</strong>g>of</str<strong>on</strong>g> combined gemcitabineand prot<strong>on</strong> radiati<strong>on</strong> in the treatment <str<strong>on</strong>g>of</str<strong>on</strong>g> pancreatic cancer. Pancreatology 2009; 9: 782-90.542. Graeser R, Bornmann C, Esser N, Ziroli V, Jantscheff P, Unger C, Hopt UT, Schaechtele C, v<strong>on</strong>Dobschuetz E, Massing U. Antimetastatic effects <str<strong>on</strong>g>of</str<strong>on</strong>g> liposomal gemcitabine and empty liposomes in anorthotopic mouse model <str<strong>on</strong>g>of</str<strong>on</strong>g> pancreatic cancer. Pancreas 2009; 38: 330-7.543. Niki T, Soejima T, Yoshikawa T, Yamamoto Y, Fujii O, Ohta Y, Tsuda M, Horita K, Tsujino K,Hirohata S, Fujino Y, Nishisaki H. 5-FU based chemoradiotherapy for unresectable locally advancedpancreatic cancer. Gan To Kagaku Ryoho 2009; 36: 63-9 (in Japanese).544. Novarino A, Satolli MA, Chiappino I, Giacobino A, Bell<strong>on</strong>e G, Rahimi F, Milanesi E, Bertetto O,Ciuffreda L. Oxaliplatin, 5-fluorouracil, and leucovorin as sec<strong>on</strong>d-line treatment for advancedpancreatic cancer. Am J Clin Oncol 2009; 32: 44-8.
545. Pino MS, Milella M, Gelibter A, Sperduti I, De Marco S, Nuzzo C, Bria E, Carpanese L, RuggeriEM, Carlini P, Cognetti F. Capecitabine and celecoxib as sec<strong>on</strong>d-line treatment <str<strong>on</strong>g>of</str<strong>on</strong>g> advancedpancreatic and biliary tract cancers. Oncology 2009; 76: 254-61.546. Niki T, Yamamoto Y, Tsuda M, Horita K, Hirohata S, Nishisaki H. Retrospective analysis <str<strong>on</strong>g>of</str<strong>on</strong>g>uracil/tegafur, cyclophosphamide and gemcitabine compared with gemcitabine m<strong>on</strong>otherapy inunresectable pancreatic cancer. Gan To Kagaku Ryoho 2009; 36: 273-8 (in Japanese).547. Sugimoto K, Okada K, Nakahira S, Okamura S, Miki H, Nakata K, Suzuki R, Yoshimura M, Uji K,Yoshida A, Tamura S. A case <str<strong>on</strong>g>of</str<strong>on</strong>g> metastatic pancreatic cancer after combinati<strong>on</strong> chemotherapy withuracil-tegafur and gemcitabine. Gan To Kagaku Ryoho 2009; 36: 321-3.548. Yoo C, Hwang JY, Kim JE, Kim TW, Lee JS, Park DH, Lee SS, Seo DW, Lee SK, Kim MH, HanDJ, Kim SC, Lee JL. A randomised phase II study <str<strong>on</strong>g>of</str<strong>on</strong>g> modified FOLFIRI.3 vs modified FOLFOX assec<strong>on</strong>d-line therapy in patients with gemcitabine-refractory advanced pancreatic cancer. Br J Cancer2009; 101: 1658-63.549. Carvajal RD, Tse A, Shah MA, Lefkowitz RA, G<strong>on</strong>en M, Gilman-Rosen L, Kortmansky J, KelsenDP, Schwartz GK, O'Reilly EM. A phase II study <str<strong>on</strong>g>of</str<strong>on</strong>g> flavopiridol (Alvocidib) in combinati<strong>on</strong> withdocetaxel in refractory, metastatic pancreatic cancer. Pancreatology 2009; 9: 404-9.550. Okamoto N, Inaba K, K<strong>on</strong>no H. C<strong>on</strong>tinuous treatment with S-1, an effective strategy for an olderadult with unresectable advanced pancreatic cancer with perit<strong>on</strong>eal disseminati<strong>on</strong> – a case report.Gan To Kagaku Ryoho 2009; 36: 1187-9 (in Japanese).551. Brell JM, Matin K, Evans T, Volkin RL, Kiefer GJ, Schlesselman JJ, Dranko S, Rath L, SchmotzerA, Lenzner D, Ramanathan RK. Phase II study <str<strong>on</strong>g>of</str<strong>on</strong>g> docetaxel and gefitinib as sec<strong>on</strong>d-line therapy ingemcitabine pretreated patients with advanced pancreatic cancer. Oncology 2009; 76: 270-4.552. Maemura K, Shinchi H, Noma H, Mataki Y, Kurahara H, Maeda S, Natsugoe S, Takao S.Chemoradiotherapy for locally recurrence after primary resecti<strong>on</strong> <str<strong>on</strong>g>of</str<strong>on</strong>g> biliary-pancreatic cancer. Gan ToKagaku Ryoho 2009; 36: 265-8 (in Japanese).553. Hirooka Y, Itoh A, Kawashima H, Hara K, N<strong>on</strong>ogaki K, Kasugai T, Ohno E, Ishikawa T,Matsubara H, Ishigami M, Katano Y, Ohmiya N, Niwa Y, Yamamoto K, Kaneko T, Nieda M,Yokokawa K, Goto H. A combinati<strong>on</strong> therapy <str<strong>on</strong>g>of</str<strong>on</strong>g> gemcitabine with immunotherapy for patients withinoperable locally advanced pancreatic cancer. Pancreas 2009; 38: e69-74.554. Black JW. Reflecti<strong>on</strong>s <strong>on</strong> some pilot trials <str<strong>on</strong>g>of</str<strong>on</strong>g> gastrin receptor blockade in pancreatic cancer. Eur JCancer 2009; 45: 360-4.555. Karacay H, Sharkey RM, Gold DV, Ragland DR, McBride WJ, Rossi EA, Chang CH, GoldenbergDM. Pretargeted radioimmunotherapy <str<strong>on</strong>g>of</str<strong>on</strong>g> pancreatic cancer xenografts: TF10-90Y-IMP-288 al<strong>on</strong>e andcombined with gemcitabine. J Nucl Med 2009; 50: 2008-16.556. Eguchi H, Ishikawa O, Ohigashi H, Takahashi H, Yano M, Nishiyama K, Tomita Y, Uehara R,Takehara A, Nakamura Y, Nakagawa H. Serum REG4 level is a predictive biomarker for the resp<strong>on</strong>seto preoperative chemoradiotherapy in patients with pancreatic cancer. Pancreatology 2009; 9: 791-8.557. Zhang D, Ma QY, Shen SG, Hu HT. Inhibiti<strong>on</strong> <str<strong>on</strong>g>of</str<strong>on</strong>g> pancreatic cancer cell proliferati<strong>on</strong> bypropranolol occurs through apoptosis inducti<strong>on</strong>: the study <str<strong>on</strong>g>of</str<strong>on</strong>g> beta-adrenoceptor antag<strong>on</strong>ist'santicancer effect in pancreatic cancer cell. Pancreas 2009; 38: 94-10.558. Ohguri T, Imada H, Yahara K, Narisada H, Morioka T, Nakano K, Korogi Y. C<strong>on</strong>currentchemoradiotherapy with gemcitabine plus regi<strong>on</strong>al hyperthermia for locally advanced pancreaticcarcinoma: initial experience. Radiat Med 2008; 26: 587-96.559. Miller RC, Iott MJ, Corsini MM. Review <str<strong>on</strong>g>of</str<strong>on</strong>g> adjuvant radiochemotherapy for resected pancreaticcancer and results from Mayo Clinic for the 5th JUCTS symposium. Int J Radiat Oncol Biol Phys 2009;75: 364-8.
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REVIEW OF LITERATURE ONCLINICAL PAN
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ABBREVIATIONAAPacute alcoholicABPac
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FMF AIPfocal mass-forming autoimmun
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ODPopen distal pancreatectomyOForga
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USUTDTVESDVTEZESWHOXIAPUnited State
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Ectopic pancreasCircumportal annula
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SymptomsEndocopic ultrasography (EU
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HSP27HuRIGF-1 receptorIntegrinesInt
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HemodialysisSerous cystadenomasSero
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CRPC-reactive proteinCRTchemoradiot
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ITNPintrathecal narcotics pumpJCGAI
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QSRquantitative systematic
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PANCREATIC HISTORYEarly conceptsPan
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derived from broadly Harveian anato
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acute appendicitis, intestinal obst
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dogma and its implied presence <str
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In the late 19th century, explorato
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performed. In 1880, Carl Thiersch <
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cancer was reported by Nestor Dimit
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Modern pancreatic historyHoward Reb
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PANCREATIC DEVELOPMENT, EMBRYOLOGY
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preparations. They were also employ
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pancreas can be diagnosed without t
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PANCREATIC PHYSIOLOGYSphincter <str
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acid profile and d
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hormones. The roles of</str
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ACUTE PANCREATITISAcute pancreatiti
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necrosis or a severe course, and lo
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of 245 cases <stro
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plasty of the mino
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no significant difference. The stro
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Urinary trypsinogen-2There is not a
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groups. None of th
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evaluated the presence or absence <
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adical, etc, further studies are st
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Precut at sphincterotomyPrecut is p
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indications [204].Hypercalcemia-ind
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endoscopic retrograde cholangiopanc
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(before ERCP), serum TAP was detect
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concentration and clinical symptoms
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However, the recipients of<
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less safe for predominantly cephali
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increased mortality. Mortality in p
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Epidemiology and demographyChinaCHR
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for the first time the significance
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endoscopic ultrasound accurately de
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possible to at least reduce relapse
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etiologies have been proposed and a
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patients, can be performed with mod
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negative binomial model. One hundre
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Halofuginone did n
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years, the risk of
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patients with a proven exocrine pan
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high-risk patients [296].Cystic fib
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TNF-alpha promoter were performed.
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were validated in another series <s
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vascular invasion (14/15). Abnormal
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and other lymph nodes, salivary gla
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HEREDITARY PANCREATITISPatients wit
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Classification of
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historically, but recent life-style
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carcinogen exposure with cancer ris
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the risk of pancre
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conducted a cohort analysis <strong
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emain to be solved in screening for
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considered for women with Lynch syn
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Annexin A5Protein misfolding is a c
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CTNNB1To use fluorescence in situ h
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expression was not associated with
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(ECM) are not fully understood. In
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lines. However, the role of
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andomized to high-dose vitamin A, t
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Synuclein-gammaPerineural invasion
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interventions. Cancer nests were ma
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the optimal combination of<
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which is essential in tumor and nod
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provide conclusive evidence for the
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MD-CT is suitable for evaluating tu
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approved study and imaged during sh
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Quantum dotsIt was reported the suc
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clearly have a very high incidence
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patients for operation and when cou
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demonstrated using the confocal mic
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cancer [468].To evaluate pancreatic
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pancreaticoduodenectomy (PD). The s
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safe option as an interposition gra
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a curative surgery, while double-by
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%), pseudocyst (3 %), and trauma (3
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procedure is failing to progress la
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Glucos metabolism after pancreatect
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Quality of lifeOne
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was observed in the NACRT group. Th
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interval 0.80 to 0.96]. On subgroup
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ate in patients with pancreatic can
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median survival time was 7 versus 7
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and the endoscopic ultrasound-guide
- Page 193 and 194:
local recurrence of</strong
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CurcuminCurcumin has been shown to
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size >1.5 cm (odds ratio 2.4), and
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adenocarcinoma must be addressed at
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Molecular biologyCD44v6The purpose
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IPMN were studied. Two-dimensional
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the NT-IPMN-Br group. Eleven patien
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metastatic neoplasms showing cystic
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Solid pseudopapillary neoplasms <st
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The tumor cells were negative for p
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Duodenal tumorsColorectal polyposis
- Page 215 and 216: Colorectal carcinomaPancreatic meta
- Page 217 and 218: It was described a case of<
- Page 219 and 220: evaluation. The purpose of<
- Page 221 and 222: perforation of a p
- Page 223 and 224: the 28 had pancreatic duct injury <
- Page 225 and 226: ENDOCRINE PANCREATIC TUMORSHistoryA
- Page 227 and 228: 25-111 pg/mL). Mean Hemoglobin A1C
- Page 229 and 230: clinical features, misdiagnosis occ
- Page 231 and 232: achieved in selected cases by tissu
- Page 233 and 234: Overall survivalPancreatic neuroend
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- Page 237 and 238: 044. Fitz RH. The symptomatology an
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