468. Riall TS. What is the effect <str<strong>on</strong>g>of</str<strong>on</strong>g> age <strong>on</strong> pancreatic resecti<strong>on</strong>? Adv Surg 2009; 43: 233-49.469. Pratt WB, Gangavati A, Agarwal K, Schreiber R, Lipsitz LA, Callery MP, Vollmer CM Jr.Establishing standards <str<strong>on</strong>g>of</str<strong>on</strong>g> quality for elderly patients undergoing pancreatic resecti<strong>on</strong>. Arch Surg 2009;144: 950-6.470. Fragulidis G, Arkadopoulos N, Vassiliou I, Marinis A, <strong>The</strong>odosopoulos T, Stafyla V, Kyriazi M,Karapanos K, Dafnios N, Polydorou A, Voros D, Smyrniotis V. Pancreatic leakage afterpancreaticoduodenectomy: the impact <str<strong>on</strong>g>of</str<strong>on</strong>g> the isolated jejunal loop length and anastomotic technique <str<strong>on</strong>g>of</str<strong>on</strong>g>the pancreatic stump. Pancreatology 2009; 9: e177-82.471. Berger AC, Howard TJ, Kennedy EP, Sauter PK, Bower-Cherry M, Dutkevitch S, Hyslop T,Schmidt CM, Rosato EL, Lavu H, Nakeeb A, Pitt HA, Lillemoe KD, Yeo CJ. Does type <str<strong>on</strong>g>of</str<strong>on</strong>g>pancreaticojejunostomy after pancreaticoduodenectomy decrease rate <str<strong>on</strong>g>of</str<strong>on</strong>g> pancreatic fistula? Arandomized, prospective, dual-instituti<strong>on</strong> trial. J Am Coll Surg 2009; 208: 738-47.472. Fragulidis GP, Arkadopoulos N, Vassiliou I, Marinis A, <strong>The</strong>odosopoulos T, Stafyla V, Kyriazi M,Karapanos K, Dafnios N, Polydorou A, Voros D, Smyrniotis V. Pancreatic leakage afterpancreaticoduodenectomy: the impact <str<strong>on</strong>g>of</str<strong>on</strong>g> the isolated jejunal loop length and anastomotic technique <str<strong>on</strong>g>of</str<strong>on</strong>g>the pancreatic stump. Pancreas 2009; 38: e177-82.473. You D, Jung K, Lee H, Heo J, Choi S, Choi D.. Comparis<strong>on</strong> <str<strong>on</strong>g>of</str<strong>on</strong>g> different pancreatic anastomosistechniques using the definiti<strong>on</strong>s <str<strong>on</strong>g>of</str<strong>on</strong>g> the Internati<strong>on</strong>al Study Group <str<strong>on</strong>g>of</str<strong>on</strong>g> Pancreatic Surgery: a singlesurge<strong>on</strong>'s experience. Pancreas 2009; 38: 896-92.474. Ozdemir A, Karakoc D, Hamaloglu E, Ozenc A. Pancreaticojejunostomy afterpancreaticoduodenectomy: results <str<strong>on</strong>g>of</str<strong>on</strong>g> a new technique. Hepatogastroenterology 2009; 56: 285-9.475. Tomimaru Y, Takeda Y, Kobayashi S, Marubashi S, Lee CM, Tanemura M, Nagano H, KitagawaT, D<strong>on</strong>o K, Umeshita K, Wakasa K, M<strong>on</strong>den M. Comparis<strong>on</strong> <str<strong>on</strong>g>of</str<strong>on</strong>g> postoperative morphological changesin remnant pancreas between pancreaticojejunostomy and pancreaticogastrostomy afterpancreaticoduodenectomy. Pancreas 2009; 38: 203-7.476. Yamamoto M, Hayashi MS, Nguyen NT, Nguyen TD, McCloud S, Imagawa DK. Use <str<strong>on</strong>g>of</str<strong>on</strong>g>Seamguard to prevent pancreatic leak following distal pancreatectomy. Arch Surg 2009; 144: 894-9.477. Guzman EA, Nels<strong>on</strong> RA, Kim J, Pigazzi A, Trisal V, Paz B, Di Ellenhorn J. Increased incidence <str<strong>on</strong>g>of</str<strong>on</strong>g>pancreatic fistulas after the introducti<strong>on</strong> <str<strong>on</strong>g>of</str<strong>on</strong>g> a bioabsorbable staple line reinforcement in distalpancreatic resecti<strong>on</strong>s. Am Surg 2009; 75: 954-7.478. Fujino Y, Matsumoto I, Ajiki T, Kuroda Y. Clinical reappraisal <str<strong>on</strong>g>of</str<strong>on</strong>g> total pancreatectomy forpancreatic disease. Hepatogastroenterology 2009; 56: 1525-8.479. Harao M, Hishinuma S, Tomihawa M, Baba H, Ogata Y. Whole stomach and spleen preservingtotal pancreatectomy: a new surgical technique for pancreatic cancer. Hepatogastroenterology 2009;56: 1549-51.480. Martin RC 2nd, Scoggins CR, Egnatashvili V, Staley CA, McMasters KM, Kooby DA. Arterial andvenous resecti<strong>on</strong> for pancreatic adenocarcinoma: operative and l<strong>on</strong>g-term outcomes. Arch Surg 2009;144: 154-9.481. Stauffer JA, Dougherty MK, Kim GP, Nguyen JH. Interpositi<strong>on</strong> graft with polytetrafluoroethylenefor mesenteric and portal vein rec<strong>on</strong>structi<strong>on</strong> after pancreaticoduodenectomy. Br J Surg 2009; 96:247-52.482. Braşoveanu V, Dumitraşcu T, Bacalbaşa N, Zamfir R. Splenic artery used for replaced comm<strong>on</strong>hepatic artery rec<strong>on</strong>structi<strong>on</strong> during pancreatoduodenectomy – a case report. Chirurgia 2009; 104:499-504.
483. Rosa F, Pacelli F, Papa V, Tortorelli AP, Bossola M, Doglietto GB. Iatrogenic lesi<strong>on</strong> <str<strong>on</strong>g>of</str<strong>on</strong>g> the hepaticartery in the course <str<strong>on</strong>g>of</str<strong>on</strong>g> pancreatic surgery. Chir Ital 2009; 61: 485-92 (in Italian).484. Sauvanet A. Lymph node resecti<strong>on</strong> for carcinoma <str<strong>on</strong>g>of</str<strong>on</strong>g> the pancreas. J Chir 2008; 145 Spc No 4:12S31-5 (in French).485. Chen XL, Ma Y, Wan Y, Duan LG. Experimental study <str<strong>on</strong>g>of</str<strong>on</strong>g> the safety <str<strong>on</strong>g>of</str<strong>on</strong>g> pancreas cryosurgery: thecomparis<strong>on</strong> <str<strong>on</strong>g>of</str<strong>on</strong>g> 2 different techniques <str<strong>on</strong>g>of</str<strong>on</strong>g> cryosurgery. Pancreatology 2009; 9: 92-6.486. You DD, Jung KU, Lee HG, Heo JS, Choi SH, Choi DW. Comparis<strong>on</strong> <str<strong>on</strong>g>of</str<strong>on</strong>g> different pancreaticanastomosis techniques using the definiti<strong>on</strong>s <str<strong>on</strong>g>of</str<strong>on</strong>g> the Internati<strong>on</strong>al Study Group <str<strong>on</strong>g>of</str<strong>on</strong>g> Pancreatic surgery: asingle surge<strong>on</strong>'s experience. Pancreatology 2009; 9: 896-902.487. Kato K, Yamada, Suguru S, Sugimoto H, Kanazumi N, Nomoto S, Takeda S, Kodera Y, Morita S,Nakao A. Prognostic factors for survival after extended pancreatectomy for pancreatic head cancer:influence <str<strong>on</strong>g>of</str<strong>on</strong>g> resecti<strong>on</strong> margin status <strong>on</strong> survival. Pancreas 2009; 38: 605-12.488. Kelemen D, Papp R, Baracs J, Káposztás Z, Al-Farhat Y, Horváth OP. Treatment <str<strong>on</strong>g>of</str<strong>on</strong>g> pancreaticand periampullary tumours in our department in the last 10 years. Magy Seb 2009; 62: 287-92 (inHungarian).489. Howard TJ, Krug JE, Yu J, Zyromski NJ, Schmidt CM, Jacobs<strong>on</strong> LE, Madura JA, Wiebke EA,Lillemoe KD. A margin-negative R0 resecti<strong>on</strong> accomplished with minimal postoperative complicati<strong>on</strong>sis the surge<strong>on</strong>'s c<strong>on</strong>tributi<strong>on</strong> to l<strong>on</strong>g-term survival in pancreatic cancer. J Gastrointest Surg 2006; 10:1338-5.490. Kuhlmann KF, de Castro SM, Wesseling JG, ten Kate FJ, Offerhaus GJ, Busch OR, van GulikTM, Obertop H, Gouma DJ. Surgical treatment <str<strong>on</strong>g>of</str<strong>on</strong>g> pancreatic adenocarcinoma: actual survival andprognostic factors in 343 patients. Eur J Cancer 2004; 40: 549-58.491. Adham M, Jaeck D, Le Borgne J, Oussoultzouglou E, Chenard-Neu MP, Mosnier JF, ScoazecJY, Mornex F, Partensky C. 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REVIEW OF LITERATURE ONCLINICAL PAN
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ABBREVIATIONAAPacute alcoholicABPac
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FMF AIPfocal mass-forming autoimmun
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ODPopen distal pancreatectomyOForga
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USUTDTVESDVTEZESWHOXIAPUnited State
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Ectopic pancreasCircumportal annula
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SymptomsEndocopic ultrasography (EU
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HSP27HuRIGF-1 receptorIntegrinesInt
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HemodialysisSerous cystadenomasSero
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CRPC-reactive proteinCRTchemoradiot
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ITNPintrathecal narcotics pumpJCGAI
- Page 23 and 24:
QSRquantitative systematic
- Page 25 and 26:
PANCREATIC HISTORYEarly conceptsPan
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derived from broadly Harveian anato
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acute appendicitis, intestinal obst
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dogma and its implied presence <str
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In the late 19th century, explorato
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performed. In 1880, Carl Thiersch <
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cancer was reported by Nestor Dimit
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Modern pancreatic historyHoward Reb
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PANCREATIC DEVELOPMENT, EMBRYOLOGY
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preparations. They were also employ
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pancreas can be diagnosed without t
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PANCREATIC PHYSIOLOGYSphincter <str
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acid profile and d
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hormones. The roles of</str
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ACUTE PANCREATITISAcute pancreatiti
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necrosis or a severe course, and lo
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of 245 cases <stro
- Page 59 and 60:
plasty of the mino
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no significant difference. The stro
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Urinary trypsinogen-2There is not a
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groups. None of th
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evaluated the presence or absence <
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adical, etc, further studies are st
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Precut at sphincterotomyPrecut is p
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indications [204].Hypercalcemia-ind
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endoscopic retrograde cholangiopanc
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(before ERCP), serum TAP was detect
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concentration and clinical symptoms
- Page 81 and 82:
However, the recipients of<
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less safe for predominantly cephali
- Page 85 and 86:
increased mortality. Mortality in p
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Epidemiology and demographyChinaCHR
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for the first time the significance
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endoscopic ultrasound accurately de
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possible to at least reduce relapse
- Page 95 and 96:
etiologies have been proposed and a
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patients, can be performed with mod
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negative binomial model. One hundre
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Halofuginone did n
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years, the risk of
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patients with a proven exocrine pan
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high-risk patients [296].Cystic fib
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TNF-alpha promoter were performed.
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were validated in another series <s
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vascular invasion (14/15). Abnormal
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and other lymph nodes, salivary gla
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HEREDITARY PANCREATITISPatients wit
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Classification of
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historically, but recent life-style
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carcinogen exposure with cancer ris
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the risk of pancre
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conducted a cohort analysis <strong
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emain to be solved in screening for
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considered for women with Lynch syn
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Annexin A5Protein misfolding is a c
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CTNNB1To use fluorescence in situ h
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expression was not associated with
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(ECM) are not fully understood. In
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lines. However, the role of
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andomized to high-dose vitamin A, t
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Synuclein-gammaPerineural invasion
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interventions. Cancer nests were ma
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the optimal combination of<
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which is essential in tumor and nod
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provide conclusive evidence for the
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MD-CT is suitable for evaluating tu
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approved study and imaged during sh
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Quantum dotsIt was reported the suc
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clearly have a very high incidence
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patients for operation and when cou
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demonstrated using the confocal mic
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cancer [468].To evaluate pancreatic
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pancreaticoduodenectomy (PD). The s
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safe option as an interposition gra
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a curative surgery, while double-by
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%), pseudocyst (3 %), and trauma (3
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procedure is failing to progress la
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Glucos metabolism after pancreatect
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Quality of lifeOne
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was observed in the NACRT group. Th
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interval 0.80 to 0.96]. On subgroup
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ate in patients with pancreatic can
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median survival time was 7 versus 7
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and the endoscopic ultrasound-guide
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local recurrence of</strong
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CurcuminCurcumin has been shown to
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size >1.5 cm (odds ratio 2.4), and
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adenocarcinoma must be addressed at
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Molecular biologyCD44v6The purpose
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IPMN were studied. Two-dimensional
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the NT-IPMN-Br group. Eleven patien
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metastatic neoplasms showing cystic
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Solid pseudopapillary neoplasms <st
- Page 211 and 212: The tumor cells were negative for p
- Page 213 and 214: Duodenal tumorsColorectal polyposis
- Page 215 and 216: Colorectal carcinomaPancreatic meta
- Page 217 and 218: It was described a case of<
- Page 219 and 220: evaluation. The purpose of<
- Page 221 and 222: perforation of a p
- Page 223 and 224: the 28 had pancreatic duct injury <
- Page 225 and 226: ENDOCRINE PANCREATIC TUMORSHistoryA
- Page 227 and 228: 25-111 pg/mL). Mean Hemoglobin A1C
- Page 229 and 230: clinical features, misdiagnosis occ
- Page 231 and 232: achieved in selected cases by tissu
- Page 233 and 234: Overall survivalPancreatic neuroend
- Page 235 and 236: REFERENCES001. Metter CC. History <
- Page 237 and 238: 044. Fitz RH. The symptomatology an
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- Page 255 and 256: 358. Koornstra JJ, Mourits MJ, Sijm
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