405. T<strong>on</strong>ack S, Aspinall-O'Dea M, Neoptolemos JP, Costello E. Pancreatic cancer: proteomicapproaches to a challenging disease. Pancreatology 2009; 9: 567-76.406. Cui Y, Wu J, Z<strong>on</strong>g M, S<strong>on</strong>g G, Jia Q, Jiang J, Han J. Proteomic pr<str<strong>on</strong>g>of</str<strong>on</strong>g>iling in pancreatic cancer withand without lymph node metastasis. Int J Cancer 2009; 124: 1614-21.407. Shi C, Hruban RH, Klein AP. Familial pancreatic cancer. Arch Pathol Lab Med 2009; 133: 365-74.408. Klein AP, Borges M, Griffith M, Brune K, H<strong>on</strong>g SM, Omura N, Hruban RH, Goggins M. Absence<str<strong>on</strong>g>of</str<strong>on</strong>g> deleterious palladin mutati<strong>on</strong>s in patients with familial pancreatic cancer. Cancer EpidemiolBiomarkers Prev 2009; 18: 1328-30.409. Shi C, H<strong>on</strong>g SM, Lim P, Kamiyama H, Khan M, Anders RA, Goggins M, Hruban RH, EshlemanJR. KRAS2 mutati<strong>on</strong>s in human pancreatic acinar-ductal metaplastic lesi<strong>on</strong>s are limited to those withPanIN: implicati<strong>on</strong>s for the human pancreatic cancer cell <str<strong>on</strong>g>of</str<strong>on</strong>g> origin. Mol Cancer Res 2009; 7: 230-6.410. Snyder CS, Kaushal S, K<strong>on</strong>o Y, Cao HS, H<str<strong>on</strong>g>of</str<strong>on</strong>g>fman RM, Bouvet M. Complementarity <str<strong>on</strong>g>of</str<strong>on</strong>g> ultrasoundand fluorescence imaging in an orthotopic mouse model <str<strong>on</strong>g>of</str<strong>on</strong>g> pancreatic cancer. BMC Cancer 2009; 9:106.411. Levy MJ, Glees<strong>on</strong> FC, Zhang L. Endoscopic ultrasound fine-needle aspirati<strong>on</strong> detecti<strong>on</strong> <str<strong>on</strong>g>of</str<strong>on</strong>g>extravascular migratory metastasis from a remotely located pancreatic cancer. Clin GastroenterolHepatol 2009; 7: 246-8.412. Shibata K, Iwaki K, Kai S, Ohta M, Kitano S. Increased levels <str<strong>on</strong>g>of</str<strong>on</strong>g> both carbohydrate antigen 19-9and Duke pancreatic m<strong>on</strong>ocl<strong>on</strong>al antigen type 2 reflect postoperative prognosis in patients withpancreatic carcinoma. Pancreas 2009; 38: 619-24.413. Mayo SC, Austin DF, Sheppard BC, Mori M, Shipley DK, Billingsley KG. Evolving preoperativeevaluati<strong>on</strong> <str<strong>on</strong>g>of</str<strong>on</strong>g> patients with pancreatic cancer: does laparoscopy have a role in the current era? J AmColl Surg 2009; 208: 87-95.414. Yamada S, Nakao A, Fujii T, Sugimoto H, Kanazumi N, Nomoto S, Kodera Y, Takeda S.Pancreatic cancer with paraaortic lymph node metastasis: a c<strong>on</strong>traindicati<strong>on</strong> for radical surgery?Pancreas 2009; 38: e13-7.415. Klimstra DS, Pitman MB, Hruban RH. An algorithmic approach to the diagnosis <str<strong>on</strong>g>of</str<strong>on</strong>g> pancreaticneoplasms. Arch Pathol Lab Med 2009; 133: 454-64.416. Mroczko B, Lukaszewicz-Zajac M, Wereszczynska-Siemiatkowska U, Groblewska M, Gryko M,Kedra B, Jurkowska G, Szmitkowski M. Clinical significance <str<strong>on</strong>g>of</str<strong>on</strong>g> the measurements <str<strong>on</strong>g>of</str<strong>on</strong>g> serum matrixmetalloproteinase-9 and its inhibitor (tissue inhibitor <str<strong>on</strong>g>of</str<strong>on</strong>g> metalloproteinase-1) in patients with pancreaticcancer: metalloproteinase-9 as an independent prognostic factor. Pancreas 2009; 38: 613-8.417. Faccioli N, Crippa S, Bassi C, D'On<str<strong>on</strong>g>of</str<strong>on</strong>g>rio M. C<strong>on</strong>trast-enhanced ultras<strong>on</strong>ography <str<strong>on</strong>g>of</str<strong>on</strong>g> the pancreas.Pancreatology 2009; 9: 560-6.418. Badea R, Seicean A, Diac<strong>on</strong>u B, Stan-Iuga R, Sparchez Z, Tantau M, Socaciu M. C<strong>on</strong>trastenhancedultrasound <str<strong>on</strong>g>of</str<strong>on</strong>g> the pancreas – a method bey<strong>on</strong>d its potential or a new diagnostic standard? JGastrointestin Liver Dis 2009; 18: 237-42.419. Iglesias García J, Lariño Noia J, Domínguez Muñoz JE. Endoscopic ultrasound in the diagnosisand staging <str<strong>on</strong>g>of</str<strong>on</strong>g> pancreatic cancer. Rev Esp Enferm Dig 2009; 101: 631-8.420. Sreenarasimhaiah J. Interventi<strong>on</strong>al endoscopic ultrasound: the next fr<strong>on</strong>tier in gastrointestinalendoscopy. Am J Med Sci 2009: 338: 319-24.
421. Horwhat JD, Gerke H, Acosta RD, Pavey DA, Jowell PS. Focal or diffuse "fullness" <str<strong>on</strong>g>of</str<strong>on</strong>g> thepancreas <strong>on</strong> CT. Usually benign, but EUS plus/minus FNA is warranted to identify malignancy. JOP2009; 10: 37-42.422. Al-Haddad M, Khashab M, Zyromski N, Pungpap<strong>on</strong>g S, Wallace MB, Scolapio J, Woodward T,Noh K, Raim<strong>on</strong>do M. Risk factors for hyperechogenic pancreas <strong>on</strong> endoscopic ultrasound: a casec<strong>on</strong>trolstudy. Pancreas 2009; 38: 672-5.423. Tadic C, Kujundzic M, Stoos-Veic T, Kaic G, Vukelic-Markovic M. Role <str<strong>on</strong>g>of</str<strong>on</strong>g> repeated endoscopicultrasound-guided fine needle aspirati<strong>on</strong> in small solid pancreatic masses with previous indeterminateand negative cytological finnings. Dig Dis 2008; 26: 377-82.424. Krishna NB, LaBundy JL, Saripalli S, Safdar R, Agarwal B. Diagnostic value <str<strong>on</strong>g>of</str<strong>on</strong>g> EUS-FNA inpatients suspected <str<strong>on</strong>g>of</str<strong>on</strong>g> having pancreatic cancer with a focal lesi<strong>on</strong> <strong>on</strong> CT ccan/MRI but withoutobstructive jaundice. Pancreas 2009; 38: 625-30.425. Eloubeidi MA, Tamhane A. Prospective assessment <str<strong>on</strong>g>of</str<strong>on</strong>g> diagnostic utility and complicati<strong>on</strong>s <str<strong>on</strong>g>of</str<strong>on</strong>g>endoscopic ultrasound-guided fine needle aspirati<strong>on</strong>. Results from a newly developed academicendoscopic ultrasound program. Dig Dis 2008; 26: 356-63.426. Spier BJ, Johns<strong>on</strong> EA, Gopal DV, Frick T, Einstein MM, Byrne S, Koscik RL, Liou JI, BroxmeyerT, Selvaggi SM, Pfau PR. Predictors <str<strong>on</strong>g>of</str<strong>on</strong>g> malignancy and recommended follow-up in patients withnegative endoscopic ultrasound-guided fine-needle aspirati<strong>on</strong> <str<strong>on</strong>g>of</str<strong>on</strong>g> suspected pancreatic lesi<strong>on</strong>s. Can JGastroenterol 2009; 23: 279-86.427.Carrara S, Arcidiac<strong>on</strong>o PG, Giussani A, Test<strong>on</strong>i PA. Acute hemorrhage with retroperit<strong>on</strong>ealhematoma after endoscopic ultrasound-guided fine-needle aspirati<strong>on</strong> <str<strong>on</strong>g>of</str<strong>on</strong>g> an intraductal papillarymucinous neoplasm <str<strong>on</strong>g>of</str<strong>on</strong>g> the pancreas. Am J Gastroenterol 2009; 104: 1610-1.428. Thomas T, Kaye PV, Ragunath K, Aithal G. Efficacy, safety, and predictive factors for a positiveyield <str<strong>on</strong>g>of</str<strong>on</strong>g> EUS-guided Trucut biopsy: a large tertiary referral center experience. 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Endoscopic ultras<strong>on</strong>ography versus helical CT indiagnosis and staging <str<strong>on</strong>g>of</str<strong>on</strong>g> pancreatic cancer. Tunis Med 2008; 86: 346-9.432. Rezai P, Mulcahy MF, Tochetto SM, Berggruen S, Yaghmai V. Morphological analysis <str<strong>on</strong>g>of</str<strong>on</strong>g>pancreatic adenocarcinoma <strong>on</strong> multidetector row computed tomography: implicati<strong>on</strong>s for treatmentresp<strong>on</strong>se evaluati<strong>on</strong>. Pancreatology 2009; 9: 799-803.433. Klauss M, Alt CD, Welzel T, Werner J, Büchler MW, Richter GM, Kauffman n GW, Kauczor HU,Grenacher L. Multidetector CT evaluati<strong>on</strong> <str<strong>on</strong>g>of</str<strong>on</strong>g> the course <str<strong>on</strong>g>of</str<strong>on</strong>g> n<strong>on</strong>resectable pancreatic carcinomas withneoadjuvant therapy. Pancreatology 2009; 9: 621-30.434. 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- Page 1 and 2:
REVIEW OF LITERATURE ONCLINICAL PAN
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ABBREVIATIONAAPacute alcoholicABPac
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FMF AIPfocal mass-forming autoimmun
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ODPopen distal pancreatectomyOForga
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USUTDTVESDVTEZESWHOXIAPUnited State
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Ectopic pancreasCircumportal annula
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SymptomsEndocopic ultrasography (EU
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HSP27HuRIGF-1 receptorIntegrinesInt
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HemodialysisSerous cystadenomasSero
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CRPC-reactive proteinCRTchemoradiot
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ITNPintrathecal narcotics pumpJCGAI
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QSRquantitative systematic
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PANCREATIC HISTORYEarly conceptsPan
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derived from broadly Harveian anato
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acute appendicitis, intestinal obst
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dogma and its implied presence <str
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In the late 19th century, explorato
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performed. In 1880, Carl Thiersch <
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cancer was reported by Nestor Dimit
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Modern pancreatic historyHoward Reb
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PANCREATIC DEVELOPMENT, EMBRYOLOGY
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preparations. They were also employ
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pancreas can be diagnosed without t
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PANCREATIC PHYSIOLOGYSphincter <str
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acid profile and d
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hormones. The roles of</str
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ACUTE PANCREATITISAcute pancreatiti
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necrosis or a severe course, and lo
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of 245 cases <stro
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plasty of the mino
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no significant difference. The stro
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Urinary trypsinogen-2There is not a
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groups. None of th
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evaluated the presence or absence <
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adical, etc, further studies are st
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Precut at sphincterotomyPrecut is p
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indications [204].Hypercalcemia-ind
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endoscopic retrograde cholangiopanc
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(before ERCP), serum TAP was detect
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concentration and clinical symptoms
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However, the recipients of<
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less safe for predominantly cephali
- Page 85 and 86:
increased mortality. Mortality in p
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Epidemiology and demographyChinaCHR
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for the first time the significance
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endoscopic ultrasound accurately de
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possible to at least reduce relapse
- Page 95 and 96:
etiologies have been proposed and a
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patients, can be performed with mod
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negative binomial model. One hundre
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Halofuginone did n
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years, the risk of
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patients with a proven exocrine pan
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high-risk patients [296].Cystic fib
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TNF-alpha promoter were performed.
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were validated in another series <s
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vascular invasion (14/15). Abnormal
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and other lymph nodes, salivary gla
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HEREDITARY PANCREATITISPatients wit
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Classification of
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historically, but recent life-style
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carcinogen exposure with cancer ris
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the risk of pancre
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conducted a cohort analysis <strong
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emain to be solved in screening for
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considered for women with Lynch syn
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Annexin A5Protein misfolding is a c
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CTNNB1To use fluorescence in situ h
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expression was not associated with
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(ECM) are not fully understood. In
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lines. However, the role of
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andomized to high-dose vitamin A, t
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Synuclein-gammaPerineural invasion
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interventions. Cancer nests were ma
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the optimal combination of<
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which is essential in tumor and nod
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provide conclusive evidence for the
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MD-CT is suitable for evaluating tu
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approved study and imaged during sh
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Quantum dotsIt was reported the suc
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clearly have a very high incidence
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patients for operation and when cou
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demonstrated using the confocal mic
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cancer [468].To evaluate pancreatic
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pancreaticoduodenectomy (PD). The s
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safe option as an interposition gra
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a curative surgery, while double-by
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%), pseudocyst (3 %), and trauma (3
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procedure is failing to progress la
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Glucos metabolism after pancreatect
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Quality of lifeOne
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was observed in the NACRT group. Th
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interval 0.80 to 0.96]. On subgroup
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ate in patients with pancreatic can
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median survival time was 7 versus 7
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and the endoscopic ultrasound-guide
- Page 193 and 194:
local recurrence of</strong
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CurcuminCurcumin has been shown to
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size >1.5 cm (odds ratio 2.4), and
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adenocarcinoma must be addressed at
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Molecular biologyCD44v6The purpose
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IPMN were studied. Two-dimensional
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the NT-IPMN-Br group. Eleven patien
- Page 207 and 208: metastatic neoplasms showing cystic
- Page 209 and 210: Solid pseudopapillary neoplasms <st
- Page 211 and 212: The tumor cells were negative for p
- Page 213 and 214: Duodenal tumorsColorectal polyposis
- Page 215 and 216: Colorectal carcinomaPancreatic meta
- Page 217 and 218: It was described a case of<
- Page 219 and 220: evaluation. The purpose of<
- Page 221 and 222: perforation of a p
- Page 223 and 224: the 28 had pancreatic duct injury <
- Page 225 and 226: ENDOCRINE PANCREATIC TUMORSHistoryA
- Page 227 and 228: 25-111 pg/mL). Mean Hemoglobin A1C
- Page 229 and 230: clinical features, misdiagnosis occ
- Page 231 and 232: achieved in selected cases by tissu
- Page 233 and 234: Overall survivalPancreatic neuroend
- Page 235 and 236: REFERENCES001. Metter CC. History <
- Page 237 and 238: 044. Fitz RH. The symptomatology an
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