655. Endo K, Sata N, Shimura K, Yasuda Y. Pancreatic arteriovenous malformati<strong>on</strong>: a case report <str<strong>on</strong>g>of</str<strong>on</strong>g>hemodynamic and three-dimensi<strong>on</strong>al morphological analysis using multi-detector row computedtomography and post-processing methods. JOP 2009; 10: 59-63.656. Phelan HA, Velmahos GC, Jurkovich GJ, Friese RS, Minei JP, Menaker JA, Philp A, Evans HL,Gunn ML, Eastman AL, Rowell SE, Allis<strong>on</strong> CE, Barbosa RL, Norwood SH, Tabbara M, Dente CJ,Carrick MM, Wall MJ, Feeney J, O'Neill PJ, Srinivas G, Brown CV, Reifsnyder AC, Hassan MO, AlbertS, Pascual JL, Str<strong>on</strong>g M, Moore FO, Spain DA, Purtill MA, Edwards B, Strauss J, Durham RM,Duchesne JC, Greiffenstein P, Cothren CC. An evaluati<strong>on</strong> <str<strong>on</strong>g>of</str<strong>on</strong>g> multidetector computed tomography indetecting pancreatic injury: results <str<strong>on</strong>g>of</str<strong>on</strong>g> a multicenter AAST study. J Trauma 2009; 66: 641-6.657. M<strong>on</strong>tesano G, Zanella L, Favetta U, Del B<strong>on</strong>o P, Voccia L, Rossi FS. Rupture <str<strong>on</strong>g>of</str<strong>on</strong>g> the pancreaticisthmus due to blunt abdominal trauma. Chir Ital 2009; 61: 123-6 (in Italian).658. Thomas H, Madanur M, Bartlett A, Marang<strong>on</strong>i G, Heat<strong>on</strong> N, Rela M. Pancreatic trauma – 12-yearexperience from a tertiary center. Pancreas 2009; 86: 113-6.659. Gaines BA. Intra-abdominal solid organ injury in children: diagnosis and treatment. J Trauma2009; 67 (2 suppl): S135-9.660. Velmahos GC, Tabbara M, Gross R, Willette P, Hirsch E, Burke P, Emh<str<strong>on</strong>g>of</str<strong>on</strong>g>f T, Gupta R, WinchellRJ, Patters<strong>on</strong> LA, Man<strong>on</strong>-Matos Y, Alam HB, Rosenblatt M, Hurst J, Brotman S, Crookes B, SartorelliK, Chang Y. Blunt pancreatoduodenal injury: a multicenter study <str<strong>on</strong>g>of</str<strong>on</strong>g> the Research C<strong>on</strong>sortium <str<strong>on</strong>g>of</str<strong>on</strong>g> NewEngland Centers for Trauma (ReCONECT). Arch Surg 2009; 144: 413-9.661. Laituri C, Teixeira A, Lube MW, Seims A, Cravens J. Trauma laparotomy: evaluating thenecessity <str<strong>on</strong>g>of</str<strong>on</strong>g> histological examinati<strong>on</strong>. Am Surg 2009; 75: 1124-7.662. Ong SL, Garcea G, Pollard CA, Furness PN, Steward WP, Rajesh A, Spencer L, Lloyd DM, BerryDP, Dennis<strong>on</strong> AR. A fuller understanding <str<strong>on</strong>g>of</str<strong>on</strong>g> pancreatic neuroendocrine tumours combined withaggressive management improves outcome. Pancreatology 2009; 9: 583-600.663. Toyomasu Y, Fukuchi M, Yoshida T, Tajima K, Osawa H, Motegi M, Iijima T, Nagashima K,Ishizaki M, Mochiki E, Kuwano H. Treatment <str<strong>on</strong>g>of</str<strong>on</strong>g> hyperinsulinemic hypoglycemia due to diffusenesidioblastosis in adults: a case report. Am Surg 2009; 75: 331-4.664. Öberg K. Genetics and molecular pathology <str<strong>on</strong>g>of</str<strong>on</strong>g> neuroendocrine gastrointestinal and pancreatictumors (gastroenteropancreatic neuroendocrine tumors). Curr Opin Endocrinol Diabetes Obes 2009;16: 72-8.665. Capelli P, Martign<strong>on</strong>i G, Pedica F, Falc<strong>on</strong>i M, Ant<strong>on</strong>ello D, Malpeli G, Scarpa A. Endocrineneoplasms <str<strong>on</strong>g>of</str<strong>on</strong>g> the pancreas: pathologic and genetic features. Arch Pathol Lab Med 2009; 133: 350-64.666. Landry CS, Waguespack SG, Perrier ND. Surgical management <str<strong>on</strong>g>of</str<strong>on</strong>g> n<strong>on</strong>multiple endocrineneoplasia endocrinopathies: state-<str<strong>on</strong>g>of</str<strong>on</strong>g>-the-art <str<strong>on</strong>g>review</str<strong>on</strong>g>. Surg Clin North Am 2009; 89: 1069-89.667. Åkerström G, Stålberg P. Surgical management <str<strong>on</strong>g>of</str<strong>on</strong>g> MEN-1 and -2: state <str<strong>on</strong>g>of</str<strong>on</strong>g> the art. Surg Clin NorthAm 2009; 89: 1047-68.668. Gauger PG, Doherty GM, Broome JT, Miller BS, Thomps<strong>on</strong> NW. Completi<strong>on</strong> pancreatectomyand duodenectomy for recurrent MEN-1 pancreaticoduodenal endocrine neoplasms. Surgery 2009;146: 801-6.669. Shen HC, He M, Powell A, Adem A, Lorang D, Heller C, Grover AC, Ylaya K, Hewitt SM, MarxSJ, Spiegel AM, Libutti SK. Recapitulati<strong>on</strong> <str<strong>on</strong>g>of</str<strong>on</strong>g> pancreatic neuroendocrine tumors in human multipleendocrine neoplasia type I syndrome via Pdx1-directed inactivati<strong>on</strong> <str<strong>on</strong>g>of</str<strong>on</strong>g> Men1. Cancer Res 2009; 69:1858-66.
670. Lej<strong>on</strong>klou M, Edfeldt K, Johanss<strong>on</strong> TA, Stalberg P, Skogseid B. Neurogenin 3 and neurogenicdifferentiati<strong>on</strong> 1 are retained in the cytoplasm <str<strong>on</strong>g>of</str<strong>on</strong>g> multiple endocrine neoplasia type 1 islet andpancreatic endocrine tumor cells. Pancreas 2009; 38: 259-66.671. Dörffel Y, Wermke W. Neuroendocrine tumors: characterizati<strong>on</strong> with c<strong>on</strong>trast-enhancedultras<strong>on</strong>ography. Ultraschall Med 2008; 29: 506-14.672. Borbath I, Jamar F, Delaunoit T, Demetter P, Demolin G, Hendlisz A, Pattyn P, Peeters M,Roeyen G, Van Cutsem E, Van Hootegem P, Van Laethem JL, Verslype C, Pauwels S. Diagnosticpitfalls in digestive neuroendocrine tumours. Acta Gastroenterol Belg 2009; 72: 29-33.673. Verslype C, Cart<strong>on</strong> S, Borbath I, Delaunoit T, Demetter P, Demolin G, Hendlisz A, Pattyn P,Pauwels S, Peeters M, Roeyen G, Van Hootegem P, Van Laethem JL, Van Cutsem E. <strong>The</strong>antiproliferative effect <str<strong>on</strong>g>of</str<strong>on</strong>g> somatostatin analogs: <strong>clinical</strong> relevance in patients with neuroendocrinegastro-entero-pancreatic tumours. Acta Gastrenterol Belg 2009; 72: 54-8.674. He X, Wang J, Wu X, Kang L, Lan P. Pancreatic somatostatinoma manifested as severehypoglycaemia. J Gastrointestin Liver Dis 2009; 18: 221-4.675. S<strong>on</strong>g S, Shi R, Li B, Liu Y. Diagnosis and treatment <str<strong>on</strong>g>of</str<strong>on</strong>g> pancreatic vasoactive intestinal peptideendocrine tumors. Pancreas 2009; 38: Aug 5 [Epub ahead <str<strong>on</strong>g>of</str<strong>on</strong>g> print].676. Grobmyer SR, Vogel SB, McGuigan JE, Copeland EM, Hochwald SN. Reoperative surgery insporadic Zollinger-Ellis<strong>on</strong> Syndrome: l<strong>on</strong>gterm results. J Am Coll Surg 2009; 208: 718-22.677. Mathur A, Gorden P, Libutti SK. Insulinoma. Surg Clin North Am 2009; 89: 1105-21.678. Heni M, Schott S, Horger M, Dudziak K, Thamer C, Häring HU, Fritsche A, Müssig K. A rarecause <str<strong>on</strong>g>of</str<strong>on</strong>g> hypoglycaemia in a patient with type 2 diabetes. Dtsch Med Wochenschr 2009; 134 SupplFalldatenbank F2 (in German).679. Nakano K, Yamashita S, Soma I, Hayashi N, Higaki N, Murakami M, Hayashida H, Kan K,Ichihara T, Sak<strong>on</strong> M, Ayata M. A case <str<strong>on</strong>g>of</str<strong>on</strong>g> n<strong>on</strong>functi<strong>on</strong>ing islet cell tumor with extensive calcificati<strong>on</strong>.Nipp<strong>on</strong> Shokakibyo Gakkai Zasshi 2009; 106: 1494-9 (in Japanese).680. Pedic<strong>on</strong>e R, Adham M, Hervieu V, Lombard-Bohas C, Guibal A, Scoazec JY, Chayvialle JA,Partensky C. L<strong>on</strong>g-term survival after pancreaticoduodenectomy for endocrine tumors <str<strong>on</strong>g>of</str<strong>on</strong>g> the ampulla<str<strong>on</strong>g>of</str<strong>on</strong>g> Vater and minor papilla. Pancreas 2009; 38: 638-43.681. Roeyen G, Chapelle T, Borbath I, Delaunoit T, Demetter P, Demolin G, Hendlisz A, Pattyn P,Pauwels S, Peeters M, Van Cutsemo E, Van Hootegem P, Van Laethem JL, Verslype C, Ysebaert D.<strong>The</strong> role <str<strong>on</strong>g>of</str<strong>on</strong>g> surgery and transplantati<strong>on</strong> in neuroendocrine tumours. Acta Gastroenterol Belg 2009; 72:39-43.682. Matsubayashi H, Fukutomi A, Boku N, Uesaka K, Ono H. Diagnosis and treatment <str<strong>on</strong>g>of</str<strong>on</strong>g> pancreaticendocrine tumors. Gan To Kagaku Ryoho 2009; 36: 1611-8 (in Japanese).683. Delaunoit T, Van den Eynde M, Borbath I, Demetter P, Demolin G, Pattyn P, Pauwels S, PeetersM, Roeyen G, Van Cutsem E, Van Hootegem P, Van Laethem JL, Verslype C, Hendlisz A. Role <str<strong>on</strong>g>of</str<strong>on</strong>g>chemotherapy in gastro-entero-pancreatic neuroendocrine tumors: the end <str<strong>on</strong>g>of</str<strong>on</strong>g> a story? ActaGastroenterol Belg 2009; 72: 49-53.684. Hendlisz A, Flamen P, Van den Eynde M, Borbath I, Demetter P, Demolin G, Pattyn P, PauwelsS, Peeters M, Roeyen G, Van Cutsemo E, Van Hootegem P, Van Laethem JL, Verslype C, DelaunoitT. Locoregi<strong>on</strong>al and radioisotopic targeted treatment <str<strong>on</strong>g>of</str<strong>on</strong>g> neuroendocrine tumours. Acta GastroenterolBelg 2009; 72: 44-8.685. Strosberg J, Gardner N, Kvols L. Survival and prognostic factor analysis in patients withmetastatic pancreatic endocrine carcinomas. Pancreas 2009; 38: 255-8.
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REVIEW OF LITERATURE ONCLINICAL PAN
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ABBREVIATIONAAPacute alcoholicABPac
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FMF AIPfocal mass-forming autoimmun
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ODPopen distal pancreatectomyOForga
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USUTDTVESDVTEZESWHOXIAPUnited State
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Ectopic pancreasCircumportal annula
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SymptomsEndocopic ultrasography (EU
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HSP27HuRIGF-1 receptorIntegrinesInt
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HemodialysisSerous cystadenomasSero
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CRPC-reactive proteinCRTchemoradiot
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ITNPintrathecal narcotics pumpJCGAI
- Page 23 and 24:
QSRquantitative systematic
- Page 25 and 26:
PANCREATIC HISTORYEarly conceptsPan
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derived from broadly Harveian anato
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acute appendicitis, intestinal obst
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dogma and its implied presence <str
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In the late 19th century, explorato
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performed. In 1880, Carl Thiersch <
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cancer was reported by Nestor Dimit
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Modern pancreatic historyHoward Reb
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PANCREATIC DEVELOPMENT, EMBRYOLOGY
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preparations. They were also employ
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pancreas can be diagnosed without t
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PANCREATIC PHYSIOLOGYSphincter <str
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acid profile and d
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hormones. The roles of</str
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ACUTE PANCREATITISAcute pancreatiti
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necrosis or a severe course, and lo
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of 245 cases <stro
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plasty of the mino
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no significant difference. The stro
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Urinary trypsinogen-2There is not a
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groups. None of th
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evaluated the presence or absence <
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adical, etc, further studies are st
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Precut at sphincterotomyPrecut is p
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indications [204].Hypercalcemia-ind
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endoscopic retrograde cholangiopanc
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(before ERCP), serum TAP was detect
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concentration and clinical symptoms
- Page 81 and 82:
However, the recipients of<
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less safe for predominantly cephali
- Page 85 and 86:
increased mortality. Mortality in p
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Epidemiology and demographyChinaCHR
- Page 89 and 90:
for the first time the significance
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endoscopic ultrasound accurately de
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possible to at least reduce relapse
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etiologies have been proposed and a
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patients, can be performed with mod
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negative binomial model. One hundre
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Halofuginone did n
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years, the risk of
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patients with a proven exocrine pan
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high-risk patients [296].Cystic fib
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TNF-alpha promoter were performed.
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were validated in another series <s
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vascular invasion (14/15). Abnormal
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and other lymph nodes, salivary gla
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HEREDITARY PANCREATITISPatients wit
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Classification of
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historically, but recent life-style
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carcinogen exposure with cancer ris
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the risk of pancre
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conducted a cohort analysis <strong
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emain to be solved in screening for
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considered for women with Lynch syn
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Annexin A5Protein misfolding is a c
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CTNNB1To use fluorescence in situ h
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expression was not associated with
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(ECM) are not fully understood. In
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lines. However, the role of
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andomized to high-dose vitamin A, t
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Synuclein-gammaPerineural invasion
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interventions. Cancer nests were ma
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the optimal combination of<
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which is essential in tumor and nod
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provide conclusive evidence for the
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MD-CT is suitable for evaluating tu
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approved study and imaged during sh
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Quantum dotsIt was reported the suc
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clearly have a very high incidence
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patients for operation and when cou
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demonstrated using the confocal mic
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cancer [468].To evaluate pancreatic
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pancreaticoduodenectomy (PD). The s
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safe option as an interposition gra
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a curative surgery, while double-by
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%), pseudocyst (3 %), and trauma (3
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procedure is failing to progress la
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Glucos metabolism after pancreatect
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Quality of lifeOne
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was observed in the NACRT group. Th
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interval 0.80 to 0.96]. On subgroup
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ate in patients with pancreatic can
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median survival time was 7 versus 7
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and the endoscopic ultrasound-guide
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local recurrence of</strong
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CurcuminCurcumin has been shown to
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size >1.5 cm (odds ratio 2.4), and
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adenocarcinoma must be addressed at
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Molecular biologyCD44v6The purpose
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IPMN were studied. Two-dimensional
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the NT-IPMN-Br group. Eleven patien
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metastatic neoplasms showing cystic
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Solid pseudopapillary neoplasms <st
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The tumor cells were negative for p
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Duodenal tumorsColorectal polyposis
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Colorectal carcinomaPancreatic meta
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It was described a case of<
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evaluation. The purpose of<
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perforation of a p
- Page 223 and 224: the 28 had pancreatic duct injury <
- Page 225 and 226: ENDOCRINE PANCREATIC TUMORSHistoryA
- Page 227 and 228: 25-111 pg/mL). Mean Hemoglobin A1C
- Page 229 and 230: clinical features, misdiagnosis occ
- Page 231 and 232: achieved in selected cases by tissu
- Page 233 and 234: Overall survivalPancreatic neuroend
- Page 235 and 236: REFERENCES001. Metter CC. History <
- Page 237 and 238: 044. Fitz RH. The symptomatology an
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