242. Kilian M, Gregor JI, Heukamp I, Wagner C, Walz KM, Schimke I, Kristiansen G, Wenger FA.Early inhibiti<strong>on</strong> <str<strong>on</strong>g>of</str<strong>on</strong>g> prostaglandin synthesis by n-3 fatty acids determinates histologic severity <str<strong>on</strong>g>of</str<strong>on</strong>g>necrotizing pancreatitis. Pancreas 2009; 38: 436-41.243. Yuan H, Jin X, Sun JB, Li F, Feng Q, Zhang CQ, Cao Y, Wang Y. Protective effect <str<strong>on</strong>g>of</str<strong>on</strong>g> HMGB1 ABox <strong>on</strong> organ injury <str<strong>on</strong>g>of</str<strong>on</strong>g> acute pancreatitis in mice. Pancreas 2009; 38: 143-8.244. Mann O, Tiefenbacher WJ, Kaifi J, Schneider C, Kluth D, Bloechle C, Yekebas E, Izbicki JR,Strate T. Effect <str<strong>on</strong>g>of</str<strong>on</strong>g> platelet-activating factor antag<strong>on</strong>ist WEB 2086 <strong>on</strong> microcirculatory disorders inacute experimental pancreatitis <str<strong>on</strong>g>of</str<strong>on</strong>g> graded severity. Pancreas 2009; 86: 58-64.245. Wang LW, Li ZS, Li S, Jin ZD, Zou, Duo W, Chen F. Prevalence and <strong>clinical</strong> features <str<strong>on</strong>g>of</str<strong>on</strong>g> chr<strong>on</strong>icpancreatitis in China: a retrospective multicenter analysis over 10 years. Pancreas 2009; 38: 248-54.246. Bhasin DK, Singh G, Rana SS, Chowdry SM, Shafiq N, Malhotra S, Sinha SK. Clinical pr<str<strong>on</strong>g>of</str<strong>on</strong>g>ile <str<strong>on</strong>g>of</str<strong>on</strong>g>idiopathic chr<strong>on</strong>ic pancreatitis in North India. Clin Gastroenterol Hepatol 2009; 7: 594-9.247. Díte P, Novotný I, Precechtelová M, Růzicka M, Záková A, Trna J, Hermannová M, Sevcíková A.Incidence <str<strong>on</strong>g>of</str<strong>on</strong>g> pancreatic carcinoma in pers<strong>on</strong>s with chr<strong>on</strong>ic pancreatitis. Vnitr Lek 2009; 55: 18-21 (inCzech).248. Aoyagi H, Okada T, Hasatani K, Mibayashi H, Hayashi Y, Tsuji S, Kaneko Y, Yamagishi M.Impact <str<strong>on</strong>g>of</str<strong>on</strong>g> cystic fibrosis transmembrane c<strong>on</strong>ductance regulator gene mutati<strong>on</strong> <strong>on</strong> the occurrence <str<strong>on</strong>g>of</str<strong>on</strong>g>chr<strong>on</strong>ic pancreatitis in Japanese patients. J Int Med Res 2009; 37: 378-84.249. Chang MC, Chang YT, Wei SC, Liang PC, Jan IS, Su YN, Kuo CH, W<strong>on</strong>g JM. Associati<strong>on</strong> <str<strong>on</strong>g>of</str<strong>on</strong>g>novel chymotrypsin C gene variati<strong>on</strong>s and haplotypes in patients with chr<strong>on</strong>ic pancreatitis in Chinesein Taiwan. Pancreatology 2009; 9: 287-92.250. Mora J, Comas L , Ripoll E, G<strong>on</strong>çalves P, Queraltó J, G<strong>on</strong>zález-Sastre F, Farré A. Geneticmutati<strong>on</strong>s in a Spanish populati<strong>on</strong> with chr<strong>on</strong>ic pancreatitis. Pancreatology 2009; 9: 644-51.251. Diac<strong>on</strong>u B. Risk factors in chr<strong>on</strong>ic pancreatitis. Rom J Intern Med 2009; 47: 3-8.252. Girish BN, Vaidyanathan K, Ananth Rao N, Rajesh G, Reshmi S, Balakrishnan V. Chr<strong>on</strong>icpancreatitis is associated with hyperhomocysteinemia and derangements in transsulfurati<strong>on</strong> andtransmethylati<strong>on</strong> pathways. Pancreatology 2009; 9: e11-6.253. Vinokurova LV, Drozdov VN, Tkachenko EV, Trubitsyna IE, Varvanina GG. Etiology andpathogenesis <str<strong>on</strong>g>of</str<strong>on</strong>g> duodenal mucosa lesi<strong>on</strong> in chr<strong>on</strong>ic pancreatitis. Ter Arkh 2009; 81: 65-8 (in Russian).254. Schrader H, Menge B, Belyaev O, Uhl W, Schmidt WE, Meier JJ. Amino acid malnutriti<strong>on</strong> inpatients with chr<strong>on</strong>ic pancreatitis and pancreatic carcinoma- Pancreas 2009; 38: 416-21.255. Madarasingha NP, Satgurunathan K, Fernando R. Pancreatic panniculitis: A rare form <str<strong>on</strong>g>of</str<strong>on</strong>g>panniculitis. Dermatol Online J 2009; 15: 17.256. Bhutani MS, Arantes V, Verma D, Moezzi J, Suryaprasad S, Kapadia AS, Gopalswamy N.Histopathologic correlati<strong>on</strong> <str<strong>on</strong>g>of</str<strong>on</strong>g> endoscopic ultrasound findings <str<strong>on</strong>g>of</str<strong>on</strong>g> chr<strong>on</strong>ic pancreatitis in humanautopsies. Pancreas 2009; 38: 820-4.258. Gardner TB, Janec EM, Gord<strong>on</strong> SR. Relati<strong>on</strong>ship between patient symptoms andendos<strong>on</strong>ographic findings in chr<strong>on</strong>ic pancreatitis. Pancreatology 2009; 9: 398-403.259. Vegting IL, Tabbers MM, Taminiau JA, Ar<strong>on</strong>s<strong>on</strong> DC, Benninga MA, Rauws EA. Is endoscopicretrograde cholangiopancreatography valuable and safe in children <str<strong>on</strong>g>of</str<strong>on</strong>g> all ages? J Peditr GastroenterolNutr 2009; 48: 66-71.
260. Nakamura H, Morifuji M, Murakami Y, Uemura K, Ohge H, Hayashidani Y, Sudo T, Sueda T.Usefulness <str<strong>on</strong>g>of</str<strong>on</strong>g> a 13C-labeled mixed triglyceride breath test for assessing pancreatic exocrine functi<strong>on</strong>after pancreatic surgery. Surgery 2009; 145: 168-75.261. Andrea P, Andreas DW, Marc B, Katharina H, Michael T, Michael B, Klaus P, Ansgar LW.Pancreas and liver injury are associated in individuals with increased alcohol c<strong>on</strong>sumpti<strong>on</strong>. ClinGastroenterol Hepatol 2009 Jun 25 [Epub ahead <str<strong>on</strong>g>of</str<strong>on</strong>g> print].262. Tsujimoto T, Kawaratani H, Yoshiji H, Uemura M, Fukui H. Recent developments in the treatment<str<strong>on</strong>g>of</str<strong>on</strong>g> alcoholic chr<strong>on</strong>ic pancreatitis. Curr Drug Abuse Rev 2008; 1: 197-202.263. Pelli H, Sand J, Nordback I. Can the recurrence <str<strong>on</strong>g>of</str<strong>on</strong>g> alcohol-induced pancreatitis be prevented?Duodecim 2009; 125: 1195-200 (in Finnish).264. Levenick JM, Gord<strong>on</strong> SR, Sutt<strong>on</strong> JE, Suriawinata A, Gardner TB. A comprehensive, case-based<str<strong>on</strong>g>review</str<strong>on</strong>g> <str<strong>on</strong>g>of</str<strong>on</strong>g> groove pancreatitis. Pancreas 2009; 38: e169-75.265. Mullhaupt B, Ammann RW. Total pancreatectomy for intractable pain in chr<strong>on</strong>ic pancreatitis?Pancreatology 2009; 9: 110-1 (letter).266. P<strong>on</strong>gprasobchai S, Manatsathit S. Natural course <str<strong>on</strong>g>of</str<strong>on</strong>g> abdominal pain in chr<strong>on</strong>ic pancreatitis withintermittent (type A) pain after c<strong>on</strong>servative treatment. J Med Assoc Thai 2009; 92 (suppl 2): S43-8.267. Ceyhan GO, Deucker S, Demir IE, Erkan M, Schmelz M, Bergmann F, Müller MW, Giese T,Büchler MW, Giese NA, Friess H. Neural fractalkine expressi<strong>on</strong> is closely linked to pain and pancreaticneuritis in human chr<strong>on</strong>ic pancreatitis. Lab Invest 2009; 89: 347-61.268. K<strong>on</strong>gkam P, Wagner DL, Sherman S, Fogel EL, Whittaker SC, Watkins JL, McHenry L, LehmanGA. Intrathecal narcotic infusi<strong>on</strong> pumps for intractable pain <str<strong>on</strong>g>of</str<strong>on</strong>g> chr<strong>on</strong>ic pancreatitis: a pilot series. Am JGastroenterol 2009; 104: 1249-55.269. Winstead NC, Wilcox CM. Clinical trials <str<strong>on</strong>g>of</str<strong>on</strong>g> pancreatic enzyme replacement for painful chr<strong>on</strong>icpancreatitis – a <str<strong>on</strong>g>review</str<strong>on</strong>g>. Pancreatology 2009; 9: 344-50.270. Colombo C, Fredella C, Russo MC, Faelli N, Motta V, Valmarana L, L<strong>on</strong>go L, D'Orazio C.Efficacy and tolerability <str<strong>on</strong>g>of</str<strong>on</strong>g> Cre<strong>on</strong> for children in infants and toddlers with pancreatic exocrineinsufficiency caused by cystic fibrosis: an open-label, single-arm, multicenter study. Pancreas 2009;38: 693-9.271. Hill JS, McPhee JT, Whalen GF, Sullivan ME, Warshaw AL, Tseng JF. In-hospital mortality afterpancreatic resecti<strong>on</strong> for chr<strong>on</strong>ic pancreatitis: populati<strong>on</strong>-based estimates from the nati<strong>on</strong>wide inpatientsample. J Am Coll Surg 2009; 209: 468-76.272. Das MK, Roy H, Afaque Y, Mukherjee A, Gautam D. Pancreaticogastrostomy in cases <str<strong>on</strong>g>of</str<strong>on</strong>g> chr<strong>on</strong>icpancreatitis: a preliminary study. J Indian Med Assoc 2008; 106: 797-8.273. Pakosz-Golanowsha M, Post M, Lubikowski J, Butkiewicz J, Białek A, Raszeja-Wyszomirska J,Wiechowska-Kozłowska A, Milkiewicz P, Wójcicki M. Partingt<strong>on</strong>-Rochelle pancreaticojejunostomy forchr<strong>on</strong>ic pancreatitis: analysis <str<strong>on</strong>g>of</str<strong>on</strong>g> outcome including quality <str<strong>on</strong>g>of</str<strong>on</strong>g> life. Hepatogastroenterology 2009; 56:1533-7.274. Niclauss N, Morel P, Vol<strong>on</strong>te F, Bosco D, Berney T. Pancreas and islets <str<strong>on</strong>g>of</str<strong>on</strong>g> Langerhanstransplantati<strong>on</strong>: current status in 2009 and perspectives. Rev Med Suisse 2009; 5: 1266-70 (inFrench).
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REVIEW OF LITERATURE ONCLINICAL PAN
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ABBREVIATIONAAPacute alcoholicABPac
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FMF AIPfocal mass-forming autoimmun
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ODPopen distal pancreatectomyOForga
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USUTDTVESDVTEZESWHOXIAPUnited State
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Ectopic pancreasCircumportal annula
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SymptomsEndocopic ultrasography (EU
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HSP27HuRIGF-1 receptorIntegrinesInt
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HemodialysisSerous cystadenomasSero
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CRPC-reactive proteinCRTchemoradiot
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ITNPintrathecal narcotics pumpJCGAI
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QSRquantitative systematic
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PANCREATIC HISTORYEarly conceptsPan
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derived from broadly Harveian anato
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acute appendicitis, intestinal obst
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dogma and its implied presence <str
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In the late 19th century, explorato
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performed. In 1880, Carl Thiersch <
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cancer was reported by Nestor Dimit
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Modern pancreatic historyHoward Reb
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PANCREATIC DEVELOPMENT, EMBRYOLOGY
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preparations. They were also employ
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pancreas can be diagnosed without t
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PANCREATIC PHYSIOLOGYSphincter <str
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acid profile and d
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hormones. The roles of</str
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ACUTE PANCREATITISAcute pancreatiti
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necrosis or a severe course, and lo
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of 245 cases <stro
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plasty of the mino
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no significant difference. The stro
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Urinary trypsinogen-2There is not a
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groups. None of th
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evaluated the presence or absence <
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adical, etc, further studies are st
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Precut at sphincterotomyPrecut is p
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indications [204].Hypercalcemia-ind
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endoscopic retrograde cholangiopanc
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(before ERCP), serum TAP was detect
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concentration and clinical symptoms
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However, the recipients of<
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less safe for predominantly cephali
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increased mortality. Mortality in p
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Epidemiology and demographyChinaCHR
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for the first time the significance
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endoscopic ultrasound accurately de
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possible to at least reduce relapse
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etiologies have been proposed and a
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patients, can be performed with mod
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negative binomial model. One hundre
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Halofuginone did n
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years, the risk of
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patients with a proven exocrine pan
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high-risk patients [296].Cystic fib
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TNF-alpha promoter were performed.
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were validated in another series <s
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vascular invasion (14/15). Abnormal
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and other lymph nodes, salivary gla
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HEREDITARY PANCREATITISPatients wit
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Classification of
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historically, but recent life-style
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carcinogen exposure with cancer ris
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the risk of pancre
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conducted a cohort analysis <strong
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emain to be solved in screening for
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considered for women with Lynch syn
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Annexin A5Protein misfolding is a c
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CTNNB1To use fluorescence in situ h
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expression was not associated with
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(ECM) are not fully understood. In
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lines. However, the role of
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andomized to high-dose vitamin A, t
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Synuclein-gammaPerineural invasion
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interventions. Cancer nests were ma
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the optimal combination of<
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which is essential in tumor and nod
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provide conclusive evidence for the
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MD-CT is suitable for evaluating tu
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approved study and imaged during sh
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Quantum dotsIt was reported the suc
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clearly have a very high incidence
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patients for operation and when cou
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demonstrated using the confocal mic
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cancer [468].To evaluate pancreatic
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pancreaticoduodenectomy (PD). The s
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safe option as an interposition gra
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a curative surgery, while double-by
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%), pseudocyst (3 %), and trauma (3
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procedure is failing to progress la
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Glucos metabolism after pancreatect
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Quality of lifeOne
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was observed in the NACRT group. Th
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interval 0.80 to 0.96]. On subgroup
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ate in patients with pancreatic can
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median survival time was 7 versus 7
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and the endoscopic ultrasound-guide
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local recurrence of</strong
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CurcuminCurcumin has been shown to
- Page 197 and 198: size >1.5 cm (odds ratio 2.4), and
- Page 199 and 200: adenocarcinoma must be addressed at
- Page 201 and 202: Molecular biologyCD44v6The purpose
- Page 203 and 204: IPMN were studied. Two-dimensional
- Page 205 and 206: the NT-IPMN-Br group. Eleven patien
- Page 207 and 208: metastatic neoplasms showing cystic
- Page 209 and 210: Solid pseudopapillary neoplasms <st
- Page 211 and 212: The tumor cells were negative for p
- Page 213 and 214: Duodenal tumorsColorectal polyposis
- Page 215 and 216: Colorectal carcinomaPancreatic meta
- Page 217 and 218: It was described a case of<
- Page 219 and 220: evaluation. The purpose of<
- Page 221 and 222: perforation of a p
- Page 223 and 224: the 28 had pancreatic duct injury <
- Page 225 and 226: ENDOCRINE PANCREATIC TUMORSHistoryA
- Page 227 and 228: 25-111 pg/mL). Mean Hemoglobin A1C
- Page 229 and 230: clinical features, misdiagnosis occ
- Page 231 and 232: achieved in selected cases by tissu
- Page 233 and 234: Overall survivalPancreatic neuroend
- Page 235 and 236: REFERENCES001. Metter CC. History <
- Page 237 and 238: 044. Fitz RH. The symptomatology an
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