179. Hardt PD, Mayer K, Ewald N. Exocrine pancreatic involvement in critically ill patients. Curr OpinClin Nutr Metab Care 2009; 12: 168-74.180. Pradeep K, Wig J, Panda NB, Prasad R. Dose-related effect <str<strong>on</strong>g>of</str<strong>on</strong>g> prop<str<strong>on</strong>g>of</str<strong>on</strong>g>ol <strong>on</strong> pancreatic enzymesand triglyceride levels in patients undergoing n<strong>on</strong>-abdominal surgery. Anaesth Intensive Care 2009;37: 27-31.181. Sliwińska-Mossoń M, Milnerowicz H, Zuchniewicz A, Andrzejak R, Ant<strong>on</strong>owicz-Juchniewicz J.Influence <str<strong>on</strong>g>of</str<strong>on</strong>g> tobacco smoking <strong>on</strong> amylase activity in serum pers<strong>on</strong>s occupati<strong>on</strong>al exposed to heavymetals. Przegl Lek 2008; 65: 495-7 (in Polish).182. Chuang TY, Chao CL, Lin BJ, Lu SC. Gestati<strong>on</strong>al hyperlipidemic pancreatitis caused by type IIIhyperlipoproteinemia with apolipoprotein E2/E2 homozygote. Pancreas 2009; 38: 716-7.183. Cole RP. Heparin treatment for severe hypertriglyceridemia in diabetic ketoacidosis. Arch InternMed 2009; 169: 1439-41.184. Radenkovic D, Bajec D, Ivancevic N, Milic N, Bumbasirevic V, Jeremic V, Djukic V, Stefanovic B,Stefanovic B, Milosevic-Zbutega G, Gregoric P. d-Dimer in acute pancreatitis: a new approach for anearly assessment <str<strong>on</strong>g>of</str<strong>on</strong>g> organ failure. Pancreas 2009; 38: 655-60.185. Ocampo C, Zandalazini H, Kohan G, Silva W, Szelagowsky C, Oria A. Computed tomographicprognostic factors for predicting local complicati<strong>on</strong>s in patients with pancreatic necrosis. Pancreas2009; 38: 137-42.186. Shinya S, Sasaki T, Nakagawa Y, Guiquing Z, Yamamoto F, Yamashita Y. <strong>The</strong> efficacy <str<strong>on</strong>g>of</str<strong>on</strong>g>diffusi<strong>on</strong>-weighted imaging for the detecti<strong>on</strong> and evaluati<strong>on</strong> <str<strong>on</strong>g>of</str<strong>on</strong>g> acute pancreatitis.Hepatogastroenterology 2009; 56: 1407-10.187. Kim YK, Kim CS, Han YM. Role <str<strong>on</strong>g>of</str<strong>on</strong>g> fat-suppressed T1-weighted magnetic res<strong>on</strong>ance imaging inpredicting severity and prognosis <str<strong>on</strong>g>of</str<strong>on</strong>g> acute pancreatitis: an intraindividual comparis<strong>on</strong> withmultidetector computed tomography. J Comput Assist Tomogr 2009; 33: 651-6.188. Wilcox CM, Kilgore M. Cost minimizati<strong>on</strong> analysis comparing diagnostic strategies in unexplainedpancreatitis. Pancreas 2009; 38: 117-21.189. Mitura K, Romanczuk M. Ruptured ectopic pregnancy mimicking acute pancreatitis. Ginekol Pol2009; 80: 383-5.190. Morinville VD, Barmada MM, Lowe ME. Increasing incidence <str<strong>on</strong>g>of</str<strong>on</strong>g> acute pancreatitis at an americanpediatric tertiary care center: is greater awareness am<strong>on</strong>g physicians resp<strong>on</strong>sible? Pancreatology2009; 9: 5-8.191. Treep<strong>on</strong>gkaruna S, Th<strong>on</strong>gpak N, Pakakasama S, Pienvichit P, Sirachainan N, H<strong>on</strong>geng S. Acutepancreatitis in children with acute lymphoblastic leukemia after chemotherapy. J Pediatr HematolOncol 2009; 31: 812-5.192. Zhang X, Wu D, Jiang X. ICAM-1 and acute pancreatitis complicated by acute lung injury. JOP2009; 10: 8-14.193. Koseki H, Tsurumoto T, Osaki M, Shindo H. Multifocal oste<strong>on</strong>ecrosis caused by traumaticpancreatitis in a child. A case report. J B<strong>on</strong>e Joint Surg Am 2009; 91: 2229-31.194. D'Amore L, Venosi S, Gossetti F, Negro A, Vermeil V, M<strong>on</strong>temurro L, Negro P. Abdominal aorticaneurysm following acute pancreatitis. Ann Ital Chir 2008; 79: 367-9.195. Pyun DK, Kim KJ, Ye BD, Bye<strong>on</strong> JS, Myung SJ, Yang SK, Kim JH, Yo<strong>on</strong> SN. Two cases <str<strong>on</strong>g>of</str<strong>on</strong>g>col<strong>on</strong>ic obstructi<strong>on</strong> after acute pancreatitis. Korean J Gastroenterol 2009; 54: 180-5 (in Korean).
196. Park JH, Lee TH, Che<strong>on</strong> SL, Sun JH, Choi IK, Kim YS, Choi YW, Kang YW. Severe acute liverand pancreas damage in anorexia nervosa. Korean J Gastroenterol 2009; 54: 257-60 (in Korean).197. Sanjay P, Yeeting S, Whigham C, Juds<strong>on</strong> HK, Kulli C, Polignano FM, Tait IS. Managementguidelines for gallst<strong>on</strong>e pancreatitis. Are the targets achievable? JOP 2009; 10: 43-7.198. Ainsworth AP, Svendsen LB. Routinely performed endoscopic retrogradecholangiopancreatography should not be recommended for gallst<strong>on</strong>e-induced acute pancreatitis.Ugeskr Laeger 2009; 171: 2566-8 (in Danish).199. Nebiker CA, Frey DM, Hamel CT, Oertli D, Kettelhack C. Early versus delayed cholecystectomyin patients with biliary acute pancreatitis. Surgery 2009; 145: 260-4.200. Manes G, Di Giorgio P, Repici A, Macarri G, Ardizz<strong>on</strong>e S, Porro GB. An analysis <str<strong>on</strong>g>of</str<strong>on</strong>g> the factorsassociated with the development <str<strong>on</strong>g>of</str<strong>on</strong>g> complicati<strong>on</strong>s in patients undergoing precut sphincterotomy: aprospective, c<strong>on</strong>trolled, randomized, multicenter study. Am J Gastroenterol 2009; 104: 2412-7.201. van Santvoort HC, Besselink MG, de Vries AC, Boermeester MA, Fischer K, Bollen TL, CirkelGA, Schaapherder AF, Nieuwenhuijs VB, van Goor H, Dej<strong>on</strong>g CH, van Eijck CH, Witteman BJ,Weusten BL, van Laarhoven CJ, Wahab PJ, Tan AC, Schwartz MP, van der Harst E, Cuesta MA,Siersema PD, Gooszen HG, van Erpecum KJ; Dutch Acute Pancreatitis Study Group. Collaborators(41): van Ramshorst B, Timmer R, Brink MA, Mundt M, Frankhuisen R, C<strong>on</strong>sten EC, Nooteboom A,Jansen JB, B<strong>on</strong>gaerts GT, Buscher HC, Rosman C, Ootes L, Houben B, Ahmed Ali U, Zeguers V,Roeterdink A, Rijnhart HG, van Leeuwen MS, Haasnoot A, Rutten JP, van Dam R, Drixler TA,Spillenaar Bilgen EJ, van Embden P, van Ruler O, Gouma DJ, Bruno MJ, H<str<strong>on</strong>g>of</str<strong>on</strong>g>ker HS, Ploeg RJ, KruijtSpanjer MR, Buitenhuis HT, van Vliet SU, Ramcharan S, Lange JF, Wijffels NA, van Walraven LA,Kubben FJ, van der Wal BC, van 't H<str<strong>on</strong>g>of</str<strong>on</strong>g> G, Kuipers EJ, Poley JW. Early endoscopic retrogradecholangiopancreatography in predicted severe acute biliary pancreatitis: a prospective multicenterstudy. Ann Surg 2009; 250: 68-75.202. Brauer BC, Chen YK, Fukami N, Shah RJ. Single-operator EUS-guidedcholangiopancreatography for difficult pancreaticobiliary access (with video). Gastrointest Endosc2009; 70: 471-9.203. Horakova M, Vadovicova I, Katuscak I, Janik J, Makovnik P, Sadl<strong>on</strong>ova J. C<strong>on</strong>siderati<strong>on</strong> <str<strong>on</strong>g>of</str<strong>on</strong>g>endoscopic retrograde cholangiopancreatography in cases <str<strong>on</strong>g>of</str<strong>on</strong>g> acute biliary pancreatitis. Bratisl LekListy 2009; 110: 553-8.204. Sandzén B, Haapamäki MM, Nilss<strong>on</strong> E, Stenlund HC, Oman M. Cholecystectomy andsphincterotomy in patients with mild acute biliary pancreatitis in Sweden 1988-2003: a nati<strong>on</strong>wideregister study. BMC Gastroenterol 2009; 9: 80.205. Egea Valenzuela J, Belchí Segura E, Sánchez Torres A, Carballo Alvarez F. Acute pancreatitisassociated with hypercalcemia. A report <str<strong>on</strong>g>of</str<strong>on</strong>g> two cases. Rev Esp Enferm Dig 2009; 101: 65-9.206. Phatak UP, Park AJ, Latif SU, Bultr<strong>on</strong> G, Pashankar DS, Husain SZ. Recurrent acute pancreatitisin a child with primary hyperparathyroidism. J Pediatr Endocrinol Metab 2008; 21: 1191-4.207. Benedetti A, Parent ME, Siemiatycki J. Lifetime c<strong>on</strong>sumpti<strong>on</strong> <str<strong>on</strong>g>of</str<strong>on</strong>g> alcoholic beverages and risk <str<strong>on</strong>g>of</str<strong>on</strong>g>13 types <str<strong>on</strong>g>of</str<strong>on</strong>g> cancer in men: results from a case-c<strong>on</strong>trol study in M<strong>on</strong>treal. Cancer Detect Prev 2009;32: 352-62.208. P<strong>on</strong>gprasobchai S, Thamcharoen R, Manatsathit S. Changing <str<strong>on</strong>g>of</str<strong>on</strong>g> the etiology <str<strong>on</strong>g>of</str<strong>on</strong>g> acutepancreatitis after using a systematic search. J Med Assoc Thai 2009; 92 Suppl 2: S38-42.209. Nordback I, Pelli H, Lappalainen-Lehto R, Järvinen S, Räty S, Sand J. <strong>The</strong> recurrence <str<strong>on</strong>g>of</str<strong>on</strong>g> acutealcohol-associated pancreatitis can be reduced: a randomized c<strong>on</strong>trolled trial. Gastroenterology 2009;136: 848-55.
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REVIEW OF LITERATURE ONCLINICAL PAN
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ABBREVIATIONAAPacute alcoholicABPac
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FMF AIPfocal mass-forming autoimmun
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ODPopen distal pancreatectomyOForga
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USUTDTVESDVTEZESWHOXIAPUnited State
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Ectopic pancreasCircumportal annula
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SymptomsEndocopic ultrasography (EU
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HSP27HuRIGF-1 receptorIntegrinesInt
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HemodialysisSerous cystadenomasSero
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CRPC-reactive proteinCRTchemoradiot
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ITNPintrathecal narcotics pumpJCGAI
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QSRquantitative systematic
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PANCREATIC HISTORYEarly conceptsPan
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derived from broadly Harveian anato
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acute appendicitis, intestinal obst
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dogma and its implied presence <str
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In the late 19th century, explorato
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performed. In 1880, Carl Thiersch <
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cancer was reported by Nestor Dimit
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Modern pancreatic historyHoward Reb
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PANCREATIC DEVELOPMENT, EMBRYOLOGY
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preparations. They were also employ
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pancreas can be diagnosed without t
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PANCREATIC PHYSIOLOGYSphincter <str
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acid profile and d
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hormones. The roles of</str
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ACUTE PANCREATITISAcute pancreatiti
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necrosis or a severe course, and lo
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of 245 cases <stro
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plasty of the mino
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no significant difference. The stro
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Urinary trypsinogen-2There is not a
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groups. None of th
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evaluated the presence or absence <
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adical, etc, further studies are st
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Precut at sphincterotomyPrecut is p
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indications [204].Hypercalcemia-ind
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endoscopic retrograde cholangiopanc
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(before ERCP), serum TAP was detect
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concentration and clinical symptoms
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However, the recipients of<
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less safe for predominantly cephali
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increased mortality. Mortality in p
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Epidemiology and demographyChinaCHR
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for the first time the significance
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endoscopic ultrasound accurately de
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possible to at least reduce relapse
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etiologies have been proposed and a
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patients, can be performed with mod
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negative binomial model. One hundre
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Halofuginone did n
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years, the risk of
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patients with a proven exocrine pan
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high-risk patients [296].Cystic fib
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TNF-alpha promoter were performed.
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were validated in another series <s
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vascular invasion (14/15). Abnormal
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and other lymph nodes, salivary gla
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HEREDITARY PANCREATITISPatients wit
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Classification of
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historically, but recent life-style
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carcinogen exposure with cancer ris
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the risk of pancre
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conducted a cohort analysis <strong
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emain to be solved in screening for
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considered for women with Lynch syn
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Annexin A5Protein misfolding is a c
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CTNNB1To use fluorescence in situ h
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expression was not associated with
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(ECM) are not fully understood. In
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lines. However, the role of
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andomized to high-dose vitamin A, t
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Synuclein-gammaPerineural invasion
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interventions. Cancer nests were ma
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the optimal combination of<
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which is essential in tumor and nod
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provide conclusive evidence for the
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MD-CT is suitable for evaluating tu
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approved study and imaged during sh
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Quantum dotsIt was reported the suc
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clearly have a very high incidence
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patients for operation and when cou
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demonstrated using the confocal mic
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cancer [468].To evaluate pancreatic
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pancreaticoduodenectomy (PD). The s
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safe option as an interposition gra
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a curative surgery, while double-by
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%), pseudocyst (3 %), and trauma (3
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procedure is failing to progress la
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Glucos metabolism after pancreatect
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Quality of lifeOne
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was observed in the NACRT group. Th
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interval 0.80 to 0.96]. On subgroup
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ate in patients with pancreatic can
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median survival time was 7 versus 7
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and the endoscopic ultrasound-guide
- Page 193 and 194: local recurrence of</strong
- Page 195 and 196: CurcuminCurcumin has been shown to
- Page 197 and 198: size >1.5 cm (odds ratio 2.4), and
- Page 199 and 200: adenocarcinoma must be addressed at
- Page 201 and 202: Molecular biologyCD44v6The purpose
- Page 203 and 204: IPMN were studied. Two-dimensional
- Page 205 and 206: the NT-IPMN-Br group. Eleven patien
- Page 207 and 208: metastatic neoplasms showing cystic
- Page 209 and 210: Solid pseudopapillary neoplasms <st
- Page 211 and 212: The tumor cells were negative for p
- Page 213 and 214: Duodenal tumorsColorectal polyposis
- Page 215 and 216: Colorectal carcinomaPancreatic meta
- Page 217 and 218: It was described a case of<
- Page 219 and 220: evaluation. The purpose of<
- Page 221 and 222: perforation of a p
- Page 223 and 224: the 28 had pancreatic duct injury <
- Page 225 and 226: ENDOCRINE PANCREATIC TUMORSHistoryA
- Page 227 and 228: 25-111 pg/mL). Mean Hemoglobin A1C
- Page 229 and 230: clinical features, misdiagnosis occ
- Page 231 and 232: achieved in selected cases by tissu
- Page 233 and 234: Overall survivalPancreatic neuroend
- Page 235 and 236: REFERENCES001. Metter CC. History <
- Page 237 and 238: 044. Fitz RH. The symptomatology an
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