210. Pelli H, Lappalainen-Lehto R, Piir<strong>on</strong>en A, Järvinen S, Sand J, Nordback I. Pancreatic damageafter the first episode <str<strong>on</strong>g>of</str<strong>on</strong>g> acute alcoholic pancreatitis and its associati<strong>on</strong> with the later recurrence rate.Pancreatology 2009; 9: 245-51.211. Martinez-Torres H, Rodriguez-Lomeli X, Davalos-Cobian C, Garcia-Correa J, Mald<strong>on</strong>ado-Martinez JM, Medrano-Muñoz F, Fuentes-Orozco C, G<strong>on</strong>zalez-Ojeda A. Oral allopurinol to preventhyperamylasemia and acute pancreatitis after endoscopic retrograde cholangiopancreatography.World J Gastroenterol 2009; 15: 1600-6.212. Matsushita M, Takakuwa H, Shimeno N, Uchida K, Nishio A, Okazaki K. Epinephrine sprayed <strong>on</strong>the papilla for preventi<strong>on</strong> <str<strong>on</strong>g>of</str<strong>on</strong>g> post-ERCP pancreatitis. J Gastroenterol 2009; 44: 71-5.213. Sherman S, Cheng CL, Costamagna G, Binmoeller KF, Puespoek A, Aithal GP, Kozarek RA,Chen YK, Van Steenbergen W, Tenner S, Freeman M, M<strong>on</strong>roe P, Geffner M, Deviere J. Efficacy <str<strong>on</strong>g>of</str<strong>on</strong>g>recombinant human interleukin-10 in preventi<strong>on</strong> <str<strong>on</strong>g>of</str<strong>on</strong>g> post-endoscopic retrogradecholangiopancreatography pancreatitis in subjects with increased risk. Pancreas 2009; 38: 267-74.214. Bai Y, Gao F, Gao J, Zou DW, Li ZS. Prophylactic antibiotics cannot prevent endoscopicretrograde cholangiopancreatography-induced cholangitis: a meta-analysis. Pancreas 2009; 38: 126-30.215. Bai Y, Gao F, Gao J, Zou DW, Li ZS. Prophylactic antibiotics cannot prevent endoscopicretrograde cholangiopancreatography-induced cholangitis: a meta-analysis. Pancreas 2009; 38: 126-30.216. Pezzilli R, Mariani A, Gabbrielli A, Morselli-Labate AM, Barassi A. Serum and urine trypsinogenactivati<strong>on</strong> peptide in assessing post-endoscopic retrograde cholangiopancreatography pancreatitis.Pancreatology 2009; 9: 108-9 (letter).217. Mast JJ, Morak MJ, Brett BT, van Eijck CH. Ischemic acute necrotizing pancreatitis in a marath<strong>on</strong>runner. JOP 2009; 10: 53-4.218. Sasaki Y, Aoki S, Aoki K, Achiwa K, Yama T, Kubota M, Ishikawa D, Mizutani T, Kunii S,Watanabe K, Okumura A. Acute pancreatitis associated with the administrati<strong>on</strong> <str<strong>on</strong>g>of</str<strong>on</strong>g> ceftriax<strong>on</strong>e in anadult patient. Nipp<strong>on</strong> Shokakibyo Gakkai Zasshi 2009; 106: 569-75 (in Japanese).219. Lee KH, Shelat VG, Low HC, Ho KY, Diddapur RK. Recurrent pancreatitis sec<strong>on</strong>dary topancreatic ascariasis. Singapore Med J 2009; 50: 218-9.220. Turkulov V, Madle-Samardzija N, Canak G, Gavrancić C, Vukadinov J, Doder R. Various <strong>clinical</strong>manifestati<strong>on</strong>s <str<strong>on</strong>g>of</str<strong>on</strong>g> brucellosis infekti<strong>on</strong>. Med Pregl 2008; 61: 517-20 (in Serbian).221. Baburaj P, Ant<strong>on</strong>y T, Louis F, Harikrishnan BL. Acute abdomen due to acute pancreatitis - a rarepresentati<strong>on</strong> <str<strong>on</strong>g>of</str<strong>on</strong>g> leptospirosis. Assoc Physicians India 2008; 56: 911-2.222. Petrov MS, Loveday BP, Pylypchuk RD, McIlroy K, Phillips AR, Windsor JA. Systematic <str<strong>on</strong>g>review</str<strong>on</strong>g>and meta-analysis <str<strong>on</strong>g>of</str<strong>on</strong>g> enteral nutriti<strong>on</strong> formulati<strong>on</strong>s in acute pancreatitis. Br J Surg 2009; 96: 1243-52.223. Hen K, Bogdański P, Pupek-Musialik D. Successful treatment <str<strong>on</strong>g>of</str<strong>on</strong>g> severe hypertriglyceridemia withplasmapheresis – case report. Pol Merkur Lekarski 2009; 26: 62-4 (in Polish).224. Ishikawa T, Imai M, Kamimura H, Ushiki T, Tsuchiya A, Togashi T, Watanabe K, Seki K, Ohta H,Yoshida T, Kamimura T. <strong>The</strong>rapeutic efficacy <str<strong>on</strong>g>of</str<strong>on</strong>g> c<strong>on</strong>tinuous arterial infusi<strong>on</strong> <str<strong>on</strong>g>of</str<strong>on</strong>g> the protease inhibitorand the antibiotics and via celiac and superior mesenteric artery for severe acute pancreatitis – pilotstudy. Hepatogastroenterology 2009; 56: 524-8.225. Yang C, Guanghua F, Wei Z, Zh<strong>on</strong>g J, Penghui J, Xin F, Xiping Z. Combinati<strong>on</strong> <str<strong>on</strong>g>of</str<strong>on</strong>g> hem<str<strong>on</strong>g>of</str<strong>on</strong>g>iltrati<strong>on</strong>and perit<strong>on</strong>eal dialysis in the treatment <str<strong>on</strong>g>of</str<strong>on</strong>g> severe acute pancreatitis. Pancreatology 2009; 9: 16-9.
226. Botoi G, Andercou A. Early and prol<strong>on</strong>ged perit<strong>on</strong>eal lavage with laparoscopy in severe acutepancreatitis. Chirurgia 2009; 104: 49-53 (in Romanian).227. Besselink MG, van Santvoort HC, Boermeester MA, Nieuwenhuijs VB, van Goor H, Dej<strong>on</strong>g CH,Schaapherder AF, Gooszen HG; Dutch Acute Pancreatitis Study Group.Collaborators (53). Timing andimpact <str<strong>on</strong>g>of</str<strong>on</strong>g> infecti<strong>on</strong>s in acute pancreatitis. Br J Surg 2009; 96: 267-73.228. Besselink MG, van Santvoort HC, Renooij W, de Smet MB, Boermeester MA, Fischer K,Timmerman HM, Ahmed Ali U, Cirkel GA, Bollen TL, van Ramshorst B, Schaapherder AF, WittemanBJ, Ploeg RJ, van Goor H, van Laarhoven CJ, Tan AC, Brink MA, van der Harst E, Wahab PJ, vanEijck CH, Dej<strong>on</strong>g CH, van Erpecum KJ, Akkermans LM, Gooszen HG; Dutch Acute Pancreatitis StudyGroup. Intestinal barrier dysfuncti<strong>on</strong> in a randomized trial <str<strong>on</strong>g>of</str<strong>on</strong>g> a specific probiotic compositi<strong>on</strong> in acutepancreatitis. Ann Surg 2009; 250: 712-9.229. Koretz RL. Probiotics, critical illness, and methodologic bias. Nutr Clin Pract 2009; 24: 45-9.230. Marusić S, Sićaja M, Kujundzić M, Banić M, Jaksić O, Vrazić H. <strong>The</strong> utilizati<strong>on</strong> <str<strong>on</strong>g>of</str<strong>on</strong>g> antibiotics in themanagement <str<strong>on</strong>g>of</str<strong>on</strong>g> acute pancreatitis – experience from <strong>on</strong>e transiti<strong>on</strong>al country university hospital. CollAntropol 2008; 32: 1189-94.231. Navaneethan U, Vege SS, Chari ST, Bar<strong>on</strong> TH. Minimally invasive techniques in pancreaticnecrosis. Pancreatology 2009; 9: 867-75.232. Becker V, Huber W, Meining A, Prinz A, Umgelter A, Ludwig L, Bajbouj M, Gaa J, Schmid RM.Infected necrosis in severe pancreatitis – combined n<strong>on</strong>surgical multi-drainage with directedtransabdominal high-volume lavage in critically ill patients. Pancreatology 2009; 9: 280-6.233. Babu BI, Siriwardena AK. Practical strategies for case selecti<strong>on</strong> in minimally invasivenecrosectomy. Pancreatology 2009; 9: 9-12.234. Hasibeder WR, Torgersen C, Rieger M, Dünser M. Critical care <str<strong>on</strong>g>of</str<strong>on</strong>g> the patient with acutepancreatitis. Anaesth Intensive Care 2009; 37: 190-206.235. Kvinlaug K, Kriegler S, Moser M. Emphysematous pancreatitis: a less aggressive form <str<strong>on</strong>g>of</str<strong>on</strong>g> infectedpancreatic necrosis? Pancreas 2009; 38: 667-71.236. Neri V, Ambrosi A, Fersini A, Tartaglia N, Valentino TP. Minimally invasive treatment <str<strong>on</strong>g>of</str<strong>on</strong>g> acuteintrahepatic fluid collecti<strong>on</strong>s with acute biliary pancreatitis. JSLS 2009; 13: 269-72.237. Coelho D, Ardengh JC, Eulálio JM, Manso JE, Mönkemüller K, Coelho JF. Management <str<strong>on</strong>g>of</str<strong>on</strong>g>infected and sterile pancreatic necrosis by programmed endoscopic necrosectomy. Dig Dis 2008; 26:364-9.238. Prochazka V, Al-Eryani S, Herman M. Endoscopic treatment <str<strong>on</strong>g>of</str<strong>on</strong>g> multiple pancreatic abscessescase report and <str<strong>on</strong>g>review</str<strong>on</strong>g> <str<strong>on</strong>g>of</str<strong>on</strong>g> the <str<strong>on</strong>g>literature</str<strong>on</strong>g>. Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub2009; 153: 27-30.239. Rocha FG, Benoit E, Zinner MJ, Whang EE, Banks PA, Ashley SW, Mortele KJ. Impact <str<strong>on</strong>g>of</str<strong>on</strong>g>radiologic interventi<strong>on</strong> <strong>on</strong> mortality in necrotizing pancreatitis: the role <str<strong>on</strong>g>of</str<strong>on</strong>g> organ failure. Arch Surg 2009;144: 261-5.240. Pezzilli R, Morselli-Labate AM, Campana D, Casadei R, Brocchi E, Corinaldesi R. Evaluati<strong>on</strong> <str<strong>on</strong>g>of</str<strong>on</strong>g>patient-reported outcome in subjects treated medically for acute pancreatitis: a follow-up study.Pancreatology 2009; 9: 375-82.241. Jha RK, Ma Q, Sha H, Palikhe M. Protective effect <str<strong>on</strong>g>of</str<strong>on</strong>g> resveratrol in severe acute pancreatitisinducedbrain injury. Pancreas 2009; 38: 947-53.
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REVIEW OF LITERATURE ONCLINICAL PAN
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ABBREVIATIONAAPacute alcoholicABPac
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FMF AIPfocal mass-forming autoimmun
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ODPopen distal pancreatectomyOForga
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USUTDTVESDVTEZESWHOXIAPUnited State
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Ectopic pancreasCircumportal annula
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SymptomsEndocopic ultrasography (EU
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HSP27HuRIGF-1 receptorIntegrinesInt
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HemodialysisSerous cystadenomasSero
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CRPC-reactive proteinCRTchemoradiot
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ITNPintrathecal narcotics pumpJCGAI
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QSRquantitative systematic
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PANCREATIC HISTORYEarly conceptsPan
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derived from broadly Harveian anato
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acute appendicitis, intestinal obst
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dogma and its implied presence <str
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In the late 19th century, explorato
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performed. In 1880, Carl Thiersch <
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cancer was reported by Nestor Dimit
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Modern pancreatic historyHoward Reb
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PANCREATIC DEVELOPMENT, EMBRYOLOGY
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preparations. They were also employ
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pancreas can be diagnosed without t
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PANCREATIC PHYSIOLOGYSphincter <str
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acid profile and d
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hormones. The roles of</str
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ACUTE PANCREATITISAcute pancreatiti
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necrosis or a severe course, and lo
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of 245 cases <stro
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plasty of the mino
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no significant difference. The stro
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Urinary trypsinogen-2There is not a
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groups. None of th
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evaluated the presence or absence <
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adical, etc, further studies are st
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Precut at sphincterotomyPrecut is p
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indications [204].Hypercalcemia-ind
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endoscopic retrograde cholangiopanc
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(before ERCP), serum TAP was detect
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concentration and clinical symptoms
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However, the recipients of<
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less safe for predominantly cephali
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increased mortality. Mortality in p
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Epidemiology and demographyChinaCHR
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for the first time the significance
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endoscopic ultrasound accurately de
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possible to at least reduce relapse
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etiologies have been proposed and a
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patients, can be performed with mod
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negative binomial model. One hundre
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Halofuginone did n
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years, the risk of
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patients with a proven exocrine pan
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high-risk patients [296].Cystic fib
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TNF-alpha promoter were performed.
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were validated in another series <s
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vascular invasion (14/15). Abnormal
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and other lymph nodes, salivary gla
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HEREDITARY PANCREATITISPatients wit
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Classification of
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historically, but recent life-style
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carcinogen exposure with cancer ris
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the risk of pancre
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conducted a cohort analysis <strong
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emain to be solved in screening for
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considered for women with Lynch syn
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Annexin A5Protein misfolding is a c
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CTNNB1To use fluorescence in situ h
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expression was not associated with
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(ECM) are not fully understood. In
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lines. However, the role of
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andomized to high-dose vitamin A, t
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Synuclein-gammaPerineural invasion
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interventions. Cancer nests were ma
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the optimal combination of<
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which is essential in tumor and nod
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provide conclusive evidence for the
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MD-CT is suitable for evaluating tu
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approved study and imaged during sh
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Quantum dotsIt was reported the suc
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clearly have a very high incidence
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patients for operation and when cou
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demonstrated using the confocal mic
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cancer [468].To evaluate pancreatic
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pancreaticoduodenectomy (PD). The s
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safe option as an interposition gra
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a curative surgery, while double-by
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%), pseudocyst (3 %), and trauma (3
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procedure is failing to progress la
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Glucos metabolism after pancreatect
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Quality of lifeOne
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was observed in the NACRT group. Th
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interval 0.80 to 0.96]. On subgroup
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ate in patients with pancreatic can
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median survival time was 7 versus 7
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and the endoscopic ultrasound-guide
- Page 193 and 194:
local recurrence of</strong
- Page 195 and 196: CurcuminCurcumin has been shown to
- Page 197 and 198: size >1.5 cm (odds ratio 2.4), and
- Page 199 and 200: adenocarcinoma must be addressed at
- Page 201 and 202: Molecular biologyCD44v6The purpose
- Page 203 and 204: IPMN were studied. Two-dimensional
- Page 205 and 206: the NT-IPMN-Br group. Eleven patien
- Page 207 and 208: metastatic neoplasms showing cystic
- Page 209 and 210: Solid pseudopapillary neoplasms <st
- Page 211 and 212: The tumor cells were negative for p
- Page 213 and 214: Duodenal tumorsColorectal polyposis
- Page 215 and 216: Colorectal carcinomaPancreatic meta
- Page 217 and 218: It was described a case of<
- Page 219 and 220: evaluation. The purpose of<
- Page 221 and 222: perforation of a p
- Page 223 and 224: the 28 had pancreatic duct injury <
- Page 225 and 226: ENDOCRINE PANCREATIC TUMORSHistoryA
- Page 227 and 228: 25-111 pg/mL). Mean Hemoglobin A1C
- Page 229 and 230: clinical features, misdiagnosis occ
- Page 231 and 232: achieved in selected cases by tissu
- Page 233 and 234: Overall survivalPancreatic neuroend
- Page 235 and 236: REFERENCES001. Metter CC. History <
- Page 237 and 238: 044. Fitz RH. The symptomatology an
- Page 239 and 240: 089. McClusky DA, Skandalakis LJ, C
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