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Name (Title):
Yufang Zhu (ICYS-Sengen researcher)
Affiliation:
International Center for Young Scientists (Sengen), MINS
Address:
1-2-1 Sengen, Tsukuba, Ibaraki, 305-0047, Japan
Email: ZHU.Yufang@nims.go.jp
Home Page:
Presentation Title:
An Efficient Route to Rattle-type Fe3O4@SiO2 Hollow Mesoporous Spheres Using Colloidal
Carbon Spheres Templates
Abstract:
In the last few years, more and more reports on
mesoprous silica based drug delivery systems have been
produced [1] , because amorphous mesoporous silica
materials are a kind of satisfactory drug carrier with the
non-toxic nature, adjustable pore diameter, and very
high specific surface area with abundant Si-OH bonds
on the pore surface. The studies showed that the
mesoporous silica spheres with hollow core/mesoporous
shell provide much higher drug loading capacity than
the conventional mesoporous silica such as MCM-41
and SBA-15, and they also have the sustained release
property [2] . Furthermore, microspheres are widely
accepted as useful drug delivery systems because they
can be ingested or injected and present a homogeneous
morphology. On the other hand, the superparamagnetic
properties of the magnetic nanoparticles (such as Fe3O4,
Poster Session PIR-8
Fig. 1 SEM and TEM images of Fe3O4@SiO2
hollow mesoporous spheres
γ-Fe2O3 and FePt) are of great interest for drug delivery [3] . They can carry the drugs and be guided
to the targeted organs or locations inside the body, which will facilitate the therapeuthic
efficiency and avoid the damage of normal organs or tissues due to the drug toxicity before
targeting the desired positions.
Obviously, to combine the magnetic nanoparticles and hollow mesoporous silica spheres to
form rattle-type magnetic core/mesoporous shell silica spheres will realize high drug loading and
the magnetic targeting delivery. Here we reported an efficient route to prepare rattle-type
Fe3O4@SiO2 hollow mesoporous spheres with the large cavities by using colloidal carbon spheres
as the templates.
References:
[1] M.Vallet-Regí, A.Rámila, R. P. Del Real, J. Pérez-Pariente, Chem. Mater. 13 (2001) 308.
[2] Y. Zhu, J. Shi, W. Shen, X. Dong, J. Feng, M. Ruan, Y. Li, Angew. Chem. Int. Ed. 44 (2005)
5083.
[3] A. Lübbe, C. Bergemann, J. Brock, D. G. McClure, J. Magn. Magn. Mater. 194 (1999) 149.
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