Duke University 2009-2010 - Office of the Registrar - Duke University

faculty include contaminant hydrology, crustal fluids, environmental geophysics, hydrogeology, mathematical models
of multiphase transport, waste treatment, and watershed hydrology. The broad range of faculty expertise in hydrology
allows graduate students to obtain well-balanced training in the classroom. The Center for Hydrologic Science
represents Duke University as a Member of the Consortium of Universities for the Advancement of Hydrologic
Science, Inc. (CUAHSI).
The center offers fellowships for graduate study in hydrology and organizes a lecture series that attracts speakers
of international stature. Monthly brown bag colloquia are organized for student and faculty presentations from Duke,
as well as from nearby University of North Carolina and North Carolina State University. For students engaged in PhD
research, the center offers a certificate in hydrology that is granted in addition to the PhD in their host department.
Further information on the Center for Hydrologic Science and its certificate program may be obtained via mail (Center
for Hydrologic Science, Box 90287, Duke University, Durham, NC 27708-0287), e-mail (Miguel.Medina@duke.edu).
Immunology
Professor Krangel, Interim Chair (318 Jones); Associate Professor Zhuang, Director of Graduate Studies (328 Jones);
Professors Abraham, Buckley, Burks, Chao, Coffman, Cousins, Frank, Hall, Haynes, Hoffman, Kelsoe, Kepler,
Krangel, Lefkowitz, Lyerly, Pisetsky, St.Clair, Tedder, Weinberg, Weinhold; Associate Professors Clay, Gunn, He,
Levesque, Kondo, Markert, Staats, Szabolcs, Tomaras, Yang, Zhang, Zhong, Zhuang; Assistant Professors Cowell, Li,
Lin, Rathmell, Shinohara, Taylor, Unniraman; Associate Research Professor Sarzotti-Kelsoe; Assistant Research
Professors Haas, Poe, Williams, Zhu; Adjunct Professor Barker; Adjunct Assistant Professors Cook, Demarest, Gray,
Sarafova
Immunology is the study of the cells, proteins, and genes that protect against infection and malignancy.
Immunology encompasses innate and natural, nonspecific defense mechanisms, as well as specific immune responses
that generate immunologic memory. The department’s focus is on lymphocytes, and their cellular biology, physiology,
genetics and development. Immunology is by its nature a bridging science. The roots of immunology lie in the study
of infectious disease, vaccine development, organ transplantation, immunity to malignancy, and immunotherapy.
Modern research in immunology draws on recent advances in cell and molecular biology, biochemistry, genomics and
informatics to determine how the immune system functions. In turn, immunology has contributed to understanding
biological structure, eukaryotic gene organization and expression, signal transduction, and intracellular protein
transport and assembly.
The Department of Immunology offers graduate work leading to the PhD degree. Research programs are available
in many aspects of molecular and cellular immunology, including immunogenetics. The department is a participating
member in the following University Programs: Cell and Molecular Biology, Genetics, the Medical Scientist Training
Program, and the Developmental Biology Training Program.
The Department of Immunology has outstanding facilities for carrying out all aspects of immunologic research. A
description of the PhD program, prerequisites for admission, and research in the department may be found at: http://
immunology.mc.duke.edu or by e-mailing dgs-immunology@duke.edu.
Immunology (IMMUNOL)
201. Laboratory Rotation. Laboratory rotation for first year Immunology graduate students, first semester. Department
consent required. Instructor: Staff. 1 unit.
202. Laboratory Rotation. Laboratory rotation for first year Immunology graduate students, second semester.
Department consent required. Instructor: Staff. 1 unit.
213S. Computational Immunology. 3 units. C-L: see Computational Biology and Bioinformatics 223
244. Principles of Immunology. An introduction to the molecular and cellular basis of the immune response. Topics
include anatomy of the lymphoid system, lymphocyte biology, antigen-antibody interactions, humoral and cellular
effector mechanisms, and control of immune responses. Prerequisites: Biology 119 and Chemistry 151L or equivalents.
Instructors: He and Zhang. 3 units. C-L: Biology 244
258. Structural Biochemistry I. 2 units. C-L: see Biochemistry 258; also C-L: Cell and Molecular Biology 258, Cell
Biology 258, University Program in Genetics 258, Structural Biology and Biophysics 258, Computational Biology and
Bioinformatics 258
259. Structural Biochemistry II. 2 units. C-L: see Biochemistry 259; also C-L: Cell Biology 259, Computational
Biology and Bioinformatics 259, Structural Biology and Biophysics 259, University Program in Genetics 259
268. Biochemical Genetics II: From RNA to Protein. 2 units. C-L: see Biochemistry 268; also C-L: Cell Biology 268,
University Program in Genetics 268
291. Comprehensive Immunology. An intensive course in the biology of the immune system and the structure and
function of its component parts. Major topics discussed are: properties of antigens; specificity of antibody molecules
and their biologic functions; cells and organs of the lymphoid system; structure and function of complement;
inflammation and nonspecific effector mechanisms; cellular interactions and soluble mediators in lymphocyte
activation, replication, and differentiation; regulation of immune responses; molecular structure and genetic
organization of immunoglobulins, histocompatibility antigens, and T-cell receptor. Required course for all students
Departments, Programs, and Course Offerings 149