Duke University 2009-2010 - Office of the Registrar - Duke University

video imaging, Typhoon Trio phosphorimaging station, four-color fluorescent scanning/multiplexing, zebrafish
facility, mouse genetics, and micromanipulation
The Department of Cell Biology participates in several university-wide interdisciplinary training programs,
including genetics, cell and molecular biology, developmental biology, neurobiology, pharmacology, cancer biology,
biomedical engineering, and toxicology. Admission to graduate training in cell biology is through one of these
interdisciplinary training programs. For more information, contact the director of graduate studies (see above).
Cell Biology (CELLBIO)
200. Cell and Tissue Biology. This is the introductory medical school and graduate course in microscopic anatomy.
Students participate in lectures and laboratories on the structure and function of cells and tissues of the body. The courses
provides practical experience in the use of the light microscope analyzing an extensive slide collection of mammalian
tissues. 3 credits. McIntosh and staff. 3 units.
201. Microscopic Anatomy. Histology of all major organs of the body. Structure and cell biology at both the level of
the light and electron microscope. 3 credits. McIntosh and staff. 3 units.
202. Medical Physiology. Medical and graduate level course on organ and cell physiology. Human and medical aspects
are stressed. 4 credits. Anderson and staff. 4 units.
203. Introduction to Physiology. Modern organ physiology; cellular physiology, organ system physiology including
cardiovascular, respiratory, renal gastrointestinal, endocrine, reproductive, muscle and nervous. Mini course.
Prerequisite: elementary biology. Instructors: Jakoi and Vigna. 3 units.
206. Physiology and Medicine of Extreme Environments. Advanced topics in the physiology and medicine of ambient
pressure, immersion, gravity, temperature, and gas composition. Environments considered include: diving and
hyperbaric medicine; hot/cold terrestrial and water operations; microgravity and high-g acceleration; high altitude.
Basic mechanisms and medical management of : decompression sickness; altitude sickness; hypothermia and
hyperthermia; hypoxia; carbon monoxide poisoning; oxygen toxicity. Practical applications: pressure vessel design and
operation; life support equipment; cardiorespiratory physiology measurements at low and high pressure, simulated dive
and flight (optional.) Prerequisites: Human anatomy and physiology. Instructor: Staff. 3 units.
208. Stem Cell Course. The course is designed for first-year graduate students to learn the fundamentals of stem cell
biology and to gain familiarity with current research in the field. The course will be presented in a lecture and discussion
format based on the primary literature. Topics include: stem cell concepts, methodologies for stem cell research,
embryonic stem cells, adult stem cells, cloning and stem cell reprogramming and clinical applications of stem cell
research. Prerequisites: undergraduate level cell biology, molecular biology, and genetics. Instructors: Hogan and Reya.
3 units. C-L: Molecular Cancer Biology 208, Pharmacology and Cancer Biology 208
210. Research Independent Study. Individual Research in a field of special interest under the supervision of a faculty
member, the central goal of which is a substantive paper or written report containing significant analysis and interpretation
of a previously approved topic. Consent of instructor required. Instructor: Staff. Variable credit. C-L: Marine
Sciences
241. Cell Biological Processes. This course is a graduate level introduction to the molecular mechanisms that underlie
cellular processes and the experimental techniques used in cell biological research. The lectures will address the
processes that cells use to organize themselves into tissues and organs, communicate through second messengers,
generate specialized compartments for protein segregation, process information, move and differentiate will be
addressed. Preparatory for CBI 251 and CBI 280. Minicourse, 1st half-semester. Instructor: Schachat. 2 units.
243. Respiratory Proteins and the Environment. Structure, function and evolution of copper and iron based respiratory
proteins in response to environmental oxygen levels and physiological needs. Lectures and readings on the balance
between pathways for metabolic oxygen utilization and alternative disease-causing pathways involving oxidative and
nitrosative reactions. Interactive molecular graphics and student presentations supplement text and lectures. Covers
molecular adaptations, circulation, allostery, reaction kinetics and thermodynamics, reactive oxygen and nitrogen
species, gene expression, blood pathogens, malaria, sickle cell anemia. (Given at Beaufort) Instructor: C. Bonaventura.
3 units. C-L: Environment 243, Marine Sciences
258. Structural Biochemistry I. 2 units. C-L: see Biochemistry 258; also C-L: Cell and Molecular Biology 258,
University Program in Genetics 258, Immunology 258, Structural Biology and Biophysics 258, Computational Biology
and Bioinformatics 258
259. Structural Biochemistry II. 2 units. C-L: see Biochemistry 259; also C-L: Immunology 259, Computational
Biology and Bioinformatics 259, Structural Biology and Biophysics 259, University Program in Genetics 259
268. Biochemical Genetics II: From RNA to Protein. 2 units. C-L: see Biochemistry 268; also C-L: Immunology 268,
University Program in Genetics 268
280. Student Seminar. Preparation and presentation of seminars to students and faculty on topics of broad interest to
cell biology and physiology. Required of Department of Cell Biology students. Instructor: Staff. 1 unit.
282. Mechanisms of Development/Developmental Genetics. Half-semester minicourse targeted to first-year graduate
students in the Biological Sciences. Taught sequentially in the Fall semester with Biology 283. Introduces basic
Departments, Programs, and Course Offerings 73