Duke University 2009-2010 - Office of the Registrar - Duke University

concepts of cell specification, morphogenesis, induction, and other mechanisms that enable cells, tissues and organs to
assemble the animal. Emphasis is on model organisms, mainly Drosophila, C. elegans, mouse, and zebrafish, where
genomics, mutations, gene modifiers, epistasis analyses, gene knockouts, and transgenesis, plus many other genetic
approaches have yielded important insights into the differentiation of cells and the development of complex organisms.
Cross-listed with Biology 282. Instructors: Kirby, Klingensmith, and McClay. 2 units. C-L: Biology 282
283. Developmental Genetics. Half-semester mini-course targeted to first year graduate students in the Biological
Sciences. Taught sequentially in the Fall semester with Biology 282. Focuses on genetic approaches to solve
mechanistic problems of development. Emphasis is on model organisms, mainly Drosophilia, C. elegans, mouse and
zebrafish, where genomics, mutations, gene modifiers, epistasis analysis, gene knockouts, and transgenesis, plus many
other genetic approaches have yielded important insights into the differentiation of cell and the development of complex
organisms. Cross-listed with Biology 283. Instructors: Kirby, Klingensmith, and McClay. 2 units. C-L: Biology 283
296. Developmental Biology Colloquium. Instructor: Staff. 3 units.
301. Human Structure & Function. Core course of preclinical curriculum presents scientific principles underlying
structure and function of the normal human body. Focuses on gross anatomy, microscopic anatomy, and physiology of
nine organ systems providing the foundation for the practice of medicine. Registration of non-Pathologist's Assistant
students requires permission of Course Director. Instructor: Jakoi and Staff. 12 units.
312. Research. Specific areas of investigation include: membrane structure; extracellular matrix; cell adhesion; cell
motility; cytoskeletal elements; chromosome structure and movement; genetics and molecular biology of contractile
proteins; muscle ultrastructure; gamete biology; molecular and structural biology of photoreceptors; hormone receptors;
cell growth; developmental biology; membrane transport and electrophysiology; metabolism; cardiovascular
physiology; microcirculation; hyperbaric physiology; and theoretical studies and computer modeling of physiological
processes. Instructor: Staff. Variable credit.
320. Research Problems in Cell Biology. Coverage of selected topics important in current cell biology research. Format
includes faculty lectures and directed readings of current research papers presented and discussed by students.
Instructor: Hogan and staff. 3 units.
346. The Mouse as a Model Organism. Graduate level introduction to the mouse as a model system. Course will cover
embryology, genetics, and molecular manipulation of the mouse embryo. Suitable for students who plan to focus on
mouse development and for those who plan to use the mouse to address a biological problem. Minicourse 2nd halfsemester.
Instructor: Capel. 2 units. C-L: University Program in Genetics 346
417. Cellular Signaling. Mechanism of action of hormones at the cellular level including hormone-receptor interactions,
secondary messenger systems for hormones, mechanisms of regulation of hormone responsiveness, regulation of
growth, differentiation and proliferation, mechanisms of transport and ion channels, stimulus sensing and transduction.
Some lectures stress the clinical correlation of the basic course concepts. Instructor: Caron, Casey, Means, and invited
lecturers. 3 units. C-L: Biochemistry 417, Molecular Cancer Biology 417, Pharmacology and Cancer Biology 417
Cell and Molecular Biology (Certificate Program)
Daniel Lew, Director (Department of Pharmacology and Cancer Biology); Meta Kuehn, Director of Graduate Studies
(Department of Biochemistry); 134 participating faculty
Research training in cell, developmental, and molecular biology is found in one of eight departments/programs at
Duke University: Biochemistry, Biology, Cell Biology, Immunology, Molecular Genetics and Microbiology,
Neurobiology, Pathology and Pharmacology, and Cancer Biology. To effectively utilize this broad spectrum of
expertise for the training of promising scientists while still providing a coherent curriculum, the Duke University
Program in Cell and Molecular Biology has been established, bringing together the research foci of approximately 144
faculty.
The program offers a certificate of graduate studies, with the doctoral degree awarded by the chosen Department.
Students admitted to CMB have up to one academic year to affiliate with a degree program. During the first and second
years students typically take a selection of courses providing a broad-based approach to key areas of cell and
molecular biology, with the specific course selection tailored to the individual student. Research training is stressed
throughout the program and dissertation research usually begins by the third semester. Applicants must have
demonstrated, in addition to overall academic excellence, a proficiency in the biological and physical sciences.
For additional information, please visit our Web site, http://cmb.duke.edu or e-mail to: cmbtgp@biochem.duke.edu.
Cell and Molecular Biology (CMB)
247. Macromolecular Synthesis. Fundamentals of DNA replication, transcription, and translation. Transcriptional and
translational regulation mechanisms. Consent of instructor required for undergraduates. Second half of fall semester.
Instructor: MacAlpine and Yao. 2 units. C-L: University Program in Genetics 247
258. Structural Biochemistry I. 2 units. C-L: see Biochemistry 258; also C-L: Cell Biology 258, University Program
in Genetics 258, Immunology 258, Structural Biology and Biophysics 258, Computational Biology and Bioinformatics
258
Departments, Programs, and Course Offerings 74