SOUCHES AFRICAINES DU VIRUS DE LA ROUGEOLE : ETUDE ...

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Consensus ATGTCACCRC AACGAGACCG GATAAATGCC TTCTACAAAG ATAACCCTTA TCCCAAGGGA AGTAGGATAG TTATTAACAG AGAACATCTT ATGATTGACA 100 HA 954_véro ........G. .......... .......... .......... .......... .......... .......... .......... .......... .......... 100 HA 954_PBL ........A. .......... .......... .......... .......... .......... .......... .......... .......... .......... 100 HA 954_B95a ........G. .......... .......... .......... .......... .......... .......... .......... .......... .......... 100 Consensus GACCTTATGT TTTGCTGGCT GTTCTGTTCG TCATGTTTCT GAGCTTGATC GGGTTGCTGG CCATTGCAGG CATTAGACTT CATCGGGCAG CCATCTACAC 200 HA 954_véro .......... .......... .......... .......... .......... .......... .......... .......... .......... .......... 200 HA 954_PBL .......... .......... .......... .......... .......... .......... .......... .......... .......... .......... 200 HA 954_B95a .......... .......... .......... .......... .......... .......... .......... .......... .......... .......... 200 Consensus CGCGGAGATC CATAAAAGCC TCAGCACCAA TCTAGATGTA ACTAACTCAA TCGAGCATCA GGTCAAGGAC GTGCTGACAC CACTCTTTAA AATCATCGGG 300 HA 954_véro .......... .......... .......... .......... .......... .......... .......... .......... .......... .......... 300 HA 954_PBL .......... .......... .......... .......... .......... .......... .......... .......... .......... .......... 300 HA 954_B95a .......... .......... .......... .......... .......... .......... .......... .......... .......... .......... 300 Consensus GATGAAGTGG GCCTGAGAAC ACCTCAGAGA TTCACTGACC TAGTGAAATT CATCTCTGAC AAGATTAAAT TCCTTAATCC GGATAGGGAG TACGACTTCA 400 HA 954_véro .......... .......... .......... .......... .......... .......... .......... .......... .......... .......... 400 HA 954_PBL .......... .......... .......... .......... .......... .......... .......... .......... .......... .......... 400 HA 954_B95a .......... .......... .......... .......... .......... .......... .......... .......... .......... .......... 400 Consensus GAGATCTCAC TTGGTGTATC AACCCGCCAG AGAGAATCAA ACTGGATTAT GATCAATACT GTGCAGATGT GGCTGCTGAA GAGCTCATGA ATGCATTGGT 500 HA 954_véro .......... .......... .......... .......... .......... .......... .......... .......... .......... .......... 500 HA 954_PBL .......... .......... .......... .......... .......... .......... .......... .......... .......... .......... 500 HA 954_B95a .......... .......... .......... .......... .......... .......... .......... .......... .......... .......... 500 Consensus GAACTCAACT CTACTGGAGA CCAGAACAAC CAATCAGTTC CTAGCTGTCT CAAAGGGAAA CTGCTCAGGG CCCACTACAA TCAGAGGTCA ATTCTCAAAC 600 HA 954_véro .......... .......... .......... .......... .......... .......... .......... .......... .......... .......... 600 HA 954_PBL .......... .......... .......... .......... .......... .......... .......... .......... .......... .......... 600 HA 954_B95a .......... .......... .......... .......... .......... .......... .......... .......... .......... .......... 600 Consensus ATGTCGCTGT CCTTATTGGA CCTGTACTTA GGTCGGGGTT ACAATGTGTC ATCTATAGTC ACTATGACAT CCCAGGGAAT GTATGGGGGA ACCTACTTAG 700 HA 954_véro .......... .......... .......... .......... .......... .......... .......... .......... .......... .......... 700 HA 954_PBL .......... .......... .......... .......... .......... .......... .......... .......... .......... .......... 700 HA 954_B95a .......... .......... .......... .......... .......... .......... .......... .......... .......... .......... 700 Consensus TGGAAAAGCC TAATCTGAGC AGCAAAGGGT CAGAGTTGTC ACAACTGAGC ATGTACCGAG TGTTTGAAGT AGGTGTTATC AGAAACCCGG GTTTGGGGGC 800 HA 954_véro .......... .......... .......... .......... .......... .......... .......... .......... .......... .......... 800 HA 954_PBL .......... .......... .......... .......... .......... .......... .......... .......... .......... .......... 800 HA 954_B95a .......... .......... .......... .......... .......... .......... .......... .......... .......... .......... 800 Consensus TCCGGTGTTC CATATGACAA ACTATTTTGA GCAACCAGTC AGTAATGATC TCGGCAACTG TATGGTAGCT TTGGGGGAGC TCAAACTCGC AGCCCTTTGT 900 HA 954_véro .......... .......... .......... .......... .......... .......... .......... .......... .......... .......... 900 HA 954_PBL .......... .......... .......... .......... .......... .......... .......... .......... .......... .......... 900 HA 954_B95a .......... .......... .......... .......... .......... .......... .......... .......... .......... .......... 900 Consensus CACGGGGAAG ATTCTATCAC AATTCCCTAT CAGGGATCAG GGAAAGGTGT CAGCTTCCAG CTCGTCAAGC TAGGTGTCTG GAAATCCCCA ACCGACATGC 1000 HA 954_véro .......... .......... .......... .......... .......... .......... .......... .......... .......... .......... 1000 HA 954_PBL .......... .......... .......... .......... .......... .......... .......... .......... .......... .......... 1000 HA 954_B95a .......... .......... .......... .......... .......... .......... .......... .......... .......... .......... 1000 Consensus AATCCTGGGT CCCCTTATCA ACGGATGATC CAGTGGTAGA CAGGCTTTAC CTCTCATCTC ACAGAGGTGT CATCGCTGAC AATCAAGCAA AATGGGCTGT 1100 HA 954_véro .......... .......... .......... .......... .......... .......... .......... .......... .......... .......... 1100 HA 954_PBL .......... .......... .......... .......... .......... .......... .......... .......... .......... .......... 1100 HA 954_B95a .......... .......... .......... .......... .......... .......... .......... .......... .......... .......... 1100 Consensus CCCGACAACA CGAACAGATG ACAAGTTGCG AATGGAGACA TGCTTCCAGC AGGCGTGTAA AGGTAAAATC CAAGCACTCT GCGAGAATCC CGAGTGGGCA 1200 HA 954_véro .......... .......... .......... .......... .......... .......... .......... .......... .......... .......... 1200 HA 954_PBL .......... .......... .......... .......... .......... .......... .......... .......... .......... .......... 1200 HA 954_B95a .......... .......... .......... .......... .......... .......... .......... .......... .......... .......... 1200 Consensus CCATTGAAGG ATAACAGGAT TCCTTCATAC GGGGTCCTGT CTGTTGATCT GAGTCTGACA GTTGAGCTTA AAATCAAGAT TGCTTCGGGA TTCGGACCAT 1300 HA 954_véro .......... .......... .......... .......... .......... .......... .......... .......... .......... .......... 1300 HA 954_PBL .......... .......... .......... .......... .......... .......... .......... .......... .......... .......... 1300 HA 954_B95a .......... .......... .......... .......... .......... .......... .......... .......... .......... .......... 1300 Consensus TGATTACGCA CGGCTCAGGG ATGGACCTAT ACAAATCCAA CCGCAACAAT GTGTATTGGC TGACTATCCC GCCAATGAGG AATCTAGCCT TAGGTGTAAT 1400 HA 954_véro .......... .......... .......... .......... .......... .......... .......... .......... .......... .......... 1400 HA 954_PBL .......... .......... .......... .......... .......... .......... .......... .......... .......... .......... 1400 HA 954_B95a .......... .......... .......... .......... .......... .......... .......... .......... .......... .......... 1400 Consensus CAACACATTG GCGTGGATAC CGAGATTCAA GGTTAGTCCC AACCTCTTCA CTGTCCCAAT TAAGGAAGCA GGCGAAGACT GCCATGCCCC AACATACCTA 1500 HA 954_véro .......... .......... .......... .......... .......... .......... .......... .......... .......... .......... 1500 HA 954_PBL .......... .......... .......... .......... .......... .......... .......... .......... .......... .......... 1500 HA 954_B95a .......... .......... .......... .......... .......... .......... .......... .......... .......... .......... 1500 Consensus CCTGCGGAGG TGGACGGTGA TGTCAAACTC AGTTCCAATC TGGTGATTCT ACCTGGTCAA GATCTCCAAT ATGTTTTGGC AACCTACGAT ACTTCCAGGG 1600 HA 954_véro .......... .......... .......... .......... .......... .......... .......... .......... .......... .......... 1600 HA 954_PBL .......... .......... .......... .......... .......... .......... .......... .......... .......... .......... 1600 HA 954_B95a .......... .......... .......... .......... .......... .......... .......... .......... .......... .......... 1600 Consensus TTGAACATGC TGTGGTTTAT TACGTTTACA GCCCAAGCCG CTCATTTTCT TACTTTTATC CTTTTAGGTT GCCTATAAAG GGGGTCCCAA TCGAATTACA 1700 HA 954_véro .......... .......... .......... .......... .......... .......... .......... .......... .......... .......... 1700 HA 954_PBL .......... .......... .......... .......... .......... .......... .......... .......... .......... .......... 1700 HA 954_B95a .......... .......... .......... .......... .......... .......... .......... .......... .......... .......... 1700 Consensus AGTGGAATGC TTCACATGGG ACCAAAAACT CTGGTGCCGT CACTTCTGTG TGCTTGCGGA CTCGGAATCC GGTGGACATA TCACTCACTC TGGGATGGTG 1800 HA 954_véro .......... .......... .......... .......... .......... .......... .......... .......... .......... .......... 1800 HA 954_PBL .......... .......... .......... .......... .......... .......... .......... .......... .......... .......... 1800 HA 954_B95a .......... .......... .......... .......... .......... .......... .......... .......... .......... .......... 1800 Consensus GGCATGGGAG TCAGCTGCAC AGCCACCCGG GAAGATGGGA CCAATCGCAG ATAG 1854 HA 954_véro .......... .......... .......... .......... .......... .... 1854 HA 954_PBL .......... .......... .......... .......... .......... .... 1854 HA 954_B95a .......... .......... .......... .......... .......... .... 1854 Annexe 1: Comparaison des séquences des gène H et F de la souche G954 après passage dans les cellules Véros, les PBLet les cellules B95a.
Consensus ATATCCATCA TGGGTCTCAA GGTGAACGTC TCTGCCATAT TCATGGCAGT ACTGTTAACT CTCCAAACAC CCGCCGGTCA AATCCATTGG GGCAATCTCT 100 F 954_véro .......... .......... .......... .......... .......... .......... .......... .......... .......... .......... 100 F 954_B95a .......... .......... .......... .......... .......... .......... .......... .......... .......... .......... 100 F 954_PBL .......... .......... .......... .......... .......... .......... .......... .......... .......... .......... 100 Consensus CTAAGATAGG GGTAGTAGGA ATAGGAAGTG CAAGCTACAA AGTTATGACT CGTTCCAGCC ATCAATCATT AGTCATAAAA TTAATGCCCA ATATAACTCT 200 F 954_véro .......... .......... .......... .......... .......... .......... .......... .......... .......... .......... 200 F 954_B95a .......... .......... .......... .......... .......... .......... .......... .......... .......... .......... 200 F 954_PBL .......... .......... .......... .......... .......... .......... .......... .......... .......... .......... 200 Consensus CCTCAATAAC TGCACGAAGG TAGAGATTGC AGAGTACAGG AGACTACTAA GAACAGTTCT GGAACCAATT AGAGATGCAC TTAATGCAAT GACCCAGAAC 300 F 954_véro .......... .......... .......... .......... .......... .......... .......... .......... .......... .......... 300 F 954_B95a .......... .......... .......... .......... .......... .......... .......... .......... .......... .......... 300 F 954_PBL .......... .......... .......... .......... .......... .......... .......... .......... .......... .......... 300 Consensus ATAAGGCCGG TTCAGAGCGT AGCTTCAAGT AGGAGACACA AGAGATTTGC GGGAGTAGTC CTGGCAGGTG CGGCCCTAGG CGTTGCCACA GCTGCTCAGA 400 F 954_véro .......... .......... .......... .......... .......... .......... .......... .......... .......... .......... 400 F 954_B95a .......... .......... .......... .......... .......... .......... .......... .......... .......... .......... 400 F 954_PBL .......... .......... .......... .......... .......... .......... .......... .......... .......... .......... 400 Consensus TAACAGCCGG CATTGCACTT CACCGGTCCA TGCTGAACTC TCAAGCCATC GACAATCTGA GAGCGAGCCT GGAAACTACT AATCAGGCAA TTGAGGCAAT 500 F 954_véro .......... .......... .......... .......... .......... .......... .......... .......... .......... .......... 500 F 954_B95a .......... .......... .......... .......... .......... .......... .......... .......... .......... .......... 500 F 954_PBL .......... .......... .......... .......... .......... .......... .......... .......... .......... .......... 500 Consensus CAGACAAGCA GGGCAGGAGA TGATCTTGGC TGTTCAGGGT GTCCAAGACT ACATCAATAA TGAGCTGATA CCATCTATGA ACCAGCTATC TTGTGATTTA 600 F 954_véro .......... .......... .......... .......... .......... .......... .......... .......... .......... .......... 600 F 954_B95a .......... .......... .......... .......... .......... .......... .......... .......... .......... .......... 600 F 954_PBL .......... .......... .......... .......... .......... .......... .......... .......... .......... .......... 600 Consensus ATCGGCCAGA AGCTCGGGCT CAAATTGCTC AGATACTATA CAGAAATCCT GTCATTATTT GGCCCCAGCC TACGAGACCC CATATCTGCG GAGATATCTA 700 F 954_véro .......... .......... .......... .......... .......... .......... .......... .......... .......... .......... 700 F 954_B95a .......... .......... .......... .......... .......... .......... .......... .......... .......... .......... 700 F 954_PBL .......... .......... .......... .......... .......... .......... .......... .......... .......... .......... 700 Consensus TCCAGGCTTT GAGCTATGCA CTTGGAGGAG ATATCAATAA GGTGTTAGAA AAGCTCGGAT ACAGTGGAGG CGATTTACTG GGCATCTTAG AGAGCAGAGG 800 F 954_véro .......... .......... .......... .......... .......... .......... .......... .......... .......... .......... 800 F 954_B95a .......... .......... .......... .......... .......... .......... .......... .......... .......... .......... 800 F 954_PBL .......... .......... .......... .......... .......... .......... .......... .......... .......... .......... 800 Consensus AATAAAGGCT CGGATAACTC ACGTCGACAC AGAGTCCTAC TTCATTGTCC TCAGTATAGC CTATCCGACA CTGTCCGAGA TTAAGGGGGT GATTGTCCAC 900 F 954_véro .......... .......... .......... .......... .......... .......... .......... .......... .......... .......... 900 F 954_B95a .......... .......... .......... .......... .......... .......... .......... .......... .......... .......... 900 F 954_PBL .......... .......... .......... .......... .......... .......... .......... .......... .......... .......... 900 Consensus CGGCTAGAGG GGGTCTCGTA CAACATAGGC TCTCAAGAGT GGTATACCAC TGTGCCCAAG TATGTTGCAA CCCAAGGGTA CCTTATCTCG AATTTTGATG 1000 F 954_véro .......... .......... .......... .......... .......... .......... .......... .......... .......... .......... 1000 F 954_B95a .......... .......... .......... .......... .......... .......... .......... .......... .......... .......... 1000 F 954_PBL .......... .......... .......... .......... .......... .......... .......... .......... .......... .......... 1000 Consensus AGTCATCGTG TACCTTCATG CCAGAGGGGA CTGTGTGCAG CCAAAATGCC TTGTACCCGA TGAGTCCTCT GCTCCAAGAA TGCCTCCGGG GGTCCACCAA 1100 F 954_véro .......... .......... .......... .......... .......... .......... .......... .......... .......... .......... 1100 F 954_B95a .......... .......... .......... .......... .......... .......... .......... .......... .......... .......... 1100 F 954_PBL .......... .......... .......... .......... .......... .......... .......... .......... .......... .......... 1100 Consensus GTCCTGTGCT CGTACACTCG TATCCGGGTC TTTTGGGAAC CGGTTCATTT TATCACAAGG GAACCTAATA GCCAATTGTG CATCAATTCT TTGCAAGTGT 1200 F 954_véro .......... .......... .......... .......... .......... .......... .......... .......... .......... .......... 1200 F 954_B95a .......... .......... .......... .......... .......... .......... .......... .......... .......... .......... 1200 F 954_PBL .......... .......... .......... .......... .......... .......... .......... .......... .......... .......... 1200 Consensus TACACAACAG GAACGATCAT TAATCAAGAC CCTGACAAGA TCCTAACATA CATCGCTGCC GATCGCTGCC CGGTAGTCGA GGTAAACGGC GTGACCATCC 1300 F 954_véro .......... .......... .......... .......... .......... .......... .......... .......... .......... .......... 1300 F 954_B95a .......... .......... .......... .......... .......... .......... .......... .......... .......... .......... 1300 F 954_PBL .......... .......... .......... .......... .......... .......... .......... .......... .......... .......... 1300 Consensus AAGTCGGGAG CAGGAGGTAT CCAGACGCTG TGTATTTGCA CAGAATTGAC CTCGGTCCTC CCATATCATT GGAGAGGTTG GACGTAGGGA CAAATCTGGG 1400 F 954_véro .......... .......... .......... .......... .......... .......... .......... .......... .......... .......... 1400 F 954_B95a .......... .......... .......... .......... .......... .......... .......... .......... .......... .......... 1400 F 954_PBL .......... .......... .......... .......... .......... .......... .......... .......... .......... .......... 1400 Consensus GAATGCAATT GCCAAATTGG AGGATGCCAA GGAATTGTTG GAGTCATCGG ACCAGATATT GAGGAGTATG AAAGGTTTAT CGAGCACTAG CATAGTCTAC 1500 F 954_véro .......... .......... .......... .......... .......... .......... .......... .......... .......... .......... 1500 F 954_B95a .......... .......... .......... .......... .......... .......... .......... .......... .......... .......... 1500 F 954_PBL .......... .......... .......... .......... .......... .......... .......... .......... .......... .......... 1500 Consensus ATCCTGATTG CAGTGTGTCT TGGAGGGCTG ATAGGGATCC CCACTTTAAT ATGTTGCTGC AGGGGGCGTT GTAACAAAAA GGGAGAACAA GTTGGTATGT 1600 F 954_véro .......... .......... .......... .......... .......... .......... .......... .......... .......... .......... 1600 F 954_B95a .......... .......... .......... .......... .......... .......... .......... .......... .......... .......... 1600 F 954_PBL .......... .......... .......... .......... .......... .......... .......... .......... .......... .......... 1600 Consensus CAAGACCAGG CCTAAAGCCT GATCTTACAG GAACATCAAA ATCCTATGTA AGGTCGCTTT GA 1662 F 954_véro .......... .......... .......... .......... .......... .......... .. 1662 F 954_B95a .......... .......... .......... .......... .......... .......... .. 1662 F 954_PBL .......... .......... .......... .......... .......... .......... .. 1662 Annexe 1: suite
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UNIVERSITE JOSEPH FOURIER-GRENOBLE
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Je remercie le Dr Florence PRADEL e
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II.3 2. Les nouveaux vaccins……
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VI.3. La rougeole au Cameroun : Etu
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CHAPITRE I : LE VIRUS DE LA ROUGEOL
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I.Le virus de la rougeole 2. Classi
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I.Le virus de la rougeole 3. Struct
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I.Le virus de la rougeole 5. Cycle
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I.Le virus de la rougeole 5. Cycle
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Récepteur cellulaire Etat natif H
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I.Le virus de la rougeole 6. Pathol
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Page 31 and 32:
Page 33 and 34:
II. La vaccination 1. Les vaccins i
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II. La vaccination 2. Les vaccins v
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Figure 6 : Souches vaccinales utili
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II. La vaccination 3. Les nouvelles
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II. La vaccination 3. Les nouvelles
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II. La vaccination 4. Position actu
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CHAPITRE III. ETUDES EPIDEMIOLOGIQU
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III. Etudes épidémiologiques 1. I
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III. Etudes épidémiologiques 2. P
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III. Etudes épidémiologiques 4. R
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IV. Epidémiologie moléculaire du
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V. La rougeole en Afrique 1. La rou
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Figure 8: Répartition des cas de r
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VI. Etude des souches Africaines du
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VI.1.4. Article 1 : Adaptation des
Page 91 and 92: 1506 NOTES J. VIROL. FIG. 1. MV inf
Page 93 and 94: 1508 NOTES J. VIROL. FIG. 3. Flow c
Page 95 and 96: VI. Etude des souches Africaines du
Page 97 and 98: Figure 9 : Répartition géographiq
Page 103 and 104: Measles virus strains circulating i
Page 105 and 106: In 1983, measles viruses isolated i
Page 107 and 108: obtained for the two 1983 isolates
Page 109 and 110: easons. The available data for meas
Page 111 and 112: Malvoisin E, Wild TF. 1990. Contrib
Page 113 and 114: 106 0.005 100 82 100 86 98 New York
Page 115 and 116: Table 1 : African measles strains u
Page 117 and 118: VI.3. LA ROUGEOLE AU CAMEROUN : ETU
Page 129 and 130: CHAPITRE VII. DISCUSSION 122
Page 131 and 132: VII. Discussion 1. Interaction viru
Page 133 and 134: VII. Discussion 1. Interaction viru
Page 135 and 136: VII. Discussion 2. Epidémiologie C
Page 137 and 138: VII. Discussion 2. Epidémiologie f
Page 139 and 140: CHAPITRE VIII. CONCLUSION ET PERSPE
Page 141: ANNEXES 134
Page 145 and 146: Consensus MTEIYDFDKS AWDIKGSIAP IQP
Page 147 and 148: Consensus ATGTCACCGC AACGAGACCG GAT
Page 149 and 150: Consensus MSPQRDRINA FYKDNPYPKG SRI
Page 151 and 152: Consensus MGLKVNVSAI FMAVLLTLQT PAG
Page 153 and 154: Aaby, P., Bukh, J., Lisse, I. M. &
Page 155 and 156: Bouteille, M., Fontaine C., Vedrenn
Page 157 and 158: Davenport, M. P., Quinn, C. L., Chi
Page 159 and 160: Foege, W. (1971). Measles vaccinati
Page 161 and 162: Griffin, D. E., Ward, B. J., Jaureg
Page 163 and 164: Holt, E. A., Moulton, L. H., Siberr
Page 165 and 166: Kok, P. W., Kenya, P. R. & Ensering
Page 167 and 168: Markowitz, L. E., Albrecht, P., Rho
Page 169 and 170: Norrby, E., Enders-Ruckles, G. & Me
Page 171 and 172: Poland, G. A., Jacobson, R. M., Col
Page 173 and 174: Siber, G. R., Werner, B. G., Halsey
Page 175 and 176: Truong, A. T., Mulders, M. N., Gaut
Page 177 and 178: WHO, World Health Organisation, Exp
Page 179 and 180: TABLE DES ILLUSTRATIONS Figure 1. R
Page 181: Abstract Despite the availability o
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