SOUCHES AFRICAINES DU VIRUS DE LA ROUGEOLE : ETUDE ...

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Consensus ATGTCACCGC AACGAGACCG GATAAATGCC TTCTACAAAG ATAACCCTTA TCCCAAGGGA AGTAGGATAG TTATTAACAG AGAACATCTT ATGATTGACA 100 HA G954 .......... .......... .......... .......... .......... .......... .......... .......... .......... .......... 100 HA Lys .......... .......... .......... .......... .......... .......... .......... .......... .......... .......... 100 Consensus GACCTTATGT TTTGCTGGCT GTTCTGTTCG TCATGTTTCT GAGCTTGATC GGGTTGCTGG CCATTGCAGG CATTAGACTT CATCGGGCAG CCATCTACAC 200 HA G954 .......... .......... .......... .......... .......... .......... .......... .......... .......... .......... 200 HA Lys .......... .......... .......... .......... .......... .......... .......... .......... .......... .......... 200 Consensus CGCGGAGATC CATAAAAGCC TCAGCACCAA TCTAGATGTA ACTAACTCAA TCGAGCATCA GGTCAAGGAC GTGCTGACAC CACTCTTTAA AATCATCGGG 300 HA G954 .......... .......... .......... .......... .......... .......... .......... .......... .......... .......... 300 HA Lys .......... .......... .......... .......... .......... .......... .......... .......... .......... .......... 300 Consensus GATGAAGTGG GCCTGAGAAC ACCTCAGAGA TTCACTGACC TAGTGAAATT CATCTCTGAC AAGATTAAAT TCCTTAATCC GGATAGGGAG TACGACTTCA 400 HA G954 .......... .......... .......... .......... .......... .......... .......... .......... .......... .......... 400 HA Lys .......... .......... .......... .......... .......... .......... .......... .......... .......... .......... 400 Consensus GAGATCTCAC TTGGTGTATC AACCCGCCAG AGAGAATCAA ACTGGATTAT GATCAATACT GTGCAGATGT GGCTGCTGAA GAGCTCATGA ATGCATTGGT 500 HA G954 .......... .......... .......... .......... .......... .......... .......... .......... .......... .......... 500 HA Lys .......... .......... .......... .......... .......... .......... .......... .......... .......... .......... 500 Consensus GAACTCAACT CTACTGGAGA CCAGAACAAC CAATCAGTTC CTAGCTGTCT CAAAGGGAAA CTGCTCAGGG CCCACTACAA TCAGAGGTCA ATTCTCAAAC 600 HA G954 .......... .......... .......... .......... .......... .......... .......... .......... .......... .......... 600 HA Lys .......... .......... .......... .......... .......... .......... .......... .......... .......... .......... 600 Consensus ATGTCGCTGT CCTTATTGGA CCTGTACTTA GGTCGGGGTT ACAATGTGTC ATCTATAGTC ACTATGACAT CCCAGGGAAT GTATGGGGGA ACCTACYTAG 700 HA G954 .......... .......... .......... .......... .......... .......... .......... .......... .......... ......T... 700 HA Lys .......... .......... .......... .......... .......... .......... .......... .......... .......... ......C... 700 Consensus TGGAAAAGCC TAATCTGAGC AGCAAAGGGT CAGAGTTGTC ACAACTGAGC ATGTACCGAG TGTTTGAAGT AGGTGTTATC AGAAACCCGG GTTTGGGGGC 800 HA G954 .......... .......... .......... .......... .......... .......... .......... .......... .......... .......... 800 HA Lys .......... .......... .......... .......... .......... .......... .......... .......... .......... .......... 800 Consensus TCCGGTGTTC CATATGACAA ACTATTTTGA GCAACCAGTC AGTAATGATC TCGGCAACTG TATGGTAGCT TTGGGGGAGC TCAAACTCGC AGCCCTTTGT 900 HA G954 .......... .......... .......... .......... .......... .......... .......... .......... .......... .......... 900 HA Lys .......... .......... .......... .......... .......... .......... .......... .......... .......... .......... 900 Consensus CACGGGGAAG ATTCTATCAC AATTCCCTAT CAGGGATCAG GGAAAGGTGT CAGCTTCCAG CTCGTCAAGC TRGGTGTCTG GAAATCCCCA ACCGACATGC 1000 HA G954 .......... .......... .......... .......... .......... .......... .......... .A........ .......... .......... 1000 HA Lys .......... .......... .......... .......... .......... .......... .......... .G........ .......... .......... 1000 Consensus AATCCTGGGT CCCCTTATCA ACGGATGATC CAGTGGTAGA CAGGCTTTAC CTCTCATCTC ACAGAGGTGT CATCGCTGAC AATCAAGCAA AATGGGCTGT 1100 HA G954 .......... .......... .......... .......... .......... .......... .......... .......... .......... .......... 1100 HA Lys .......... .......... .......... .......... .......... .......... .......... .......... .......... .......... 1100 Consensus CCCGACAACA CGAACAGATG ACAAGTTGCG AATGGAGACA TGCTTCCAGC AGGCGTGTAA AGGTAAAATC CAAGCACTCT GCGAGAATCC CGAGTGGGCA 1200 HA G954 .......... .......... .......... .......... .......... .......... .......... .......... .......... .......... 1200 HA Lys .......... .......... .......... .......... .......... .......... .......... .......... .......... .......... 1200 Consensus CCATTGAARG ATAACAGGAT TCCTTCATAC GGGGTCCTGT CTGTTGATCT GAGTCTGACA GTTGAGCTTA AAATCAARAT TGCTTCGGGA TTCGGACCAT 1300 HA G954 ........G. .......... .......... .......... .......... .......... .......... .......G.. .......... .......... 1300 HA Lys ........A. .......... .......... .......... .......... .......... .......... .......A.. .......... .......... 1300 Consensus TGATYACGCA CGGCTCAGGG ATGGACCTAT ACAAATCCAA CCGCAACAAT GTGTATTGGC TGACTATCCC GCCAATGAGG AATCTAGCCT TAGGTGTAAT 1400 HA G954 ....T..... .......... .......... .......... .......... .......... .......... .......... .......... .......... 1400 HA Lys ....C..... .......... .......... .......... .......... .......... .......... .......... .......... .......... 1400 Consensus CAACACATTG GCGTGGATAC CGAGATTCAA GGTTAGTCCC AACCTCTTCA CTGTCCCAAT TAAGGAAGCA GGCGAAGACT GCCATGCCCC AACATACCTA 1500 HA G954 .......... .......... .......... .......... .......... .......... .......... .......... .......... .......... 1500 HA Lys .......... .......... .......... .......... .......... .......... .......... .......... .......... .......... 1500 Consensus CCTGCGGAGG TGGACGGTGA TGTCAAACTC AGTTCCAATC TGGTGATTCT ACCTGGTCAA GATCTCCAAT AYGTYTTGGC AACCTACGAT ACTTCCAGGG 1600 HA G954 .......... .......... .......... .......... .......... .......... .......... .T..T..... .......... .......... 1600 HA Lys .......... .......... .......... .......... .......... .......... .......... .C..C..... .......... .......... 1600 Consensus TTGAACATGC TGTGGTTTAT TACGTTTACA GCCCAAGCCG CTCATTTTCT TACTTTTATC CTTTTAGGTT GCCTATAAAG GGGGTCCCAA TCGAATTACA 1700 HA G954 .......... .......... .......... .......... .......... .......... .......... .......... .......... .......... 1700 HA Lys .......... .......... .......... .......... .......... .......... .......... .......... .......... .......... 1700 Consensus AGTGGAATGC TTCACATGGG ACCAAAAACT CTGGTGCCGT CACTTCTGTG TGCTTGCGGA CTCGGAATCC GGTGGACATA TCACTCACTC TGGGATGGTG 1800 HA G954 .......... .......... .......... .......... .......... .......... .......... .......... .......... .......... 1800 HA Lys .......... .......... .......... .......... .......... .......... .......... .......... .......... .......... 1800 Consensus GGCATGGGAG TCAGCTGCAC AGCCACCCGG GAAGATGGRA CCAATCGCAG ATAG 1854 HA G954 .......... .......... .......... ........G. .......... .... 1854 HA Lys .......... .......... .......... ........A. .......... .... 1854 Annexe 7 : Comparaison des séquences des gènes HA de la souches G954 isolée en Gambie en 1993 et de la souche Lys-1 isolée à Lyon en 1994 sur un patient arrivant de la Gambie
Consensus MGLKVNVSAI FMAVLLTLQT PAGQIHWGNL SKIGVVGIGS ASYKVMTRSS HQSLVIKLMP NITLLNNCTR VEIAE 75 Trans of F lys .......... .......... .......... .......... .......... ........I. .........K ..... 75 Trans of F G954 .......... .......... .......... .......... .......... .......... .........K ..... 75 Trans of F CR67 .........V .......... .......... .......... .......... .......... .......... ..... 75 Trans of F CR 72 .........V .......... .......... .......... .......... .......... .......... ..... 75 Trans of F Edmonsto .......... .......... .T........ .......... .......... .......... .......... ..... 75 Consensus YRRLLRTVLE PIRDALNAMT QNIRPVQSVA SSRRHKRFAG VV<strong>LA</strong>GAALGV ATAAQITAGI ALHRSMLNSQ AIDNL 150 Trans of F lys .......... .......... .......... ..M....... .......... .......... .......... ..... 150 Trans of F G954 .......... .......... .......... .......... .......... .......... .......... ..... 150 Trans of F CR67 .......... .......... .......... .......... .......... .......... .......... ..... 150 Trans of F CR 72 .......... .......... .......... .......... .......... .......... .......... ..... 150 Trans of F Edmonsto .......... .......... .......... .......... .......... .......... ...Q...... ..... 150 Consensus RASLETTNQA IEAIRQAGQE MI<strong>LA</strong>VQGVQD YINNELIPSM NQLSCDLIGQ KLGLKLLRYY TEILSLFGPS LRDPI 225 Trans of F lys .......... .......... .......... .......... .......... .......... .......... ..... 225 Trans of F G954 .......... .......... .......... .......... .......... .......... .......... ..... 225 Trans of F CR67 .......... .......... .......... .......... .......... .......... .......... ..... 225 Trans of F CR 72 .......... .......... .......... .......... .......... .......... .......... ..... 225 Trans of F Edmonsto .......... .......... .......... .......... .......... .......... .......... ..... 225 Consensus SAEISIQALS YALGGDINKV LEKLGYSGGD LLGILESRGI KARITHVDTE SYFIVLSIAY PTLSEIKGVI VHRLE 300 Trans of F lys .......... .......... .......... .......... .......... .......... .......... ..... 300 Trans of F G954 .......... .......... .......... .......... .......... .......... .......... ..... 300 Trans of F CR67 .......... .......... .......... .......... .......... .......... .......... ..... 300 Trans of F CR 72 .......... .......... .......... .......... .......... .......... .......... ..... 300 Trans of F Edmonsto .......... .......... .......... .......... .......... .......... .......... ..... 300 Consensus GVSYNIGSQE WYTTVPKYVA TQGYLISNFD ESSCTFMPEG TVCSQNALYP MSPLLQECLR GSTKSCARTL VSGSF 375 Trans of F lys .......... .......... .......... .......... .......... .......... .......... ..... 375 Trans of F G954 .......... .......... .......... .......... .......... .......... .......... ..... 375 Trans of F CR67 .......... .......... .......... .......... .......... .......... .......... ..... 375 Trans of F CR 72 .......... ...P...... .......... .......... .......... .......... .......... ..... 375 Trans of F Edmonsto .......... .......... .......... .......... .......... .......... .......... ..... 375 Consensus GNRFILSQGN LIANCASILC KCYTTGTIIN QDPDKILTYI AADRCPVVEV NGVTIQVGSR RYPDAVYLHR IDLGP 450 Trans of F lys .......... .......... .......... .......... .......... .......... .......... ..... 450 Trans of F G954 .......... .......... .......... .......... .......... .......... .......... ..... 450 Trans of F CR67 .......... .......... .......... .......... .......... .......... .......... ..... 450 Trans of F CR 72 .......... .......... .......... .......... .......... .......... .......... ..... 450 Trans of F Edmonsto .......... .......... .......... .......... ...H...... .......... .......... ..... 450 Consensus PISLERLDVG TNLGNAIAKL EDAKELLESS DQILRSMKGL SSTSIVYILI AVCLGGLIGI PTLICCCRGR CNKKG 525 Trans of F lys .......... .......... .......... .......... .......... .......... .......... ..... 525 Trans of F G954 .......... .......... .......... .......... .......... .......... .......... ..... 525 Trans of F CR67 .......... .......... .......... .......... .......... .......... .......... ..... 525 Trans of F CR 72 .......... .......... .......... .......... .......... .......... .......... ..... 525 Trans of F Edmonsto .......... .......... .......... .......... .......... .......... .A........ ..... 525 Consensus EQVGMSRPGL KPDLTGTSKS YVRSL 550 Trans of F lys .......... .......... ..... 550 Trans of F G954 .......... .......... ..... 550 Trans of F CR67 .......... .......... ..... 550 Trans of F CR 72 .......... .......... ..... 550 Trans of F Edmonsto .......... .......... ..... 550
Page 1 and 2:
UNIVERSITE JOSEPH FOURIER-GRENOBLE
Page 3 and 4:
Je remercie le Dr Florence PRADEL e
Page 5 and 6:
II.3 2. Les nouveaux vaccins……
Page 7 and 8:
VI.3. La rougeole au Cameroun : Etu
Page 9 and 10:
CHAPITRE I : LE VIRUS DE LA ROUGEOL
Page 11 and 12:
I.Le virus de la rougeole 2. Classi
Page 13 and 14:
I.Le virus de la rougeole 3. Struct
Page 15 and 16:
Page 17 and 18:
Page 19 and 20:
I.Le virus de la rougeole 5. Cycle
Page 21 and 22:
I.Le virus de la rougeole 5. Cycle
Page 23 and 24:
Récepteur cellulaire Etat natif H
Page 25 and 26:
I.Le virus de la rougeole 6. Pathol
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Page 29 and 30:
Page 31 and 32:
Page 33 and 34:
II. La vaccination 1. Les vaccins i
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II. La vaccination 2. Les vaccins v
Page 37 and 38:
Figure 6 : Souches vaccinales utili
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II. La vaccination 3. Les nouvelles
Page 41 and 42:
II. La vaccination 3. Les nouvelles
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II. La vaccination 4. Position actu
Page 45 and 46:
CHAPITRE III. ETUDES EPIDEMIOLOGIQU
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III. Etudes épidémiologiques 1. I
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III. Etudes épidémiologiques 2. P
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III. Etudes épidémiologiques 4. R
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Page 55 and 56:
Page 57 and 58:
Page 59 and 60:
Page 61 and 62:
IV. Epidémiologie moléculaire du
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Page 65 and 66:
Page 67 and 68:
Page 69 and 70:
Page 71 and 72:
Page 73 and 74:
V. La rougeole en Afrique 1. La rou
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Page 77 and 78:
Page 79 and 80:
Figure 8: Répartition des cas de r
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Page 83 and 84:
VI. Etude des souches Africaines du
Page 85 and 86:
Page 87 and 88:
Page 89 and 90:
VI.1.4. Article 1 : Adaptation des
Page 91 and 92:
1506 NOTES J. VIROL. FIG. 1. MV inf
Page 93 and 94:
1508 NOTES J. VIROL. FIG. 3. Flow c
Page 95 and 96:
Page 97 and 98:
Figure 9 : Répartition géographiq
Page 99 and 100: VI. Etude des souches Africaines du
Page 103 and 104: Measles virus strains circulating i
Page 105 and 106: In 1983, measles viruses isolated i
Page 107 and 108: obtained for the two 1983 isolates
Page 109 and 110: easons. The available data for meas
Page 111 and 112: Malvoisin E, Wild TF. 1990. Contrib
Page 113 and 114: 106 0.005 100 82 100 86 98 New York
Page 115 and 116: Table 1 : African measles strains u
Page 117 and 118: VI.3. LA ROUGEOLE AU CAMEROUN : ETU
Page 129 and 130: CHAPITRE VII. DISCUSSION 122
Page 131 and 132: VII. Discussion 1. Interaction viru
Page 133 and 134: VII. Discussion 1. Interaction viru
Page 135 and 136: VII. Discussion 2. Epidémiologie C
Page 137 and 138: VII. Discussion 2. Epidémiologie f
Page 139 and 140: CHAPITRE VIII. CONCLUSION ET PERSPE
Page 141 and 142: ANNEXES 134
Page 143 and 144: Consensus ATATCCATCA TGGGTCTCAA GGT
Page 145 and 146: Consensus MTEIYDFDKS AWDIKGSIAP IQP
Page 147 and 148: Consensus ATGTCACCGC AACGAGACCG GAT
Page 149: Consensus MSPQRDRINA FYKDNPYPKG SRI
Page 153 and 154: Aaby, P., Bukh, J., Lisse, I. M. &
Page 155 and 156: Bouteille, M., Fontaine C., Vedrenn
Page 157 and 158: Davenport, M. P., Quinn, C. L., Chi
Page 159 and 160: Foege, W. (1971). Measles vaccinati
Page 161 and 162: Griffin, D. E., Ward, B. J., Jaureg
Page 163 and 164: Holt, E. A., Moulton, L. H., Siberr
Page 165 and 166: Kok, P. W., Kenya, P. R. & Ensering
Page 167 and 168: Markowitz, L. E., Albrecht, P., Rho
Page 169 and 170: Norrby, E., Enders-Ruckles, G. & Me
Page 171 and 172: Poland, G. A., Jacobson, R. M., Col
Page 173 and 174: Siber, G. R., Werner, B. G., Halsey
Page 175 and 176: Truong, A. T., Mulders, M. N., Gaut
Page 177 and 178: WHO, World Health Organisation, Exp
Page 179 and 180: TABLE DES ILLUSTRATIONS Figure 1. R
Page 181: Abstract Despite the availability o
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