SOUCHES AFRICAINES DU VIRUS DE LA ROUGEOLE : ETUDE ...

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Véro G954 Véro Hallé Véro F0 (60kDa) F1 (40kDa) Annexe 2 : Marquage de la protéine F par Western Blot des extraits de cellules Véros infectées par la souche G954 ou par la souche Hallé
Consensus MTEIYDFDKS AWDIKGSIAP IQPTTYSDGR LVPQVRVIDP GLGDRK<strong>DE</strong>CF MYMFLLGVVE 60 Trans of M G954/B95 .......... .......... .......... .......... .......... .......... 60 Trans of M Edmonsto .......... .......... .......... .......... .......... .......... 60 Trans of M G954/ver .......... .......... .......... .......... .......... .......... 60 89 Consensus DSDPLGPPIG RAFGSLPLGV GRSTAKPEKL LKEATELDIV VRRTAGLNEK LVFYNNTPLT 120 Trans of M G954/B95 .......... .......... ........E. .......... .......... .......... 120 Trans of M Edmonsto .......... .......... .......... .......... .......... .......... 120 Trans of M G954/ver .......... .......... .......... .......... .......... .......... 120 Consensus LLTPWRKVLT TGSVFNANQV CNAVNLIPLD TPQRFRVVYM SITRLSDNGY YTVPRRMLEF 180 Trans of M G954/B95 .......... .......... .......... .......... .......... .......... 180 Trans of M Edmonsto .......... .......... .S........ .......... .......... .......... 180 Trans of M G954/ver .......... .......... .......... .......... .......... .......... 180 Consensus RSVNAVAFNL LVTLRIDKAI GPGKIIDNTE QLPEATFMVH IGNFRRKKSE VYSADYCKMK 240 Trans of M G954/B95 .......... .......... .......... .......... .......... .......... 240 Trans of M Edmonsto .......... .......... .......... .......... .......... .......... 240 Trans of M G954/ver .......... .......... .......... .......... .......... .......... 240 Consensus IEKMGLVFAL GGIGGTSLHI RSTGKMSKTL HAQLGFKKTL CYPLMDINED LNRLLWRSRC 300 Trans of M G954/B95 .......... .......... .......... .......... .......... .......... 300 Trans of M Edmonsto .......... .......... .......... .......... .......... .......... 300 Trans of M G954/ver .......... .......... .......... .......... .......... .......... 300 Consensus KIVRIQAVLQ PSVPQEFRIY DDVIINDDQG LFKVL 335 Trans of M G954/B95 .......... .......... .......... ..... 335 Trans of M Edmonsto .......... .......... .......... ..... 335 Trans of M G954/ver .......... .......... .......... ..... 335 Annexe 3 : Comparaison des séquences de la protéine M de la souche G954 dans les cellules B95a et après adaptation aux cellules Véro avec celle de la souche vaccinale Edmonston. La mutation au niveau de la position 89 est indiquée.
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UNIVERSITE JOSEPH FOURIER-GRENOBLE
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Je remercie le Dr Florence PRADEL e
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II.3 2. Les nouveaux vaccins……
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VI.3. La rougeole au Cameroun : Etu
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CHAPITRE I : LE VIRUS DE LA ROUGEOL
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I.Le virus de la rougeole 2. Classi
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I.Le virus de la rougeole 3. Struct
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I.Le virus de la rougeole 5. Cycle
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I.Le virus de la rougeole 5. Cycle
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Récepteur cellulaire Etat natif H
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I.Le virus de la rougeole 6. Pathol
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II. La vaccination 1. Les vaccins i
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II. La vaccination 2. Les vaccins v
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Figure 6 : Souches vaccinales utili
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II. La vaccination 3. Les nouvelles
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II. La vaccination 3. Les nouvelles
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II. La vaccination 4. Position actu
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CHAPITRE III. ETUDES EPIDEMIOLOGIQU
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III. Etudes épidémiologiques 1. I
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III. Etudes épidémiologiques 2. P
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III. Etudes épidémiologiques 4. R
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IV. Epidémiologie moléculaire du
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V. La rougeole en Afrique 1. La rou
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Figure 8: Répartition des cas de r
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VI. Etude des souches Africaines du
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VI.1.4. Article 1 : Adaptation des
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1506 NOTES J. VIROL. FIG. 1. MV inf
Page 93 and 94: 1508 NOTES J. VIROL. FIG. 3. Flow c
Page 95 and 96: VI. Etude des souches Africaines du
Page 97 and 98: Figure 9 : Répartition géographiq
Page 103 and 104: Measles virus strains circulating i
Page 105 and 106: In 1983, measles viruses isolated i
Page 107 and 108: obtained for the two 1983 isolates
Page 109 and 110: easons. The available data for meas
Page 111 and 112: Malvoisin E, Wild TF. 1990. Contrib
Page 113 and 114: 106 0.005 100 82 100 86 98 New York
Page 115 and 116: Table 1 : African measles strains u
Page 117 and 118: VI.3. LA ROUGEOLE AU CAMEROUN : ETU
Page 129 and 130: CHAPITRE VII. DISCUSSION 122
Page 131 and 132: VII. Discussion 1. Interaction viru
Page 133 and 134: VII. Discussion 1. Interaction viru
Page 135 and 136: VII. Discussion 2. Epidémiologie C
Page 137 and 138: VII. Discussion 2. Epidémiologie f
Page 139 and 140: CHAPITRE VIII. CONCLUSION ET PERSPE
Page 141 and 142: ANNEXES 134
Page 143: Consensus ATATCCATCA TGGGTCTCAA GGT
Page 147 and 148: Consensus ATGTCACCGC AACGAGACCG GAT
Page 149 and 150: Consensus MSPQRDRINA FYKDNPYPKG SRI
Page 151 and 152: Consensus MGLKVNVSAI FMAVLLTLQT PAG
Page 153 and 154: Aaby, P., Bukh, J., Lisse, I. M. &
Page 155 and 156: Bouteille, M., Fontaine C., Vedrenn
Page 157 and 158: Davenport, M. P., Quinn, C. L., Chi
Page 159 and 160: Foege, W. (1971). Measles vaccinati
Page 161 and 162: Griffin, D. E., Ward, B. J., Jaureg
Page 163 and 164: Holt, E. A., Moulton, L. H., Siberr
Page 165 and 166: Kok, P. W., Kenya, P. R. & Ensering
Page 167 and 168: Markowitz, L. E., Albrecht, P., Rho
Page 169 and 170: Norrby, E., Enders-Ruckles, G. & Me
Page 171 and 172: Poland, G. A., Jacobson, R. M., Col
Page 173 and 174: Siber, G. R., Werner, B. G., Halsey
Page 175 and 176: Truong, A. T., Mulders, M. N., Gaut
Page 177 and 178: WHO, World Health Organisation, Exp
Page 179 and 180: TABLE DES ILLUSTRATIONS Figure 1. R
Page 181: Abstract Despite the availability o
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