SOUCHES AFRICAINES DU VIRUS DE LA ROUGEOLE : ETUDE ...

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Consensus KVSSTLASEL GITAEDARLV SEIAMHTTED RISRAVGPRQ AQVSFLHGDQ 50 Trans of N CR83 .......... .......... .......... .......... .......... 50 Trans of N CR82 .......... .......... .......... .......... .......... 50 Trans of N CR72 .......... .......... .......... .......... .......... 50 Trans of N CR67 .......... .......... .......... .......... .......... 50 Consensus SENELPRLGG KEDRRVKQSR GEAGESHRET GPSRASDARA AHPPTGTPLD 100 Trans of N CR83 .......... .......... .......... .......... .......... 100 Trans of N CR82 .......... .......... .......... .......... .......... 100 Trans of N CR72 .......... .......... .......... .......... .......... 100 Trans of N CR67 .......... .......... .......... .......... .......... 100 Consensus IDTASEFSQD PQDSRRSADA LLRLQAMAGI SEEQDSDTDT PRVYNDRDLL 150 Trans of N CR83 .......... .......... .......... .......... .......... 150 Trans of N CR82 .......... .......... .......... .......... .......... 150 Trans of N CR72 .......... .......... .......... .......... .......... 150 Trans of N CR67 .......... .......... .......... .......... .......... 150 Consensus D 151 Trans of N CR83 . 151 Trans of N CR82 . 151 Trans of N CR72 . 151 Trans of N CR67 . 151 Annexe 5 (suite) : Comparaison des séquences de la partie C-terminale de la protéine N des souches CR67, CR72, CR82, CR83 isolées au Cameroun en 2001.
Consensus MSPQRDRINA FYKDNPYPKG SRIVINREHL MIDRPYVLLA VLFVMFLSLI GLLAIAGIRL HRAAIYTAEI HKSLS 75 Trans of HA CR67 .......... .......... .......... .......... .......... .......... .......... ..... 75 Trans of HA CR72 .......... .......... .......... .......... .......... .......... .......... ..... 75 Trans of HA B1 .......... .......... .......... .......... .......... .......... .......... ..... 75 Trans of HA Y14 .......... .......... .......... .......... .......... .......... .......... ..... 75 Trans of HA Y22 .......... .......... .......... .......... .......... .......... .......... ..... 75 Consensus TNLDVTNSIE HQVKDVLTPL FKIIGDEVGL RTPQRFTDLV KFISDKIKFL NPDREYDFRD LTWCINPPER IKLDY 150 Trans of HA CR67 .......... .......... .......... ......S... .......... .......... .......... ..... 150 Trans of HA CR72 .......... .......... .......... ......S... .......... .......... .......... ..... 150 Trans of HA B1 .......... .......... .......... .......... .......... .......... .......... ..... 150 Trans of HA Y14 .......... .......... .......... .......... .......... .......... .......... ..... 150 Trans of HA Y22 .......... .......... .......... .......... .......... .......... .......... ..... 150 Consensus DQYCADVAAE ELMNALVNST LLETRTTNQF LAVSKGNCSG PTTIRGQFSN MSLSLLDLYL GRGYNVSSIV TMTSQ 225 Trans of HA CR67 .......... .......... .......... .......... .......... .......... .......... ..... 225 Trans of HA CR72 .......... .......... .......... .......... .......... .......... .......... ..... 225 Trans of HA B1 .......... .......... .......... .......... .......... .......... .......... ..... 225 Trans of HA Y14 .......... .......... .......... .......... .......... .......... .......... ..... 225 Trans of HA Y22 .......... .......... .......... .......... .......... .......... .......... ..... 225 Consensus GMYGGTYLVE KPNLSSKGSE LSQLSMYRVF EVGVIRNPGL GAPVFHMTNY FEQPVSNDLG NCMVALGELK LAALC 300 Trans of HA CR67 .......... ....N..... .......... .......... .......... .......G.. .......... ..... 300 Trans of HA CR72 .......... ....N..... .......... .......... .......... .......G.. .......... ..... 300 Trans of HA B1 .......... .......... .......... .......... .......... .......... .......... ..... 300 Trans of HA Y14 .......... .......... .......... .......... .......... .......... .......... ..... 300 Trans of HA Y22 .......... .......... ..H....... .......... .......... .......... .......... ..... 300 Consensus HGEDSITIPY QGSGKGVSFQ LVKLGVWKSP TDMQSWVPLS TDDPVIDRLY LSSHRGVIAD NQAKWAVPTT RTDDK 375 Trans of HA CR67 ..D....... .......... .......... .......... .....V.... .......... .......... ..... 375 Trans of HA CR72 ..D....... .......... .......... .......... .....V.... .......... .......... ..... 375 Trans of HA B1 .......... .......... .......... .......... .......... .......... .......... ..... 375 Trans of HA Y14 .......... .......... .......... .......... .......... .......... .......... ..... 375 Trans of HA Y22 .......... .......... .......... .......... .......... .......... .......... ..... 375 Consensus LRMETCFQQA CKGKIQALCE NPEWAPLKDN RIPSYGVLSV DLSLTVELKI KIASGFGPLI THGSGMDLYK SNHNN 450 Trans of HA CR67 .......... .......... .......... .......... .......... .......... .......... ..R.. 450 Trans of HA CR72 .......... .......... .......... .......... .......... .......... .......... ..R.. 450 Trans of HA B1 .......... .......... .......... .......... .......... .......... .......... ..... 450 Trans of HA Y14 .......... .......... .......... .......... .......... .......... .......... ..... 450 Trans of HA Y22 .......... .......... .......... .......... .......... .......... .......... ..... 450 Consensus VYWLTIPPMR NLALGVINTL EWIPRFKVSP NLFTVPIKEA GEDCHAPTYL PAEVDGDVKL SSNLVILPGQ DLQYV 525 Trans of HA CR67 .......... .......... .......... .......... .......... .......... .......... ..... 525 Trans of HA CR72 .......... .......... .......... .......... .......... .......... .......... ..... 525 Trans of HA B1 .......... .......... .......... .......... .......... .......... .......... ..... 525 Trans of HA Y14 .......... .......... .......... .......... .......... .......... .......... ..... 525 Trans of HA Y22 .......... .......... .......... .......... .......... .......... .......... ..... 525 Consensus LATYDTSRVE HAVVYYVYSP SRSFSYFYPF RLPIKGVPIE LQVECFTWDQ KLWCRHFCVL ADSESGGHIT HSGMV 600 Trans of HA CR67 .......... .......... .......... .......... .......... .......... .......... ..... 600 Trans of HA CR72 .......... .......... .......... .......... .......... .......... .......... ..... 600 Trans of HA B1 .......... .......... G......... .......... .......... .......... .......... ..... 600 Trans of HA Y14 .......... .......... G......... .......... .......... .......... .......... ..... 600 Trans of HA Y22 .......... .......... .......... .......... .......... .......... .......... ..... 600 Consensus GMGVSCTATR EDGTNRR 617 Trans of HA CR67 .......... ....... 617 Trans of HA CR72 .......... ....... 617 Trans of HA B1 .......... ....... 617 Trans of HA Y14 .......... ....... 617 Trans of HA Y22 .......... ....... 617 Annexe 6: Comparaison des séquences des protéines HA des souches du Cameroun ; Y14 et Y22 (1983), CR67, CR72 (2001), B1 (référence clade B1).
Page 1 and 2:
UNIVERSITE JOSEPH FOURIER-GRENOBLE
Page 3 and 4:
Je remercie le Dr Florence PRADEL e
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II.3 2. Les nouveaux vaccins……
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VI.3. La rougeole au Cameroun : Etu
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CHAPITRE I : LE VIRUS DE LA ROUGEOL
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I.Le virus de la rougeole 2. Classi
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I.Le virus de la rougeole 3. Struct
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I.Le virus de la rougeole 5. Cycle
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I.Le virus de la rougeole 5. Cycle
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Récepteur cellulaire Etat natif H
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I.Le virus de la rougeole 6. Pathol
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II. La vaccination 1. Les vaccins i
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II. La vaccination 2. Les vaccins v
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Figure 6 : Souches vaccinales utili
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II. La vaccination 3. Les nouvelles
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II. La vaccination 3. Les nouvelles
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II. La vaccination 4. Position actu
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CHAPITRE III. ETUDES EPIDEMIOLOGIQU
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III. Etudes épidémiologiques 1. I
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III. Etudes épidémiologiques 2. P
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III. Etudes épidémiologiques 4. R
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IV. Epidémiologie moléculaire du
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V. La rougeole en Afrique 1. La rou
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Figure 8: Répartition des cas de r
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VI. Etude des souches Africaines du
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VI.1.4. Article 1 : Adaptation des
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1506 NOTES J. VIROL. FIG. 1. MV inf
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1508 NOTES J. VIROL. FIG. 3. Flow c
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Page 97 and 98: Figure 9 : Répartition géographiq
Page 99 and 100: VI. Etude des souches Africaines du
Page 103 and 104: Measles virus strains circulating i
Page 105 and 106: In 1983, measles viruses isolated i
Page 107 and 108: obtained for the two 1983 isolates
Page 109 and 110: easons. The available data for meas
Page 111 and 112: Malvoisin E, Wild TF. 1990. Contrib
Page 113 and 114: 106 0.005 100 82 100 86 98 New York
Page 115 and 116: Table 1 : African measles strains u
Page 117 and 118: VI.3. LA ROUGEOLE AU CAMEROUN : ETU
Page 129 and 130: CHAPITRE VII. DISCUSSION 122
Page 131 and 132: VII. Discussion 1. Interaction viru
Page 133 and 134: VII. Discussion 1. Interaction viru
Page 135 and 136: VII. Discussion 2. Epidémiologie C
Page 137 and 138: VII. Discussion 2. Epidémiologie f
Page 139 and 140: CHAPITRE VIII. CONCLUSION ET PERSPE
Page 141 and 142: ANNEXES 134
Page 143 and 144: Consensus ATATCCATCA TGGGTCTCAA GGT
Page 145 and 146: Consensus MTEIYDFDKS AWDIKGSIAP IQP
Page 147: Consensus ATGTCACCGC AACGAGACCG GAT
Page 151 and 152: Consensus MGLKVNVSAI FMAVLLTLQT PAG
Page 153 and 154: Aaby, P., Bukh, J., Lisse, I. M. &
Page 155 and 156: Bouteille, M., Fontaine C., Vedrenn
Page 157 and 158: Davenport, M. P., Quinn, C. L., Chi
Page 159 and 160: Foege, W. (1971). Measles vaccinati
Page 161 and 162: Griffin, D. E., Ward, B. J., Jaureg
Page 163 and 164: Holt, E. A., Moulton, L. H., Siberr
Page 165 and 166: Kok, P. W., Kenya, P. R. & Ensering
Page 167 and 168: Markowitz, L. E., Albrecht, P., Rho
Page 169 and 170: Norrby, E., Enders-Ruckles, G. & Me
Page 171 and 172: Poland, G. A., Jacobson, R. M., Col
Page 173 and 174: Siber, G. R., Werner, B. G., Halsey
Page 175 and 176: Truong, A. T., Mulders, M. N., Gaut
Page 177 and 178: WHO, World Health Organisation, Exp
Page 179 and 180: TABLE DES ILLUSTRATIONS Figure 1. R
Page 181: Abstract Despite the availability o
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