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4. Kinetik
36
Abbildung 4.1.: Postulierter Mechanismus der Benzaldehydlyase.
Hydroxybenzyl-ThDP, 4
ThDP (Ylid-Form), 1
( R)-2-HPP
S
H
O
C
O P 2O 6 3-
S
OH
N
O P 2O 6 3-
H
CH 3
N
CH 3
Pyr
O
Pyr
+
H
O
- H +
H
+ H +
+
-
H
O
O
3-
O P
S
2O6 ThDP (Ylid-Form), 1
ThDP
S
- H +
H
O P 2O 6 3-
N
CH 3
N
CH 3
+ H +
Pyr
Pyr
Pyr
Pyr
CH3 CH3 H O N
H O N
C
3-
O P C
3-
S
2O6 O P
S
2O6 Enamin Carbanion, 3
OH
-
+
H
O
O
OH
+
O
1,2-Dihydroxy-
1,2-Diphenylethyl-ThDP, 2
-
H
O
S
HO
C
O P 2O 6 3-
N
O
CH 3
Pyr