Effekt selektiver und nicht selektiver nichtsteroidaler Antiphlogistika ...

Summary
In the analysis an infiltration of neutrophils was found in the muscularis externa and
serosa of the injured jejunum samples after ischemia and reperfusion. Even the nonmanipulated
control samples showed a significant infiltration with neutrophils. This
indicates a inflammatory response of the whole bowl which needs to be investigated
in a future study. The esinophils were found only rarely and isolated in the muscularis
externa and serosa. That indicates an inferior role of eosinophils for the inflammation
reaction caused by ischemia and reperfusion. The COX-1 was expressed constitutive
in several strong characteristics in the circulare muscle of the muscularis externa of
the equine jejunum. COX-2 presented itself as an inducible enzyme through ischemia
and reperfusion. The expression in the muscularis was less than COX-1 and was
found particularly in the longitudinal muscle of the muscularis externa. Moreover, the
endothelial cells and very likely fibrocytes, as well as lymphocytes and macrophages
were similar to COX-1 and COX-2 positive. There was no significant difference
between the different flunixin meglumin und firocoxib samples regarding neither
neutrophils and eosinophils nor COX-1 and COX-2 producing cells.
The study showed that ischemia and reperfusion induce neutrophile inflammation in
the muscularis externa of the jejunum, even in non-manipulated control samples on
which the NSAIDs did not have an influence. Moreover, the study revealed a different
expression of COX-1 and COX-2 in the circulare and longitudinal muscle of the
muscularis externa, which was constitutive for the COX-1 and inducible for the
COX-2.
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