A systematic review of the effectiveness of adalimumab

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144 Appendix 3 TABLE 69 Studies excluded from clinical effectiveness review (cont’d) Citation Reason for exclusion/comment Ferraro-Peyret et al., 2004223 Non-randomised study investigating infliximab treatment and autoantibodies in RA and ankylosing spondylitis patients Genovese et al., 2001 224 Three-year outcomes from the extension of etanercept ERA trial in which patient no longer remained on randomised treatment. Abstract Genovese et al., 2002 225 Four-year outcomes from the extension of etanercept ERA trial in which patient no longer remained on randomised treatment. Abstract Genovese et al., 2003 226 Five-year outcomes from the extension of etanercept ERA trial in which patient no longer remained on randomised treatment. Abstract Gomez-Puerta et al., 2004 227 Observational study of using etanercept after treatment failure with infliximab with no control group Korczowska et al., 2003 228 Non-randomised study investigating infliximab treatment and bone turnover Kucharz et al., 2003 229 Non-randomised study investigating infliximab treatment and serum endostatin level Osborn, 2002 230 Abstract. Double-blind controlled study of single injection of intra-articular etanercept versus saline in RA patients. No mention of randomisation Saadeh et al., 2002 231 Non-randomised study investigating infliximab treatment and asthma control in RA patients. Abstract Smith et al., 2004 232 Case report of treating renal amyloidosis complicating RA with etanercept Yazici et al., 2001 233 Review articles Non-randomised study comparing the efficacy of etanercept with infliximab. Abstract Breedveld, 2001 234 Review of TNF blockade in RA Calin, 2003 235 Review of infliximab Muhlhauser, 2003 236 Review of etanercept (German) Pugsley, 2001 237 Review of etanercept Rashmi and Ujala, 2004 238 Review of novel therapeutic approach for RA Rau, 2002 239 Review of adalimumab treatment in RA Sautner, 2005 240 Review of adalimumab (German) Vervaeren, 2002 241 Review of new treatment in RA (French) Winning, 2001 242 Review of infliximab treatment in RA Yung, 2001 243 Review of etanercept News articles/commentaries/editorials Anonymous, 2003 244 Summary of adalimumab DE019 (German) Anonymous, 2004 245 News on Genovese et al., 2004 157 listed above, which compared the combination of anakinra and etanercept and etanercept alone Bain and Brazil, 2003 246 Commentary on adalimumab Becker, 2004 247 News article on adalimumab (German) Boers, 2001248 Letter. Commentary on ATTRACT Bruhn, 2002249 Commentary on adalimumab (German) Bruhn, 2004250 News article on TEMPO (German) Choy, 2004251 Editorial on combination therapy Cutolo, 2001252 Commentary on an etanercept RCT Czajka, 2001253 News article on ATTRACT (German) Haneveld, 2004254 News article on TEMPO (Dutch) Hellwig, 2003255 Commentary on adalimumab (German) Masche, 2003256 Commentary on adalimumab (German) Matucci-Cerinic, 2004257 Commentary on ARMADA Moreland, 2004258 Commentary on an infliximab RCT Moreland, 2004259 Commentary on an adalimumab RCT Rothschild, 2002260 Conference news report regarding TNF therapies continued
TABLE 69 Studies excluded from clinical effectiveness review (cont’d) Citation Reason for exclusion/comment Irrelevant (conference news reports; cost studies) Braddock, 2004 261 Conference news report Croasdell, 2003 262 Conference news report Evans, 2003 263 Conference news report Levy et al., 2004 264 Conference news report Oelke, 2002 265 Conference news report Trepman et al., 2003 266 Conference news report Yung, 2002 267 Conference news report van de Putte et al., 2002 268 Cost study for an adalimumab trial. Abstract EULAR, European League Against Rheumatism. © Queen’s Printer and Controller of HMSO 2006. All rights reserved. Health Technology Assessment 2006; Vol. 10: No. 42 145
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A systematic review of the effectiv
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A systematic review of the effectiv
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Objectives: This report reviews the
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Glossary and list of abbreviations
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viii Glossary and list of abbreviat
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Background Rheumatoid arthritis (RA
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increased risk of serious infection
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Summary RA is a common, chronic, in
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(IL-2) and interleukin-6 (IL-6), pr
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Assessment of response to DMARDs Re
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combination with methotrexate or al
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disease between clinic appointments
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14 Effectiveness in juvenile arthri
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16 Effectiveness adalimumab plus me
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18 Effectiveness Monoclonal Antibod
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20 TABLE 1 Description of included
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22 TABLE 2 Quality of included RCTs
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24 Effectiveness change in modified
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26 Effectiveness TABLE 4 Meta-analy
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28 Effectiveness Review: Adalimumab
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30 Effectiveness Review: Adalimumab
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32 TABLE 6 Effectiveness Descriptio
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34 TABLE 6 Effectiveness Descriptio
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36 TABLE 7 Effectiveness Quality of
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38 Effectiveness etanercept trials.
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40 Effectiveness TABLE 9 Summary of
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42 Effectiveness Review: Etanercept
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54 Effectiveness TABLE 11 Summary o
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56 TABLE 12 Description of included
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58 TABLE 13 Quality of included RCT
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60 Effectiveness per week and escal
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62 Effectiveness significant advant
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64 Effectiveness Review: Infliximab
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66 Effectiveness Review: Infliximab
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68 Effectiveness FIGURE 44 Malignan
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70 TABLE 17 Effectiveness Summary o
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Summary of review of existing econo
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TABLE 20 Summary of published ICERs
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TABLE 21 Published etanercept econo
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TABLE 23 Published economic analyse
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TABLE 25 Treatment sequences: adali
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management of RA, i.e. 1st and 2nd
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To estimate the long-term consequen
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TABLE 32 TNF inhibitors as last act
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TABLE 34 Basic structure of the mod
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een quit on grounds of toxicity, ad
Page 109 and 110: TABLE 39 Strategy set: adalimumab a
Page 111 and 112: TABLE 43 Beta distributions for HAQ
Page 113 and 114: TABLE 44 Early cessation of DMARDs:
Page 115 and 116: TABLE 46 Unit costs for tests and v
Page 117 and 118: following properties, according to
Page 119 and 120: TABLE 52 Base case: TNF inhibitors
Page 121 and 122: TABLE 54 Base case: TNF inhibitors
Page 123 and 124: TABLE 59 Third TNF inhibitor follow
Page 125 and 126: TABLE 65 Sensitivity analyses: TNF
Page 127 and 128: TABLE 67 Sensitivity analyses: TNF
Page 129: The substantial economic impact of
Page 133 and 134: Summary Effectiveness: principal fi
Page 135 and 136: inhibitors, although the incrementa
Page 137 and 138: introduce bias which generally exag
Page 139: Adalimumab, etanercept and inflixim
Page 143 and 144: 1. Jobanputra P, Barton P, Bryan S,
Page 145 and 146: 46. Young A, Dixey J, Cox N, Davies
Page 147 and 148: tumor necrosis factor therapy in th
Page 149 and 150: arthritis: a 12-week, double-blind,
Page 151 and 152: 171. Geborek P, Crnkic M, Petersson
Page 153 and 154: 216. Schotte H, Willeke P, Mickholz
Page 155 and 156: The Health Assessment Questionnaire
Page 157 and 158: Cochrane Library (CENTRAL) 2005 Iss
Page 159: Appendix 3 © Queen’s Printer and
Page 164 and 165: 148 Appendix 4 TABLE 71 Meta-analys
Page 166 and 167: 150 Appendix 4 TABLE 73 Meta-analys
Page 168 and 169: 152 Appendix 4 Infliximab versus pl
Page 170 and 171: 154 Appendix 4 Infliximab plus MTX
Page 173: Ovid MEDLINE(R) 1966 to February we
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Page 179 and 180: TABLE 79 Wong et al., 2002 161 © Q
Page 181 and 182: TABLE 80 Kobelt et al., 2003 162 (c
Page 183 and 184: TABLE 82 Brennan et al., 2004 160
Page 185 and 186: TABLE 83 Kobelt et al., 2004 163 (c
Page 187 and 188: TABLE 85 Bansback et al., 2005 166
Page 189: TABLE 86 Kobelt et al., 2005 167 (c
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Page 195 and 196: Extensive sensitivity analysis was
Page 197 and 198: TABLE 96 Variation 1: TNF inhibitor
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TABLE 117 Variation 6: TNF inhibito
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TABLE 132 Variation 10: TNF inhibit
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No. 25 A rapid and systematic revie
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246 Health Technology Assessment Pr
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