A systematic review of the effectiveness of adalimumab
A systematic review of the effectiveness of adalimumab
A systematic review of the effectiveness of adalimumab
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© Queen’s Printer and Controller <strong>of</strong> HMSO 2006. All rights reserved.<br />
Health Technology Assessment 2006; Vol. 10: No. 42<br />
TABLE 76 Meta-analyses: infliximab i.v. all doses versus placebo with ongoing MTX in MTX partial responders/non-responders,<br />
end <strong>of</strong> trial<br />
Comparison or outcome Studies N included Statistical method Effect size (95% CI)<br />
in analysis<br />
ACR20 responder 5111,133,137,138,140 ACR50 responder 5111,133,137,138,140 ACR70 responder 2111,133 RD ACR20 responder 5111,133,137,138,140 RD ACR50 responder 5111,133,137,138,140 RD ACR70 responder 2111,133 SJC, end <strong>of</strong> study result 2111,133 Patient’s global assessment, end <strong>of</strong> 2111,133 study result<br />
HAQ, mean change from baseline 2 111,133<br />
DAS28, end <strong>of</strong> study result 1140 Modified van de Heijde–Sharp score, 2133,140 mean change from baseline<br />
Withdrawal for any reasons 4 111,133,137,138<br />
Withdrawal due to lack <strong>of</strong> efficacy 3133,137,138 Withdrawal due to adverse events 5111,133,137,138,140 Death 2111,133 SAEs 2111,133 Malignancy: all 3111,133,137 Malignancy: skin cancer excluding 3111,133,137 melanoma<br />
Malignancy: all cancer excluding 3 111,133,137<br />
non-melanoma skin cancer<br />
Serious infection 4 111,133,137,138<br />
Any infection 2111,133 * Statistically significant result (p < 0.05).<br />
1555 RR (fixed) 2.50 (2.10 to 2.99)*<br />
1555 RR (fixed) 3.68 (2.72 to 4.98)*<br />
1448 RR (fixed) 3.79 (2.34 to 6.15)*<br />
1555 RD (fixed) 0.34 (0.29 to 0.39)*<br />
1555 RD (fixed) 0.24 (0.21 to 0.28)*<br />
1448 RD (fixed) 0.12 (0.09 to 0.14)*<br />
1401 WMD (fixed) –5.28 (–6.27 to –4.29)*<br />
1400 WMD (fixed) –1.60 (–1.91 to –1.29)*<br />
1381 WMD (fixed) –0.29 (–0.36 to –0.23)*<br />
24 WMD (fixed) –1.80 (–2.68 to –0.92)*<br />
373 WMD (fixed) –6.79 (–9.19 to –4.39)*<br />
1595 RR (random) 0.45 (0.16 to 1.28)<br />
513 RR (fixed) 0.27 (0.18 to 0.40)*<br />
1619 RR (fixed) 1.66 (0.97 to 2.82)<br />
1510 RR (fixed) 0.55 (0.16 to 1.81)<br />
1510 RR (fixed) 0.92 (0.67 to 1.27)<br />
1567 RR (fixed) 2.64 (0.62 to 11.26)<br />
1567 RR (fixed) 1.68 (0.31 to 9.04)<br />
1567 RR (fixed) 2.30 (0.40 to 13.17)<br />
1595 RR (fixed) 1.29 (0.72 to 2.31)<br />
1510 RR (random) [Commercial-inconfidence<br />
information<br />
removed]<br />
153