A systematic review of the effectiveness of adalimumab
A systematic review of the effectiveness of adalimumab
A systematic review of the effectiveness of adalimumab
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Appendix 10<br />
TABLE 107 Variation 4: TNF inhibitors third (early RA values) (100,000 patients)<br />
Option Cost (£) QSE QALYs QSE<br />
Adal 48,100 97 5.2549 0.0131<br />
Etan 60,598 117 5.5899 0.0135<br />
Adal+MTX 48,344 98 5.4002 0.0129<br />
Etan+MTX 60,707 118 5.6922 0.0135<br />
Infl+MTX 47,877 93 5.3595 0.0130<br />
Base 16,461 23 4.6139 0.0125<br />
Comparison Diff. cost (£) QSE Diff. QALY QSE<br />
Adal – Base 31,639 95 0.6409 0.0136<br />
Etan – Base 44,137 114 0.9759 0.0141<br />
Ad+M – Base 31,883 96 0.7863 0.0136<br />
Et+M – Base 44,246 115 1.0782 0.0142<br />
In+M – Base 31,415 91 0.7455 0.0135<br />
Ad+M – Adal 244 130 0.1454 0.0141<br />
Et+M – Etan 109 153 0.1023 0.0150<br />
Etan – Adal 12,498 142 0.3350 0.0145<br />
Et+M – Ad+M 12,363 142 0.2919 0.0145<br />
Ad+M – In+M 467 127 0.0408 0.0140<br />
Et+M – In+M 12,831 141 0.3327 0.0145<br />
Comparison ICER (£ per QALY) Quasi-CI<br />
Adal – Base 49,400 47,300 to 51,600<br />
Etan – Base 45,200 43,900 to 46,600<br />
Ad+M – Base 40,500 39,200 to 42,000<br />
Et+M – Base 41,000 40,000 to 42,200<br />
In+M – Base 42,100 40,600 to 43,700<br />
Ad+M – Adal Adal+MTX more effective than Adal alone; diff. cost not significant<br />
Et+M – Etan Etan+MTX more effective than Etan alone; diff. cost not significant<br />
Etan – Adal 37,300 34,200 to 41,000<br />
Et+M – Ad+M 42,400 38,400 to 47,200<br />
Ad+M – In+M 11,500 6,110 to 92,700<br />
Et+M – In+M 38,600 35,400 to 42,400<br />
TABLE 108 Variation 4: TNF inhibitors third (late RA values) (200,000 patients)<br />
Option Cost (£) QSE QALYs QSE<br />
Adal 47,417 68 4.5550 0.0092<br />
Etan 59,961 83 5.0714 0.0094<br />
Adal+MTX 47,781 69 4.8287 0.0091<br />
Etan+MTX 60,035 83 5.0689 0.0095<br />
Infl+MTX 47,068 66 4.5821 0.0092<br />
Base 16,382 16 4.6147 0.0088<br />
Comparison Diff. cost (£) QSE Diff. QALY QSE<br />
Adal – Base 31,034 67 –0.0596 0.0093<br />
Etan – Base 43,579 80 0.4568 0.0097<br />
Ad+M – Base 31,399 67 0.2141 0.0093<br />
Et+M – Base 43,652 81 0.4542 0.0097<br />
In+M – Base 30,686 64 –0.0325 0.0093<br />
Ad+M – Adal 364 90 0.2737 0.0093<br />
Et+M – Etan 73 107 –0.0025 0.0101<br />
Etan – Adal 12,545 99 0.5164 0.0097<br />
Et+M – Ad+M 12,254 100 0.2402 0.0098<br />
In+M – Ad+M 713 89 0.2466 0.0094<br />
Et+M – In+M 12,967 98 0.4867 0.0098<br />
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