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• Dental sealants have proved 100-percent effective<br />

in protecting the chewing surfaces <strong>of</strong> children’s<br />

molars and premolars, where most<br />

cavities occur.<br />

• In 1990, <strong>NIH</strong> researchers performed the first<br />

trial <strong>of</strong> gene therapy in humans. Scientists are<br />

increasingly able to locate, identify, and describe<br />

the functions <strong>of</strong> many <strong>of</strong> the genes in the human<br />

genome. The ultimate goal is to develop screening<br />

tools and gene therapies for cancer and<br />

many other diseases.<br />

<strong>NIH</strong> Research in the 21st Century<br />

<strong>NIH</strong> has enabled scientists to learn much since its<br />

humble beginnings. But many discoveries remain<br />

to be made:<br />

• Better ways to prevent and treat cancer, heart disease,<br />

stroke, blindness, arthritis, diabetes, kidney<br />

diseases, Alzheimer’s disease, communication<br />

disorders, mental illness, drug abuse and alcoholism,<br />

AIDS, and other unconquered diseases.<br />

• Ways to continue improving the health <strong>of</strong><br />

infants and children, women, and minorities.<br />

• Better ways to understand the aging process,<br />

and behavior and lifestyle practices that affect<br />

health.<br />

These are some <strong>of</strong> the areas where the <strong>NIH</strong>’s<br />

investment in health research promises to yield the<br />

greatest good for the greatest number <strong>of</strong> people.<br />

For more about <strong>NIH</strong> visit its Web site at<br />

http://www.nih.gov.<br />

145<br />

Appendix I

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