C - Michigan Technological University

More documents

Recommendations

Info

mammalian hibernators and other stress-tolerant vertebrates. Apoptosis, 2010.15(3): p. 386-99.164. Cai, D., et al., Akt phosphorylation and kinase activity are down-regulated duringhibernation in the 13-lined ground squirrel. Brain Res, 2004. 1014(1-2): p. 14-21.165. Eddy, S.F. and K.B. Storey, Differential expression of Akt, PPARgamma, andPGC-1 during hibernation in bats. Biochem Cell Biol, 2003. 81(4): p. 269-74.166. Hillion, J.A., et al., Involvement of Akt in preconditioning-induced tolerance toischemia in PC12 cells. J Cereb Blood Flow Metab, 2006. 26(10): p. 1323-31.167. Kops, G.J., et al., Forkhead transcription factor FOXO3a protects quiescent cellsfrom oxidative stress. Nature, 2002. 419(6904): p. 316-21.168. Sato, T., et al., Testicular dynamics in Syrian hamsters exposed to both shortphotoperiod and low ambient temperature. Anat Histol Embryol, 2005. 34(4): p.220-4.169. Cerri, S., et al., Cell proliferation and death in the brain of active and hibernatingfrogs. J Anat, 2009. 215(2): p. 124-31.170. Hassager, C., et al., The carboxy-terminal pyridinoline cross-linked telopeptide oftype I collagen in serum as a marker of bone resorption: the effect of nandrolonedecanoate and hormone replacement therapy. Calcif Tissue Int, 1994. 54(1): p.30-3.171. Eriksen, E.F., et al., Serum markers of type I collagen formation and degradationin metabolic bone disease: correlation with bone histomorphometry. J BoneMiner Res, 1993. 8(2): p. 127-32.172. Sadowski, J.A., et al., Phylloquinone in plasma from elderly and young adults:factors influencing its concentration. Am J Clin Nutr, 1989. 50(1): p. 100-8.173. Donahue, S.W., et al., Hibernating bears as a model for preventing disuseosteoporosis. J Biomech, 2006. 39(8): p. 1480-8.174. McGee, M.E., et al., Black bear femoral geometry and cortical porosity are notadversely affected by ageing despite annual periods of disuse (hibernation). JAnat, 2007. 210(2): p. 160-9.175. Zerwekh, J.E., et al., The effects of twelve weeks of bed rest on bone histology,biochemical markers of bone turnover, and calcium homeostasis in elevennormal subjects. J Bone Miner Res, 1998. 13(10): p. 1594-601.176. Shackelford, L.C., et al., Resistance exercise as a countermeasure to disuseinducedbone loss. J Appl Physiol, 2004. 97(1): p. 119-29.177. Loken, H.F., et al., Ultracentrifugal analysis of protein-bound and free calcium inhuman serum. J Biol Chem, 1960. 235: p. 3654-8.148
178. Toribara, T.Y., A.R. Terepka, and P.A. Dewey, The ultrafiltrable calcium ofhuman serum. I. Ultrafiltration methods and normal values. J Clin Invest, 1957.36(5): p. 738-48.179. Katz, S. and I.M. Klotz, Interactions of calcium with serum albumin. ArchBiochem Biophys, 1953. 44(2): p. 351-61.180. Pittas, A.G., et al., Association between serum osteocalcin and markers ofmetabolic phenotype. J Clin Endocrinol Metab, 2009. 94(3): p. 827-32.181. Kindblom, J.M., et al., Plasma osteocalcin is inversely related to fat mass andplasma glucose in elderly Swedish men. J Bone Miner Res, 2009. 24(5): p. 785-91.182. Fernandez-Real, J.M., et al., The relationship of serum osteocalcin concentrationto insulin secretion, sensitivity, and disposal with hypocaloric diet and resistancetraining. J Clin Endocrinol Metab, 2009. 94(1): p. 237-45.183. Im, J.A., et al., Relationship between osteocalcin and glucose metabolism inpostmenopausal women. Clin Chim Acta, 2008. 396(1-2): p. 66-9.184. Shea, M.K., et al., Gamma-carboxylation of osteocalcin and insulin resistance inolder men and women. Am J Clin Nutr, 2009. 90(5): p. 1230-5.185. Saleem, U., T.H. Mosley, Jr., and I.J. Kullo, Serum osteocalcin is associated withmeasures of insulin resistance, adipokine levels, and the presence of metabolicsyndrome. Arterioscler Thromb Vasc Biol, 2010. 30(7): p. 1474-8.186. Richards, J.B., et al., Serum adiponectin and bone mineral density in women. JClin Endocrinol Metab, 2007. 92(4): p. 1517-23.187. Shetty, S., C.M. Kusminski, and P.E. Scherer, Adiponectin in health and disease:evaluation of adiponectin-targeted drug development strategies. TrendsPharmacol Sci, 2009. 30(5): p. 234-9.188. Sibilia, V., et al., Linking chronic tryptophan deficiency with impaired bonemetabolism and reduced bone accrual in growing rats. J Cell Biochem, 2009.107(5): p. 890-8.189. Nomura, S., et al., 5-HT2A receptor antagonist increases circulating adiponectinin patients with type 2 diabetes. Blood Coagul Fibrinolysis, 2005. 16(6): p. 423-8.190. Uchida-Kitajima, S., et al., 5-Hydroxytryptamine 2A receptor signaling cascademodulates adiponectin and plasminogen activator inhibitor 1 expression inadipose tissue. FEBS Lett, 2008. 582(20): p. 3037-44.191. Wade, J.M., et al., Synergistic impairment of glucose homeostasis in ob/ob micelacking functional serotonin 2C receptors. Endocrinology, 2008. 149(3): p. 955-61.149
Page 1 and 2:
EXPLORATION OF THE ROLE OF SERUM FA
Page 3 and 4:
Table of contentsIndex of Figures .
Page 5 and 6:
Chapter Four - Attempts to find an
Page 7 and 8:
Index of figures1.1. Simplified sch
Page 9 and 10:
6.17. Longitudinal analysis of OPG
Page 11 and 12:
6.49. Longitudinal analysis of ColI
Page 13 and 14:
A.2. Complete list of BSALP correla
Page 15 and 16:
List of abbreviationsα-MEM. Alpha-
Page 17 and 18:
PCR. Polymerase chain reactionPer1
Page 19 and 20:
G2/M checkpoint. The point in the c
Page 21 and 22:
Species names13-lined ground squirr
Page 23 and 24:
Chapter One - Background and signif
Page 25 and 26:
1.3 Bone turnover is unbalanced dur
Page 27 and 28:
pro-apoptosis regulator BAX. An imp
Page 29 and 30:
low-dose administration of parathyr
Page 31 and 32:
decrease in bone trabecular thickne
Page 33 and 34:
experience periodic arousals in whi
Page 35 and 36:
ears must have evolved a mechanism
Page 37 and 38:
1.7.6 Hypothesis 2: OCN interacts w
Page 39 and 40:
ain, heart, and femoral muscle of h
Page 41 and 42:
Hypothesis 3a: Serum concentrations
Page 44:
were released. Behavior indicating
Page 47 and 48:
2.3 ResultsSerum activity of the bo
Page 49 and 50:
(p
Page 51 and 52:
post-hibernation sampling in the be
Page 53 and 54:
also unclear whether ucOCN may affe
Page 55 and 56:
atios of intact to fragmented OCN m
Page 57 and 58:
Table 2.3—Bone marker “seasonal
Page 59 and 60:
Table 2.7—Chemistry panel “seas
Page 61 and 62:
ABNormalized BSALPBSALP (U/L)CO N D
Page 63 and 64:
Total Calcium (mg/dL)A1.21.151.11.0
Page 65 and 66:
ABTotal OCN (ng/mL)150100500O N D J
Page 67 and 68:
Adiponectin (ng/mL)AB40003500300025
Page 69 and 70:
ABNormalized InsulinInsulin (μU/mL
Page 71 and 72:
surrounding and encompassing hibern
Page 73 and 74:
decreased from 788+30 ng/mL in preh
Page 75 and 76:
120-122]. Most small hibernators ar
Page 77 and 78:
ears. Similarly, serum NPY increase
Page 79 and 80:
Table 3.2—Serum factor longitudin
Page 81 and 82:
Leptin (ng/mL)ABO N D J F M A M O N
Page 83 and 84:
Norepinephrine (ng/mL)A807060504030
Page 85 and 86:
IGF‐1 (ng/mL)AN D J F M A MB10009
Page 87 and 88:
2008. Samples were collected as des
Page 89 and 90:
sampling points. It is possible to
Page 91 and 92:
C‐Terminal PTH (Relative)AB504030
Page 93 and 94:
Chapter Five — Serum from hiberna
Page 95 and 96:
Synergy HT Multi-Detection Micropla
Page 97 and 98:
gene specific primers and 12.5 μL
Page 99 and 100:
involved in the reduced caspase-3/7
Page 101 and 102:
hibernation cycles without problem
Page 103 and 104:
filtered seasonal bear serum and fo
Page 105 and 106:
which is dependent upon caspase-3 a
Page 107 and 108:
Caspase‐3/7 ActivityO N D J F M A
Page 109 and 110:
6Caspase‐3/7 Activity54321**0Vehi
Page 111 and 112:
ABCaspase‐3/7 Activity9876543210*
Page 113 and 114:
eyond the G1/S checkpoint, thus ind
Page 115 and 116:
ears, it is possible that tissue se
Page 117 and 118:
PTH1R, RANKL, Runx2, Smurf1, TLR4,
Page 119 and 120: factors Runx2 and OCN also increase
Page 121 and 122: Table 6.3—Gene expression 3 hour
Page 123 and 124: Table 6.5—Gene expression 6 day d
Page 125 and 126: Cyclin D1 Gene ExpressionO N D J F
Page 127 and 128: Smurf1 Gene ExpressionO N D J F M A
Page 129 and 130: BAK Gene ExpressionO N D J F M A MM
Page 131 and 132: M‐CSF Gene ExpressionO N D J F M
Page 133 and 134: Per1 Gene ExpressionO N D J F M A M
Page 135 and 136: Akt Gene ExpressionO N D J F M A MM
Page 137 and 138: Bcl‐2 Gene ExpressionO N D J F M
Page 139 and 140: Cyclin D1 Gene ExpressionO N D J F
Page 141 and 142: OPN Gene ExpressionO N D J F M A MM
Page 143 and 144: 2PTH1R Gene Expression1.510.50O N D
Page 145 and 146: TLR4 Gene ExpressionO N D J F M A M
Page 147 and 148: Bcl‐2 Gene ExpressionO N D J F M
Page 149 and 150: OCN Gene ExpressionO N D J F M A MM
Page 151 and 152: PTH1R Gene ExpressionO N D J F M A
Page 153 and 154: TLR4 Gene ExpressionO N D J F M A M
Page 155 and 156: condition in renal patients in whic
Page 157 and 158: hibernation. This report brings to
Page 159 and 160: 14. Kaneps, A.J., S.M. Stover, and
Page 161 and 162: 41. Chowdhury, I., B. Tharakan, and
Page 163 and 164: 68. Ashe, M.C., et al., Bone geomet
Page 165 and 166: 95. Perrien, D.S., et al., Aging al
Page 167 and 168: 122. Lesser, R.W., et al., Renal re
Page 169: 151. Confavreux, C.B., R.L. Levine,
Page 173 and 174: 206. Luo, X.H., et al., Adiponectin
Page 175 and 176: 233. Florant, G.L., et al., Fat-cel
Page 177 and 178: 259. Bhasin, S., et al., Older men
Page 179 and 180: 284. Miura, M., et al., A crucial r
Page 181 and 182: Appendix A—Complete tables of cor
Page 183 and 184: Table A.5—Complete list of ionize
Page 185 and 186: Table A.7—Complete list of adipon
Page 187 and 188: Table A.12—Complete list of norep
show all

C - Michigan Technological University

Create successful ePaper yourself

Delete template?

Save as template?