Bipolar Disorders: Mixed States, Rapid-Cycling, and Atypical Forms

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10 A. Marneros and F. K. GoodwinFig. 1.5 The first book in psychiatric literature on mixed states (Weygandt, 1899).
11 Beyond major depression and euphoric maniaFig. 1.6 Wilhelm Weygandt (1870–1939).not use the term ‘‘mixed states’’ per se in 1893; rather he noted that ‘‘the cases aremixed’’ (pp. 366–7). But even before the first use of the term ‘‘mixed states’’ in1896, Kraepelin described ‘‘manic stupor’’ (1893, pp. 366–7), later characterized byhim as the most convincing type of mixed state (1899, p. 396). In the finaldescription of mixed states (eighth edition of the handbook in 1913,pp. 1284–303), Kraepelin defined six types (Table 1.2).Although Kraepelin, as the one who clarified and systematized previous observations,is undoubtedly the definer of the concept, the work of Wilhelm Weygandt(Fig. 1.6) makes it difficult to distinguish the respective roles of the two men withregard to the development of the final concept. It is, however, beyond any doubtthat the clarification of former views, the systematic descriptions, and theoreticalformulations are the work of Kraepelin. Mixed states belonged to the core ofKraepelin’s ‘‘manic-depressive insanity’’ (Koukopoulos and Koukopoulos, 1999;Marneros, 1999; Marneros and Angst, 2000; Angst and Marneros, 2001). However,
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Page 5 and 6: Bipolar DisordersMixed States, Rapi
Page 7 and 8: ContentsList of contributorsPreface
Page 9 and 10: ContributorsValadeta Ajdacic PhDPsy
Page 11 and 12: ixList of contributorsAlexia E. Kou
Page 13: PrefaceBipolar disorders have a lon
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3Rapid-cycling bipolar disorder1 2O
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63 Rapid-cycling bipolar disorderPs
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65 Rapid-cycling bipolar disorderOn
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67 Rapid-cycling bipolar disorderBr
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69 Rapid-cycling bipolar disorderin
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71 Rapid-cycling bipolar disorderLa
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73 Rapid-cycling bipolar disorderre
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75 Rapid-cycling bipolar disorderCo
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77 Rapid-cycling bipolar disorderDe
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79 Rapid-cycling bipolar disorderan
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81 Rapid-cycling bipolar disorderTa
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83 Rapid-cycling bipolar disorderRE
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85 Rapid-cycling bipolar disorderJo
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87 Rapid-cycling bipolar disorderde
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89 Bipolar I and bipolar II: a dich
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101 Bipolar I and bipolar II: a dic
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5Recurrent brief depression as an i
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111 Recurrent brief depressionRecur
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113 Recurrent brief depressionbeen
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115 Recurrent brief depressioncorre
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117 Recurrent brief depressionThere
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Chronic 4.8 18.2 9.1 10 NCRapid-cyc
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121 Recurrent brief depressionTable
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123 Recurrent brief depressionPreva
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125 Recurrent brief depressionWe fo
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127 Recurrent brief depressionREFER
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129 Recurrent brief depressionMarne
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6Atypical depression and its relati
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133 Atypical depression and bipolar
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7Agitated depression: spontaneous a
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159 Agitated depression: spontaneou
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8Schizoaffective mixed statesAndrea
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189 Schizoaffective mixed statescon
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191 Schizoaffective mixed stateswas
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193 Schizoaffective mixed statesUni
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195 Schizoaffective mixed statesTab
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197 Schizoaffective mixed statesday
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199 Schizoaffective mixed statesTot
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201 Schizoaffective mixed statesBip
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203 Schizoaffective mixed statesThe
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205 Schizoaffective mixed statesMar
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9Acute and transient psychotic diso
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209 Acute and transient psychotic d
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Table 9.10 (cont.)ATPD(n ¼ 39)Bipo
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Table 9.11 (cont.)Bipolar affective
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Table 9.14b Significant differences
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10Bipolar disorder in children and
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239 Bipolar disorder in children an
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Pellegrini et al. (1986) 16 23 (7-1
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253 Atypical features of bipolarity
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12Comorbidity in mixed states and r
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265 Comorbidity in mixed states and
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13Challenges in the genetics of bip
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279 Challenges in the genetics of b
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Table 13.1 Proportion of first-degr
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Table 13.3 Summary of recent bipola
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13q32 = 3.321q22 = 3.6Liu, C.et al.
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14Biological aspects of rapid cycli
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313 Rapid cycling and mixed statesa
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315 Rapid cycling and mixed statesa
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317 Rapid cycling and mixed statesi
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319 Rapid cycling and mixed statesC
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321 Rapid cycling and mixed statesJ
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323 Rapid cycling and mixed statesW
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325 The treatment of bipolar mixed
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16The use of atypical antipsychotic
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355 Use of atypical antipsychotic a
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17Investigational strategies: treat
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371 Investigational strategiesBIPOL
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373 Investigational strategiesinsta
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375 Investigational strategiesWhat
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377 Investigational strategiesTable
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379 Investigational strategiescateg
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381 Investigational strategiesTable
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383 Investigational strategies2. Th
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385 Investigational strategiesSachs
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387 Indexclinical course and outcom
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389 Indexdepressive mixed states 51
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391 IndexLange, J. 163learning disa
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393 Indexpsychopharmacological revo
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395 Indexmania, acute 334mixed stat
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Bipolar Disorders: Mixed States, Rapid-Cycling, and Atypical Forms

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