Bipolar Disorders: Mixed States, Rapid-Cycling, and Atypical Forms

Table 10.3 High-risk studies (only those with offspring < 18 years old)AuthorBPDparents:sample sizeBPD-offspring:sample size(ages)Controloffspring(parent’sclinical status) Follow-upStandardizedinterview:offspring/directinterviewsFamilyStandardized history/blindinterview: interviews/parents/spouse psychosocialdiagnosis. a assessmentMcKnew et al. (1979) 13 30 (5–15) N Once(4 monthslater)Conners et al. (1979) 59unipolar+ bipolarN/Y Y/N N/Y/N130 (ages ?) N N N/N Y/N N/N/NWaters andMarchenko-Bauer(1980) 16 50 (> 15) N N Y/Y Y/Y N/N/NCytryn et al. (1982) 13 19 (5–13) 21 (‘‘normal’’?) N N/Y Y/N N/Y/NDecina et al. (1983) 31 24 (7–14) 18 (‘‘normal’’ ?) N N/? N/N N/N/NKuyler et al. (1980) 49 49 (6–18) N N N/N Y/Y N/N/NZahn-Waxler et al.(1984) 77 (1–2.5years old) 20 (‘‘normal’’?)Once(2.5 yearsold)Labobservation Y N/N/NKashani et al. (1985) 5 9 (7–17) 41 (unipolar) N Y/Y ?/Y N/Y/NLaRoche et al. (1985) 22 39 (5–18) N N N/Y Y/N N/?/YGershon et al. (1985) 20 29 (6–17) 37 (‘‘normal’’) N Y/Y Y/Y N/Y/NKlein et al. (1985) 24 37 (15–21) 22 (psychiatric) N Y/ Y/Y N/Y/N