Bipolar Disorders: Mixed States, Rapid-Cycling, and Atypical Forms

306 K. Merikangas and K. YuMerikangas, K. R., Avenevoli, S., Acharyya, S., Zhang, H., and Angst, J. (2002a). The spectrum ofsocial phobia in the Zurich cohort study of young adults. Biol. Psychiatry, 51, 81–91.Merikangas, K. R., Chakravarti, A., Moldin, S. O., et al. (2002b). Future of genetics of mooddisorders research: workgroup on genetics for NIMH strategic plan for mood disorders.Biol. Psychiatry, 52, 457–77.Moldin, S. O. (1997). Detection and replication of linkage to a complex human disease. Genet.Epidemiol., 14, 1023–8.Morissette, J., Villeneuve, A., Bordeleau, L., et al. (1999). Genome-wide search for linkage ofbipolar affective disorders in a very large pedigree derived from a homogeneous population inQuebec points to a locus of major effect on chromosome 12q23–q24. Am. J. Med. Genet.,88, 567–87.Morton, N. E. (1955). Sequential tests for the detection of linkage. Am. J. Hum. Genet., 7, 277.Murray, C. J. L. and Lopez, A. D. (1996). The Global Burden of Disease and Injury Series, vol. 1.A Comprehensive Assessment of Mortality and Disability from Diseases, Injuries and Risk Factorsin 1990 and Projected to 2020. Cambridge, MA: Harvard School of Public Health on behalf ofthe World Health Organization and the World Bank, Harvard University Press.Murray, K. T. and Sines, J. O. (1996). Parsing the genetic and nongenetic variance in children’sdepressive behavior. J. Affect. Disord., 38, 23–34.National Institute of Mental Health Research Roundtable on Prepubertal Bipolar Disorder(2001). J. Am. Acad. Child Adolesc. Psychiatry, 40, 871–8.Neuman, R. J., Geller, B., Rice, J. P., and Todd, R. D. (1997). Increased prevalence and earlieronset of mood disorders among relatives of prepubertal versus adult probands. J. Am. Acad.Child Adolesc. Psychiatry, 36, 466–73.Nöthen, M. M., Cichon, S., Rohleder, H., et al. (1999). Evaluation of linkage of bipolar affectivedisorder to chromosome 18 in a sample of 57 German families. Mol. Psychiatry, 4, 76–84.Nurnberger, J. I. Jr., Guroff, J. J., Hamovit, J., Berrettini, W., and Gershon, E. S. (1988). A familystudy of rapid-cycling bipolar illness. J. Affect. Disord., 15, 87–91.O’Connor, T. G., Neiderhiser, J. M., Neiderhiser, D. R., Hetherington, E. M., and Plomin, R.(1998). Genetic contributions to continuity, change and co-occurrence of antisocial anddepressive symptoms in adolescence. J. Child Psychol. Psychiatry, 39, 323–36.Ohara, K., Nagai, M., Tsukamoto, T., et al. (1998a). Functional polymorphism in the serotonintransporter promoter at the SLC6A4 locus and mood disorders. Biol. Psychiatry, 44, 550–4.Ohara, K., Nagai, M., Suzuki, Y., and Ohara, K. (1998b). Low activity allele of catechol-omethyltransferasegene and Japanese unipolar depression. Neuroreport, 9, 1305–8.Omenn, G. S. and Motulsky, A. G. (1978). Ecogenetics. Genetic variation in susceptibilityto environmental agents. In Genetic Issues in Public Health and Medicine, ed. B. H. Cohen,A. M. Lilienfeld, and P. C. Huang, pp. 83–111. Springfield, IL: Thomas.Ottman, R. (1995). Gene–environment interaction and public health. Am.J.Hum.Genet., 56,821–3.Pages, K. P. and Dunner, D. L. (1997) Focus on dysthymic disorder and chronic depressions.In The Psychiatric Clinics of North America Annual of Drug Therapy, ed. D. L. Dunner andJ. F. Rosenbaum, pp. 91–109. Philadelphia, PA: Saunders.Parker, G. (1979). Parental characteristics in relation to depressive disorders. Br. J. Psychiatry,134, 138–47.