Bipolar Disorders: Mixed States, Rapid-Cycling, and Atypical Forms

Table 13.1 Proportion of first-degree relatives of bipolar (BP) and major depressive disorder probands with a lifetime history of bipolar and majordepressive disorderRates/100 subtype in relatives by proband subtypeStudy Probands (n) Relatives (n) BP–BP BP–UP UP–BP UP–UP Control–BP Control–UPGershon et al. (1975) Bipolar 54 411 19.6 11.5 11.0 20.1 0.2 0.5Unipolar 16 113Controls 75 619Gershon et al. (1982) Bipolar 130 739 21.9 2.6 8.0 3.0 0.4 5.7Unipolar 30 166Controls 43 265Weissman et al. (1984b) Unipolar 133 810 1.5 3.2 1.5 4.1Controls 82 591Tsuang et al. (1985) Bipolar 100 230 21.2 1.9 11.9 2.3 0.2 4.8Unipolar 225 500Controls 160 543Heun and Maier (1993) Bipolar 80 504 7.1 17.1 1.3 19.0 0.9 7.7Unipolar 108 306Controls 80 221Total rates/100 6.2 12.2 2.2 13.6 0.6 3.8Relative risk (versus control) 10.3 3.2 3.5 3.6UP, unipolar.Ratio weighted for sample size.